LOCUS       NM_017069               1786 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Rattus norvegicus gamma-aminobutyric acid type A receptor subunit
            alpha 3 (Gabra3), mRNA.
ACCESSION   NM_017069
VERSION     NM_017069.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1786)
  AUTHORS   Montoya-Gress,L., Juarez-Rojas,L., Almanza-Perez,J.,
            Farfan-Garcia,E., Gomez-Quiroz,L., Ommati,M.M., Heidari,R.,
            Querejeta-Villagomez,E., Alatorre-Perez,A. and Retana-Marquez,S.
  TITLE     Changes in D4 and GABAA subunit alpha3 receptors in the thalamic
            reticular nucleus caused by unilateral lesion of the globus
            pallidus
  JOURNAL   Acta Neurobiol Exp (Wars) 84 (3), 275-287 (2024)
   PUBMED   39392023
  REMARK    GeneRIF: Changes in D4 and GABAA subunit alpha3 receptors in the
            thalamic reticular nucleus caused by unilateral lesion of the
            globus pallidus.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1786)
  AUTHORS   Ordaz,R.P., Garay,E., Limon,A., Perez-Samartin,A.,
            Sanchez-Gomez,M.V., Robles-Martinez,L., Cisneros-Mejorado,A.,
            Matute,C. and Arellano,R.O.
  TITLE     GABAA Receptors Expressed in Oligodendrocytes Cultured from the
            Neonatal Rat Contain alpha3 and gamma1 Subunits and Present
            Differential Functional and Pharmacological Properties
  JOURNAL   Mol Pharmacol 99 (2), 133-146 (2021)
   PUBMED   33288547
  REMARK    GeneRIF: GABAA Receptors Expressed in Oligodendrocytes Cultured
            from the Neonatal Rat Contain alpha3 and gamma1 Subunits and
            Present Differential Functional and Pharmacological Properties.
REFERENCE   3  (bases 1 to 1786)
  AUTHORS   Liu,X., Wei,F., Cheng,Y., Zhang,Y., Jia,G., Zhou,J., Zhu,M.,
            Shan,Y., Sun,X., Yu,L., Merzenich,M.M., Lurie,D.I., Zheng,Q. and
            Zhou,X.
  TITLE     Auditory Training Reverses Lead (Pb)-Toxicity-Induced Changes in
            Sound-Azimuth Selectivity of Cortical Neurons
  JOURNAL   Cereb Cortex 29 (8), 3294-3304 (2019)
   PUBMED   30137254
REFERENCE   4  (bases 1 to 1786)
  AUTHORS   Nair,B., Johar,K., Priya,A. and Wong-Riley,M.T.
  TITLE     Specificity protein 4 (Sp4) transcriptionally regulates inhibitory
            GABAergic receptors in neurons
  JOURNAL   Biochim Biophys Acta 1863 (1), 1-9 (2016)
   PUBMED   26469128
  REMARK    GeneRIF: Sp4 functionally regulates the transcription of Gabra1
            (GABAA alpha1) and Gabra2 (GABAA alpha2), but not Gabra3 (GABAA
            alpha3) subunit genes.
REFERENCE   5  (bases 1 to 1786)
  AUTHORS   Sarkar,S. and Chang,S.L.
  TITLE     Ethanol concentration-dependent alterations in gene expression
            during acute binge drinking in the HIV-1 transgenic rat
  JOURNAL   Alcohol Clin Exp Res 37 (7), 1082-1090 (2013)
   PUBMED   23413777
REFERENCE   6  (bases 1 to 1786)
  AUTHORS   Sigamoni,M.
  TITLE     Planning nursing education for 2000 AD: in pursuit of reality
  JOURNAL   Nurs J India 83 (7), 163-168 (1992)
   PUBMED   1298923
REFERENCE   7  (bases 1 to 1786)
  AUTHORS   Wisden,W. and Seeburg,P.H.
  TITLE     GABAA receptor channels: from subunits to functional entities
  JOURNAL   Curr Opin Neurobiol 2 (3), 263-269 (1992)
   PUBMED   1379501
  REMARK    Review article
REFERENCE   8  (bases 1 to 1786)
  AUTHORS   Laurie,D.J., Seeburg,P.H. and Wisden,W.
