LOCUS       NM_183326               3637 bp    mRNA    linear   ROD 16-JUN-2024
DEFINITION  Rattus norvegicus gamma-aminobutyric acid type A receptor subunit
            alpha 1 (Gabra1), mRNA.
ACCESSION   NM_183326 XM_220350
VERSION     NM_183326.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3637)
  AUTHORS   Wang,G.Y., Luan,Z.L., Che,N.W., Yan,D.B., Sun,X.W., Zhang,C. and
            Yin,J.
  TITLE     Inhibition of microRNA-129-2-3p protects against refractory
            temporal lobe epilepsy by regulating GABRA1
  JOURNAL   Brain Behav 11 (7), e02195 (2021)
   PUBMED   34029007
  REMARK    GeneRIF: Inhibition of microRNA-129-2-3p protects against
            refractory temporal lobe epilepsy by regulating GABRA1.
REFERENCE   2  (bases 1 to 3637)
  AUTHORS   Germann,A.L., Pierce,S.R., Tateiwa,H., Sugasawa,Y., Reichert,D.E.,
            Evers,A.S., Steinbach,J.H. and Akk,G.
  TITLE     Intrasubunit and Intersubunit Steroid Binding Sites Independently
            and Additively Mediate alpha1beta2gamma2L GABAA Receptor
            Potentiation by the Endogenous Neurosteroid Allopregnanolone
  JOURNAL   Mol Pharmacol 100 (1), 19-31 (2021)
   PUBMED   33958479
  REMARK    GeneRIF: Intrasubunit and Intersubunit Steroid Binding Sites
            Independently and Additively Mediate alpha1beta2gamma2L GABAA
            Receptor Potentiation by the Endogenous Neurosteroid
            Allopregnanolone.
REFERENCE   3  (bases 1 to 3637)
  AUTHORS   Maingret,F. and Groc,L.
  TITLE     Characterization of the Functional Cross-Talk between Surface GABAA
            and Dopamine D5 Receptors
  JOURNAL   Int J Mol Sci 22 (9), 4867 (2021)
   PUBMED   34064454
  REMARK    GeneRIF: Characterization of the Functional Cross-Talk between
            Surface GABAA and Dopamine D5 Receptors.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3637)
  AUTHORS   Shimizu,Y., Shimizu,T., Zou,S., Ono,H., Hata,Y., Yamamoto,M.,
            Aratake,T., Shimizu,S., Higashi,Y., Karashima,T. and Saito,M.
  TITLE     Stimulation of brain alpha7-nicotinic acetylcholine receptors
            suppresses the rat micturition through brain GABAergic receptors
  JOURNAL   Biochem Biophys Res Commun 548, 84-90 (2021)
   PUBMED   33636639
  REMARK    GeneRIF: Stimulation of brain alpha7-nicotinic acetylcholine
            receptors suppresses the rat micturition through brain GABAergic
            receptors.
REFERENCE   5  (bases 1 to 3637)
  AUTHORS   Sun,W. and Yuill,M.B.
  TITLE     Role of the GABAa and GABAb receptors of the central nucleus of the
            amygdala in compulsive cocaine-seeking behavior in male rats
  JOURNAL   Psychopharmacology (Berl) 237 (12), 3759-3771 (2020)
   PUBMED   32875348
  REMARK    GeneRIF: Role of the GABAa and GABAb receptors of the central
            nucleus of the amygdala in compulsive cocaine-seeking behavior in
            male rats.
REFERENCE   6  (bases 1 to 3637)
  AUTHORS   Wisden,W. and Seeburg,P.H.
  TITLE     GABAA receptor channels: from subunits to functional entities
  JOURNAL   Curr Opin Neurobiol 2 (3), 263-269 (1992)
   PUBMED   1379501
  REMARK    Review article
REFERENCE   7  (bases 1 to 3637)
  AUTHORS   Sigel,E., Baur,R., Kellenberger,S. and Malherbe,P.
  TITLE     Point mutations affecting antagonist affinity and agonist dependent
            gating of GABAA receptor channels
  JOURNAL   EMBO J 11 (6), 2017-2023 (1992)
   PUBMED   1376242
REFERENCE   8  (bases 1 to 3637)
  AUTHORS   Laurie,D.J., Seeburg,P.H. and Wisden,W.
  TITLE     The distribution of 13 GABAA receptor subunit mRNAs in the rat
            brain. II. Olfactory bulb and cerebellum
  JOURNAL   J Neurosci 12 (3), 1063-1076 (1992)
   PUBMED   1312132
REFERENCE   9  (bases 1 to 3637)
  AUTHORS   Wisden,W., Laurie,D.J., Monyer,H. and Seeburg,P.H.
