LOCUS       NM_017065               1996 bp    mRNA    linear   ROD 03-JUL-2024
DEFINITION  Rattus norvegicus gamma-aminobutyric acid type A receptor subunit
            beta 3 (Gabrb3), mRNA.
ACCESSION   NM_017065
VERSION     NM_017065.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1996)
  AUTHORS   Ghit,A., Assal,D., Al-Shami,A.S. and Hussein,D.E.E.
  TITLE     GABAA receptors: structure, function, pharmacology, and related
            disorders
  JOURNAL   J Genet Eng Biotechnol 19 (1), 123 (2021)
   PUBMED   34417930
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1996)
  AUTHORS   Menzikov,S.A., Zaichenko,D.M., Moskovtsev,A.A., Morozov,S.G. and
            Kubatiev,A.A.
  TITLE     Ectopic GABAA receptor beta3 subunit determines Cl- / HCO3- -ATPase
            and chloride transport in HEK 293FT cells
  JOURNAL   FEBS J 288 (2), 699-712 (2021)
   PUBMED   32383536
  REMARK    GeneRIF: Ectopic GABAA receptor beta3 subunit determines Cl(-) /
            HCO 3 - -ATPase and chloride transport in HEK 293FT cells.
REFERENCE   3  (bases 1 to 1996)
  AUTHORS   Needs,H.I., Henley,B.S., Cavallo,D., Gurung,S., Modebadze,T.,
            Woodhall,G. and Henley,J.M.
  TITLE     Changes in excitatory and inhibitory receptor expression and
            network activity during induction and establishment of epilepsy in
            the rat Reduced Intensity Status Epilepticus (RISE) model
  JOURNAL   Neuropharmacology 158, 107728 (2019)
   PUBMED   31356824
REFERENCE   4  (bases 1 to 1996)
  AUTHORS   Laverty,D., Desai,R., Uchanski,T., Masiulis,S., Stec,W.J.,
            Malinauskas,T., Zivanov,J., Pardon,E., Steyaert,J., Miller,K.W. and
            Aricescu,A.R.
  TITLE     Cryo-EM structure of the human alpha1beta3gamma2 GABAA receptor in
            a lipid bilayer
  JOURNAL   Nature 565 (7740), 516-520 (2019)
   PUBMED   30602789
REFERENCE   5  (bases 1 to 1996)
  AUTHORS   Shukla,P.K., Meena,A.S., Rao,R. and Rao,R.
  TITLE     Deletion of TLR-4 attenuates fetal alcohol exposure-induced gene
            expression and social interaction deficits
  JOURNAL   Alcohol 73, 73-78 (2018)
   PUBMED   30312858
REFERENCE   6  (bases 1 to 1996)
  AUTHORS   Davies,P.A., Hanna,M.C., Hales,T.G. and Kirkness,E.F.
  TITLE     Insensitivity to anaesthetic agents conferred by a class of GABA(A)
            receptor subunit
  JOURNAL   Nature 385 (6619), 820-823 (1997)
   PUBMED   9039914
REFERENCE   7  (bases 1 to 1996)
  AUTHORS   Kirkness,E.F. and Fraser,C.M.
  TITLE     A strong promoter element is located between alternative exons of a
            gene encoding the human gamma-aminobutyric acid-type A receptor
            beta 3 subunit (GABRB3)
  JOURNAL   J Biol Chem 268 (6), 4420-4428 (1993)
   PUBMED   8382702
REFERENCE   8  (bases 1 to 1996)
  AUTHORS   Wagstaff,J., Chaillet,J.R. and Lalande,M.
  TITLE     The GABAA receptor beta 3 subunit gene: characterization of a human
            cDNA from chromosome 15q11q13 and mapping to a region of conserved
            synteny on mouse chromosome 7
  JOURNAL   Genomics 11 (4), 1071-1078 (1991)
   PUBMED   1664410
REFERENCE   9  (bases 1 to 1996)
  AUTHORS   Ymer,S., Schofield,P.R., Draguhn,A., Werner,P., Kohler,M. and
            Seeburg,P.H.
