LOCUS       NM_001135779            3303 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Rattus norvegicus gamma-aminobutyric acid type A receptor subunit
            alpha 2 (Gabra2), mRNA.
ACCESSION   NM_001135779 XM_006250931 XM_223378
VERSION     NM_001135779.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3303)
  AUTHORS   Tripathi,K., Hazra,S., Hazra,J.D., Mandel,S., Anunu,R., Kriebel,M.,
            Volkmer,H. and Richter-Levin,G.
  TITLE     Selective knockdown of GABAA-alpha2 subunit in the dorsal dentate
            gyrus in adulthood induces anxiety, learning and memory deficits
            and impairs synaptic plasticity
  JOURNAL   Eur J Neurosci 60 (4), 4393-4408 (2024)
   PUBMED   38858171
  REMARK    GeneRIF: Selective knockdown of GABAA-alpha2 subunit in the dorsal
            dentate gyrus in adulthood induces anxiety, learning and memory
            deficits and impairs synaptic plasticity.
REFERENCE   2  (bases 1 to 3303)
  AUTHORS   Nakamura,Y., Morrow,D.H., Nathanson,A.J., Henley,J.M.,
            Wilkinson,K.A. and Moss,S.J.
  TITLE     Phosphorylation on Ser-359 of the alpha2 subunit in GABA type A
            receptors down-regulates their density at inhibitory synapses
  JOURNAL   J Biol Chem 295 (35), 12330-12342 (2020)
   PUBMED   32620552
  REMARK    GeneRIF: Phosphorylation on Ser-359 of the alpha2 subunit in GABA
            type A receptors down-regulates their density at inhibitory
            synapses.
REFERENCE   3  (bases 1 to 3303)
  AUTHORS   Brown,L.E., Nicholson,M.W., Arama,J.E., Mercer,A., Thomson,A.M. and
            Jovanovic,J.N.
  TITLE     gamma-Aminobutyric Acid Type A (GABAA) Receptor Subunits Play a
            Direct Structural Role in Synaptic Contact Formation via Their
            N-terminal Extracellular Domains
  JOURNAL   J Biol Chem 291 (27), 13926-13942 (2016)
   PUBMED   27129275
REFERENCE   4  (bases 1 to 3303)
  AUTHORS   Nair,B., Johar,K., Priya,A. and Wong-Riley,M.T.
  TITLE     Specificity protein 4 (Sp4) transcriptionally regulates inhibitory
            GABAergic receptors in neurons
  JOURNAL   Biochim Biophys Acta 1863 (1), 1-9 (2016)
   PUBMED   26469128
  REMARK    GeneRIF: Sp4 functionally regulates the transcription of Gabra1
            (GABAA alpha1) and Gabra2 (GABAA alpha2), but not Gabra3 (GABAA
            alpha3) subunit genes.
REFERENCE   5  (bases 1 to 3303)
  AUTHORS   Obradovic,A.L., Scarpa,J., Osuru,H.P., Weaver,J.L., Park,J.Y.,
            Pathirathna,S., Peterkin,A., Lim,Y., Jagodic,M.M., Todorovic,S.M.
            and Jevtovic-Todorovic,V.
  TITLE     Silencing the alpha2 subunit of gamma-aminobutyric acid type A
            receptors in rat dorsal root ganglia reveals its major role in
            antinociception posttraumatic nerve injury
  JOURNAL   Anesthesiology 123 (3), 654-667 (2015)
   PUBMED   26164299
  REMARK    GeneRIF: The Gabra2 receptor in the dorsal root ganglia plays an
            important role in the pathophysiology of neuropathic pain caused by
            sciatic nerve injury.
REFERENCE   6  (bases 1 to 3303)
  AUTHORS   Wisden,W. and Seeburg,P.H.
  TITLE     GABAA receptor channels: from subunits to functional entities
  JOURNAL   Curr Opin Neurobiol 2 (3), 263-269 (1992)
   PUBMED   1379501
  REMARK    Review article
REFERENCE   7  (bases 1 to 3303)
  AUTHORS   Laurie,D.J., Seeburg,P.H. and Wisden,W.
  TITLE     The distribution of 13 GABAA receptor subunit mRNAs in the rat
            brain. II. Olfactory bulb and cerebellum
  JOURNAL   J Neurosci 12 (3), 1063-1076 (1992)
   PUBMED   1312132
REFERENCE   8  (bases 1 to 3303)
  AUTHORS   Wisden,W., Laurie,D.J., Monyer,H. and Seeburg,P.H.
  TITLE     The distribution of 13 GABAA receptor subunit mRNAs in the rat
            brain. I. Telencephalon, diencephalon, mesencephalon
  JOURNAL   J Neurosci 12 (3), 1040-1062 (1992)
   PUBMED   1312131
REFERENCE   9  (bases 1 to 3303)
  AUTHORS   Khrestchatisky,M., MacLennan,A.J., Tillakaratne,N.J., Chiang,M.Y.
            and Tobin,A.J.
