LOCUS       NM_001393775            3794 bp    mRNA    linear   ROD 16-JUN-2024
DEFINITION  Rattus norvegicus gamma-aminobutyric acid type A receptor subunit
            gamma 2 (Gabrg2), transcript variant 1, mRNA.
ACCESSION   NM_001393775
VERSION     NM_001393775.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3794)
  AUTHORS   Ghit,A., Assal,D., Al-Shami,A.S. and Hussein,D.E.E.
  TITLE     GABAA receptors: structure, function, pharmacology, and related
            disorders
  JOURNAL   J Genet Eng Biotechnol 19 (1), 123 (2021)
   PUBMED   34417930
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3794)
  AUTHORS   Germann,A.L., Pierce,S.R., Tateiwa,H., Sugasawa,Y., Reichert,D.E.,
            Evers,A.S., Steinbach,J.H. and Akk,G.
  TITLE     Intrasubunit and Intersubunit Steroid Binding Sites Independently
            and Additively Mediate alpha1beta2gamma2L GABAA Receptor
            Potentiation by the Endogenous Neurosteroid Allopregnanolone
  JOURNAL   Mol Pharmacol 100 (1), 19-31 (2021)
   PUBMED   33958479
  REMARK    GeneRIF: Intrasubunit and Intersubunit Steroid Binding Sites
            Independently and Additively Mediate alpha1beta2gamma2L GABAA
            Receptor Potentiation by the Endogenous Neurosteroid
            Allopregnanolone.
REFERENCE   3  (bases 1 to 3794)
  AUTHORS   Zheng,Y., Zhou,Y., Wu,Q., Yue,J., Ying,X., Li,S., Lou,X., Yang,G.,
            Tu,W., Zhou,K. and Jiang,S.
  TITLE     Effect of electroacupuncture on the expression of P2 x 4, GABAA
            gamma 2 and long-term potentiation in spinal cord of rats with
            neuropathic pain
  JOURNAL   Brain Res Bull 162, 1-10 (2020)
   PUBMED   32428626
  REMARK    GeneRIF: Effect of electroacupuncture on the expression of P2 x 4,
            GABAA gamma 2 and long-term potentiation in spinal cord of rats
            with neuropathic pain.
REFERENCE   4  (bases 1 to 3794)
  AUTHORS   Rajgor,D., Purkey,A.M., Sanderson,J.L., Welle,T.M., Garcia,J.D.,
            Dell'Acqua,M.L. and Smith,K.R.
  TITLE     Local miRNA-Dependent Translational Control of GABAAR Synthesis
            during Inhibitory Long-Term Potentiation
  JOURNAL   Cell Rep 31 (12), 107785 (2020)
   PUBMED   32579917
  REMARK    GeneRIF: Local miRNA-Dependent Translational Control of GABAAR
            Synthesis during Inhibitory Long-Term Potentiation.
REFERENCE   5  (bases 1 to 3794)
  AUTHORS   Gall,Z., Kelemen,K., Mihaly,I., Salamon,P., Miklossy,I.,
            Zsigmond,B. and Kolcsar,M.
  TITLE     Role of Lacosamide in Preventing Pentylenetetrazole
            Kindling-Induced Alterations in the Expression of the Gamma-2
            Subunit of the GABAA Receptor in Rats
  JOURNAL   Curr Mol Pharmacol 13 (3), 251-260 (2020)
   PUBMED   31894752
  REMARK    GeneRIF: Role of Lacosamide in Preventing Pentylenetetrazole
            Kindling-Induced Alterations in the Expression of the Gamma-2
            Subunit of the GABAA Receptor in Rats.
REFERENCE   6  (bases 1 to 3794)
  AUTHORS   Wisden,W. and Seeburg,P.H.
  TITLE     GABAA receptor channels: from subunits to functional entities
  JOURNAL   Curr Opin Neurobiol 2 (3), 263-269 (1992)
   PUBMED   1379501
  REMARK    Review article
REFERENCE   7  (bases 1 to 3794)
  AUTHORS   Laurie,D.J., Seeburg,P.H. and Wisden,W.