  TITLE     GABAA receptor beta subunit heterogeneity: functional expression of
            cloned cDNAs
  JOURNAL   EMBO J 8 (6), 1665-1670 (1989)
   PUBMED   2548852
REFERENCE   10 (bases 1 to 1996)
  AUTHORS   Lolait,S.J., O'Carroll,A.M., Kusano,K., Muller,J.M.,
            Brownstein,M.J. and Mahan,L.C.
  TITLE     Cloning and expression of a novel rat GABAA receptor
  JOURNAL   FEBS Lett 246 (1-2), 145-148 (1989)
   PUBMED   2540033
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 27, 2020 this sequence version replaced NM_017065.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.3215.1,
                                           SRR26360176.179365.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-151               JAXUCZ010000001.1  117603460-117603610
            152-243             JAXUCZ010000001.1  117603736-117603827
            244-311             JAXUCZ010000001.1  117604024-117604091
            312-532             JAXUCZ010000001.1  117773320-117773540
            533-615             JAXUCZ010000001.1  117795274-117795356
            616-753             JAXUCZ010000001.1  117798574-117798711
            754-906             JAXUCZ010000001.1  117821296-117821448
            907-1151            JAXUCZ010000001.1  117825450-117825694
            1152-1996           JAXUCZ010000001.1  117833825-117834669
FEATURES             Location/Qualifiers
     source          1..1996
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1996
                     /gene="Gabrb3"
                     /note="gamma-aminobutyric acid type A receptor subunit
                     beta 3"
                     /db_xref="GeneID:24922"
                     /db_xref="RGD:2651"
     exon            1..151
                     /gene="Gabrb3"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..1493
                     /gene="Gabrb3"
                     /note="gamma-aminobutyric acid receptor subunit beta-3;
                     testis gamma-aminobutyric acid receptor subunit beta 3;
                     GABA(A) receptor subunit beta-3; Gamma-aminobutyric acid
                     receptor beta 3; gamma-aminobutyric acid (GABA-A)
                     receptor, subunit beta 3; gamma-aminobutyric acid (GABA) A
                     receptor, beta 3; GABA-alpha receptor beta-3 subunit;
                     gamma-aminobutyric acid type A receptor beta 3 subunit;
                     GABAAR subunit beta-3"
                     /codon_start=1
                     /product="gamma-aminobutyric acid receptor subunit beta-3
                     precursor"
                     /protein_id="NP_058761.2"
                     /db_xref="GeneID:24922"
                     /db_xref="RGD:2651"
                     /translation="MWGFAGGRLFGIFSAPVLVAVVCCAQSVNDPGNMSFVKETVDKL
                     LKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYSGI
                     PLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAA
                     CMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRL
                     VSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARV
                     ALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGR
                     GPQRQKKLAEKTAKAKNDRSKSEINRVDAHGNILLAPMDVHNEMNEVAGSVGDTRNSA
                     ISFDNSGIQYRKQSMPKEGHGRYMGDRSIPHKKTHLRRRSSQLKIKIPDLTDVNAIDR
                     WSRIVFPFTFSLFNLVYWLYYVN"
     exon            152..243
