LOCUS       NP_058988                465 aa            linear   ROD 24-JUN-2024
DEFINITION  gamma-aminobutyric acid receptor subunit rho-2 precursor [Rattus
            norvegicus].
ACCESSION   NP_058988
VERSION     NP_058988.1
DBSOURCE    REFSEQ: accession NM_017292.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 465)
  AUTHORS   Mejia,C., Garcia-Alcocer,G., Berumen,L.C., Rosas-Arellano,A.,
            Miledi,R. and Martinez-Torres,A.
  TITLE     Expression of GABArho subunits during rat cerebellum development
  JOURNAL   Neurosci Lett 432 (1), 1-6 (2008)
   PUBMED   18201822
  REMARK    GeneRIF: The expression of GABA(C) receptors in the cerebellum adds
            a new dimension to the regulation of GABAergic neurotransmission
REFERENCE   2  (residues 1 to 465)
  AUTHORS   Alakuijala,A., Alakuijala,J. and Pasternack,M.
  TITLE     Evidence for a functional role of GABA receptors in the rat mature
            hippocampus
  JOURNAL   Eur J Neurosci 23 (2), 514-520 (2006)
   PUBMED   16420458
REFERENCE   3  (residues 1 to 465)
  AUTHORS   Ma,D.Q., Whitehead,P.L., Menold,M.M., Martin,E.R.,
            Ashley-Koch,A.E., Mei,H., Ritchie,M.D., Delong,G.R., Abramson,R.K.,
            Wright,H.H., Cuccaro,M.L., Hussman,J.P., Gilbert,J.R. and
            Pericak-Vance,M.A.
  TITLE     Identification of significant association and gene-gene interaction
            of GABA receptor subunit genes in autism
  JOURNAL   Am J Hum Genet 77 (3), 377-388 (2005)
   PUBMED   16080114
REFERENCE   4  (residues 1 to 465)
  AUTHORS   Alakuijala,A., Palgi,M., Wegelius,K., Schmidt,M., Enz,R.,
            Paulin,L., Saarma,M. and Pasternack,M.
  TITLE     GABA receptor rho subunit expression in the developing rat brain
  JOURNAL   Brain Res Dev Brain Res 154 (1), 15-23 (2005)
   PUBMED   15617751
  REMARK    GeneRIF: GABA(C) receptors are specifically involved in aspects of
            visual image motion processing in the rat brain.
REFERENCE   5  (residues 1 to 465)
  AUTHORS   Burman,K.J., Ige,A.O., White,J.H., Marshall,F.H., Pangalos,M.N.,
            Emson,P.C., Minson,J.B. and Llewellyn-Smith,I.J.
  TITLE     GABAB receptor subunits, R1 and R2, in brainstem catecholamine and
            serotonin neurons
  JOURNAL   Brain Res 970 (1-2), 35-46 (2003)
   PUBMED   12706246
  REMARK    GeneRIF: The proportion of neurons in the brainstem with
            immunoreactivity for the GABA(B)R2 subunit included catecholamine
            and serotonin neurons.
REFERENCE   6  (residues 1 to 465)
  AUTHORS   Croci,C., Brandstatter,J.H. and Enz,R.
  TITLE     ZIP3, a new splice variant of the PKC-zeta-interacting protein
            family, binds to GABAC receptors, PKC-zeta, and Kv beta 2
  JOURNAL   J Biol Chem 278 (8), 6128-6135 (2003)
   PUBMED   12431995
REFERENCE   7  (residues 1 to 465)
  AUTHORS   McCall,M.A., Lukasiewicz,P.D., Gregg,R.G. and Peachey,N.S.
  TITLE     Elimination of the rho1 subunit abolishes GABA(C) receptor
            expression and alters visual processing in the mouse retina
  JOURNAL   J Neurosci 22 (10), 4163-4174 (2002)
   PUBMED   12019334
REFERENCE   8  (residues 1 to 465)
  AUTHORS   Didelon,F., Sciancalepore,M., Savic',N., Mladinic',M., Bradbury,A.
            and Cherubini,E.
  TITLE     gamma-Aminobutyric acidA rho receptor subunits in the developing
            rat hippocampus
  JOURNAL   J Neurosci Res 67 (6), 739-744 (2002)
   PUBMED   11891787
  REMARK    GeneRIF: The rho1 and rho2 products appeared to be developmentally
            regulated; they were found to be more pronounced in adulthood.
