LOCUS       NM_017291               4187 bp    mRNA    linear   ROD 16-JUN-2024
DEFINITION  Rattus norvegicus gamma-aminobutyric acid type A receptor subunit
            rho 1 (Gabrr1), mRNA.
ACCESSION   NM_017291
VERSION     NM_017291.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4187)
  AUTHORS   Jensen,R.
  TITLE     Effects of GABACR and mGluR1 antagonists on contrast response
            functions of Sprague-Dawley and P23H rat retinal ganglion cells
  JOURNAL   PLoS One 12 (12), e0189980 (2017)
   PUBMED   29253887
  REMARK    GeneRIF: GABACR and mGluR1 have roles in contrast response
            functions of Sprague-Dawley and P23H rat retinal ganglion cells
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4187)
  AUTHORS   Chaumont,S., Andre,C., Perrais,D., Boue-Grabot,E., Taly,A. and
            Garret,M.
  TITLE     Agonist-dependent endocytosis of gamma-aminobutyric acid type A
            (GABAA) receptors revealed by a gamma2(R43Q) epilepsy mutation
  JOURNAL   J Biol Chem 288 (39), 28254-28265 (2013)
   PUBMED   23935098
  REMARK    GeneRIF: Gabrr1 containing gamma2(R43Q) are addressed to the cell
            membrane but undergo clathrin-mediated dynamin-dependent
            endocytosis
REFERENCE   3  (bases 1 to 4187)
  AUTHORS   Schlicker,K. and Schmidt,M.
  TITLE     Contribution of GABA(C) receptors to inhibition in the rodent
            accessory optic system
  JOURNAL   Exp Brain Res 199 (3-4), 235-244 (2009)
   PUBMED   19902194
  REMARK    GeneRIF: GABAergic neurons in the SGS express GABAC receptors
            whereas the majority of tectothalamic CB-ir neurons and
            intrinsicall
REFERENCE   4  (bases 1 to 4187)
  AUTHORS   Grabert,J., Jost,B., Patz,S. and Wahle,P.
  TITLE     GABA(C) receptors are expressed in GABAergic and non-GABAergic
            neurons of the rat superior colliculus and visual cortex
  JOURNAL   Exp Brain Res 199 (3-4), 245-252 (2009)
   PUBMED   19198818
  REMARK    GeneRIF: In the stratum griseum superficiale, primarily GABAergic
            neurons express GABA(C) receptors.
            Erratum:[Exp Brain Res. 2009 Dec;199(3-4):253. Wahle, Petra
            [corrected to Wahle, P]; Schmidt, Matthias [removed]]
REFERENCE   5  (bases 1 to 4187)
  AUTHORS   Yang,L., Nakayama,Y., Hattori,N., Liu,B. and Inagaki,C.
  TITLE     GABAC-receptor stimulation activates cAMP-dependent protein kinase
            via A-kinase anchoring protein 220
  JOURNAL   J Pharmacol Sci 106 (4), 578-584 (2008)
   PUBMED   18385542
  REMARK    GeneRIF: Suggest that GABA(C)-receptor rho subunit stimulation
            activates PKA via A-kinase anchoring protein 220(AKAP220).
REFERENCE   6  (bases 1 to 4187)
  AUTHORS   Ekema,G.M., Zheng,W. and Lu,L.
  TITLE     Interaction of GABA receptor/channel rho(1) and gamma(2) subunit
  JOURNAL   Invest Ophthalmol Vis Sci 43 (7), 2326-2333 (2002)
   PUBMED   12091434
REFERENCE   7  (bases 1 to 4187)
  AUTHORS   McCall,M.A., Lukasiewicz,P.D., Gregg,R.G. and Peachey,N.S.
  TITLE     Elimination of the rho1 subunit abolishes GABA(C) receptor
            expression and alters visual processing in the mouse retina
  JOURNAL   J Neurosci 22 (10), 4163-4174 (2002)
   PUBMED   12019334
REFERENCE   8  (bases 1 to 4187)
  AUTHORS   Didelon,F., Sciancalepore,M., Savic',N., Mladinic',M., Bradbury,A.
            and Cherubini,E.
