LOCUS       NM_021841               2456 bp    mRNA    linear   ROD 16-JUN-2024
DEFINITION  Rattus norvegicus gamma-aminobutyric acid type A receptor subunit
            alpha6 (Gabra6), mRNA.
ACCESSION   NM_021841
VERSION     NM_021841.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2456)
  AUTHORS   Xiong,B., Karim,F., Eloy,D.J. and Ye,J.H.
  TITLE     Gabra6100Q allele Sprague-Dawley rats have a higher sensitivity to
            hypnosis induced by isoflurane and ethanol than the wild type rats
  JOURNAL   Neurosci Lett 762, 136142 (2021)
   PUBMED   34332026
  REMARK    GeneRIF: Gabra6100Q allele Sprague-Dawley rats have a higher
            sensitivity to hypnosis induced by isoflurane and ethanol than the
            wild type rats.
REFERENCE   2  (bases 1 to 2456)
  AUTHORS   Ghit,A., Assal,D., Al-Shami,A.S. and Hussein,D.E.E.
  TITLE     GABAA receptors: structure, function, pharmacology, and related
            disorders
  JOURNAL   J Genet Eng Biotechnol 19 (1), 123 (2021)
   PUBMED   34417930
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2456)
  AUTHORS   Yang,L., Xu,T., Zhang,K., Wei,Z., Li,X., Huang,M., Rose,G.M. and
            Cai,X.
  TITLE     The essential role of hippocampal alpha6 subunit-containing GABAA
            receptors in maternal separation stress-induced adolescent
            depressive behaviors
  JOURNAL   Behav Brain Res 313, 135-143 (2016)
   PUBMED   27388150
  REMARK    GeneRIF: Results indicate that the Gabra6-containing GABAA receptor
            is a key modulator of hippocampal synaptic transmission and likely
            plays a crucial role in the pathophysiology of maternal
            separation-induced depression.
REFERENCE   4  (bases 1 to 2456)
  AUTHORS   Accardi,M.V., Brown,P.M., Miraucourt,L.S., Orser,B.A. and Bowie,D.
  TITLE     alpha6-Containing GABAA Receptors Are the Principal Mediators of
            Inhibitory Synapse Strengthening by Insulin in Cerebellar Granule
            Cells
  JOURNAL   J Neurosci 35 (26), 9676-9688 (2015)
   PUBMED   26134650
REFERENCE   5  (bases 1 to 2456)
  AUTHORS   Kramer,P.R. and Bellinger,L.L.
  TITLE     Infusion of Gabralpha6 siRNA into the trigeminal ganglia increased
            the myogenic orofacial nociceptive response of ovariectomized rats
            treated with 17beta-estradiol
  JOURNAL   Neuroscience 278, 144-153 (2014)
   PUBMED   25128322
  REMARK    GeneRIF: Results suggest estradiol decreased the orofacial
            nociceptive response, in part, by causing an increase in Gabralpha6
            expression.
REFERENCE   6  (bases 1 to 2456)
  AUTHORS   Wisden,W. and Seeburg,P.H.
  TITLE     GABAA receptor channels: from subunits to functional entities
  JOURNAL   Curr Opin Neurobiol 2 (3), 263-269 (1992)
   PUBMED   1379501
  REMARK    Review article
REFERENCE   7  (bases 1 to 2456)
  AUTHORS   Laurie,D.J., Seeburg,P.H. and Wisden,W.
  TITLE     The distribution of 13 GABAA receptor subunit mRNAs in the rat
            brain. II. Olfactory bulb and cerebellum
  JOURNAL   J Neurosci 12 (3), 1063-1076 (1992)
   PUBMED   1312132
REFERENCE   8  (bases 1 to 2456)
  AUTHORS   Wisden,W., Laurie,D.J., Monyer,H. and Seeburg,P.H.
  TITLE     The distribution of 13 GABAA receptor subunit mRNAs in the rat
            brain. I. Telencephalon, diencephalon, mesencephalon
  JOURNAL   J Neurosci 12 (3), 1040-1062 (1992)
   PUBMED   1312131
REFERENCE   9  (bases 1 to 2456)
  AUTHORS   Wieland,H.A., Luddens,H. and Seeburg,P.H.