                     /gene="Gabrb3"
                     /inference="alignment:Splign:2.1.0"
     exon            244..311
                     /gene="Gabrb3"
                     /inference="alignment:Splign:2.1.0"
     exon            312..532
                     /gene="Gabrb3"
                     /inference="alignment:Splign:2.1.0"
     exon            533..615
                     /gene="Gabrb3"
                     /inference="alignment:Splign:2.1.0"
     exon            616..753
                     /gene="Gabrb3"
                     /inference="alignment:Splign:2.1.0"
     exon            754..906
                     /gene="Gabrb3"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1151
                     /gene="Gabrb3"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1996
                     /gene="Gabrb3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagcagccc cggctgcggg tcgcgacggc ggcggggcgc cccctccccc gtgccggggc
       61 gcggcgaagg gatgtggggc tttgcgggag gaaggctttt cggcatcttc tcggccccgg
      121 tgctggtggc ggtggtttgc tgcgcccaga gcgtaaacga ccccgggaac atgtcctttg
      181 tgaaggagac ggtcgacaag ctgttgaaag gctacgacat tcgcctgaga ccggacttcg
      241 ggggtccccc agtctgcgtg gggatgaaca tcgacatcgc cagcatcgac atggtttctg
      301 aagtcaacat ggattatacc ttaactatgt atttccaaca atattggaga gataaaaggc
      361 tcgcctactc tgggatccct ctcaacctca cgcttgacaa tcgagtggct gaccagctct
      421 gggtgcctga cacatatttc ttaaatgaca aaaagtcatt tgtgcacgga gtgacagtga
      481 aaaaccgcat gatccgcctc caccctgatg gaacagtgct gtacgggctc aggatcacca
      541 ccacagcagc ttgcatgatg gacctcagaa gatacccact ggatgagcaa aactgcaccc
      601 tggaaattga aagctatgga tacaccacgg atgacattga attttactgg cgtggcgggg
      661 acaaggctgt tactggcgtg gaaaggatcg agctcccaca gttctccatt gtggagcacc
      721 gtctggtctc caggaatgtt gtcttcgcca caggtgccta ccctcgactc tcattgagtt
      781 ttcggttgaa gagaaacatt gggtacttca tacttcagac gtatatgccc tcaatactga
      841 tcacaatcct ctcatgggtg tccttctgga tcaattatga tgcatctgct gctcgagttg
      901 ccctagggat taccaccgtg ctcaccatga caaccatcaa cactcacctt cgagagactc
      961 tacccaaaat cccctacgtc aaagccatcg acatgtacct gatgggttgc ttcgtctttg
     1021 tattcctggc acttctggag tatgcctttg tcaactatat tttctttgga cgaggtcccc
     1081 aacggcagaa gaagcttgca gagaagacag ccaaggccaa gaatgatcga tccaagagtg
     1141 aaatcaaccg ggtggatgct cacgggaata tcctactagc accgatggat gttcacaatg
     1201 aaatgaatga ggttgcaggc agcgttggtg acaccaggaa ttcagcaata tcctttgaca
     1261 actcaggaat ccagtatagg aaacagagca tgcccaagga agggcatggg cggtacatgg
     1321 gagacagaag catcccgcac aagaagacgc acctacggag gaggtcttcg cagctcaaaa
     1381 tcaaaatccc tgatctaacc gatgtgaatg ccatagacag atggtcccgg atcgtgtttc
     1441 cattcacctt ttctctcttc aacttagttt actggctgta ctatgttaac tgagtgactg
     1501 tacttgattt ttcaaagact tcatttaaca ctgagtgaaa tattaccctg cctgtcaagt
     1561 ttttatacca gtatacacac acacacacaa acaaacgcac acacaaacac acacatacac
     1621 aaacacacac acacacacat acacagacac acacaattgt atatatatgt gaactttctc
     1681 agcatatata taaaatacac gtgtatatga gaatgtatgt gtatatgttt atgtacactg
     1741 gtgagagtgc ctgtgtatgt aaaacaaata cgcatacata ccatacattt tgcaactatg
     1801 gacaatttaa cacaggatgc atattaaaga aagtcatagc tttttttttc ttttttaatt
     1861 gaaagggaca agtatctaaa tattatgcct caagaatgag ggcgtgaaac acagtcatcc
     1921 caaagtgtgt cttttattat cataagtttt tgcttaagaa tcaaaacgga attcttagtt
     1981 aatctttggg cactcc
//