  TITLE     The distribution of 13 GABAA receptor subunit mRNAs in the rat
            brain. II. Olfactory bulb and cerebellum
  JOURNAL   J Neurosci 12 (3), 1063-1076 (1992)
   PUBMED   1312132
REFERENCE   9  (bases 1 to 1786)
  AUTHORS   Wisden,W., Laurie,D.J., Monyer,H. and Seeburg,P.H.
  TITLE     The distribution of 13 GABAA receptor subunit mRNAs in the rat
            brain. I. Telencephalon, diencephalon, mesencephalon
  JOURNAL   J Neurosci 12 (3), 1040-1062 (1992)
   PUBMED   1312131
REFERENCE   10 (bases 1 to 1786)
  AUTHORS   Seeburg,P.H., Wisden,W., Verdoorn,T.A., Pritchett,D.B., Werner,P.,
            Herb,A., Luddens,H., Sprengel,R. and Sakmann,B.
  TITLE     The GABAA receptor family: molecular and functional diversity
  JOURNAL   Cold Spring Harb Symp Quant Biol 55, 29-40 (1990)
   PUBMED   1966765
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Aug 30, 2012 this sequence version replaced NM_017069.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X51991.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            RefSeq Select criteria           :: based on conservation, longest
                                                protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-194               JAXUCZ010000021.1  155543677-155543870 c
            195-377             JAXUCZ010000021.1  155449540-155449722 c
            378-499             JAXUCZ010000021.1  155427269-155427390 c
            500-567             JAXUCZ010000021.1  155397869-155397936 c
            568-788             JAXUCZ010000021.1  155378386-155378606 c
            789-871             JAXUCZ010000021.1  155355432-155355514 c
            872-1015            JAXUCZ010000021.1  155334151-155334294 c
            1016-1168           JAXUCZ010000021.1  155328182-155328334 c
            1169-1380           JAXUCZ010000021.1  155317164-155317375 c
            1381-1786           JAXUCZ010000021.1  155303928-155304333 c
FEATURES             Location/Qualifiers
     source          1..1786
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq37"
     gene            1..1786
                     /gene="Gabra3"
                     /note="gamma-aminobutyric acid type A receptor subunit
                     alpha 3"
                     /db_xref="GeneID:24947"
                     /db_xref="RGD:2648"
     exon            1..194
                     /gene="Gabra3"
                     /inference="alignment:Splign:2.1.0"
     exon            195..377
                     /gene="Gabra3"
                     /inference="alignment:Splign:2.1.0"
     CDS             238..1719
                     /gene="Gabra3"
                     /note="gamma-aminobutyric acid receptor subunit alpha-3;
                     GABA(A) receptor subunit alpha-3; Gamma-animobutyric acid
                     (GABA) A receptor, alpha 3; gamma-aminobutyric acid
                     (GABA-A) receptor, subunit alpha 3; gamma-aminobutyric
                     acid type A receptor alpha3 subunit; GABA-A receptor
                     alpha-3 subunit; gamma-aminobutyric acid (GABA) A
                     receptor, alpha 3; GABAAR subunit alpha-3"
                     /codon_start=1
                     /product="gamma-aminobutyric acid receptor subunit alpha-3
                     precursor"
                     /protein_id="NP_058765.3"
                     /db_xref="GeneID:24947"
                     /db_xref="RGD:2648"
                     /translation="MITTQMWHFYVTRVGLLLLISILPGTTGQGESRRQEPGDFVKQD
                     IGGLSPKHAPDIPDDSTDNITIFTRILDRLLDGYDNRLRPGLGDAVTEVKTDIYVTSF