  TITLE     The distribution of 13 GABAA receptor subunit mRNAs in the rat
            brain. II. Olfactory bulb and cerebellum
  JOURNAL   J Neurosci 12 (3), 1063-1076 (1992)
   PUBMED   1312132
REFERENCE   8  (bases 1 to 3794)
  AUTHORS   Wisden,W., Laurie,D.J., Monyer,H. and Seeburg,P.H.
  TITLE     The distribution of 13 GABAA receptor subunit mRNAs in the rat
            brain. I. Telencephalon, diencephalon, mesencephalon
  JOURNAL   J Neurosci 12 (3), 1040-1062 (1992)
   PUBMED   1312131
REFERENCE   9  (bases 1 to 3794)
  AUTHORS   Draguhn,A., Verdorn,T.A., Ewert,M., Seeburg,P.H. and Sakmann,B.
  TITLE     Functional and molecular distinction between recombinant rat GABAA
            receptor subtypes by Zn2+
  JOURNAL   Neuron 5 (6), 781-788 (1990)
   PUBMED   1702644
REFERENCE   10 (bases 1 to 3794)
  AUTHORS   Seeburg,P.H., Wisden,W., Verdoorn,T.A., Pritchett,D.B., Werner,P.,
            Herb,A., Luddens,H., Sprengel,R. and Sakmann,B.
  TITLE     The GABAA receptor family: molecular and functional diversity
  JOURNAL   Cold Spring Harb Symp Quant Biol 55, 29-40 (1990)
   PUBMED   1966765
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1 and CB740905.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1377001.1,
                                           SRR26643298.59670.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMEA5760433 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-288               JAXUCZ010000010.1  26965236-26965523   c
            289-725             CB740905.1         12-448
            726-802             JAXUCZ010000010.1  26933782-26933858   c
            803-885             JAXUCZ010000010.1  26931092-26931174   c
            886-1023            JAXUCZ010000010.1  26928539-26928676   c
            1024-1176           JAXUCZ010000010.1  26887056-26887208   c
            1177-1382           JAXUCZ010000010.1  26882910-26883115   c
            1383-1406           JAXUCZ010000010.1  26880724-26880747   c
            1407-3794           JAXUCZ010000010.1  26876926-26879313   c
FEATURES             Location/Qualifiers
     source          1..3794
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q21"
     gene            1..3794
                     /gene="Gabrg2"
                     /note="gamma-aminobutyric acid type A receptor subunit
                     gamma 2"
                     /db_xref="GeneID:29709"
                     /db_xref="RGD:61966"
     exon            1..361
                     /gene="Gabrg2"
                     /inference="alignment:Splign:2.1.0"
     CDS             258..1682
                     /gene="Gabrg2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; gamma-aminobutyric acid receptor subunit
                     gamma-2; GABA(A) receptor subunit gamma-2;
                     gamma-aminobutyric acid (GABA-A) receptor, subunit gamma
                     2; gamma-aminobutyric acid A receptor, gamma 2;
                     gamma-aminobutyric acid (GABA) A receptor, gamma 2;
                     gamma-aminobutyric acid type A receptor gamma 2 subunit;
                     GABAAR subunit gamma-2"
                     /codon_start=1
                     /product="gamma-aminobutyric acid receptor subunit gamma-2
                     isoform 1 precursor"