  TITLE     A single histidine in GABAA receptors is essential for
            benzodiazepine agonist binding
  JOURNAL   J Biol Chem 267 (3), 1426-1429 (1992)
   PUBMED   1346133
REFERENCE   10 (bases 1 to 2456)
  AUTHORS   Kleingoor,C., Ewert,M., von Blankenfeld,G., Seeburg,P.H. and
            Kettenmann,H.
  TITLE     Inverse but not full benzodiazepine agonists modulate recombinant
            alpha 6 beta 2 gamma 2 GABAA receptors in transfected human
            embryonic kidney cells
  JOURNAL   Neurosci Lett 130 (2), 169-172 (1991)
   PUBMED   1665550
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Oct 24, 2022 this sequence version replaced NM_021841.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.59816.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-321               JAXUCZ010000010.1  27326914-27327234   c
            322-440             JAXUCZ010000010.1  27326593-27326711   c
            441-508             JAXUCZ010000010.1  27325767-27325834   c
            509-729             JAXUCZ010000010.1  27323709-27323929   c
            730-812             JAXUCZ010000010.1  27323552-27323634   c
            813-956             JAXUCZ010000010.1  27323125-27323268   c
            957-1109            JAXUCZ010000010.1  27322602-27322754   c
            1110-1369           JAXUCZ010000010.1  27321121-27321380   c
            1370-2456           JAXUCZ010000010.1  27311965-27313051   c
FEATURES             Location/Qualifiers
     source          1..2456
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q21"
     gene            1..2456
                     /gene="Gabra6"
                     /note="gamma-aminobutyric acid type A receptor subunit
                     alpha6"
                     /db_xref="GeneID:29708"
                     /db_xref="RGD:61861"
     exon            1..321
                     /gene="Gabra6"
                     /inference="alignment:Splign:2.1.0"
     CDS             284..1645
                     /gene="Gabra6"
                     /note="gamma-aminobutyric acid receptor subunit alpha-6;
                     GABA-A receptor alpha-6 subunit; gamma-aminobutyric acid
                     (GABA) A receptor, alpha 6; GABA(A) receptor subunit
                     alpha-6; gamma-aminobutyric acid (GABA-A) receptor,
                     subunit alpha 6; gamma-aminobutyric acid A receptor, alpha
                     6; gamma-aminobutyric acid type A receptor alpha 6
                     subunit; GABAAR subunit alpha-6"
                     /codon_start=1
                     /product="gamma-aminobutyric acid receptor subunit alpha-6
                     precursor"
                     /protein_id="NP_068613.2"
                     /db_xref="GeneID:29708"
                     /db_xref="RGD:61861"
                     /translation="MLLLLPWLFSLLWIENAQAQLEDEGNFYSENVSRILDNLLEGYD
                     NRLRPGFGGAVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWTDERLKFKGPAEILS
                     LNNLMVSKIWTPDTFFQNGKKSIAHNMTTPNKLFRLMQNGTILYTMRLTINADCPMRL
                     VNFPMDGHACPLKFGSYAYPKSEIIYTWKKGPLYSVEVPEESSSLLQYDLIGQTVSSE
                     TIKSNTGEYVIMTVYFHLQRKMGYFMIQIYTPCIMTVILSQVSFWINKESVPARTVFG
                     ITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNLQSQK
                     AERQAQTAAKPPVAKSKTTESLEAEIVVHSDSKYHLKKRISSLTLPIVPSSEASKVLS
                     RTPILPSTPVTPPLLLPAIGGTSKIDQYSRILFPVAFAGFNLVYWIVYLSKDTMEVSS
                     TVE"
     exon            322..440
                     /gene="Gabra6"
                     /inference="alignment:Splign:2.1.0"
     exon            441..508
                     /gene="Gabra6"
                     /inference="alignment:Splign:2.1.0"