  TITLE     Sequence and regional distribution of the mRNA encoding the alpha 2
            polypeptide of rat gamma-aminobutyric acidA receptors
  JOURNAL   J Neurochem 56 (5), 1717-1722 (1991)
   PUBMED   1849552
REFERENCE   10 (bases 1 to 3303)
  AUTHORS   Seeburg,P.H., Wisden,W., Verdoorn,T.A., Pritchett,D.B., Werner,P.,
            Herb,A., Luddens,H., Sprengel,R. and Sakmann,B.
  TITLE     The GABAA receptor family: molecular and functional diversity
  JOURNAL   Cold Spring Harb Symp Quant Biol 55, 29-40 (1990)
   PUBMED   1966765
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On or before Jul 26, 2021 this sequence version replaced
            XM_006250931.4, NM_001135779.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.54190.1,
                                           SRR26360194.2050052.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                JAXUCZ010000014.1  37451218-37451271
            55-141              JAXUCZ010000014.1  37452210-37452296
            142-257             JAXUCZ010000014.1  37454712-37454827
            258-325             JAXUCZ010000014.1  37514112-37514179
            326-546             JAXUCZ010000014.1  37532174-37532394
            547-629             JAXUCZ010000014.1  37534002-37534084
            630-773             JAXUCZ010000014.1  37538700-37538843
            774-926             JAXUCZ010000014.1  37539841-37539993
            927-1129            JAXUCZ010000014.1  37570556-37570758
            1130-3303           JAXUCZ010000014.1  37581834-37584007
FEATURES             Location/Qualifiers
     source          1..3303
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p11"
     gene            1..3303
                     /gene="Gabra2"
                     /note="gamma-aminobutyric acid type A receptor subunit
                     alpha 2"
                     /db_xref="GeneID:289606"
                     /db_xref="RGD:61856"
     exon            1..54
                     /gene="Gabra2"
                     /inference="alignment:Splign:2.1.0"
     exon            55..141
                     /gene="Gabra2"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..1426
                     /gene="Gabra2"
                     /note="gamma-aminobutyric acid receptor subunit alpha-2;
                     gamma-aminobutyric acid receptor A2 subunit; GABA(A)
                     receptor subunit alpha-2; gamma-aminobutyric acid (GABA-A)
                     receptor, subunit alpha 2; GABAAR subunit alpha-2;
                     gamma-aminobutyric acid (GABA) A receptor, alpha 2;
                     gamma-aminobutyric acid type A receptor alpha2 subunit"
                     /codon_start=1
                     /product="gamma-aminobutyric acid receptor subunit alpha-2
                     precursor"
                     /protein_id="NP_001129251.3"
                     /db_xref="GeneID:289606"
                     /db_xref="RGD:61856"
                     /translation="MRTKLSTCNVWFPLLVLLVWNPARLVLANIQEDEAKNNITIFTR
                     ILDRLLDGYDNRLRPGLGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERL
                     KFKGPMNILRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRL
                     TVQAECPMHLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLNQY
                     DLLGQSIGKETIKSSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNR
                     ESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATV
                     NYFTKRGWAWDGKSVVNDKKKEKGSVMIQNNAYAVAVANYAPNLSKDPVLSTISKSAT
                     TPEPNKKPENKPAEAKKTFNSVSKIDRMSRIVFPVLFGTFNLVYWATYLNREPVLGVS
                     P"
     exon            142..257
                     /gene="Gabra2"
                     /inference="alignment:Splign:2.1.0"
     exon            258..325
                     /gene="Gabra2"
                     /inference="alignment:Splign:2.1.0"
     exon            326..546
                     /gene="Gabra2"
                     /inference="alignment:Splign:2.1.0"
     exon            547..629
                     /gene="Gabra2"
                     /inference="alignment:Splign:2.1.0"
     exon            630..773
                     /gene="Gabra2"
                     /inference="alignment:Splign:2.1.0"
     exon            774..926
                     /gene="Gabra2"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1129
