LOCUS       NM_024370               1638 bp    mRNA    linear   ROD 16-JUN-2024
DEFINITION  Rattus norvegicus gamma-aminobutyric acid type A receptor subunit
            gamma 3 (Gabrg3), mRNA.
ACCESSION   NM_024370
VERSION     NM_024370.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1638)
  AUTHORS   Baer,K., Essrich,C., Benson,J.A., Benke,D., Bluethmann,H.,
            Fritschy,J.M. and Luscher,B.
  TITLE     Postsynaptic clustering of gamma-aminobutyric acid type A receptors
            by the gamma3 subunit in vivo
  JOURNAL   Proc Natl Acad Sci U S A 96 (22), 12860-12865 (1999)
   PUBMED   10536013
REFERENCE   2  (bases 1 to 1638)
  AUTHORS   Neelands,T.R. and Macdonald,R.L.
  TITLE     Incorporation of the pi subunit into functional gamma-aminobutyric
            Acid(A) receptors
  JOURNAL   Mol Pharmacol 56 (3), 598-610 (1999)
   PUBMED   10462548
REFERENCE   3  (bases 1 to 1638)
  AUTHORS   Herb,A., Wisden,W., Luddens,H., Puia,G., Vicini,S. and Seeburg,P.H.
  TITLE     The third gamma subunit of the gamma-aminobutyric acid type A
            receptor family
  JOURNAL   Proc Natl Acad Sci U S A 89 (4), 1433-1437 (1992)
   PUBMED   1311098
REFERENCE   4  (bases 1 to 1638)
  AUTHORS   Knoflach,F., Rhyner,T., Villa,M., Kellenberger,S., Drescher,U.,
            Malherbe,P., Sigel,E. and Mohler,H.
  TITLE     The gamma 3-subunit of the GABAA-receptor confers sensitivity to
            benzodiazepine receptor ligands
  JOURNAL   FEBS Lett 293 (1-2), 191-194 (1991)
   PUBMED   1660002
REFERENCE   5  (bases 1 to 1638)
  AUTHORS   Sulpizio,A., Fowler,P.J. and Macko,E.
  TITLE     Antagonism of fenfluramine-induced hyperthermia: a measure of
            central serotonin inhibition
  JOURNAL   Life Sci 22 (16), 1439-1446 (1978)
   PUBMED   27681
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            X63324.1 and M81142.1.
            
            On Dec 22, 2003 this sequence version replaced NM_024370.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X63324.1, M81142.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760384 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                X63324.1           58-102
            46-1638             M81142.1           28-1620
FEATURES             Location/Qualifiers
     source          1..1638
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1638
                     /gene="Gabrg3"
                     /note="gamma-aminobutyric acid type A receptor subunit
                     gamma 3"
                     /db_xref="GeneID:79211"
                     /db_xref="RGD:621735"
     exon            1..173
                     /gene="Gabrg3"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..1524
                     /gene="Gabrg3"
                     /note="gamma-aminobutyric acid A receptor, gamma 3;
                     gamma-aminobutyric acid receptor subunit gamma-3; GABA(A)
                     receptor subunit gamma-3; GABAAR subunit gamma-3;
                     gamma-aminobutyric acid (GABA) A receptor, gamma 3;
                     GABA-alpha receptor gamma-3 subunit; gamma-aminobutyric
                     acid (GABA) A receptor, subunit gamma 3;
                     gamma-aminobutyric acid type A receptor gamma 3 subunit"
                     /codon_start=1
                     /product="gamma-aminobutyric acid receptor subunit gamma-3
                     precursor"
                     /protein_id="NP_077346.3"
                     /db_xref="GeneID:79211"
                     /db_xref="RGD:621735"
                     /translation="MAAKLLLLLCLFSGLHARSRRVEEDDSEDSPSNQKWVLAPKSQD
