LOCUS       NM_017289               1786 bp    mRNA    linear   ROD 16-JUN-2024
DEFINITION  Rattus norvegicus gamma-aminobutyric acid type A receptor subunit
            delta (Gabrd), mRNA.
ACCESSION   NM_017289
VERSION     NM_017289.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1786)
  AUTHORS   Ghit,A., Assal,D., Al-Shami,A.S. and Hussein,D.E.E.
  TITLE     GABAA receptors: structure, function, pharmacology, and related
            disorders
  JOURNAL   J Genet Eng Biotechnol 19 (1), 123 (2021)
   PUBMED   34417930
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1786)
  AUTHORS   Malaguarnera,M., Balzano,T., Castro,M.C., Llansola,M. and Felipo,V.
  TITLE     The Dual Role of the GABAA Receptor in Peripheral Inflammation and
            Neuroinflammation: A Study in Hyperammonemic Rats
  JOURNAL   Int J Mol Sci 22 (13), 6772 (2021)
   PUBMED   34202516
  REMARK    GeneRIF: The Dual Role of the GABAA Receptor in Peripheral
            Inflammation and Neuroinflammation: A Study in Hyperammonemic Rats.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1786)
  AUTHORS   Kumar,P. and Sharma,D.
  TITLE     Ameliorative effect of curcumin on altered expression of CACNA1A
            and GABRD in the pathogenesis of FeCl3-induced epilepsy
  JOURNAL   Mol Biol Rep 47 (8), 5699-5710 (2020)
   PUBMED   32803504
  REMARK    GeneRIF: Ameliorative effect of curcumin on altered expression of
            CACNA1A and GABRD in the pathogenesis of FeCl3-induced epilepsy.
REFERENCE   4  (bases 1 to 1786)
  AUTHORS   Chua,H.C. and Chebib,M.
  TITLE     GABAA Receptors and the Diversity in their Structure and
            Pharmacology
  JOURNAL   Adv Pharmacol 79, 1-34 (2017)
   PUBMED   28528665
  REMARK    Review article
REFERENCE   5  (bases 1 to 1786)
  AUTHORS   Wongsamitkul,N., Baur,R. and Sigel,E.
  TITLE     Toward Understanding Functional Properties and Subunit Arrangement
            of alpha4beta2delta gamma-Aminobutyric Acid, Type A (GABAA)
            Receptors
  JOURNAL   J Biol Chem 291 (35), 18474-18483 (2016)
   PUBMED   27382064
  REMARK    GeneRIF: the subunit arrangement of alpha4beta2delta GABAA
            receptors is not strongly predefined but is mostly satisfying the
            2:2:1 subunit stoichiometry for alpha4, beta2, and delta subunits
            and that several subunit arrangements result in receptors with
            similar functional properties tuned to physiological conditions.
REFERENCE   6  (bases 1 to 1786)
  AUTHORS   Wisden,W. and Seeburg,P.H.
  TITLE     GABAA receptor channels: from subunits to functional entities
  JOURNAL   Curr Opin Neurobiol 2 (3), 263-269 (1992)
   PUBMED   1379501
  REMARK    Review article
REFERENCE   7  (bases 1 to 1786)
  AUTHORS   Laurie,D.J., Seeburg,P.H. and Wisden,W.
  TITLE     The distribution of 13 GABAA receptor subunit mRNAs in the rat
            brain. II. Olfactory bulb and cerebellum
  JOURNAL   J Neurosci 12 (3), 1063-1076 (1992)
   PUBMED   1312132
REFERENCE   8  (bases 1 to 1786)
  AUTHORS   Wisden,W., Laurie,D.J., Monyer,H. and Seeburg,P.H.
  TITLE     The distribution of 13 GABAA receptor subunit mRNAs in the rat
            brain. I. Telencephalon, diencephalon, mesencephalon
  JOURNAL   J Neurosci 12 (3), 1040-1062 (1992)
   PUBMED   1312131
REFERENCE   9  (bases 1 to 1786)
  AUTHORS   Zhao,Z.Y. and Joho,R.H.