  TITLE     The distribution of 13 GABAA receptor subunit mRNAs in the rat
            brain. I. Telencephalon, diencephalon, mesencephalon
  JOURNAL   J Neurosci 12 (3), 1040-1062 (1992)
   PUBMED   1312131
REFERENCE   10 (bases 1 to 3637)
  AUTHORS   Wieland,H.A., Luddens,H. and Seeburg,P.H.
  TITLE     A single histidine in GABAA receptors is essential for
            benzodiazepine agonist binding
  JOURNAL   J Biol Chem 267 (3), 1426-1429 (1992)
   PUBMED   1346133
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC100061.1.
            
            On Aug 7, 2005 this sequence version replaced NM_183326.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100061.1, FQ211937.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760384 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3637
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q21"
     gene            1..3637
                     /gene="Gabra1"
                     /note="gamma-aminobutyric acid type A receptor subunit
                     alpha 1"
                     /db_xref="GeneID:29705"
                     /db_xref="RGD:61855"
     exon            1..209
                     /gene="Gabra1"
                     /inference="alignment:Splign:2.1.0"
     exon            210..298
                     /gene="Gabra1"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..1592
                     /gene="Gabra1"
                     /note="gamma-aminobutyric acid receptor subunit alpha-1;
                     GABA(A) receptor subunit alpha-1; gamma-aminobutyric acid
                     (GABA-A) receptor, subunit alpha 1; gamma-aminobutyric
                     acid A receptor, alpha 1; gamma-aminobutyric acid (GABA) A
                     receptor, alpha 1; gamma-aminobutyric acid type A receptor
                     alpha1 subunit; GABAAR subunit alpha-1"
                     /codon_start=1
                     /product="gamma-aminobutyric acid receptor subunit alpha-1
                     precursor"
                     /protein_id="NP_899155.1"
                     /db_xref="GeneID:29705"
                     /db_xref="RGD:61855"
                     /translation="MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRI
                     LDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLK
                     FKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLT
                     VRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYD
                     LLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRE
                     SVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVN
                     YFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSA
                     TIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKA
                     PTPHQ"
     exon            299..408
                     /gene="Gabra1"
                     /inference="alignment:Splign:2.1.0"
     exon            409..476
                     /gene="Gabra1"
                     /inference="alignment:Splign:2.1.0"
     exon            477..697
                     /gene="Gabra1"
                     /inference="alignment:Splign:2.1.0"
     exon            698..780
                     /gene="Gabra1"
                     /inference="alignment:Splign:2.1.0"
     exon            781..924
                     /gene="Gabra1"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1077
                     /gene="Gabra1"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1280
                     /gene="Gabra1"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..3611
                     /gene="Gabra1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgggaagcaa atttgggtat gaaatctcta gtgcaggagc acgcagagtc catgatggct
       61 caaaccgtgt gagtgagcgc ggcgcgagga cgccctccgc ccggcgcgcc cgcgctcgca
      121 cactcgcgca gctccggctc accgcgatcc tctctcccac acttttctcc cgggtctgga
      181 gcgatccggt gcccagaggg ggccccgagc tggacaagcc cgtgatgaag aaaagtcggg
      241 gtctctctga ctatctttgg gcctggaccc tcattctgag cactctctcg ggaagaagct
      301 atggacagcc ctcccaagat gaacttaagg acaacaccac tgtcttcacg aggattttgg
