LOCUS       NM_080586               1737 bp    mRNA    linear   ROD 16-JUN-2024
DEFINITION  Rattus norvegicus gamma-aminobutyric acid type A receptor subunit
            gamma 1 (Gabrg1), mRNA.
ACCESSION   NM_080586
VERSION     NM_080586.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1737)
  AUTHORS   Ordaz,R.P., Garay,E., Limon,A., Perez-Samartin,A.,
            Sanchez-Gomez,M.V., Robles-Martinez,L., Cisneros-Mejorado,A.,
            Matute,C. and Arellano,R.O.
  TITLE     GABAA Receptors Expressed in Oligodendrocytes Cultured from the
            Neonatal Rat Contain alpha3 and gamma1 Subunits and Present
            Differential Functional and Pharmacological Properties
  JOURNAL   Mol Pharmacol 99 (2), 133-146 (2021)
   PUBMED   33288547
  REMARK    GeneRIF: GABAA Receptors Expressed in Oligodendrocytes Cultured
            from the Neonatal Rat Contain alpha3 and gamma1 Subunits and
            Present Differential Functional and Pharmacological Properties.
REFERENCE   2  (bases 1 to 1737)
  AUTHORS   Dixon,C., Sah,P., Lynch,J.W. and Keramidas,A.
  TITLE     GABAA receptor alpha and gamma subunits shape synaptic currents via
            different mechanisms
  JOURNAL   J Biol Chem 289 (9), 5399-5411 (2014)
   PUBMED   24425869
  REMARK    GeneRIF: Switching the intracellular domains of the gamma2 and
            gamma1 subunits substantiated this inference. Because this region
            determines post-synaptic localization, we hypothesize that GABAARs
            containing gamma1 and gamma2 use different mechanisms for synaptic
            clustering.
REFERENCE   3  (bases 1 to 1737)
  AUTHORS   Tsuchiya,H., Oka,T., Nakamura,K., Ichikawa,A., Saper,C.B. and
            Sugimoto,Y.
  TITLE     Prostaglandin E2 attenuates preoptic expression of GABAA receptors
            via EP3 receptors
  JOURNAL   J Biol Chem 283 (16), 11064-11071 (2008)
   PUBMED   18292084
  REMARK    GeneRIF: Prostaglandin E2 attenuates preoptic expression of GABAA
            receptors via EP3 receptors
REFERENCE   4  (bases 1 to 1737)
  AUTHORS   Sarang,S.S., Lukyanova,S.M., Brown,D.D., Cummings,B.S.,
            Gullans,S.R. and Schnellmann,R.G.
  TITLE     Identification, coassembly, and activity of gamma-aminobutyric acid
            receptor subunits in renal proximal tubular cells
  JOURNAL   J Pharmacol Exp Ther 324 (1), 376-382 (2008)
   PUBMED   17959749
REFERENCE   5  (bases 1 to 1737)
  AUTHORS   Nishiyama,H., Knopfel,T., Endo,S. and Itohara,S.
  TITLE     Glial protein S100B modulates long-term neuronal synaptic
            plasticity
  JOURNAL   Proc Natl Acad Sci U S A 99 (6), 4037-4042 (2002)
   PUBMED   11891290
REFERENCE   6  (bases 1 to 1737)
  AUTHORS   Kneussel,M., Haverkamp,S., Fuhrmann,J.C., Wang,H., Wassle,H.,
            Olsen,R.W. and Betz,H.
  TITLE     The gamma-aminobutyric acid type A receptor (GABAAR)-associated
            protein GABARAP interacts with gephyrin but is not involved in
            receptor anchoring at the synapse
  JOURNAL   Proc Natl Acad Sci U S A 97 (15), 8594-8599 (2000)
   PUBMED   10900017
REFERENCE   7  (bases 1 to 1737)
  AUTHORS   Ymer,S., Draguhn,A., Wisden,W., Werner,P., Keinanen,K.,
            Schofield,P.R., Sprengel,R., Pritchett,D.B. and Seeburg,P.H.