  TITLE     Isolation of distantly related members in a multigene family using
            the polymerase chain reaction technique
  JOURNAL   Biochem Biophys Res Commun 167 (1), 174-182 (1990)
   PUBMED   1690000
  REMARK    Erratum:[Biochem Biophys Res Commun 1990 Apr 30;168(2):887]
REFERENCE   10 (bases 1 to 1786)
  AUTHORS   Shivers,B.D., Killisch,I., Sprengel,R., Sontheimer,H., Kohler,M.,
            Schofield,P.R. and Seeburg,P.H.
  TITLE     Two novel GABAA receptor subunits exist in distinct neuronal
            subpopulations
  JOURNAL   Neuron 3 (3), 327-337 (1989)
   PUBMED   2561970
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Nov 26, 2020 this sequence version replaced NM_017289.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M35162.1, BC087714.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               JAXUCZ010000005.1  171252600-171252709 c
            111-223             JAXUCZ010000005.1  171244722-171244834 c
            224-291             JAXUCZ010000005.1  171244344-171244411 c
            292-512             JAXUCZ010000005.1  171244030-171244250 c
            513-595             JAXUCZ010000005.1  171243623-171243705 c
            596-733             JAXUCZ010000005.1  171242935-171243072 c
            734-889             JAXUCZ010000005.1  171242241-171242396 c
            890-1101            JAXUCZ010000005.1  171241772-171241983 c
            1102-1786           JAXUCZ010000005.1  171240813-171241497 c
FEATURES             Location/Qualifiers
     source          1..1786
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1786
                     /gene="Gabrd"
                     /gene_synonym="GABAA-RD"
                     /note="gamma-aminobutyric acid type A receptor subunit
                     delta"
                     /db_xref="GeneID:29689"
                     /db_xref="RGD:61901"
     exon            1..110
                     /gene="Gabrd"
                     /gene_synonym="GABAA-RD"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..1392
                     /gene="Gabrd"
                     /gene_synonym="GABAA-RD"
                     /note="gamma-aminobutyric acid receptor subunit delta;
                     gamma-aminobutyric acid type A receptor delta subunit;
                     GABAA receptor delta subunit; GABA-A receptor
                     delta-subunit; GABA(A) receptor subunit delta;
                     gamma-aminobutyric acid (GABA-A) receptor, subunit delta;
                     gamma-aminobutyric acid A receptor, delta;
                     gamma-aminobutyric acid (GABA) A receptor, delta; GABAAR
                     subunit delta"
                     /codon_start=1
                     /product="gamma-aminobutyric acid receptor subunit delta
                     precursor"
                     /protein_id="NP_058985.1"
                     /db_xref="GeneID:29689"
                     /db_xref="RGD:61901"
                     /translation="MDVLGWLLLPLLLLCTQPHHGARAMNDIGDYVGSNLEISWLPNL
                     DGLMEGYARNFRPGIGGPPVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSRLSY
                     NHTNETLGLDSRFVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRITS
                     TVACDMDLAKYPMDEQECMLDLESYGYSSEDIVYYWSENQEQIHGLDRLQLAQFTITS
                     YRFTTELMNFKSAGQFPRLSLHFQLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAV
                     PARVSLGITTVLTMTTLMVSARSSLPRASAIKALDVYFWICYVFVFAALVEYAFAHFN
                     ADYRKKRKAKVKVTKPRAEMDVRNAIVLFSLSAAGVSQELAISRRQGRVPGNLMGSYR