                     GPVSDTDMEYTIDVFFRQTWHDERLKFDGPMKILPLNNLLASKIWTPDTFFHNGKKSV
                     AHNMTTPNKLLRLVDNGTLLYTMRLTIHAECPMHLEDFPMDVHACPLKFGSYAYTKAE
                     VIYSWTLGKNKSVEVAQDGSRLNQYDLLGHVVGTEIIRSSTGEYVVMTTHFHLKRKIG
                     YFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAY
                     ATAMDWFIAVCYAFVFSALIEFATVNYFTKRSWAWEGKKVPEALEMKKKTPAAPTKKT
                     STTFNIVGTTYPINLAKDTEFSTISKAAAAPSASSTPTVIASPKTTYVQDSPAETKTY
                     NSVSKVDKISRIIFPVLFAIFNLVYWATYVNRESAIKGMIRKQ"
     exon            378..499
                     /gene="Gabra3"
                     /inference="alignment:Splign:2.1.0"
     exon            500..567
                     /gene="Gabra3"
                     /inference="alignment:Splign:2.1.0"
     exon            568..788
                     /gene="Gabra3"
                     /inference="alignment:Splign:2.1.0"
     exon            789..871
                     /gene="Gabra3"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1015
                     /gene="Gabra3"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1168
                     /gene="Gabra3"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1380
                     /gene="Gabra3"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1786
                     /gene="Gabra3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttttttgat gtacagtttt taggagctca ttattatcct tggagatgga acgcgagcag
       61 acaagattgt caaaccttta tttggagcct gggttagaag gcacgcccat agagatggaa
      121 gggagaaaag agaaaaaagg aggaagctca cactttggtc ctgaagaggg aagtaagcat
      181 ctcacagcgg cttgtactgt gaatctcaca ggtctctcca agttgctgtc taagaagatg
      241 ataaccacac aaatgtggca cttctatgtg accagagttg gacttcttct tctgattagt
      301 attctacctg gaaccactgg ccaaggggag tcaagacgac aagaacctgg ggactttgtg
      361 aagcaagata ttggaggcct ctctcccaag catgccccag atattcctga cgatagtaca
      421 gataacatca ctatcttcac tagaatcttg gatcggcttc tggatggcta tgacaaccga
      481 ctgcgacctg ggcttggaga tgcagtgact gaagtgaaga cagatatcta tgtgaccagt
      541 tttggccctg tgtcagacac tgatatggaa tatactattg atgtgttttt tagacagaca
      601 tggcatgatg aaagactgaa atttgatgga ccaatgaaga tccttccact gaataatctt
      661 ctggctagta agatatggac tccagatacc ttcttccaca acggtaaaaa atcagtggct
      721 cacaatatga ccacacccaa caagctgctc agactggtag acaatgggac cctcctctat
      781 acaatgaggt taacaataca tgctgaatgc cctatgcatt tagaagattt ccccatggat
      841 gtgcatgcct gtccactgaa gtttggaagc tatgcctata ccaaagctga agtaatttat
      901 tcttggactc ttgggaagaa caaatctgtg gaagtagctc aggatggctc acgcctgaat
      961 cagtatgact tgcttggtca tgttgttggg acagagataa tccggtctag tacaggagaa
     1021 tatgtcgtca tgacaaccca ctttcatctg aagagaaaaa ttggctactt tgtcatccag
     1081 acctacttgc catgtatcat gactgtcatt ctgtcacaag tttctttctg gcttaataga
     1141 gaatctgtcc ctgctcgcac agtctttggt gtcaccactg ttctcaccat gaccaccttg
     1201 agtatcagtg ccagaaactc tttacctaaa gtggcatacg cgacggccat ggactggttc
     1261 atagccgtct gttatgcctt tgtattttct gcactgattg aatttgctac tgtcaactac
     1321 ttcaccaagc gaagttgggc ttgggaaggc aagaaggtac cagaggccct ggagatgaag
     1381 aaaaaaacac cagcagcccc aaccaagaaa acaagcacca ccttcaacat agtgggaacc
     1441 acctatccta tcaacctggc caaggatact gagttctcca ccatctccaa ggctgctgct
     1501 gctcccagtg cttcttcaac tccaacagtg attgcttccc ccaagaccac ttatgtgcaa
     1561 gacagtcctg ctgagaccaa gacctacaac agtgtcagca aggttgacaa aatttcccgc
     1621 atcatcttcc ctgtgctctt tgccatattc aatcttgtct attgggccac atatgtgaac
     1681 agggaatccg ctatcaaggg catgatccgc aaacagtaga taatagtggc agcacagcaa
     1741 ccagatcacc ccatgaagca tccaaatccc aaaccccaga gctccc
//