  TITLE     Structural and functional characterization of the gamma 1 subunit
            of GABAA/benzodiazepine receptors
  JOURNAL   EMBO J 9 (10), 3261-3267 (1990)
   PUBMED   2170110
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Nov 26, 2020 this sequence version replaced NM_080586.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X57514.1, SRR26643298.54198.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-203               JAXUCZ010000014.1  37750292-37750494
            204-352             JAXUCZ010000014.1  37771877-37772025
            353-420             JAXUCZ010000014.1  37787083-37787150
            421-641             JAXUCZ010000014.1  37797690-37797910
            642-724             JAXUCZ010000014.1  37799504-37799586
            725-862             JAXUCZ010000014.1  37803802-37803939
            863-1015            JAXUCZ010000014.1  37804063-37804215
            1016-1227           JAXUCZ010000014.1  37806783-37806994
            1228-1737           JAXUCZ010000014.1  37821142-37821651
FEATURES             Location/Qualifiers
     source          1..1737
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p11"
     gene            1..1737
                     /gene="Gabrg1"
                     /note="gamma-aminobutyric acid type A receptor subunit
                     gamma 1"
                     /db_xref="GeneID:140674"
                     /db_xref="RGD:621732"
     exon            1..203
                     /gene="Gabrg1"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..1497
                     /gene="Gabrg1"
                     /note="gamma-aminobutyric acid receptor subunit gamma-1;
                     GABA(A) receptor subunit gamma-1; gamma-aminobutyric acid
                     A receptor, gamma 1; GABAAR subunit gamma-1;
                     gamma-aminobutyric acid (GABA) A receptor, gamma 1;
                     gamma-aminobutyric acid type A receptor gamma 1 subunit"
                     /codon_start=1
                     /product="gamma-aminobutyric acid receptor subunit gamma-1
                     precursor"
                     /protein_id="NP_542153.1"
                     /db_xref="GeneID:140674"
                     /db_xref="RGD:621732"
                     /translation="MGSGKVFLFSPSLLWSQTRGVRLIFLLLTLHLGNCIDKADDEDD
                     EDLTMNKTWVLAPKIHEGDITQILNSLLQGYDNKLRPDIGVRPTVIETDVYVNSIGPV
                     DPINMEYTIDIIFAQTWFDSRLKFNSTMKVLMLNSNMVGKIWIPDTFFRNSRKSDAHW
                     ITTPNRLLRIWSDGRVLYTLRLTINAECYLQLHNFPMDEHSCPLEFSSYGYPKNEIEY
                     KWKKPSVEVADPKYWRLYQFAFVGLRNSTEISHTISGDYIIMTIFFDLSRRMGYFTIQ
                     TYIPCILTVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMD
                     LFVSVCFIFVFAALMEYGTLHYFTSNNKGKTTRDRKLKSKTSVSPGLHAGSTLIPMNN
                     ISMPQGEDDYGYQCLEGKDCATFFCCFEDCRTGSWREGRIHIRIAKIDSYSRIFFPTA
                     FALFNLVYWVGYLYL"
     exon            204..352
                     /gene="Gabrg1"
                     /inference="alignment:Splign:2.1.0"
     exon            353..420
                     /gene="Gabrg1"
                     /inference="alignment:Splign:2.1.0"
     exon            421..641
                     /gene="Gabrg1"
                     /inference="alignment:Splign:2.1.0"
     exon            642..724
                     /gene="Gabrg1"
                     /inference="alignment:Splign:2.1.0"
     exon            725..862
                     /gene="Gabrg1"
                     /inference="alignment:Splign:2.1.0"
     exon            863..1015
                     /gene="Gabrg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1227
                     /gene="Gabrg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1737
                     /gene="Gabrg1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctatgcacat tccttgtact cactgtgctg ctgctgaggt gtgaggcaaa ctccgcttgg
       61 gaactgagct agtggagaaa ggatcttaaa agcgacctga tgggttctgg gaaagtcttc
      121 cttttctctc cttccctcct gtggagtcaa actagaggag tgaggttgat attcttgtta
      181 ctaaccctgc atctgggaaa ctgcattgat aaagcagatg atgaagatga tgaagattta
      241 actatgaaca aaacatgggt cttggcacct aaaattcatg aaggagatat cacacagatt
      301 ctcaactctt tacttcaagg ctatgataac aaacttcgtc cagatatagg cgtgagaccc
      361 acagtaattg aaactgatgt ttatgtaaac agcattggac ctgttgatcc cataaacatg
      421 gagtacacga tagacatcat ttttgcccag acctggtttg atagccgttt aaagttcaac
      481 agcaccatga aagtccttat gcttaacagc aacatggtgg gaaaaatttg gatccctgac
      541 acgttcttca ggaactcaag gaaatctgat gcgcactgga taacaacgcc caatcgcctg
      601 ctgcggatat ggagtgatgg aagggttctc tacactctga gattaacaat taatgcagaa
      661 tgctaccttc aactccataa ctttcctatg gatgaacatt cctgtccact ggaattttca
      721 agctatggat accctaaaaa tgaaattgag tacaagtgga aaaagccgtc agtggaagtg
      781 gctgatccta agtactggag attgtatcag tttgcctttg tagggttaag aaattcaacc
      841 gaaatctctc acacaatctc cggagattat attatcatga ctatcttttt tgacctgagc
      901 agacggatgg gctatttcac aattcagacc tacattccgt gcattctaac agttgttctt
      961 tcctgggtgt ctttttggat caacaaagat gctgtacctg ctagaacatc cctgggtatc
     1021 actacggttt tgactatgac aaccctcagt acaatcgcta gaaaatcttt acctaaggtt
     1081 tcttacgtga cagcaatgga tctctttgtc tctgtgtgtt tcatttttgt gtttgcagca
     1141 ctcatggagt atggaacctt gcattatttt actagtaaca ataaaggaaa aaccaccaga
     1201 gacaggaagc tgaaaagcaa aacttcggta tccccaggtc tccatgctgg atctactctg
     1261 attcccatga acaacatttc tatgcctcaa ggggaagatg attatggtta ccagtgcttg
     1321 gagggcaaag actgtgctac ctttttctgt tgctttgaag actgcagaac tgggtcctgg
     1381 agagaagggc gaatacacat acgcattgcc aaaatcgact cctactccag gatctttttc
     1441 ccaacagctt ttgccttgtt caatctggtt tactgggttg gatatctata cttataagtt
     1501 ctgccaatag ataaaaaaat tcataaaaat ctggcttagt ccaatataat cacttgcatt
     1561 tcataacagg aagttagaat ttaaaatgaa agtctaccag ttaaaatctg aatcatttgg
     1621 tcatatgatt aaggctttca taaataaata agaaagaatt attcaggtta atttacctaa
     1681 ctaaacatga aattcattgt ccaatatagc acatttaaat cataaactta tattttt
//