                     SVEVEAKKEGGSRPGGPGGIRSRLKPIDADTIDIYARAVFPAAFAAVNIIYWAAYTM"
     exon            111..223
                     /gene="Gabrd"
                     /gene_synonym="GABAA-RD"
                     /inference="alignment:Splign:2.1.0"
     exon            224..291
                     /gene="Gabrd"
                     /gene_synonym="GABAA-RD"
                     /inference="alignment:Splign:2.1.0"
     exon            292..512
                     /gene="Gabrd"
                     /gene_synonym="GABAA-RD"
                     /inference="alignment:Splign:2.1.0"
     exon            513..595
                     /gene="Gabrd"
                     /gene_synonym="GABAA-RD"
                     /inference="alignment:Splign:2.1.0"
     exon            596..733
                     /gene="Gabrd"
                     /gene_synonym="GABAA-RD"
                     /inference="alignment:Splign:2.1.0"
     exon            734..889
                     /gene="Gabrd"
                     /gene_synonym="GABAA-RD"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1101
                     /gene="Gabrd"
                     /gene_synonym="GABAA-RD"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1786
                     /gene="Gabrd"
                     /gene_synonym="GABAA-RD"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggggctag ccggacctgt cccgcgcaca gcccgcaagg ccatggacgt tctgggctgg
       61 ctgctgctgc cgctccttct gctgtgcacg cagccgcacc atggcgccag agcaatgaat
      121 gacattgggg actacgtggg ctccaacctg gagatatcct ggctccccaa cctggatgga
      181 ctaatggagg gctacgcccg aaacttccga ccaggcattg gaggtcctcc agtgaatgtg
      241 gcgcttgccc tagaggtggc cagcattgac cacatctcag aagcaaatat ggaatacacc
      301 atgacagtgt tcctgcacca gagctggcga gacagcaggc tgtcctacaa ccataccaac
      361 gagaccctgg gcctggatag ccgcttcgtg gacaagctgt ggctccctga caccttcatt
      421 gtgaatgcca agtctgcctg gttccatgat gtgaccgtgg aaaacaagct tatccgccta
      481 cagcccgacg gtgtgatttt atacagcatc cgcatcacct ccacagtggc ctgtgacatg
      541 gaccttgcca agtaccccat ggacgagcag gagtgcatgc tggacctgga gagctatggc
      601 tactcttctg aggacattgt ctattattgg tcagaaaacc aggagcagat ccacgggctg
      661 gacaggctgc aactggccca gttcactatc accagttacc gcttcaccac ggagctgatg
      721 aacttcaaat cagctggcca gttccctcga ctcagcttac acttccagct tcggaggaac
      781 cggggtgtct acatcatcca gtcttacatg ccctctgtcc tcctggttgc catgtcctgg
      841 gtctccttct ggattagcca agcagcagtg cctgccagag tatctctagg catcaccact
      901 gtgctgacaa tgaccacact catggttagt gcccgctcct ccctcccgcg ggcttctgct
      961 atcaaggctc tggatgtgta tttctggatc tgctatgtct tcgtgtttgc tgccctggtg
     1021 gagtatgcat ttgcccactt caatgctgac tacaggaaga aacggaaagc caaggtcaag
     1081 gtcacgaagc caagggcaga gatggacgtg aggaacgcca ttgtcctctt ctccctctct
     1141 gctgccgggg tcagccagga gttggctatc tcccgccgtc aaggccgggt ccctgggaac
     1201 ctcatgggtt cctataggtc tgtagaagtg gaggcaaaga aggagggggg gtcccgccca
     1261 gggggcccag gaggcatccg ttccagactc aaacccatcg atgcagacac catcgacatc
     1321 tatgcccgcg ctgtgttccc ggcagccttt gcagcagtca acatcatcta ctgggcggcg
     1381 tataccatgt gacggcagtg cgtacaccac atgacggctt tacatgtacc acgtgcggtg
     1441 gttgccacaa actcctggag gaacagccct ctccgtggat cccaaagtgg gacagagagg
     1501 aggctccgct ccctgggctt tacctcaatt ttgctctacc agcctgcact tcctgtagat
     1561 ggagcaggat gggctttgca cagagggcca ttagttggcc tgtccctgaa gctgagcctg
     1621 gcactaaggt gcccttggga gctgtgaagt tttagactca ggatgggcct gatttctggg
     1681 cctttgctct gtgggatcag gatcagagag aaagagagta ggggtggatg accactctca
     1741 tggtgaactg gaggagaagg gcattatgag gcctctttgg tcccag
//