  TITLE     gamma-Aminobutyric acidA rho receptor subunits in the developing
            rat hippocampus
  JOURNAL   J Neurosci Res 67 (6), 739-744 (2002)
   PUBMED   11891787
  REMARK    GeneRIF: The rho1 and rho2 products appeared to be developmentally
            regulated; they were found to be more pronounced in adulthood.
REFERENCE   9  (bases 1 to 4187)
  AUTHORS   Wegelius,K., Reeben,M., Rivera,C., Kaila,K., Saarma,M. and
            Pasternack,M.
  TITLE     The rho 1 GABA receptor cloned from rat retina is down-modulated by
            protons
  JOURNAL   Neuroreport 7 (12), 2005-2009 (1996)
   PUBMED   8905713
REFERENCE   10 (bases 1 to 4187)
  AUTHORS   Zhang,D., Pan,Z.H., Zhang,X., Brideau,A.D. and Lipton,S.A.
  TITLE     Cloning of a gamma-aminobutyric acid type C receptor subunit in rat
            retina with a methionine residue critical for picrotoxinin channel
            block
  JOURNAL   Proc Natl Acad Sci U S A 92 (25), 11756-11760 (1995)
   PUBMED   8524843
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Feb 11, 2021 this sequence version replaced NM_017291.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X95579.1, U21070.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-233               JAXUCZ010000005.1  52320475-52320707
            234-287             JAXUCZ010000005.1  52334633-52334686
            288-394             JAXUCZ010000005.1  52336543-52336649
            395-462             JAXUCZ010000005.1  52339082-52339149
            463-686             JAXUCZ010000005.1  52340129-52340352
            687-769             JAXUCZ010000005.1  52347263-52347345
            770-910             JAXUCZ010000005.1  52348284-52348424
            911-1063            JAXUCZ010000005.1  52350930-52351082
            1064-1260           JAXUCZ010000005.1  52352925-52353121
            1261-4187           JAXUCZ010000005.1  52354623-52357549
FEATURES             Location/Qualifiers
     source          1..4187
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q21"
     gene            1..4187
                     /gene="Gabrr1"
                     /note="gamma-aminobutyric acid type A receptor subunit rho
                     1"
                     /db_xref="GeneID:29694"
                     /db_xref="RGD:61900"
     exon            1..233
                     /gene="Gabrr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..1554
                     /gene="Gabrr1"
                     /note="gamma-aminobutyric acid (GABA-A) receptor, subunit
                     rho 1; gamma-aminobutyric acid receptor subunit rho-1;
                     GABAAR subunit rho-1; GABA(A) receptor subunit rho-1;
                     GABA(C) receptor; gamma-aminobutyric acid A receptor, rho
                     1; gamma-aminobutyric acid (GABA-C) receptor, subunit rho
                     1; gamma-aminobutyric acid (GABA) receptor, rho 1;
                     gamma-aminobutyric acid (GABA) A receptor, rho 1;
                     gamma-aminobutyric acid type A receptor rho 1 subunit"
                     /codon_start=1
                     /product="gamma-aminobutyric acid receptor subunit rho-1
                     precursor"
                     /protein_id="NP_058987.3"
                     /db_xref="GeneID:29694"
                     /db_xref="RGD:61900"
                     /translation="MLAVRNMKFGIFLLWWGWVLAAESTVHWPGREVHEPSKKGSRPQ
