LOCUS       NM_012957               1425 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus gamma-aminobutyric acid type A receptor subunit
            beta 2 (Gabrb2), mRNA.
ACCESSION   NM_012957
VERSION     NM_012957.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1425)
  AUTHORS   Michalowski,M.A., Czyzewska,M.M., Izykowska,I. and Mozrzymas,J.W.
  TITLE     The beta2 subunit E155 residue as a proton sensor at the binding
            site on GABA type A receptors
  JOURNAL   Eur J Pharmacol 906, 174293 (2021)
   PUBMED   34214584
  REMARK    GeneRIF: The beta2 subunit E155 residue as a proton sensor at the
            binding site on GABA type A receptors.
REFERENCE   2  (bases 1 to 1425)
  AUTHORS   Ghit,A., Assal,D., Al-Shami,A.S. and Hussein,D.E.E.
  TITLE     GABAA receptors: structure, function, pharmacology, and related
            disorders
  JOURNAL   J Genet Eng Biotechnol 19 (1), 123 (2021)
   PUBMED   34417930
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1425)
  AUTHORS   Germann,A.L., Pierce,S.R., Tateiwa,H., Sugasawa,Y., Reichert,D.E.,
            Evers,A.S., Steinbach,J.H. and Akk,G.
  TITLE     Intrasubunit and Intersubunit Steroid Binding Sites Independently
            and Additively Mediate alpha1beta2gamma2L GABAA Receptor
            Potentiation by the Endogenous Neurosteroid Allopregnanolone
  JOURNAL   Mol Pharmacol 100 (1), 19-31 (2021)
   PUBMED   33958479
  REMARK    GeneRIF: Intrasubunit and Intersubunit Steroid Binding Sites
            Independently and Additively Mediate alpha1beta2gamma2L GABAA
            Receptor Potentiation by the Endogenous Neurosteroid
            Allopregnanolone.
REFERENCE   4  (bases 1 to 1425)
  AUTHORS   Zhu,S., Noviello,C.M., Teng,J., Walsh,R.M. Jr., Kim,J.J. and
            Hibbs,R.E.
  TITLE     Structure of a human synaptic GABAA receptor
  JOURNAL   Nature 559 (7712), 67-72 (2018)
   PUBMED   29950725
REFERENCE   5  (bases 1 to 1425)
  AUTHORS   Nguyen,Q.A. and Nicoll,R.A.
  TITLE     The GABAA Receptor beta Subunit Is Required for Inhibitory
            Transmission
  JOURNAL   Neuron 98 (4), 718-725 (2018)
   PUBMED   29706582
  REMARK    GeneRIF: In inhibitory transmission onto hippocampal CA1 pyramidal
            cells, deletion of all beta subunits 1, 2, and 3 completely
            eliminated inhibitory responses. In addition, only knockout of
            beta3, alone or in combination with another beta subunit, impaired
            inhibitory synaptic transmission. expression of beta3 alone on the
            background of the beta1-3 subunit knockout was sufficient to
            restore synaptic and extrasynaptic inhibitory ...
REFERENCE   6  (bases 1 to 1425)
  AUTHORS   Bedford,F.K., Kittler,J.T., Muller,E., Thomas,P., Uren,J.M.,
            Merlo,D., Wisden,W., Triller,A., Smart,T.G. and Moss,S.J.
  TITLE     GABA(A) receptor cell surface number and subunit stability are
            regulated by the ubiquitin-like protein Plic-1
  JOURNAL   Nat Neurosci 4 (9), 908-916 (2001)
   PUBMED   11528422
REFERENCE   7  (bases 1 to 1425)
  AUTHORS   Schaerer,M.T., Kannenberg,K., Hunziker,P., Baumann,S.W. and
            Sigel,E.
  TITLE     Interaction between GABA(A) receptor beta subunits and the
            multifunctional protein gC1q-R
  JOURNAL   J Biol Chem 276 (28), 26597-26604 (2001)
   PUBMED   11350968
REFERENCE   8  (bases 1 to 1425)
  AUTHORS   Saha,S., Sieghart,W., Fritschy,J.M., McWilliam,P.N. and Batten,T.F.
  TITLE     Gamma-aminobutyric acid receptor (GABA(A)) subunits in rat nucleus
            tractus solitarii (NTS) revealed by polymerase chain reaction (PCR)
            and immunohistochemistry
  JOURNAL   Mol Cell Neurosci 17 (1), 241-257 (2001)
   PUBMED   11161482
REFERENCE   9  (bases 1 to 1425)
  AUTHORS   Nusser,Z., Sieghart,W. and Somogyi,P.
  TITLE     Segregation of different GABAA receptors to synaptic and
            extrasynaptic membranes of cerebellar granule cells
  JOURNAL   J Neurosci 18 (5), 1693-1703 (1998)
   PUBMED   9464994
REFERENCE   10 (bases 1 to 1425)
  AUTHORS   Ymer,S., Schofield,P.R., Draguhn,A., Werner,P., Kohler,M. and
            Seeburg,P.H.
  TITLE     GABAA receptor beta subunit heterogeneity: functional expression of
            cloned cDNAs
  JOURNAL   EMBO J 8 (6), 1665-1670 (1989)
   PUBMED   2548852
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY574251.1.
            
            [WARNING] On May 3, 2024 this sequence was replaced by NM_012957.3.