                     /gene="Gabra2"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..3303
                     /gene="Gabra2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagacagaa tcagagccac tggaggaaaa catctacttc tgcttgctgt tcagcttcga
       61 aacaaggaag atgaggacaa aattgagcac ttgcaacgta tggtttccgc tgcttgttct
      121 cctggtgtgg aacccagcca ggttggtgct ggctaacatc caagaagatg aggctaaaaa
      181 taatatcacc atctttacaa gaattctaga cagacttctg gatggttacg ataatcgtct
      241 tagaccagga ctgggagaca gcattactga agtcttcacc aacatctatg tgaccagttt
      301 tggccctgtc tcagatacag atatggaata tacaatagat gttttctttc gacaaaaatg
      361 gaaagacgag cggttaaaat ttaaaggtcc catgaatatc cttcgactta acaacttaat
      421 ggctagcaaa atctggactc ctgacacctt ctttcacaac gggaaaaagt cagtggctca
      481 caatatgaca atgccaaaca agctgcttcg aatccaggat gacggaacat tgctgtacac
      541 catgaggctt acagtccaag ccgaatgtcc aatgcacttg gaggactttc caatggacgc
      601 tcactcatgc ccactgaaat ttggaagcta tgcttacacg acctcggaag tcacttatat
      661 ttggacttac aatgcttctg actctgttca ggttgctcct gatggctcta ggttaaatca
      721 gtatgatttg ctgggccagt caattgggaa ggagacaatt aaatcaagca caggtgaata
      781 cacggtaatg acagctcatt tccacttgaa aaggaaaatt gggtattttg tgattcagac
      841 ctatctgcct tgcatcatga ctgtcattct ctcccaagtg tcattctggc tgaacagaga
      901 atcggtgcca gcgagaactg tgtttggagt aacaactgtt ttgacaatga ccacattaag
      961 catcagtgct cgaaattccc ttcccaaagt ggcctatgcc actgccatgg actggtttat
     1021 cgctgtttgt tacgcgtttg tgttctctgc cttaattgaa tttgcaactg ttaattactt
     1081 cacgaaaaga ggatgggctt gggatggaaa gagtgtagta aatgacaaga aaaaagagaa
     1141 aggctccgtc atgatacaga acaacgccta tgctgtagcc gttgccaact acgccccgaa
     1201 tctttccaaa gatcctgtcc tctctaccat ttccaaaagt gcaactactc cagaaccaaa
     1261 caagaagcca gagaacaagc cagccgaagc caagaaaact ttcaacagtg tcagcaaaat
     1321 cgacagaatg tctagaatag tgttcccggt tctgtttggt acttttaatt tagtttactg
     1381 ggctacgtat ttaaaccggg agcctgtatt aggggttagt ccttgagtct agacattggt
     1441 tactttgggg ctgtattgca gtgttatatt tagtttttgt ttttgttttt gttttgtttt
     1501 catttttgct ttgtacagtc tgactaataa ctgctaattt atgacccaat atgtatagta
     1561 tgtatataat ggtagagctt accagtagac ctctaaagga gacctgcact tgctagctca
     1621 tggaaataca ggcagaaaac atcccgtgcc agaagagcca ttgccttttc aacacattta
     1681 cctaggacct agttcaaagt ggatttcaga tcccataatt tatttattaa tgttctaatt
     1741 agaatgaaag ttgagatcct atgtcacact tcgggaaacc tttgatttag atattacata
     1801 gagaactatt tctacggatg cctcaggatg atcagagatt aatattgtca ctcaaatatg
     1861 tgaaacagct aaacctctgg cctggttgct ttaggagagt tgaacccctg ctagtataat
     1921 tggaagcttg acacacataa ggagagagct agagatgtga aaaaagcatt taattactat
     1981 gtagaatatc tatagccatg tacatattac aagcatgaca agctcaagta actatgagtc
     2041 accatgacag gatgttaatt atgcttaaat aactattgga atgtcacagt cattatattt
     2101 ttagcttcag agtttatttg aaagtagtaa ctgaacctta cagttcactt caatcattgg
     2161 aaactaccta acattaaaaa aaataaaata aataggaaga tatatggact tagtccttcc
     2221 aggtgtgtgc tgtcagctga aattttctgg tgctggagaa tggaagaaag gcgccatctt
     2281 ggcagcaaca gagcaacgtt cactcgtatc agattagaaa gctgtgccaa aaactccaag
     2341 caatgagaat tcataggtgt cccaggtacg gatgagcact tatatgattc tcttctttcc
     2401 tgtttactgc aaattctgcc ttaaggcttc ttctcatcag ggctcagaag ccgctcattt
     2461 taaaggaaag ggcagttggt tggcacactt ttctgtctgg aaagcagctt tctttttcac
     2521 acaagagtta atgtaaatcc gcttttgtaa atcgcaaact ttcaatttca ttgactcgaa
     2581 tttacagcag ctttgtatac cagaagaggt tttggtaaga gttgaacatt tttaaacaat
     2641 gactttaaga catcaacaga ttgtggatta tatcacacac acacacacac acacacacac
     2701 acacacacac actcacccca cgtagctaaa ttaggaaaca tgattttcaa ttttataagg
     2761 tttctgattg ttaatgggta aaactcatgt ttcttttaat atatcaaatg atattatgta
     2821 tgtccctaaa atatgtccct gaaataagct gaactgtgtt tctgtcagac taaatttacc
     2881 tatgactgat atgtatatta gcagttatta gttgactttt aaaattaaac gcaacttcac
     2941 gatgatgttt ttgtagaaat taagtagtca agccgtggca tttcttgcaa ttttgtacag
     3001 tatttgagta tagtgcaaat caggtctgtt cacaaaatca ataaaagggg catcttctgg
     3061 aaaataagca aactctcaac accaaccaaa caccctgctg ttcctttgtc tcattcgact
     3121 tttcccgttt tatttcctag tgggatttta ctatctgctt tgcatgattg tgttcatacc
     3181 agggtcacag cttcatctta ctaacagaat tcgctatgaa gacagccttg acattaaaac
     3241 cttcctcaca aaaacaaaga gtaatccata aaccttaata aaaatattac atgagccaat
     3301 aaa
//
