LOCUS       NM_017292               1757 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus gamma-aminobutyric acid type A receptor subunit
            rho 2 (Gabrr2), mRNA.
ACCESSION   NM_017292
VERSION     NM_017292.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1757)
  AUTHORS   Mejia,C., Garcia-Alcocer,G., Berumen,L.C., Rosas-Arellano,A.,
            Miledi,R. and Martinez-Torres,A.
  TITLE     Expression of GABArho subunits during rat cerebellum development
  JOURNAL   Neurosci Lett 432 (1), 1-6 (2008)
   PUBMED   18201822
  REMARK    GeneRIF: The expression of GABA(C) receptors in the cerebellum adds
            a new dimension to the regulation of GABAergic neurotransmission
REFERENCE   2  (bases 1 to 1757)
  AUTHORS   Alakuijala,A., Alakuijala,J. and Pasternack,M.
  TITLE     Evidence for a functional role of GABA receptors in the rat mature
            hippocampus
  JOURNAL   Eur J Neurosci 23 (2), 514-520 (2006)
   PUBMED   16420458
REFERENCE   3  (bases 1 to 1757)
  AUTHORS   Ma,D.Q., Whitehead,P.L., Menold,M.M., Martin,E.R.,
            Ashley-Koch,A.E., Mei,H., Ritchie,M.D., Delong,G.R., Abramson,R.K.,
            Wright,H.H., Cuccaro,M.L., Hussman,J.P., Gilbert,J.R. and
            Pericak-Vance,M.A.
  TITLE     Identification of significant association and gene-gene interaction
            of GABA receptor subunit genes in autism
  JOURNAL   Am J Hum Genet 77 (3), 377-388 (2005)
   PUBMED   16080114
REFERENCE   4  (bases 1 to 1757)
  AUTHORS   Alakuijala,A., Palgi,M., Wegelius,K., Schmidt,M., Enz,R.,
            Paulin,L., Saarma,M. and Pasternack,M.
  TITLE     GABA receptor rho subunit expression in the developing rat brain
  JOURNAL   Brain Res Dev Brain Res 154 (1), 15-23 (2005)
   PUBMED   15617751
  REMARK    GeneRIF: GABA(C) receptors are specifically involved in aspects of
            visual image motion processing in the rat brain.
REFERENCE   5  (bases 1 to 1757)
  AUTHORS   Burman,K.J., Ige,A.O., White,J.H., Marshall,F.H., Pangalos,M.N.,
            Emson,P.C., Minson,J.B. and Llewellyn-Smith,I.J.
  TITLE     GABAB receptor subunits, R1 and R2, in brainstem catecholamine and
            serotonin neurons
  JOURNAL   Brain Res 970 (1-2), 35-46 (2003)
   PUBMED   12706246
  REMARK    GeneRIF: The proportion of neurons in the brainstem with
            immunoreactivity for the GABA(B)R2 subunit included catecholamine
            and serotonin neurons.
REFERENCE   6  (bases 1 to 1757)
  AUTHORS   Croci,C., Brandstatter,J.H. and Enz,R.
  TITLE     ZIP3, a new splice variant of the PKC-zeta-interacting protein
            family, binds to GABAC receptors, PKC-zeta, and Kv beta 2
  JOURNAL   J Biol Chem 278 (8), 6128-6135 (2003)
   PUBMED   12431995
REFERENCE   7  (bases 1 to 1757)
  AUTHORS   McCall,M.A., Lukasiewicz,P.D., Gregg,R.G. and Peachey,N.S.
  TITLE     Elimination of the rho1 subunit abolishes GABA(C) receptor
            expression and alters visual processing in the mouse retina
  JOURNAL   J Neurosci 22 (10), 4163-4174 (2002)
   PUBMED   12019334
REFERENCE   8  (bases 1 to 1757)
  AUTHORS   Didelon,F., Sciancalepore,M., Savic',N., Mladinic',M., Bradbury,A.
            and Cherubini,E.