     exon            509..729
                     /gene="Gabra6"
                     /inference="alignment:Splign:2.1.0"
     exon            730..812
                     /gene="Gabra6"
                     /inference="alignment:Splign:2.1.0"
     exon            813..956
                     /gene="Gabra6"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1109
                     /gene="Gabra6"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1369
                     /gene="Gabra6"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..2456
                     /gene="Gabra6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actttccaac tgaaccagtc agaggaggct gggtatctgc aggacttaat ctaagaccac
       61 aaacgaccct attccatgag aaaagacaga aataagacaa aaaagaaggg aacccttaac
      121 attttattgg caaaccattc atctattgga ttcctgactg gtcacagatt gagataagga
      181 atatgaagga tttggaagat ttctccagtt gattgtcaaa ggagatctgg ctgaggggag
      241 gaagaaagca ggagggtgac ctggcatttc agtgaactat aggatgctgt tgcttctccc
      301 ctggctcttc agtttactat ggatagaaaa tgcccaagct caacttgaag atgaagggaa
      361 cttctattct gaaaatgtca gtcggattct tgacaacttg ctggagggct atgacaaccg
      421 tctacggccg ggatttggag gtgctgtaac agaggtcaaa acagatatct atgtgaccag
      481 ctttgggcct gtgtcagatg tggagatgga gtacacaatg gatgttttct tccgacagac
      541 atggactgat gagaggctga agttcaaagg ccctgctgag attttgagtt taaataactt
      601 gatggtcagt aagatctgga ctccggacac atttttccaa aatgggaaaa agtcaattgc
      661 tcacaacatg accaccccta acaaactctt ccgattgatg cagaatggaa cgatcctgta
      721 caccatgagg cttaccatca acgctgactg tccgatgaga ctggttaact tccctatgga
      781 tggacacgca tgtccactca agtttgggag ctatgcctat ccgaaaagcg aaatcatata
      841 tacatggaaa aaaggaccgc tttattcagt agaggtccca gaagaatctt caagcctcct
      901 ccagtatgat ttgattgggc aaacagtttc tagtgagact attaaatcga acacaggtga
      961 atatgtaata atgacagtct acttccactt acaaaggaag atgggctatt tcatgatcca
     1021 gatttacact ccgtgcatca tgacagtcat tctctctcaa gtgtctttct ggattaataa
     1081 ggagtcggtc ccagcaagaa ccgtctttgg aatcaccacg gttttaacca tgaccacctt
     1141 aagcatcagt gctcggcact ctctacccaa agtgtcctat gcaaccgcca tggattggtt
     1201 catagctgta tgctttgcgt ttgtcttttc tgctctcatt gaattcgcag ctgtcaacta
     1261 cttcaccaat ctccagtccc agaaagccga aaggcaggca cagactgcag ccaagccccc
     1321 ggtagcaaag tcaaaaacaa ctgaatcact ggaagctgag attgttgtgc actctgactc
     1381 caagtaccat ctgaagaaga gaatcagctc tctgactttg ccaatcgttc catcttctga
     1441 ggccagcaaa gtcctcagta gaacgcccat cttaccatca acgccggtca ctcccccatt
     1501 gctcttacca gccattggcg gcaccagcaa aatagatcaa tattctcgaa ttctcttccc
     1561 agtagcattt gcaggattca accttgtgta ctggatagtt tacctttcca aagatacaat
     1621 ggaagtgagc agtactgtcg agtagtttgc agccaggaaa agctggacac tgtaattggt
     1681 tattttccat tttcctcgct tacagaacac aaattattgt gttagtataa atggtctcat
     1741 ttcagaaact aaatgtctat atttcataat atggaataag catgtttggg ctaaaaacaa
     1801 taatattact cttcaaaatt aaatttagaa agctactgaa aatatgaatt ttctgtatag
     1861 taaaattaat aataataata ataacaataa tatcagcatt tatgtggata aggtagattc
     1921 aaaatgagtt tgccaacctt tgtcttcatt gttcaatatt tttaattgtc actgtgaata
     1981 acattttcca caaagcagat atattcagat atgctgaccc ttctaaagct tgccttaaat
     2041 ttgtttattt tggcttagtt tctactctaa acatttattg gtatgtttat acagcatgct
     2101 ggaggccttt gcgattttac aagaactctc actggcattg aactgcttat attgagatta
     2161 gacatttctt tttaaccttg ctgtgttctt ttacctcaat aaaatgtggc attatataca
     2221 cataaataat acatagttta taaattatgt atgcatatgt acatagcttt agttatgctg
     2281 caatactgtt gctatttccc actaaattca cctttaagaa gatgatgctt gacataacac
     2341 caggaggttc taggaaggtc actcaatgta ctatgactgt atattctgat tcggattacc
     2401 attgtgtgtt acactttcct aaatataatg ccaaataaaa ccacaaaaag cctgca
//
