LOCUS       NM_017295               2580 bp    mRNA    linear   ROD 16-JUN-2024
DEFINITION  Rattus norvegicus gamma-aminobutyric acid type A receptor subunit
            alpha 5 (Gabra5), mRNA.
ACCESSION   NM_017295
VERSION     NM_017295.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2580)
  AUTHORS   Ngoupaye,G.T., Mokgokong,M., Madlala,T. and Mabandla,M.V.
  TITLE     Alteration of the alpha5 GABA receptor and 5HTT lead to cognitive
            deficits associated with major depressive-like behaviors in a
            14-day combined stress rat model
  JOURNAL   Int J Neurosci 133 (9), 959-976 (2023)
   PUBMED   34937496
  REMARK    GeneRIF: Alteration of the alpha5 GABA receptor and 5HTT lead to
            cognitive deficits associated with major depressive-like behaviors
            in a 14-day combined stress rat model.
REFERENCE   2  (bases 1 to 2580)
  AUTHORS   McCoy,A.M., Prevot,T.D., Mian,M.Y., Cook,J.M., Frazer,A.,
            Sibille,E.L., Carreno,F.R. and Lodge,D.J.
  TITLE     Positive Allosteric Modulation of alpha5-GABAA Receptors Reverses
            Stress-Induced Alterations in Dopamine System Function and Prepulse
            Inhibition of Startle
  JOURNAL   Int J Neuropsychopharmacol 25 (8), 688-698 (2022)
   PUBMED   35732272
  REMARK    GeneRIF: Positive Allosteric Modulation of alpha5-GABAA Receptors
            Reverses Stress-Induced Alterations in Dopamine System Function and
            Prepulse Inhibition of Startle.
REFERENCE   3  (bases 1 to 2580)
  AUTHORS   Franco-Enzastiga,U., Garcia,G., Murbartian,J., Gonzalez-Barrios,R.,
            Salinas-Abarca,A.B., Sanchez-Hernandez,B., Tavares-Ferreira,D.,
            Herrera,L.A., Barragan-Iglesias,P., Delgado-Lezama,R., Price,T.J.
            and Granados-Soto,V.
  TITLE     Sex-dependent pronociceptive role of spinal alpha5 -GABAA receptor
            and its epigenetic regulation in neuropathic rodents
  JOURNAL   J Neurochem 156 (6), 897-916 (2021)
   PUBMED   32750173
  REMARK    GeneRIF: Sex-dependent pronociceptive role of spinal alpha5 -GABAA
            receptor and its epigenetic regulation in neuropathic rodents.
REFERENCE   4  (bases 1 to 2580)
  AUTHORS   Koh,M.T., Branch,A., Haberman,R. and Gallagher,M.
  TITLE     Significance of inhibitory recruitment in aging with preserved
            cognition: limiting gamma-aminobutyric acid type A alpha5 function
            produces memory impairment
  JOURNAL   Neurobiol Aging 91, 1-4 (2020)
   PUBMED   32240868
  REMARK    GeneRIF: Significance of inhibitory recruitment in aging with
            preserved cognition: limiting gamma-aminobutyric acid type A alpha5
            function produces memory impairment.
REFERENCE   5  (bases 1 to 2580)
  AUTHORS   Donegan,J.J., Boley,A.M., Yamaguchi,J., Toney,G.M. and Lodge,D.J.
  TITLE     Modulation of extrasynaptic GABAA alpha 5 receptors in the ventral
            hippocampus normalizes physiological and behavioral deficits in a
            circuit specific manner
  JOURNAL   Nat Commun 10 (1), 2819 (2019)
   PUBMED   31249307
  REMARK    GeneRIF: Gabra5 overexpression increased tonic GABA currents and
            normalized aberrant pyramidal cell activity in the ventral
            hippocampus.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2580)
  AUTHORS   Wisden,W. and Seeburg,P.H.
  TITLE     GABAA receptor channels: from subunits to functional entities
  JOURNAL   Curr Opin Neurobiol 2 (3), 263-269 (1992)
   PUBMED   1379501
  REMARK    Review article
REFERENCE   7  (bases 1 to 2580)
  AUTHORS   Laurie,D.J., Seeburg,P.H. and Wisden,W.
  TITLE     The distribution of 13 GABAA receptor subunit mRNAs in the rat
            brain. II. Olfactory bulb and cerebellum
  JOURNAL   J Neurosci 12 (3), 1063-1076 (1992)
   PUBMED   1312132
REFERENCE   8  (bases 1 to 2580)
  AUTHORS   Wisden,W., Laurie,D.J., Monyer,H. and Seeburg,P.H.
