LOCUS       NP_001128487             383 aa            linear   ROD 03-APR-2024
DEFINITION  GA-binding protein subunit beta-1 [Rattus norvegicus].
ACCESSION   NP_001128487 XP_001053889 XP_001053947 XP_001054003 XP_344607
VERSION     NP_001128487.1
DBSOURCE    REFSEQ: accession NM_001135015.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 383)
  AUTHORS   Yang,S.J., Liang,H.L., Ning,G. and Wong-Riley,M.T.
  TITLE     Ultrastructural study of depolarization-induced translocation of
            NRF-2 transcription factor in cultured rat visual cortical neurons
  JOURNAL   Eur J Neurosci 19 (5), 1153-1162 (2004)
   PUBMED   15016074
  REMARK    GeneRIF: NRF-2alpha and NRF-2beta respond to increased neuronal
            activity by translocating from the cytoplasm to the nucleus, where
            they engage in transcriptional activation of target genes.
REFERENCE   2  (residues 1 to 383)
  AUTHORS   Schweppe,R.E., Melton,A.A., Brodsky,K.S., Aveline,L.D.,
            Resing,K.A., Ahn,N.G. and Gutierrez-Hartmann,A.
  TITLE     Purification and mass spectrometric identification of GA-binding
            protein (GABP) as the functional pituitary Ets factor binding to
            the basal transcription element of the prolactin promoter
  JOURNAL   J Biol Chem 278 (19), 16863-16872 (2003)
   PUBMED   12618435
  REMARK    GeneRIF: GA-binding protein (GABPalpha/GABPbeta)is critical and
            functionally relevant Ets factor that regulates prolactin promoter
            activity via the basal transcription element site.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On or before Sep 19, 2008 this sequence version replaced
            XP_344607.2, XP_001053889.1, XP_001054003.1, XP_001053947.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR21887622.1891599.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..383
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.1"
     Protein         1..383
                     /product="GA-binding protein subunit beta-1"
                     /EC_number="3.2.1.3"
                     /note="nuclear respiratory factor 2 beta; GA repeat
                     binding protein, beta 1; GA binding protein transcription
                     factor, beta subunit 2, 47kDa"
                     /calculated_mol_wt=41295
     Region          <10..179
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          10..35
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          38..68
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(39,43..44,47..49,51..52,56,59,68,70,72,76..77,
                     80..82,84..85,89,92,101,103,105,109..110,113..115,
                     117..118,122,125)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          70..101
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          103..133
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          <329..375
                     /region_name="ERM_helical"
                     /note="Ezrin/radixin/moesin, alpha-helical domain;
                     pfam20492"
                     /db_xref="CDD:466641"
     CDS             1..383
                     /gene="Gabpb1l"
                     /gene_synonym="Gabpb1; Gabpb2; Nrf-2beta; Nrf2b"
                     /coded_by="NM_001135015.1:1..1152"
                     /db_xref="GeneID:364738"
                     /db_xref="RGD:1310235"
ORIGIN      
        1 mslvdlgkkl leaaragqdd evrilmanga pfttdwlgts plhlaaqygh ysttevllra
       61 gvsrdartkv drtplhmaas eghasivevl lkhgadvnak dmlkmtalhw atehihqevv
      121 ellikygadv htqskfckta fdisidngne dlaeilqiam qnqintnpes pdtvtihaat
      181 pqfiigpggv vnltdetgvs avqfgnssts vlatlaalae asaplsnsse tpvvateevv
      241 taesvdgaiq qvvssvgqqv itivtdgiql gnlhsiptsg mgqpiivtmp dgqqvltvpa
      301 tdiaeetvis eeppakrqcm eiienrvesa eieerealqk qldeanreaq kyrqqllkke
      361 qeaeayrqkl eamkrlqtnk eav
//