REFERENCE   9  (residues 1 to 465)
  AUTHORS   Zhang,D., Pan,Z.H., Zhang,X., Brideau,A.D. and Lipton,S.A.
  TITLE     Cloning of a gamma-aminobutyric acid type C receptor subunit in rat
            retina with a methionine residue critical for picrotoxinin channel
            block
  JOURNAL   Proc Natl Acad Sci U S A 92 (25), 11756-11760 (1995)
   PUBMED   8524843
REFERENCE   10 (residues 1 to 465)
  AUTHORS   Ogurusu,T., Taira,H. and Shingai,R.
  TITLE     Identification of GABAA receptor subunits in rat retina: cloning of
            the rat GABAA receptor rho 2-subunit cDNA
  JOURNAL   J Neurochem 65 (3), 964-968 (1995)
   PUBMED   7643126
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D38494.1, SRR26360194.15330.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760475
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            RefSeq Select criteria           :: based on computational evidence
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q21"
     Protein         1..465
                     /product="gamma-aminobutyric acid receptor subunit rho-2
                     precursor"
                     /note="gamma-aminobutyric acid (GABA-A) receptor, subunit
                     rho 2; GABAAR subunit rho-2; gamma-aminobutyric acid
                     (GABA) A receptor, rho 2; gamma-aminobutyric acid receptor
                     subunit rho-2; GABA(A) receptor subunit rho-2; GABA(C)
                     receptor; gamma-aminobutyric acid A receptor, rho 2;
                     gamma-aminobutyric acid (GABA-C) receptor, subunit rho 2;
                     gamma-aminobutyric acid (GABA) receptor, rho 2;
                     gamma-aminobutyric acid type A receptor rho 2 subunit"
                     /calculated_mol_wt=51918
     sig_peptide     1..20
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2396
     mat_peptide     21..465
                     /product="Gamma-aminobutyric acid receptor subunit rho-2.
                     /evidence=ECO:0000255. /id=PRO_0000000490"
                     /note="propagated from UniProtKB/Swiss-Prot (P47742.3)"
                     /calculated_mol_wt=51918
     Region          61..464
                     /region_name="LIC"
                     /note="Cation transporter family protein; cl42365"
                     /db_xref="CDD:455710"
     Region          76..261
                     /region_name="LGIC_ECD"
                     /note="extracellular domain (ECD) of Cys-loop
                     neurotransmitter-gated ion channels (also known as
                     ligand-gated ion channel (LGIC)); cl28912"
                     /db_xref="CDD:475126"
     Site            order(87,89,95..96,103,122,124,136..137,139,141..142,
                     155..157,159,169,171,173,177,199,260)
                     /site_type="other"
                     /note="pentamer interface [polypeptide binding]"
                     /db_xref="CDD:349787"
     Site            120
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P47742.3)"
     Site            254
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P47742.3)"
     Site            261..281
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P47742.3)"
     Site            294..314
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P47742.3)"
     Site            326..346
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P47742.3)"
     Site            444..464
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P47742.3)"
     CDS             1..465
                     /gene="Gabrr2"
                     /coded_by="NM_017292.2:169..1566"
                     /db_xref="GeneID:29695"
                     /db_xref="RGD:61902"
ORIGIN      
        1 mpyfmrlalf lfclmalves rkprrkrwtg hletskpshl ykknldvtki rtgkprpllr
       61 vedhdftmrp afggpaipvg vdvqveslds isevdmdftm tlylrhywrd erlafpsssn
      121 rsmtfdgrlv kkiwvpdvff vhskrsfthd tttdnimlrv fpdghvlysm ritvtamcnm
      181 dfshfpldsq tcslelesya ytdedlmlyw kngdeslktd ekislsqfli qkfhttsrla
      241 fysstgwynr lyinftlrrh ifffllqtyf patlmvmlsw vsfwidhrav parvslgimt
      301 vltmstiitg vnasmprvsy iravdiylwv sfvfvflsvl eyaavnyltt vqeqkerklr
      361 dkfpctcgml hsrtmtldgs yseseansla gyprshilpe eerqdkivvh lalnseltss
      421 rkkgllkgqm glyifqntha idkysrlifp afyivfnliy wsvfs
//