                     RQRRGAHDDAHKQGSPILKRSSDITKSPLTKSEQLLRIDDHDFSMRPGFGGPAIPVGV
                     DVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMF
                     FVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIE
                     SYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINF
                     TLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMSTIITGVNA
                     SMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKERKLREKISCTCGLPQ
                     PRGVMLDSSYSDGEVNDLGGYMPENGEKPDRMMVQLTLASERGSPQRKSQRGSYVSMR
                     INTHAIDKYSRIIFPAAYILFNLIYWSIFS"
     exon            234..287
                     /gene="Gabrr1"
                     /inference="alignment:Splign:2.1.0"
     exon            288..394
                     /gene="Gabrr1"
                     /inference="alignment:Splign:2.1.0"
     exon            395..462
                     /gene="Gabrr1"
                     /inference="alignment:Splign:2.1.0"
     exon            463..686
                     /gene="Gabrr1"
                     /inference="alignment:Splign:2.1.0"
     exon            687..769
                     /gene="Gabrr1"
                     /inference="alignment:Splign:2.1.0"
     exon            770..910
                     /gene="Gabrr1"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1063
                     /gene="Gabrr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1260
                     /gene="Gabrr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..4187
                     /gene="Gabrr1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccttctaata acaaacacag caatggtgcc ttaagagagg acggtcggac ggcagctcct
       61 caccggctcc ttctcacggc ttctcgggag aactgtttga tttggaaatc tatgttggct
      121 gtccggaata tgaaatttgg catattcctt ttgtggtggg gatgggttct ggctgctgag
      181 agcacagtgc actggccagg aagagaagtt catgagccct ctaagaaagg cagcagacct
      241 cagagacaga gacgaggtgc acatgacgat gcccacaagc aaggcagccc cattctgaaa
      301 cgaagctctg acataaccaa gtcgcctctc accaagtcag agcagctgct caggatagat
      361 gaccacgact tcagcatgag gcctggcttt ggaggtcccg ccatccctgt gggtgtggat
      421 gtgcaggtgg agagtctgga cagcatctcc gaggtggaca tggacttcac catgaccctc
      481 tatctgaggc actactggaa ggacgagagg ctgtcttttc ccagtaccaa caacctcagc
      541 atgacgtttg acggccgact tgtaaagaag atatgggttc ccgacatgtt ctttgtgcac
      601 tccaaacgct ccttcatcca tgacaccacc acagacaacg tcatgttgcg ggtacagcca
      661 gatgggaaag tgctgtacag cctcagagtt acagtgacag cgatgtgcaa catggacttc
      721 agccggtttc ccctggacac acagacctgc tccctcgaaa tcgaaagcta tgcctacaca
      781 gaagacgacc tcatgctgta ctggaaaaaa ggcaatgact ccttaaagac agatgagagg
      841 atctccctct ctcagttcct cattcaagaa ttccacacca ccacaaaact agccttctac
      901 agcagtacag gctggtacaa ccgtctgtac atcaacttca ctctacgtcg tcacatcttc
      961 ttcttcttgc tccaaaccta ctttcctgcc accctcatgg tcatgctgtc ctgggtgtcc
     1021 ttctggatcg accgcagagc tgtgcctgcc agagtcccct taggcatcac cacggtgctg
     1081 accatgtcca ccatcatcac gggcgtgaac gcctccatgc ctcgagtgtc ctacatcaaa
     1141 gccgtggaca tctacctctg ggtcagcttt gtgttcgtgt ttctctcggt gttggagtac
     1201 gcagctgtca actacctgac cacagtgcag gagcggaagg aacggaagct tcgggagaag
     1261 atctcctgca cctgtgggct gccccagcct cgaggggtga tgctggacag cagctacagt
     1321 gacggggagg tgaacgacct gggtggctac atgcctgaga acggagagaa acccgaccgg
     1381 atgatggtgc agctgaccct ggcctccgag aggggctccc cacagaggaa aagccagaga