            
            On Jun 10, 2007 this sequence version replaced NM_012957.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY574251.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1425
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q21"
     gene            1..1425
                     /gene="Gabrb2"
                     /gene_synonym="GARB2"
                     /note="gamma-aminobutyric acid type A receptor subunit
                     beta 2"
                     /db_xref="GeneID:25451"
                     /db_xref="RGD:2650"
     CDS             1..1425
                     /gene="Gabrb2"
                     /gene_synonym="GARB2"
                     /note="gamma-aminobutyric acid receptor subunit beta-2;
                     GABA(A) receptor subunit beta-2; Gamma-aminobutyric acid
                     receptor beta 2; gamma-aminobutyric acid (GABA-A)
                     receptor, subunit beta 2; gamma-aminobutyric acid (GABA) A
                     receptor, beta 2; gamma-aminobutyric acid type A receptor
                     beta 2 subunit"
                     /codon_start=1
                     /product="gamma-aminobutyric acid receptor subunit beta-2
                     precursor"
                     /protein_id="NP_037089.1"
                     /db_xref="GeneID:25451"
                     /db_xref="RGD:2650"
                     /translation="MWRVRKRGYFGIWSFPLIIAAVCAQSVNDPSNMSLVKETVDRLL
                     KGYDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIP
                     LNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAAC
                     MMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLI
                     TKKVVFSTGSYPRLSLSFKLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVA
                     LGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRG
                     PQRQKKAAEKAANANNEKMRLDVNKMDPHENILLSTLEIKNEMATSEAVMGLGDPRST
                     MLAYDASSIQYRKAGLPRHSFGRNALERHVAQKKSRLRRRASQLKITIPDLTDVNAID
                     RWSRIFFPVVFSFFNIVYWLYYVN"
     exon            1..77
                     /gene="Gabrb2"
                     /gene_synonym="GARB2"
                     /inference="alignment:Splign:2.1.0"
     exon            78..169
                     /gene="Gabrb2"
                     /gene_synonym="GARB2"
                     /inference="alignment:Splign:2.1.0"
     exon            170..237
                     /gene="Gabrb2"
                     /gene_synonym="GARB2"
                     /inference="alignment:Splign:2.1.0"
     exon            238..458
                     /gene="Gabrb2"
                     /gene_synonym="GARB2"
                     /inference="alignment:Splign:2.1.0"
     exon            459..541
                     /gene="Gabrb2"
                     /gene_synonym="GARB2"
                     /inference="alignment:Splign:2.1.0"
     exon            542..679
                     /gene="Gabrb2"
                     /gene_synonym="GARB2"
                     /inference="alignment:Splign:2.1.0"
     exon            680..832
                     /gene="Gabrb2"
                     /gene_synonym="GARB2"
                     /inference="alignment:Splign:2.1.0"
     exon            833..1077
                     /gene="Gabrb2"
                     /gene_synonym="GARB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1425
                     /gene="Gabrb2"
                     /gene_synonym="GARB2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtggagag tccggaaaag gggctacttt gggatttggt catttccctt aataatcgcc
       61 gctgtctgtg ctcagagtgt caatgaccct agtaatatgt cgctggttaa agagacggtg
      121 gacagactgt tgaaaggcta tgacattcgt ctgagaccag atttcggagg tccccctgtg
      181 gcagtaggaa tgaacattga tatcgccagc atcgatatgg tttctgaagt caatatggac
      241 tacaccttga ccatgtattt ccagcaagcc tggagagata agagactgtc ctacaatgta
      301 atccctttaa acttgacttt ggacaatcga gtggcagacc agctctgggt gcctgacacc
      361 tacttcctga atgataagaa gtcatttgta catggagtga ctgtcaaaaa ccgtatgatt
      421 cgactgcatc cagatggtac tgtcctgtat ggcctcagaa tcacaactac agctgcctgc
      481 atgatggacc taaggcggta tccactggat gaacaaaact gcacgttgga gatcgaaagc
      541 tatggctata caactgatga cattgagttt tactggcgtg gcgatgacaa tgcagtcacg
      601 ggagtgacaa agattgagct tcctcagttc tccattgtag attataaact catcaccaag
      661 aaagttgttt tctccacagg ttcttatccc agattgtccc taagctttaa gctgaaaaga
      721 aacattggct acttcatcct gcagacatac atgccatcca ttctgattac catcctctcc
      781 tgggtctcct tttggatcaa ctatgatgct tctgctgcac gggttgcatt aggaattaca
      841 actgtcctga cgatgaccac aatcaatacc catctccggg agactctccc taaaattccc
      901 tatgtaaaag ccattgacat gtacctaatg gggtgctttg tctttgtctt tatggccctt
      961 ctggaatatg ctttggtcaa ctacatcttc tttgggagag gaccccagcg ccaaaagaaa
     1021 gcagctgaga aagctgctaa tgccaacaac gagaagatgc gcctggatgt caacaagatg
     1081 gacccacatg agaacatctt actcagcact cttgagataa aaaatgagat ggccacatca
     1141 gaagcagtaa tgggacttgg agaccccagg agcacaatgc ttgcctatga tgcctccagc
     1201 atccagtatc ggaaagctgg gttgcctagg catagttttg gccgcaacgc cctggaacga
     1261 catgtggcac aaaagaaaag tcgcctgagg agacgtgcct cccaactgaa aatcaccatc
     1321 cccgacttga ctgatgtgaa cgccattgat cggtggtccc gcattttctt ccctgtggtg
     1381 ttttccttct tcaacatcgt ctattggctt tactatgtga actaa
//
