LOCUS       NM_023091               3000 bp    mRNA    linear   ROD 16-JUN-2024
DEFINITION  Rattus norvegicus gamma-aminobutyric acid type A receptor subunit
            epsilon (Gabre), mRNA.
ACCESSION   NM_023091
VERSION     NM_023091.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3000)
  AUTHORS   Hengen,K.B., Nelson,N.R., Stang,K.M., Johnson,S.M., Smith,S.M.,
            Watters,J.J., Mitchell,G.S. and Behan,M.
  TITLE     Daily isoflurane exposure increases barbiturate insensitivity in
            medullary respiratory and cortical neurons via expression of
            epsilon-subunit containing GABA ARs
  JOURNAL   PLoS One 10 (3), e0119351 (2015)
   PUBMED   25748028
  REMARK    GeneRIF: Daily isoflurane exposure increases barbiturate
            insensitivity in medullary respiratory and cortical neurons via
            expression of epsilon-subunit containing GABA ARs.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3000)
  AUTHORS   Hengen,K.B., Nelson,N.R., Stang,K.M., Johnson,S.M., Crader,S.M.,
            Watters,J.J., Mitchell,G.S. and Behan,M.
  TITLE     Increased GABA(A) receptor epsilon-subunit expression on ventral
            respiratory column neurons protects breathing during pregnancy
  JOURNAL   PLoS One 7 (1), e30608 (2012)
   PUBMED   22303446
  REMARK    GeneRIF: Increased epsilon subunit expression may be critical to
            preserve respiratory function (and life) despite increased
            neurosteroid levels during pregnancy.
REFERENCE   3  (bases 1 to 3000)
  AUTHORS   Belujon,P., Baufreton,J., Grandoso,L., Boue-Grabot,E., Batten,T.F.,
            Ugedo,L., Garret,M. and Taupignon,A.I.
  TITLE     Inhibitory transmission in locus coeruleus neurons expressing GABAA
            receptor epsilon subunit has a number of unique properties
  JOURNAL   J Neurophysiol 102 (4), 2312-2325 (2009)
   PUBMED   19625540
REFERENCE   4  (bases 1 to 3000)
  AUTHORS   Pape,J.R., Bertrand,S.S., Lafon,P., Odessa,M.F., Chaigniau,M.,
            Stiles,J.K. and Garret,M.
  TITLE     Expression of GABA(A) receptor alpha3-, theta-, and epsilon-subunit
            mRNAs during rat CNS development and immunolocalization of the
            epsilon subunit in developing postnatal spinal cord
  JOURNAL   Neuroscience 160 (1), 85-96 (2009)
   PUBMED   19249336
  REMARK    GeneRIF: Our findings suggest that various combinations of GABA(A)
            alpha3-, theta- and epsilon-subunits may be assembled at a regional
            and developmental level in the brain.
REFERENCE   5  (bases 1 to 3000)
  AUTHORS   Sergeeva,O.A., Andreeva,N., Garret,M., Scherer,A. and Haas,H.L.
  TITLE     Pharmacological properties of GABAA receptors in rat hypothalamic
            neurons expressing the epsilon-subunit
  JOURNAL   J Neurosci 25 (1), 88-95 (2005)
   PUBMED   15634770
  REMARK    GeneRIF: We addressed the localization of the GABAA receptor
            epsilon subunit protein in two identified hypothalamic neuron
            groups, tuberomamillary and orexinergic, and the related functional
            properties.
REFERENCE   6  (bases 1 to 3000)
  AUTHORS   Moragues,N., Ciofi,P., Lafon,P., Tramu,G. and Garret,M.
  TITLE     GABAA receptor epsilon subunit expression in identified peptidergic
            neurons of the rat hypothalamus
  JOURNAL   Brain Res 967 (1-2), 285-289 (2003)
   PUBMED   12650990
  REMARK    GeneRIF: Expression of GABA-A receptors containing the epsilon
            subunit in neurons of the rat hypothalamus suggests that these
            receptors are likely to be involved in the GABAergic control of
            these neurons.