      361 accgactgct ggatggttat gacaatcgtc tgagaccagg cttgggagag cgtgtaactg
      421 aagtgaagac ggacatcttt gtcaccagtt tcggacccgt gtcagaccac gatatggaat
      481 atacaataga tgtgtttttc cgccaaagct ggaaggatga aagattaaaa ttcaaaggac
      541 ccatgacagt gctccggctg aacaacctga tggccagtaa aatctggact ccagatacat
      601 ttttccacaa tggaaaaaag tctgtggccc acaacatgac catgcccaat aaactcctgc
      661 gtatcacaga ggatggcaca ctgctgtaca ccatgaggtt gactgtgaga gccgaatgcc
      721 ccatgcactt agaagacttt cccatggatg cccatgcctg cccactaaaa tttgggagct
      781 atgcttatac aagagcagaa gttgtctatg agtggacaag ggagccagcc cgctcagtgg
      841 ttgtggcaga agatgggtca cgtttaaacc agtatgacct tcttgggcaa acagttgact
      901 ctggaattgt tcagtccagt actggagaat atgtggttat gacgactcac tttcacttga
      961 agagaaaaat cggctacttt gttattcaaa catatctgcc atgcataatg acagtcattc
     1021 tctcccaagt ctccttctgg cttaacagag agtcagtacc agcaagaact gtctttggag
     1081 tgacgaccgt tctgaccatg acaaccttga gtatcagtgc cagaaattcc ctcccaaagg
     1141 tggcttatgc aacggccatg gactggttta ttgcagtgtg ctatgccttc gtgttctcgg
     1201 ctctgattga gtttgccaca gtaaactatt tcaccaagag agggtatgcg tgggatggca
     1261 aaagcgtggt tccagaaaag ccaaagaaag tgaaggatcc tctcattaag aaaaacaaca
     1321 catatgctcc tacagcaacc agctataccc ctaacttagc caggggtgac cccggcttgg
     1381 caactattgc taaaagtgcg accatagaac cgaaagaagt caagcctgag acaaaaccgc
     1441 cagaacccaa gaaaaccttt aacagcgtca gcaaaatcga ccgactgtca agaatagcct
     1501 ttccgctgct atttggaatc tttaacttag tctattgggc cacgtattta aacagagagc
     1561 ctcagctaaa agcccccaca ccccatcaat aggttctttt agtcgtattc tgttgttcag
     1621 tcctctgcac tgagaatcgc tttctgttct caacgcagtg attcctgtct gctttactgc
     1681 ctctgtctta aaagaattcg aaggtttcct tatttccata tttcatatac gaacaagaga
     1741 cccctgtctg acagttcaga gcagggcaga gtattcagct cggggacagg attctgagag
     1801 gaagccagag agcaaaatca cgtcagaagg agacagacaa gaggaggaga gagggtaaga
     1861 aggtccaaag ataggaggaa agtagaagaa aaacagagct taactataac cacagagtca
     1921 tttgtagata tatatttcca aatattctca aaaaatatat ccgtcaaaaa tatttttgtg
     1981 tgaagtgttt aaaagggcaa ataacaaatg tttaatgaac tttaaatcta tgtctttatc
     2041 gcacaaatga tatagtgtgc ttatgttttt atttgtcaat gtttaagctg atatagagat
     2101 ttaatgtttg gtttgtcaaa ttaaaaattc cctaggcttt ctcttgttaa atttcactat
     2161 gtactatttt gttgttcaat gctattttag aatgtatgaa agcctaataa atagggtaag
     2221 gtgaggctgt cattgtagca ttctgaatcc aatggaggaa aaaagaaaac cctttcaatg
     2281 ggcttcattg ctatcatctg aacttttacc agtagactct atggagatga gccagcctaa
     2341 cacagatgtt tacttgatag aagctgaaat aaataaataa ataaattaga taatttaaaa
     2401 actatctttc tttttactct tattcccaca cagcccattc acccaagaat tctctattct
     2461 tatgatgaag atgctttcag aggggcaaat ctattttgca agctctagaa ttgttgaatg
     2521 tattctttta tataactaca tcaaaagctt tagattgaaa tttatgacta gccaacaaaa
     2581 aatagaatat ataaattata tatgtaaata ttcagcatga gattgtacat tgaatttttt
     2641 tttaaactta cgttctttaa atatcatgag ggatctccac ttttagctgt tagaatgttg
     2701 ttaaatgcta tggaaataca tttagagcct gcatttaaga acagaacagc ctgtaggaga
     2761 cagatgccac ttaaaccata ttgagtatga aatccaatta taccgaggac gctcataact
     2821 tcactgttgc ccagtgttca atagtagatc agttgctatc tgcttgaatg atgtcatacc
     2881 atatttttcc tgttttaggc tattgtgata aagagaaaaa aatagggaag agtagttggg
     2941 gctagagaac caactgtata ttatttctct atttgctgaa accaactatt tcaataagtg
     3001 ctgtgccacg tgtagcatcc aatataaaat acatgggaga atgtacagga actagctttt
     3061 atcgagtaat attattatta catttcattt atactgcagc aatatatttg taggtacact
     3121 atgtaagggc tttaaataaa agaggtccat taatattcct taaaaaaaca attctagcct
     3181 ttcatgattg cccagatgtt ttagaagtaa atatttatga aagaaggtat ttttgaagtc
     3241 tcctgttgtc tgatagattt ttcacagata tctaccatta gttcagaatc caccgatcat
     3301 ggtctaatca cacttataag accgtgacat gagcctttta gcataattgc caagtaagac
     3361 aattagaatc cacacctgag ttttgagcaa tgttgttttt ttttctcaaa aagctgctat
     3421 ccaatgatgt tggaaaacac agtgcctgtg tttccctaaa acgacaaatc tctggtttca
     3481 tcttaaatgt gcttcattgt ttgatttggt cctgcctaaa tttcatgagc tatgccaaaa
     3541 aaaaatggct gaaccaagga catttcatgt atagatatgt atagaaaata aaataaatta
     3601 tggctctaac aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