     1441 ggcagctatg tgagcatgag gatcaacacc cacgccattg acaaatactc aaggatcatt
     1501 ttcccagctg cttacatttt attcaatctg atatactggt caattttctc ttagatagat
     1561 gtgattgtgt aaatcttggc aggcaccaca gaagttgctg taaaaatgag aatgacagtt
     1621 taaagccatt cctacctggg ttttctctgt cccctgttca gctctccaaa gctgcaccaa
     1681 caagacacct tgtttttgca cttattaagt atcagttgtc tgcacagcag tatactaggc
     1741 gttgcaggac gttgccatga tagtaactga tgttagcggc tcccagatcc caggaagagc
     1801 acagaggcca catgtggaca tgctgcggtc cagggccagg gctctggatg cttttcacat
     1861 cgaggggttt ctacgtcggt ggaccatgtt ctttagacta cgtagatctg ggaaggacct
     1921 aaataaaact catctgcatt gggctcacag gtacataaac cccctcggct gaaagggcag
     1981 gcttcgtctg tctccgcacc tgctccacat ccccatactt aatggaaggc agtggcgctc
     2041 acagggttct tttccacaag ctgcatggct ctctccttct aagaaatgcc ctttacatgg
     2101 ctgaaatgtc cctagtagac tttgaagata gagatacatg gatcatttca tctgttttga
     2161 gggggcaaca aagctagaaa accgtgtccc tttccacgcc ttctagtcac cgtttccctc
     2221 ctctctacca cagagcaggt gctttcttca aaataaaatc ttttctcagt cgcatgacag
     2281 catcactgac tgaggcgctt gaagaggtat tcatttcttc tgcatagtca gcatttcaag
     2341 aaaactcgag gctgtttcta actcatggga atgagaagca aactgtttct taagagaaag
     2401 ataacattga aaaacaaaag aaacagacag acatcttcat ttccgttcag caagtgctgt
     2461 ctgggaacta gaaagcaatt atcttctaga ttgagcatcc catagaccag ataagctggc
     2521 ccatagcaac tgatgtcagc catgggttgt aatttgatgt attgttttaa aatagaagcc
     2581 tctatagtct ttatctagaa gatatatagc agccccaacc gaacttgctc aaacagtatt
     2641 gagcagtatg tcatttgctc tgggccacgt ctttcactca gagagacaac tacttagcat
     2701 ctgccacatc ccagcggcca ttgaagcatc ttaaccaagt cctggcccat ttagttgtgg
     2761 ttgtgttcag atttcagtga gagaatccca ggagaaacat aaatgataat ttaatattgt
     2821 ggaacatatg gttaataaat atagaggagg tctaagagac ctgtccaggg gcaaccatcc
     2881 tctgtgctgc gaaacctatc ttcatatatg tcgttatagc tcccatcatt tcaaggttaa
     2941 cttaagggat caatactaaa tagtatcata cacatggcta ttctttactc tggtcataaa
     3001 aagagctatt tgcaaattcc tacttagaag acagtctctc atttccccca ataaaaggtc
     3061 atcaaaagct tttatcaaac tcaagtggta gacttagagg gataaattaa gtaattatca
     3121 ttgattttca aaatgaccgt tcgttttgcc aagcatggtt tgcccatgca cttgggaagt
     3181 ggaatcagga gggtctggag ttcaaagcta gctttgcttt acggcatatt ggaggcaagc
     3241 atgggctatg tgaggtttaa aatggttggc ttttcatttt tattttatga aacatttacc
     3301 atcaaagcca acaactttgc cactgtcttc ttcctcacca ctaaggccac tgagctgtct
     3361 aggtttccag agcttgtaac taagcccttt gtactgtttg ggacactcca ccatttgagc
     3421 cagtgtgtag aatgctctcc tagcctgcta acctgctata ttgaagagca cagactggat
     3481 ggcttaatca acagagatat attttctcac agttctagag actgatgtcc aaggtcaagg
     3541 tgctggccga cgcagtttcc ccagaggcct gtcttgctgt ctttccaata gccactctct
     3601 tgctgcatcc ttgccttctt tcctctgtag caacaacctc tgtctagatc cctttctccc
     3661 tagttacatt gtatcagggc ccacatccat ggcctcattt aaccttagtt acttctttaa
     3721 aagccttgtc tcaaaaccat ttgctcttta gcgatctcct ccaatttgga attcttcatc
     3781 ttgggaagct ccttaggact taggaggtac ttaaagaagg tgatgctgtc catcccacag
     3841 ggaagaagcc tgttcaggtt aagctcagga aacaaataac aaattcagga agtccctgaa
     3901 actgataagc tatcaccccc cccccccaag tatatacaaa caataagaac tgctgaggtc
     3961 acttttagat aatccaaaaa ttctggaaga gacaaagacc agccaagctg cctagaaggg
     4021 acagttccaa cccatctagc tgcctgcaag tcatgctgtg agctccagat ttccagctat
     4081 gggagctgtc acccacgatg gggcaggctt ttgtaatgaa actgtctttg agtcatttct
     4141 gcacctctaa ataacctcaa taaagctcat tggttcatcc cgttgga
//