REFERENCE   7  (bases 1 to 3000)
  AUTHORS   Kasparov,S., Davies,K.A., Patel,U.A., Boscan,P., Garret,M. and
            Paton,J.F.
  TITLE     GABA(A) receptor epsilon-subunit may confer benzodiazepine
            insensitivity to the caudal aspect of the nucleus tractus solitarii
            of the rat
  JOURNAL   J Physiol 536 (Pt 3), 785-796 (2001)
   PUBMED   11691872
REFERENCE   8  (bases 1 to 3000)
  AUTHORS   Moragues,N., Ciofi,P., Lafon,P., Odessa,M.F., Tramu,G. and
            Garret,M.
  TITLE     cDNA cloning and expression of a gamma-aminobutyric acid A receptor
            epsilon-subunit in rat brain
  JOURNAL   Eur J Neurosci 12 (12), 4318-4330 (2000)
   PUBMED   11122342
REFERENCE   9  (bases 1 to 3000)
  AUTHORS   Sinkkonen,S.T., Hanna,M.C., Kirkness,E.F. and Korpi,E.R.
  TITLE     GABA(A) receptor epsilon and theta subunits display unusual
            structural variation between species and are enriched in the rat
            locus ceruleus
  JOURNAL   J Neurosci 20 (10), 3588-3595 (2000)
   PUBMED   10804200
REFERENCE   10 (bases 1 to 3000)
  AUTHORS   Davies,P.A., Hanna,M.C., Hales,T.G. and Kirkness,E.F.
  TITLE     Insensitivity to anaesthetic agents conferred by a class of GABA(A)
            receptor subunit
  JOURNAL   Nature 385 (6619), 820-823 (1997)
   PUBMED   9039914
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF189262.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF189262.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN11044071 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3000
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq37"
     gene            1..3000
                     /gene="Gabre"
                     /note="gamma-aminobutyric acid type A receptor subunit
                     epsilon"
                     /db_xref="GeneID:65191"
                     /db_xref="RGD:68320"
     exon            1..76
                     /gene="Gabre"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..2990
                     /gene="Gabre"
                     /note="gamma-aminobutyric acid receptor subunit epsilon;
                     GABA(A) receptor subunit epsilon; gamma-aminobutyric acid
                     (GABA-A) receptor, subunit epsilon; gamma-aminobutyric
                     acid A receptor, epsilon; gamma-aminobutyric acid type A
                     receptor epsilon subunit; gamma-aminobutyric acid (GABA) A
                     receptor, epsilon; GABAAR subunit epsilon"
                     /codon_start=1
                     /product="gamma-aminobutyric acid receptor subunit epsilon
                     precursor"
                     /protein_id="NP_075579.1"
                     /db_xref="GeneID:65191"
                     /db_xref="RGD:68320"
                     /translation="MLPKVLLMLLNMFLALQWRVGPHIKLENKPPAQDKVVFGPQPQP
                     VPQPLIPPESPAGDDVVFDSQPQPQSESPGHDDVFSSQPQPLPQPQPLPEPQPLPEPE