  TITLE     The distribution of 13 GABAA receptor subunit mRNAs in the rat
            brain. I. Telencephalon, diencephalon, mesencephalon
  JOURNAL   J Neurosci 12 (3), 1040-1062 (1992)
   PUBMED   1312131
REFERENCE   9  (bases 1 to 2580)
  AUTHORS   Malherbe,P., Sigel,E., Baur,R., Persohn,E., Richards,J.G. and
            Mohler,H.
  TITLE     Functional expression and sites of gene transcription of a novel
            alpha subunit of the GABAA receptor in rat brain
  JOURNAL   FEBS Lett 260 (2), 261-265 (1990)
   PUBMED   2153588
REFERENCE   10 (bases 1 to 2580)
  AUTHORS   Seeburg,P.H., Wisden,W., Verdoorn,T.A., Pritchett,D.B., Werner,P.,
            Herb,A., Luddens,H., Sprengel,R. and Sakmann,B.
  TITLE     The GABAA receptor family: molecular and functional diversity
  JOURNAL   Cold Spring Harb Symp Quant Biol 55, 29-40 (1990)
   PUBMED   1966765
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 27, 2020 this sequence version replaced NM_017295.1.
            
            Sequence Note: This sequence has been modified as follows: removed
            27 bp suspected to be vector contamination from the 5' end.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X51992.1, SRR26643298.3211.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-171               JAXUCZ010000001.1  117516436-117516606 c
            172-231             JAXUCZ010000001.1  117515752-117515811 c
            232-391             JAXUCZ010000001.1  117515234-117515393 c
            392-513             JAXUCZ010000001.1  117498785-117498906 c
            514-581             JAXUCZ010000001.1  117497111-117497178 c
            582-802             JAXUCZ010000001.1  117496786-117497006 c
            803-885             JAXUCZ010000001.1  117460151-117460233 c
            886-1029            JAXUCZ010000001.1  117433763-117433906 c
            1030-1182           JAXUCZ010000001.1  117430181-117430333 c
            1183-1394           JAXUCZ010000001.1  117416564-117416775 c
            1395-2580           JAXUCZ010000001.1  117404494-117405679 c
FEATURES             Location/Qualifiers
     source          1..2580
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..2580
                     /gene="Gabra5"
                     /note="gamma-aminobutyric acid type A receptor subunit
                     alpha 5"
                     /db_xref="GeneID:29707"
                     /db_xref="RGD:61859"
     exon            1..171
                     /gene="Gabra5"
                     /inference="alignment:Splign:2.1.0"
     exon            172..231
                     /gene="Gabra5"
                     /inference="alignment:Splign:2.1.0"
     exon            232..391
                     /gene="Gabra5"
                     /inference="alignment:Splign:2.1.0"
     CDS             306..1700
                     /gene="Gabra5"
                     /note="gamma-aminobutyric acid receptor subunit alpha-5;
                     GABA(A) receptor subunit alpha-5; gamma-aminobutyric acid
                     (GABA-A) receptor, subunit alpha 5; gamma-aminobutyric
                     acid (GABA) A receptor, alpha 5; gamma-aminobutyric acid A
                     receptor, alpha 5; GABA-A receptor alpha-5 subunit;
                     gamma-aminobutyric acid type A receptor alpha 5 subunit;
                     GABAAR subunit alpha-5"
                     /codon_start=1
                     /product="gamma-aminobutyric acid receptor subunit alpha-5
                     precursor"
                     /protein_id="NP_058991.2"
                     /db_xref="GeneID:29707"
                     /db_xref="RGD:61859"
                     /translation="MDNGMLSRFIMTKTLLVFCISMTLSSHFGFSQMPTSSVQDETND
                     NITIFTRILDGLLDGYDNRLRPGLGERITQVRTDIYVTSFGPVSDTEMEYTIDVFFRQ
                     SWKDERLRFKGPMQRLPLNNLLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLEDDGT
                     LLYTMRLTISAECPMQLEDFPMDAHACPLKFGSYAYPNSEVVYVWTNGSTKSVVVAED
                     GSRLNQYHLMGQTVGTENISTSTGEYTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQ
                     VSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSA
                     LIEFATVNYFTKRGWAWDGKKALEAAKIKKKERELILNKSTNAFTTGKLTHPPNIPKE