                     /protein_id="NP_001380704.1"
                     /db_xref="GeneID:29709"
                     /db_xref="RGD:61966"
                     /translation="MSSPNTWSTGSTVYSPVFSQKMTLWILLLLSLYPGFTSQKSDDD
                     YEDYASNKTWVLTPKVPEGDVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGP
                     VNAINMEYTIDIFFAQTWYDRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAH
                     WITTPNRMLRIWNDGRVLYTLRLTIDAECQLQLHNFPMDEHSCPLEFSSYGYPREEIV
                     YQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTI
                     QTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAM
                     DLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDKDKKKKNPLLRMFSFKAPTIDIRPR
                     SATIQMNNATHLQERDEEYGYECLDGKDCASFFCCFEDCRTGAWRHGRIHIRIAKMDS
                     YARIFFPTAFCLFNLVYWVSYLYL"
     exon            362..513
                     /gene="Gabrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            514..581
                     /gene="Gabrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            582..802
                     /gene="Gabrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            803..885
                     /gene="Gabrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1023
                     /gene="Gabrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1176
                     /gene="Gabrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1382
                     /gene="Gabrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1406
                     /gene="Gabrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..3794
                     /gene="Gabrg2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aattctatta tcctcgcaga cttgggagcc gctgcctgag ctgacgcttt gatggtatct
       61 gcaagcgttt gtactgatct ttatttctgc cccctgaata ttaattttga agcaggtagc
      121 aatacatctc ctgagtgacg ggacctacta gaggcaggtg gggggagcca gcatcaaatc
      181 atcagcataa taataataca aagggggagg gattcttctg caacccagag gcgagaggcg
      241 agaggaaaaa aaaagcgatg agttcgccaa atacatggag cactggaagc acagtctact
      301 ctcctgtatt ttcacagaaa atgacgctgt ggattctgct cctgctatcg ctctacccag
      361 gcttcactag ccaaaagtca gatgatgact atgaagatta tgcttctaat aaaacatggg
      421 tgttgactcc aaaagttccc gagggtgatg tcactgtcat cttaaacaac cttctggaag
      481 ggtacgacaa caaacttcgg cccgacatag gagtgaaacc aacattaatt catacagata
      541 tgtacgtgaa cagcattggt ccagtgaatg ctatcaatat ggaatacaca attgatattt
      601 tttttgccca aacctggtat gacagacgtt tgaaatttaa cagtaccatt aaagttctcc
      661 gattgaatag caatatggtg gggaaaatct ggattccaga cactttcttc aggaactcca
      721 aaaaagcaga tgctcactgg atcacgactc ccaacaggat gctgagaatt tggaatgatg
      781 gtcgagttct ctacacctta aggctaacaa ttgatgctga gtgccagttg caattacaca
      841 acttcccaat ggatgaacac tcctgccccc tggagttctc cagttatggt tatcctcgtg
      901 aagaaattgt ttatcaatgg aagcgcagtt ctgttgaagt gggagacaca aggtcatgga
      961 ggctgtatca gttttccttt gttggattga ggaataccac tgaagtagtg aagacaactt
     1021 ctggtgacta tgtggttatg tccgtgtact ttgatctgag cagaagaatg gggtacttta
     1081 ccatccagac ctacattccc tgcacactca ttgtggttct gtcctgggta tccttctgga
     1141 tcaataagga tgctgtccct gcaagaacat ctttaggaat cacgactgtc ctgacgatga