                     PQPQPQPQPQPQPQPLAGRQPLPQPLPWPLPQPQPEPEPQPEPQPEPQPEPQPEPQPE
                     PQPEPQPEPQPQPQPLAGRQPLPWPLPLPLPEPQPDPQPDPQPEPQPEPQPEPQPQPQ
                     TPGQVQAGRQPRPKPQPDPHPHPQPEPQPEPRLHPFHRLRLRPHPYPEPHPGPQPEPE
                     PEPEPEPQPEPQPEPQPEPQPEPEPQPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPE
                     PEPEPEPEPQPEPEPEPEPEPEPEPEPEPEPEPQPEPQPEPEPEPEPQPEPQPEPEPE
                     PEPEPEPEPEPEPEPQPEPQPEPEPQPEPQPDPEPQPEPGPEPGPEPEPEPQLEPQPE
                     PEPEPQPEPESELDLEPEPEPQPLPEPQPEPEPEPEPEPEPEPEPEPEPEPEPEPEPE
                     PEPEPELELEPQSQLEPQPSGKKLPARETELTADHTTERPRGKLTRASQILNTILSNY
                     DHKLRPSIGEKPTVVTVKVFVNSLGPISILDMEYSIDIIFYQTWYDERLRYNDTFETL
                     ILHGNVVSQLWIPDTFFRNSKRTQEYDITIPNQMALIHKDGKVLYTVRMTIDARCSLH
                     MLNFPMDSHSCPLSFSSFSYDEHEMIYKWENFKLKIDAKNTWKLLEFDFTGVNNKTEI
                     ISTPVGDFMVMTFFFNVSRRFGFIVFQNYIPSSVTTMLSWVSFWIKIEAAAARASVGV
                     SSVLTMATLGTFSRKNFPRVSYLTALDFYIAICFVLCFCTLLEFTVLNFLTYNNIERQ
                     ASPKFYQFPTNSRANARTRARARTRARARARARQQQEVFVCEIVTYEENAEEGYQWSP
                     RSRRPQCPWRRCGRSYVCFRVLRKYFCMVPGCEGNSWQRGRICIHVYRLDNYSRVLFP
                     ITFFFFNVVYWVICLNL"
     exon            77..1746
                     /gene="Gabre"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..1814
                     /gene="Gabre"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..2035
                     /gene="Gabre"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..2118
                     /gene="Gabre"
                     /inference="alignment:Splign:2.1.0"
     exon            2119..2256
                     /gene="Gabre"
                     /inference="alignment:Splign:2.1.0"
     exon            2257..2409
                     /gene="Gabre"
                     /inference="alignment:Splign:2.1.0"
     exon            2410..2609
                     /gene="Gabre"
                     /inference="alignment:Splign:2.1.0"
     exon            2610..3000
                     /gene="Gabre"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcgtgccagg caccgctgag atgttgccta aagttctcct gatgctcctc aacatgttcc
       61 tggccctcca gtggagggtt ggacctcaca ttaaactgga gaataaaccc cctgcccaag
      121 ataaggtagt ctttggccct cagcctcagc ctgtgccaca acctctgatt ccgcctgaat
      181 ctcctgctgg agatgatgta gtcttcgact ctcagcccca gccccagtcg gaatcccctg
      241 gccatgatga tgtctttagc tcccagcccc agcctctgcc ccagccccag cctctgccgg
      301 agccccagcc tctgccggag cctgagccac agccgcagcc acagccacag ccgcagccgc
      361 agccacagcc cctggctggg cgccagcctc tgccccagcc cctgccttgg cccctgcctc
      421 agcctcagcc cgaaccggag ccccagccgg agccccagcc ggagccccag cctgagcccc
      481 agccggagcc ccagcctgag ccccaaccag aaccccagcc agaaccccag cctcaacctc
      541 agcctctggc tgggcgccag cctttgcctt ggcccctgcc actgcccctg cccgagcccc
      601 aacctgatcc ccagcctgat ccccaaccgg agcctcagcc agaaccccaa cctgagcccc
