LOCUS       NM_012956               1937 bp    mRNA    linear   ROD 16-JUN-2024
DEFINITION  Rattus norvegicus gamma-aminobutyric acid type A receptor subunit
            beta1 (Gabrb1), mRNA.
ACCESSION   NM_012956
VERSION     NM_012956.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1937)
  AUTHORS   Shimizu,Y., Shimizu,T., Zou,S., Ono,H., Hata,Y., Yamamoto,M.,
            Aratake,T., Shimizu,S., Higashi,Y., Karashima,T. and Saito,M.
  TITLE     Stimulation of brain alpha7-nicotinic acetylcholine receptors
            suppresses the rat micturition through brain GABAergic receptors
  JOURNAL   Biochem Biophys Res Commun 548, 84-90 (2021)
   PUBMED   33636639
  REMARK    GeneRIF: Stimulation of brain alpha7-nicotinic acetylcholine
            receptors suppresses the rat micturition through brain GABAergic
            receptors.
REFERENCE   2  (bases 1 to 1937)
  AUTHORS   Nguyen,Q.A. and Nicoll,R.A.
  TITLE     The GABAA Receptor beta Subunit Is Required for Inhibitory
            Transmission
  JOURNAL   Neuron 98 (4), 718-725 (2018)
   PUBMED   29706582
  REMARK    GeneRIF: In inhibitory transmission onto hippocampal CA1 pyramidal
            cells, deletion of all beta subunits 1, 2, and 3 completely
            eliminated inhibitory responses. In addition, only knockout of
            beta3, alone or in combination with another beta subunit, impaired
            inhibitory synaptic transmission. expression of beta3 alone on the
            background of the beta1-3 subunit knockout was sufficient to
            restore synaptic and extrasynaptic inhibitory ...
REFERENCE   3  (bases 1 to 1937)
  AUTHORS   Janve,V.S., Hernandez,C.C., Verdier,K.M., Hu,N. and Macdonald,R.L.
  TITLE     Epileptic encephalopathy de novo GABRB mutations impair
            gamma-aminobutyric acid type A receptor function
  JOURNAL   Ann Neurol 79 (5), 806-825 (2016)
   PUBMED   26950270
REFERENCE   4  (bases 1 to 1937)
  AUTHORS   Kelley,M.H., Ortiz,J., Shimizu,K., Grewal,H., Quillinan,N. and
            Herson,P.S.
  TITLE     Alterations in Purkinje cell GABAA receptor pharmacology following
            oxygen and glucose deprivation and cerebral ischemia reveal novel
            contribution of beta1 -subunit-containing receptors
  JOURNAL   Eur J Neurosci 37 (4), 555-563 (2013)
   PUBMED   23176253
  REMARK    GeneRIF: we conclude that is a greater contribution of beta(1)
            -subunit-containing GABA(A) receptors following oxygen and glucose
            deprivation in cerebellar Purkinje cells
REFERENCE   5  (bases 1 to 1937)
  AUTHORS   Faroni,A., Terenghi,G. and Magnaghi,V.
  TITLE     Expression of functional gamma-aminobutyric acid type A receptors
            in Schwann-like adult stem cells
  JOURNAL   J Mol Neurosci 47 (3), 619-630 (2012)
   PUBMED   22215379
  REMARK    GeneRIF: Bone marrow stem cells and adult stem cells were found to
            express GABA-A alpha2 and beta3, but not beta1 mRNA transcripts.
REFERENCE   6  (bases 1 to 1937)
  AUTHORS   Davies,P.A., Hanna,M.C., Hales,T.G. and Kirkness,E.F.
  TITLE     Insensitivity to anaesthetic agents conferred by a class of GABA(A)
            receptor subunit
  JOURNAL   Nature 385 (6619), 820-823 (1997)
   PUBMED   9039914
REFERENCE   7  (bases 1 to 1937)
  AUTHORS   Malherbe,P., Draguhn,A., Multhaup,G., Beyreuther,K. and Mohler,H.
  TITLE     GABAA-receptor expressed from rat brain alpha- and beta-subunit
            cDNAs displays potentiation by benzodiazepine receptor ligands
  JOURNAL   Brain Res Mol Brain Res 8 (3), 199-208 (1990)
   PUBMED   1977069
REFERENCE   8  (bases 1 to 1937)
  AUTHORS   Sigel,E., Baur,R., Malherbe,P. and Mohler,H.