     1201 ccactctcag caccatagcc cggaagtctc tgcccaaggt ctcctatgtc acagcaatgg
     1261 atctcttcgt ctctgtttgc ttcatctttg tgttttcggc tttggtggag tatggtaccc
     1321 tgcactattt tgtgagcaac cggaaaccaa gcaaggataa agacaaaaag aagaaaaacc
     1381 ctcttcttcg gatgttttcc ttcaaggccc ctaccattga tatccgtccc agatcagcaa
     1441 cgatccaaat gaacaatgcc acccaccttc aagagaggga tgaagaatat ggctatgagt
     1501 gtttggatgg caaggactgt gccagtttct tttgctgttt tgaagactgc cgaacaggag
     1561 cctggagaca cgggaggata cacattcgca ttgccaaaat ggactcctat gctcggatct
     1621 tcttccctac cgccttctgc ttgttcaatc ttgtttactg ggtctcctat ctttatctgt
     1681 gaggaggttt gggttttatc gataggggtc ttattcgctg aatctcacga agagaaaatg
     1741 tcctttctaa gtccaacgat ctaataccct atgtggtcac tgaatgtgtt tctccgtctc
     1801 aacctagtaa tacatagaat gtcctacgat ccgtgcccaa ctctcctttg gttattgtaa
     1861 tttgaatttt agcgtgcact gtctttcaaa cctgcaaggc aaagttaagt tagaacaaga
     1921 gctgttagac tgagcaagat acctttgagc aaaagcactg caaactgaaa tctgtgagtg
     1981 tttaaagggg catcattagc ctttgattca cgtataactt agtacaaaag gtatacagct
     2041 gtgtgctacg ttcgcttggg gtcacgttgt ggtaaattgg aacaaattag aatatctccc
     2101 gtatctgtga agaatcacaa tagaagagcc tagattagaa ctctattata cctttatctc
     2161 aaggtaggaa gcaaatcccc ttcatatagt tatgtacagt gatgtaaata gttcagcgat
     2221 gtagaatgct tcaggtttaa tgcatgcatc tctttagagc caaaaaataa atgaactcat
     2281 gttatcatca tatagcattg tcttttattt tcttttcctt tgggctataa aataatatat
     2341 taatataatt acaaggattt gggtttgaaa ttttggaggg gggttcactt ccttctccct
     2401 cgtgcatgaa aattcaggtt tggaaaatta tgtttgtctt gtataacatc aaaacacctt
     2461 aaggacaatt taggctgatt gacatttgac agctctaaat aggcccgact tcatcactag
     2521 catataaagc aaatgtacgt gcttgccgat gttttacttt actttgaaga tgtgcattct
     2581 taccagaact tgctctctat ctcgatacct gcttctagtg attgcgaatg ccttgtgggc
     2641 agagtccttg tcctttcttc ttttagttct caacatcttg cactgtgcct ggcatatagt
     2701 cagtgctcaa taaacctggc tgggagcaac acgtcctctt gtagtctggt gaataccttt
     2761 ttctgacccg gaacaagcga ttcatctttt cccattactg ttgacatgtg aagcttcttt
     2821 atctgtagaa gtaaccagag aatctaaaga acggtagctt gtatgttcat cttcaaaaat
     2881 ttgttttggg caaagtgtat ttattttaaa ataatatcta tttcctatac cgatgtatgc
     2941 aattgatgaa ataagcatag agttcttgat tatcccgttt ttttttaaag aattaattat
     3001 gtctgctaaa cattctgctt gtgaacctat gaaagtatga gcaatattca tacctgactg
     3061 gtgtacagta tgcttggaaa caatgtactg aaggttaaat taaaaacgga aacaacgttg
     3121 agtaacttgc atggaggtca tagagcctct gactgtgggc tccttttgct acatagtaat
     3181 taaacggagt ttttggctga catcagacat gatgagttgg accttatagg attattctga
     3241 atccttattt ttctaaaata tgactctttt ggagtcaagg aaaatattga ttcaaatcaa
     3301 agttaaatca tagtgtaact ttatagataa tgagaagaca ataaaagaaa gtgtctctgc
     3361 taagagaaaa ccacatgaag tcattaaaat tcatctggat gaatcttgaa aatattcagc
     3421 tgctggtttt acaaaccttg aatataccag tgctttagta tttaacctta cacggatgta
     3481 aataaatgat tattttctca ttttaaaatg tcaaaatagt caatgttgac tctttgggag
     3541 agttgctggc aaatttaatt tgtgagaaac aaggtattat tgtcaacttg aaatgtgttt
     3601 ttgcagtcag gacacggaaa taaaaattaa agctagcttt ccaacatgtg tagaacactg
     3661 gcaatatgga tatatattat acatttccaa tccttaatca tcagctgctc tctgtctgtg
     3721 catttgcaaa ccttttcaca agagaattgc ctaatatatg gacttttaca ataaaaatgc
     3781 tgcattctaa tcca
//