                     TDVTLILNKLLREYDKKLRPDIGIKPTVIDVDIYVNSIGPVSSINMEYQIDIFFAQTW
                     TDSRLRFNSTMKILTLNSNMVGLIWIPDTIFRNSKTAEAHWITTPNQLLRIWNDGKIL
                     YTLRLTINAECQLQLHNFPMDAHACPLTFSSYGYPKEEMIYRWRKNSVEAADQKSWRL
                     YQFDFMGLRNTTEIVTTSAGDYVVMTIYFELSRRMGYFTIQTYIPCILTVVLSWVSFW
                     IKKDATPARTTLGITTVLTMTTLSTIARKSLPRVSYVTAMDLFVTVCFLFVFAALMEY
                     ATLNYYSSCRKPTIRKKKTSLLHPDSTRWIPDRISLQAPSNYSLLDMRPPPPVMITLN
                     NSMYWQEFEDTCVYECLDGKDCQSFFCCYEECKSGSWRRGRIHIDVSELDSYSRVFFP
                     TSFLLFNLVYWVGYLYL"
     exon            174..322
                     /gene="Gabrg3"
                     /inference="alignment:Splign:2.1.0"
     exon            323..390
                     /gene="Gabrg3"
                     /inference="alignment:Splign:2.1.0"
     exon            391..611
                     /gene="Gabrg3"
                     /inference="alignment:Splign:2.1.0"
     exon            612..694
                     /gene="Gabrg3"
                     /inference="alignment:Splign:2.1.0"
     exon            695..832
                     /gene="Gabrg3"
                     /inference="alignment:Splign:2.1.0"
     exon            833..985
                     /gene="Gabrg3"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1182
                     /gene="Gabrg3"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1242
                     /gene="Gabrg3"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1638
                     /gene="Gabrg3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagacacctg tccctctcgg tccgcagaac cagggcgctg cagcccgtgg tagtctagta
       61 agcgcccgag cgagtggaga ccaagcccgg cagaggcctc ggacccgcgc ccggagagtc
      121 atggctgcaa agctgctgct tctcctctgc ctgttctcgg gcttgcatgc tcggtccagg
      181 agggtggaag aggatgacag tgaagactct ccatcaaacc agaagtgggt cttggcaccc
      241 aaatcacaag acaccgatgt gacactgatt ctcaacaaat tgctgcgaga atatgacaaa
      301 aagttgagac cagacattgg aataaaacca actgtgatcg atgtggacat ttatgttaac
      361 agcattggtc ctgtgtcatc cataaacatg gaataccaaa ttgatatatt ttttgctcaa
      421 acctggacag acagtcgcct tcgattcaac agcacaatga aaatacttac tctgaacagc
      481 aacatggtgg gtttgatatg gataccagac accatctttc gaaactctaa aacagcagag
      541 gctcactgga tcaccacacc caaccagctc cttagaatct ggaatgatgg gaaaatcctt
      601 tacacattaa ggcttaccat caatgcagag tgccagctgc aactgcataa cttccccatg
      661 gatgcgcatg cctgcccttt gaccttctct agctatggct accccaaaga agaaatgatt
      721 tatcgttgga ggaaaaattc agttgaggca gctgatcaga aatcatggcg gctctatcag
      781 tttgacttca tgggcctcag aaacactaca gaaatcgtga ctacatctgc aggtgattat
      841 gttgtcatga ctatctactt tgaactgagt cgaagaatgg gatacttcac tatccagacg
      901 tatatcccct gcatactgac tgtggttctg tcctgggtat cattttggat caaaaaagat
      961 gcgacaccag caagaacaac attaggcatc accacggtgc taaccatgac cacactcagc
     1021 accattgcca ggaagtccct gcctcgggtg tcctatgtca ctgccatgga cctctttgtg
     1081 actgtgtgct tcttgtttgt ctttgccgca ctgatggagt atgctactct caactactat
     1141 tcgagctgtc gaaagccaac catcaggaag aaaaagacat cgttattaca tccagattca
     1201 acaagatgga ttcctgatcg aataagcctt caagcaccct ctaattattc tctcctggat
     1261 atgagacccc caccacccgt gatgatcacg ttaaacaatt ccatgtactg gcaggagttt
     1321 gaggacacct gtgtctatga gtgtctggat ggcaaagact gccagagctt cttctgctgc
     1381 tatgaggagt gcaagtctgg ctcctggaga agaggccgca tccacattga cgtctctgag
     1441 ctggactcct actctcgggt cttcttccca acgtccttcc tgctgttcaa cctggtctat
     1501 tgggttggat acctatatct ttaagtgctg ctctgaagga tgacagaaga gtacttgatt
     1561 catgtttttc cttccatcat ccccagacaa gtagtgacca accaaaaagt agcagggaag
     1621 gacactactc cagcttgt
//