  TITLE     The rat beta 1-subunit of the GABAA receptor forms a
            picrotoxin-sensitive anion channel open in the absence of GABA
  JOURNAL   FEBS Lett 257 (2), 377-379 (1989)
   PUBMED   2479580
REFERENCE   9  (bases 1 to 1937)
  AUTHORS   Ymer,S., Schofield,P.R., Draguhn,A., Werner,P., Kohler,M. and
            Seeburg,P.H.
  TITLE     GABAA receptor beta subunit heterogeneity: functional expression of
            cloned cDNAs
  JOURNAL   EMBO J 8 (6), 1665-1670 (1989)
   PUBMED   2548852
REFERENCE   10 (bases 1 to 1937)
  AUTHORS   Lolait,S.J., O'Carroll,A.M., Kusano,K., Muller,J.M.,
            Brownstein,M.J. and Mahan,L.C.
  TITLE     Cloning and expression of a novel rat GABAA receptor
  JOURNAL   FEBS Lett 246 (1-2), 145-148 (1989)
   PUBMED   2540033
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Nov 27, 2020 this sequence version replaced NM_012956.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.54180.1,
                                           SRR26360194.347452.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-151               JAXUCZ010000014.1  36902743-36902893   c
            152-243             JAXUCZ010000014.1  36902468-36902559   c
            244-311             JAXUCZ010000014.1  36901952-36902019   c
            312-532             JAXUCZ010000014.1  36724243-36724463   c
            533-615             JAXUCZ010000014.1  36547917-36547999   c
            616-753             JAXUCZ010000014.1  36456575-36456712   c
            754-906             JAXUCZ010000014.1  36456305-36456457   c
            907-1151            JAXUCZ010000014.1  36452583-36452827   c
            1152-1937           JAXUCZ010000014.1  36434339-36435124   c
FEATURES             Location/Qualifiers
     source          1..1937
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p11"
     gene            1..1937
                     /gene="Gabrb1"
                     /gene_synonym="GARB1"
                     /note="gamma-aminobutyric acid type A receptor subunit
                     beta1"
                     /db_xref="GeneID:25450"
                     /db_xref="RGD:2649"
     exon            1..151
                     /gene="Gabrb1"
                     /gene_synonym="GARB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..1496
                     /gene="Gabrb1"
                     /gene_synonym="GARB1"
                     /note="gamma-aminobutyric acid receptor subunit beta-1;
                     GABA(A) receptor subunit beta-1; gamma-aminobutyric acid
                     (GABA) A receptor, beta 1; Gamma-aminobutyric acid
                     receptor beta 1; gamma-aminobutyric acid (GABA-A)
                     receptor, subunit beta 1; GABAAR subunit beta-1;
                     gamma-aminobutyric acid type A receptor beta 1 subunit"
                     /codon_start=1
                     /product="gamma-aminobutyric acid receptor subunit beta-1
                     precursor"
                     /protein_id="NP_037088.1"
                     /db_xref="GeneID:25450"
                     /db_xref="RGD:2649"
                     /translation="MWTVQNRESLGLLSFPVMVAMVCCAHSSNEPSNMSYVKETVDRL
                     LKGYDIRLRPDFGGPPVDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSYSGI
                     PLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAA
                     CMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWNGGEGAVTGVNKIELPQFSIVDYKM
                     VSKKVEFTTGAYPRLSLSFRLKRNIGYFILQTYMPSTLITILSWVSFWINYDASAARV
                     ALGITTVLTMTTISTHLRETLPKIPYVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGK
                     GPQKKGASKQDQSANEKNKLEMNKVQVDAHGNILLSTLEIRNETSGSEVLTGVSDPKA
                     TMYSYDSASIQYRKPLSSREGFGRGLDRHGVPGKGRIRRRASQLKVKIPDLTDVNSID