  TITLE     gamma-Aminobutyric acidA rho receptor subunits in the developing
            rat hippocampus
  JOURNAL   J Neurosci Res 67 (6), 739-744 (2002)
   PUBMED   11891787
  REMARK    GeneRIF: The rho1 and rho2 products appeared to be developmentally
            regulated; they were found to be more pronounced in adulthood.
REFERENCE   9  (bases 1 to 1757)
  AUTHORS   Zhang,D., Pan,Z.H., Zhang,X., Brideau,A.D. and Lipton,S.A.
  TITLE     Cloning of a gamma-aminobutyric acid type C receptor subunit in rat
            retina with a methionine residue critical for picrotoxinin channel
            block
  JOURNAL   Proc Natl Acad Sci U S A 92 (25), 11756-11760 (1995)
   PUBMED   8524843
REFERENCE   10 (bases 1 to 1757)
  AUTHORS   Ogurusu,T., Taira,H. and Shingai,R.
  TITLE     Identification of GABAA receptor subunits in rat retina: cloning of
            the rat GABAA receptor rho 2-subunit cDNA
  JOURNAL   J Neurochem 65 (3), 964-968 (1995)
   PUBMED   7643126
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Aug 30, 2012 this sequence version replaced NM_017292.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D38494.1, SRR26360194.15330.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760475
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            RefSeq Select criteria           :: based on computational evidence
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-281               JAXUCZ010000005.1  52248478-52248758
            282-388             JAXUCZ010000005.1  52257058-52257164
            389-456             JAXUCZ010000005.1  52265728-52265795
            457-680             JAXUCZ010000005.1  52269242-52269465
            681-763             JAXUCZ010000005.1  52270200-52270282
            764-904             JAXUCZ010000005.1  52270441-52270581
            905-1057            JAXUCZ010000005.1  52273656-52273808
            1058-1254           JAXUCZ010000005.1  52274847-52275043
            1255-1757           JAXUCZ010000005.1  52285633-52286135
FEATURES             Location/Qualifiers
     source          1..1757
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q21"
     gene            1..1757
                     /gene="Gabrr2"
                     /note="gamma-aminobutyric acid type A receptor subunit rho
                     2"
                     /db_xref="GeneID:29695"
                     /db_xref="RGD:61902"
     exon            1..281
                     /gene="Gabrr2"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..1566
                     /gene="Gabrr2"
                     /note="gamma-aminobutyric acid (GABA-A) receptor, subunit
                     rho 2; GABAAR subunit rho-2; gamma-aminobutyric acid
                     (GABA) A receptor, rho 2; gamma-aminobutyric acid receptor
                     subunit rho-2; GABA(A) receptor subunit rho-2; GABA(C)
                     receptor; gamma-aminobutyric acid A receptor, rho 2;
                     gamma-aminobutyric acid (GABA-C) receptor, subunit rho 2;
                     gamma-aminobutyric acid (GABA) receptor, rho 2;
                     gamma-aminobutyric acid type A receptor rho 2 subunit"
                     /codon_start=1
                     /product="gamma-aminobutyric acid receptor subunit rho-2
                     precursor"
                     /protein_id="NP_058988.1"
                     /db_xref="GeneID:29695"
                     /db_xref="RGD:61902"
                     /translation="MPYFMRLALFLFCLMALVESRKPRRKRWTGHLETSKPSHLYKKN
                     LDVTKIRTGKPRPLLRVEDHDFTMRPAFGGPAIPVGVDVQVESLDSISEVDMDFTMTL