      661 agcctcagcc ccagacccca ggccaggtcc aggctgggcg ccaaccccgc cccaaacctc
      721 agcctgatcc ccatccccat ccgcagcctg aacctcagcc tgagccacgt ctccatccct
      781 ttcaccgtct ccgtctccgt ccccatccct atcctgagcc ccatccagga ccccagccgg
      841 agcctgagcc tgagcctgag ccggagcccc agccggagcc ccagccggag ccccagccgg
      901 agccccaacc ggagcctgag ccccagccgg agccggagcc ggagcctgag cctgagcctg
      961 agcctgagcc tgagcccgag cccgagcccg agcccgagcc tgagcctgag cctgagcctg
     1021 agcctgagcc tgagcctgag cctgagcccc agccggagcc ggagccggag ccggagccgg
     1081 agcccgaacc tgagcccgag cccgagcccg agcccgagcc tcagccagag ccccagccag
     1141 aacctgagcc tgagcccgag ccccagcccg agccccagcc cgagcccgag cccgagcccg
     1201 agcccgagcc cgagcccgag cccgaacctg aacctgagcc tcagccggag ccccagcctg
     1261 agcctgagcc ccagcctgag ccccagccag atcctgagcc tcagcctgag cccggacctg
     1321 aacctggacc tgaacctgaa cctgagcctc agctggagcc ccagccagag cctgagcctg
     1381 agccacagcc ggagcctgag tcggagctgg acctggagcc ggaaccagag ccccagcccc
     1441 tgccggagcc ccagcctgag cctgagcctg agcctgagcc ggagccggag ccggagccgg
     1501 agccggagcc ggagccggag ccggagccgg agccggagcc tgagccagaa ccggagccag
     1561 agctggaact ggagccccag tcccagctgg agcctcagcc tagtggaaag aagcttccag
     1621 caagagaaac agaactcact gctgatcata caactgaacg cccacgtgga aaactgacaa
     1681 gagcttctca aatccttaac accatcctga gcaactacga ccataaactg cgccctagca
     1741 ttggagagaa gcctaccgtg gtcactgtta aagtctttgt caacagcctc ggacctattt
     1801 ccatcctaga catggaatat tccattgaca tcatcttcta ccagacctgg tatgatgagc
     1861 gtcttcgtta caatgacacc tttgagacac ttattctaca tggcaacgtg gtgagccagt
     1921 tgtggatccc ggatactttt tttaggaatt ctaagaggac ccaagagtat gatatcacca
     1981 tacccaacca gatggctctc atccataagg atggaaaagt gttgtacaca gttaggatga
     2041 ccattgatgc aagatgctca ctccacatgc tcaattttcc aatggattct cactcttgcc
     2101 ctctgtcttt ctctagcttt tcctatgatg agcatgagat gatatacaag tgggagaatt
     2161 tcaaactcaa aatcgatgcg aagaacactt ggaagctatt ggagtttgat tttacaggag
     2221 tgaacaacaa aactgaaatc atctccaccc cagttggtga cttcatggtc atgacattct
     2281 tcttcaatgt aagcaggagg tttggcttca ttgtctttca aaactatatc ccttcatctg
     2341 ttaccacaat gctttcctgg gtgtccttct ggatcaagat agaagctgct gctgccaggg
     2401 cctctgtagg ggtcagttct gtgctcacca tggccacact gggtaccttt tctcgtaaga
     2461 atttccctcg tgtctcctat ctcacagctt tggacttcta tattgcaatt tgtttcgtct
     2521 tgtgcttctg tactctacta gagttcactg tgctcaactt cctgacctac aataatattg
     2581 aacgacaggc ttctccaaag ttctaccaat ttccaaccaa tagccgtgct aatgcacgta
     2641 ctcgtgctcg tgcccgcact cgtgctcgtg ctcgtgcccg tgctcgtcag cagcaggaag
     2701 tgtttgtgtg tgagattgtt acctatgagg aaaatgctga agagggttac cagtggtctc
     2761 caagatcaag aagacctcag tgtccctgga ggcgatgtgg ccgaagctat gtgtgcttca
     2821 gggttctcag gaagtatttc tgcatggttc ctggttgtga gggcaacagc tggcagcggg
     2881 gccgcatctg catccacgtt tatcgcctgg ataactactc gcgggtgctt ttccccatta
     2941 cattcttctt ctttaatgtg gtctactggg tgatttgcct taacctgtag gctccagctg
//