                     KWSRMFFPITFSLFNVVYWLYYVH"
     exon            152..243
                     /gene="Gabrb1"
                     /gene_synonym="GARB1"
                     /inference="alignment:Splign:2.1.0"
     exon            244..311
                     /gene="Gabrb1"
                     /gene_synonym="GARB1"
                     /inference="alignment:Splign:2.1.0"
     exon            312..532
                     /gene="Gabrb1"
                     /gene_synonym="GARB1"
                     /inference="alignment:Splign:2.1.0"
     exon            533..615
                     /gene="Gabrb1"
                     /gene_synonym="GARB1"
                     /inference="alignment:Splign:2.1.0"
     exon            616..753
                     /gene="Gabrb1"
                     /gene_synonym="GARB1"
                     /inference="alignment:Splign:2.1.0"
     exon            754..906
                     /gene="Gabrb1"
                     /gene_synonym="GARB1"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1151
                     /gene="Gabrb1"
                     /gene_synonym="GARB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1937
                     /gene="Gabrb1"
                     /gene_synonym="GARB1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgcccagccg ccgactaagt tgcattcctt gaatcttcgc agaaaagaca attctttcat
       61 cagagttagt aatgtggaca gtacaaaatc gagagagttt ggggcttctc tcttttcctg
      121 tgatggttgc catggtttgt tgtgcacaca gctccaatga acccagcaac atgtcatacg
      181 tgaaagagac agtggaccga ctgctcaaag gatatgacat tcgcttgcgg ccagactttg
      241 gagggccccc ggtggacgtc gggatgcgga tcgatgtcgc cagcatagac atggtctcgg
      301 aagtgaatat ggattataca ctcaccatgt atttccagca gtcttggaag gacaagagac
      361 tttcatattc tggaatccca ttaaatctga cccttgacaa cagggtagct gaccaactct
      421 gggtaccaga cacctacttt ctcaatgaca agaagtcatt tgtgcatggg gtcacagtga
      481 aaaaccgaat gatcaggctt catcctgatg gaactgttct ctatggacta cggatcacaa
      541 ccactgcagc ttgcatgatg gatctccgaa gataccctct ggatgagcaa aactgcaccc
      601 tggagatcga aagttatggc tataccaccg atgacatcga attttactgg aatggaggag
      661 agggagcagt aactggggtc aataaaattg agcttcccca attttcaatt gtcgactaca
      721 agatggtgtc caagaaggtg gaattcacaa caggggcata tccacgacta tcactaagtt
      781 ttcgtctaaa gagaaacatc ggttacttca ttttgcagac ctacatgccc tccacactga
      841 ttacaattct gtcctgggtg tcgttttgga tcaactatga tgcatctgca gccagagtcg
      901 ccctaggaat caccacggtg ctgaccatga caaccatcag tactcacctc agggagactc
      961 tgccaaagat cccttacgtc aaagcgattg atatctatct catgggttgt tttgtgttcg
     1021 tgttcctggc tctactggag tacgcctttg taaattacat tttcttcgga aaaggccctc
     1081 agaaaaaagg agcgagcaaa caagaccaga gtgccaatga aaagaacaaa ctggagatga
     1141 acaaagtcca ggttgatgcc cacggcaata ttctcctcag caccctggaa atcaggaatg
     1201 agaccagtgg ctccgaggtg ctcacgggtg taagtgaccc caaggccact atgtactcat
     1261 acgacagcgc cagcatccag taccgcaaac cactgagcag ccgtgagggc ttcggacgag
     1321 ggctggacag gcacggggtg cccggcaagg gtcgcatccg cagacgcgcc tctcagctca
     1381 aagtgaagat ccctgacttg actgacgtga attccataga caagtggtcc cgaatgttct
     1441 tccccatcac attttccctt tttaatgtcg tttattggct ttactatgta cactaagttc
     1501 agtctcatgg ttcggtttag actcctttcc tcctcgcttg ttttttaacc ccacagattt
     1561 ccaacagtgg taactgctat ggtttttgag gtaagagatt ccgccttcca gttggttttc
     1621 gatcttgtgt gtcagttttt attatcacac catgtttact tcaacaacaa caacaaaagg
     1681 tattttttcc tgtctactgt ggtccaaggt accagctctg taagagttcc atcaattact
     1741 ttgtttacaa acacaaagag aggtaggtgg gtgttagaca ttgttggcag tcattcttag
     1801 ttgccctgga tcttactgga ttattttaaa atgaaaatgt acagtggacc ctgccgtcca
     1861 cctgcactgt gttctgggta aactgtaacc atctcatgct gccaaacaat taaatagaaa
     1921 atttaaaaaa aaaaaaa
//