                     YLRHYWRDERLAFPSSSNRSMTFDGRLVKKIWVPDVFFVHSKRSFTHDTTTDNIMLRV
                     FPDGHVLYSMRITVTAMCNMDFSHFPLDSQTCSLELESYAYTDEDLMLYWKNGDESLK
                     TDEKISLSQFLIQKFHTTSRLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMV
                     MLSWVSFWIDHRAVPARVSLGIMTVLTMSTIITGVNASMPRVSYIRAVDIYLWVSFVF
                     VFLSVLEYAAVNYLTTVQEQKERKLRDKFPCTCGMLHSRTMTLDGSYSESEANSLAGY
                     PRSHILPEEERQDKIVVHLALNSELTSSRKKGLLKGQMGLYIFQNTHAIDKYSRLIFP
                     AFYIVFNLIYWSVFS"
     exon            282..388
                     /gene="Gabrr2"
                     /inference="alignment:Splign:2.1.0"
     exon            389..456
                     /gene="Gabrr2"
                     /inference="alignment:Splign:2.1.0"
     exon            457..680
                     /gene="Gabrr2"
                     /inference="alignment:Splign:2.1.0"
     exon            681..763
                     /gene="Gabrr2"
                     /inference="alignment:Splign:2.1.0"
     exon            764..904
                     /gene="Gabrr2"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1057
                     /gene="Gabrr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1254
                     /gene="Gabrr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1757
                     /gene="Gabrr2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcaattagt aggttgggaa actcagcctt gccaaccatg ctcgcacagc ccttcagaga
       61 agcgctgacc ggagactgga gacaggatcc atggttaagt cacagggcat cttcccctgt
      121 tcctgttgtt cccctgttcc tgcctgttgc gtcatagacg tttgcagaat gccttatttt
      181 atgagactcg ctttgttctt gttttgcctg atggctcttg tggagagcag aaaacccagg
      241 aggaagagat ggacagggca cctggaaaca tccaagccaa gtcacttgta taaaaagaac
      301 ctcgatgtga ccaagatccg gacaggaaaa cctcggcctc tgctcagggt agaggaccat
      361 gacttcacca tgaggccagc ctttggaggc ccggccatcc ctgtgggtgt ggacgtgcag
      421 gtggagagtc tggacagcat ctccgaggtg gacatggact tcaccatgac cctgtacctg
      481 aggcattact ggagggatga gaggctggcc tttcccagca gcagcaacag gagcatgacc
      541 ttcgatggca ggctggtgaa gaagatctgg gtccctgacg tcttctttgt tcactccaaa
      601 aggtcattta cccacgacac caccaccgac aacatcatgc tgcgagtgtt tcccgatggc
      661 cacgtgctgt acagcatgag gattaccgtc actgccatgt gcaacatgga cttcagccac
      721 ttccccctgg actcccagac ctgctctttg gagctagaga gctacgcgta cacggacgag
      781 gatctgatgc tgtactggaa gaacggggat gagtccctga agacggacga gaagatctcc
      841 ttgtcccagt ttctgatcca gaagttccac acgacttcca gactggcctt ctacagcagc
      901 acgggctggt acaaccgtct gtacatcaac ttcactctgc gacgtcacat cttcttcttc
      961 ttgctccaaa cctactttcc tgccaccctc atggtcatgc tgtcctgggt gtccttctgg
     1021 atcgaccaca gagctgtgcc tgctagagtt tcactgggca tcatgacggt gctgaccatg
     1081 tccaccatca tcacgggcgt gaacgcctcc atgcctcgag tgtcctacat ccgggccgtg
     1141 gacatctacc tctgggtcag ctttgtgttc gtgtttctct cagtgttgga gtacgcagct
     1201 gtcaactacc tgaccacagt gcaggaacag aaggaacgga agcttcggga caaatttcca
     1261 tgcacgtgtg gaatgcttca ttcaagaacc atgacgctgg atggaagcta cagtgaatct
     1321 gaggccaaca gcctggctgg ctacccaaga agccacattc ttccagaaga agaaaggcaa
     1381 gacaaaatag tggttcattt ggccctcaac agtgaattga cttcatccag aaagaaaggc
     1441 cttctcaaag gccaaatggg actctatatc ttccagaaca cccatgccat tgacaaatac
     1501 tccaggttga tatttcctgc cttctacata gttttcaacc taatttattg gtcagtgttt
     1561 tcctagggat tctaaggctg gatctgggaa agggcatgac catccgttgg tggatacatg
     1621 gacctaatga ccacacttcc tacaccaggc caagcagctg ctcctggctt ggaggagccc
     1681 agggacctcc agctgccctc accccatctt catggctctt ttcctagttc acactattcc
     1741 agatcacact tttgact
//