                     QLPGGTGNAVGTASIRASEEKTSESKKTYNSISKIDKMSRIVFPILFGTFNLVYWATY
                     LNREPVIKGATSPK"
     exon            392..513
                     /gene="Gabra5"
                     /inference="alignment:Splign:2.1.0"
     exon            514..581
                     /gene="Gabra5"
                     /inference="alignment:Splign:2.1.0"
     exon            582..802
                     /gene="Gabra5"
                     /inference="alignment:Splign:2.1.0"
     exon            803..885
                     /gene="Gabra5"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1029
                     /gene="Gabra5"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1182
                     /gene="Gabra5"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1394
                     /gene="Gabra5"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..2580
                     /gene="Gabra5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagccggccg gctcaggggg ctaaggaggt ctggagggct cggcgcgagc ctgagggccg
       61 gaccactaga ggtatcgggt ggcgctgcgg agcggcagca ggtgcggggt ggcggaggct
      121 gcggctccgc agtgccatcc cttattccac ctgcgctgtg cgccagcact gcaccttgca
      181 gaaccagaag cagcttgctg gctttgaacg tgtggcaaat atttcagaaa gcttcaagat
      241 caagttggag gaaaggacgg tttttcttct aaattcatct gcttcaacta ttattcttac
      301 tgggaatgga caatggaatg ctctctagat ttatcatgac caaaaccctc cttgtcttct
      361 gcatttccat gaccttatcc agtcactttg gcttttcaca aatgccaact agttctgtac
      421 aagacgagac caatgacaac atcacaatat tcaccaggat cttggacggg ctcttggatg
      481 gctatgacaa cagactgcgg cctgggctgg gagagcgaat cacgcaggtg cgaacagaca
      541 tctatgttac cagctttggc ccagtgtccg acacggaaat ggaatatacc atagatgtgt
      601 ttttccgaca aagctggaaa gatgaaaggc tgcggtttaa ggggcctatg caacgtctcc
      661 ctctcaacaa ccttcttgcc agcaaaatct ggaccccaga cacattcttc cacaatggga
      721 agaagtccat tgcgcacaac atgacgacac ccaacaagct gctgaggctg gaggatgatg
      781 gcacacttct ctacaccatg cgcctgacga tctctgctga gtgtccaatg cagcttgagg
      841 acttcccgat ggatgcccat gcttgtcccc tgaaatttgg cagttatgct taccctaatt
      901 cggaagttgt ctatgtttgg accaatggtt ccaccaagtc tgtggtggtg gcagaagatg
      961 gctccagact caaccagtac cacctcatgg ggcagacagt aggcactgag aacatcagca
     1021 ccagcacagg tgaatataca atcatgactg ctcattttca cctgaagagg aagatcgggt
     1081 actttgtcat ccagacgtac cttccctgca tcatgactgt catcttatcc caggtgtctt
     1141 tttggcttaa tcgagaatct gtcccagcta ggacagtttt tggagtgacc acagtgctga
     1201 ccatgacaac cctcagcatc agtgcccgga attcgctgcc caaagtggcc tatgccacag
     1261 ccatggactg gttcattgct gtctgctatg catttgtctt ctctgccctg attgaatttg
     1321 ccacagtcaa ctactttaca aagagaggat gggcctggga tggcaagaag gccttggaag
     1381 cagctaaaat caagaaaaaa gaacgtgaac tcatactaaa taagtcaaca aatgctttta
     1441 caactgggaa gttgacccat cctccaaaca tcccaaagga gcagcttcca ggcgggactg
     1501 ggaatgctgt gggtacagcc tcaatcagag catctgagga gaagacttct gagagtaaaa
     1561 agacctacaa cagcatcagc aagatcgaca aaatgtcccg gattgtgttc cccattttgt
     1621 ttggcacttt caatctagtt tactgggcaa catatttgaa tagggagccc gtgataaaag
     1681 gggctacctc tccaaagtaa gacaggaaac catacttgca cagaaatgaa cctgaggaga
     1741 ggtcaagctc acagagacta tttgggcgct gtctttcagg aaattttgca tgtttaataa
     1801 tatgtacaaa taatattgcc ttgatgtttc tatgtgtaac ttcaatgttt caaggatgtc
     1861 cccttaataa accaagcaaa tggccttcta caacaacggg aggcaatgac tgactctcag
     1921 atgctcagcg tcctaacatc aatagtttac aaacaagata agtatatttt taactgttct
     1981 gagtatatga cgtttttata cttcgaatgc catttcgtac catttttccc agccaacaga
     2041 acattttagg gaatccctgt gatgaccact tgacaggtga aaaagcaaag atcctcgggt
     2101 acacaaagtc catgaagagc aaactgtgga catttaagtc cagtacgaat tgcctttaac
     2161 aattcttctt gttctgaaat tagaaaaata ctgcatgaac tgacattaag aagtagaata
     2221 agcaaacatt tatgcagaca aatttaatga caagcccata gtgtcttaga ttagtagatc
     2281 aaataattcc ccaaggaaaa gaaatcaact gattcaaaat taattttgtt gttttttgtg
     2341 aaaaatgaat ttatttctca ccccgcccca acacctttac aaccttaata atgaccaaga
     2401 aagcaaaatc ttaaaacctt aaagcaacaa ggccttggtc tttggtggtg gtattctgtg
     2461 gccattgttt ctggaccctg ggtcctcttg ctgctgcttc agcgctgaga aattgtaatt
     2521 gagttatttt ctgttttatt tccctgtaca tatttcatga ttggattatc gctctgttag
//
