LOCUS       NM_031028               4399 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Rattus norvegicus gamma-aminobutyric acid type B receptor subunit 1
            (Gabbr1), mRNA.
ACCESSION   NM_031028
VERSION     NM_031028.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4399)
  AUTHORS   Lorrai,I., Shankula,C., Marquez Gaytan,J., Maccioni,R., Lobina,C.,
            Maccioni,P., Brizzi,A., Mugnaini,C., Gessa,G.L., Sanna,P.P.,
            Corelli,F. and Colombo,G.
  TITLE     Development of tolerance upon repeated administration with the
            GABAB receptor positive allosteric modulator, COR659, on alcohol
            drinking in rodents
  JOURNAL   Am J Drug Alcohol Abuse 48 (6), 662-672 (2022)
   PUBMED   36095322
REFERENCE   2  (bases 1 to 4399)
  AUTHORS   Wang,H. and Haas,J.S.
  TITLE     GABABR Modulation of Electrical Synapses and Plasticity in the
            Thalamic Reticular Nucleus
  JOURNAL   Int J Mol Sci 22 (22), 12138 (2021)
   PUBMED   34830020
  REMARK    GeneRIF: GABABR Modulation of Electrical Synapses and Plasticity in
            the Thalamic Reticular Nucleus.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4399)
  AUTHORS   Liu,X.J., Wang,H.J., Wang,X.Y., Ning,Y.X. and Gao,J.
  TITLE     GABABR1 in DRN mediated GABA to regulate 5-HT expression in
            multiple brain regions in male rats with high and low aggressive
            behavior
  JOURNAL   Neurochem Int 150, 105180 (2021)
   PUBMED   34509561
  REMARK    GeneRIF: GABABR1 in DRN mediated GABA to regulate 5-HT expression
            in multiple brain regions in male rats with high and low aggressive
            behavior.
REFERENCE   4  (bases 1 to 4399)
  AUTHORS   Smirnova,E.Y., Chizhov,A.V. and Zaitsev,A.V.
  TITLE     Presynaptic GABAB receptors underlie the antiepileptic effect of
            low-frequency electrical stimulation in the 4-aminopyridine model
            of epilepsy in brain slices of young rats
  JOURNAL   Brain Stimul 13 (5), 1387-1395 (2020)
   PUBMED   32717394
  REMARK    GeneRIF: Presynaptic GABAB receptors underlie the antiepileptic
            effect of low-frequency electrical stimulation in the
            4-aminopyridine model of epilepsy in brain slices of young rats.
REFERENCE   5  (bases 1 to 4399)
  AUTHORS   Sun,Z., Sun,L. and Tu,L.
  TITLE     GABAB Receptor-Mediated PI3K/Akt Signaling Pathway Alleviates
            Oxidative Stress and Neuronal Cell Injury in a Rat Model of
            Alzheimer's Disease
  JOURNAL   J Alzheimers Dis 76 (4), 1513-1526 (2020)
   PUBMED   32651311
  REMARK    GeneRIF: GABAB Receptor-Mediated PI3K/Akt Signaling Pathway
            Alleviates Oxidative Stress and Neuronal Cell Injury in a Rat Model
            of Alzheimer's Disease.
REFERENCE   6  (bases 1 to 4399)
  AUTHORS   Kuner,R., Kohr,G., Grunewald,S., Eisenhardt,G., Bach,A. and
            Kornau,H.C.
  TITLE     Role of heteromer formation in GABAB receptor function
  JOURNAL   Science 283 (5398), 74-77 (1999)
   PUBMED   9872744
REFERENCE   7  (bases 1 to 4399)
  AUTHORS   White,J.H., Wise,A., Main,M.J., Green,A., Fraser,N.J., Disney,G.H.,
            Barnes,A.A., Emson,P., Foord,S.M. and Marshall,F.H.
  TITLE     Heterodimerization is required for the formation of a functional
            GABA(B) receptor
  JOURNAL   Nature 396 (6712), 679-682 (1998)
   PUBMED   9872316
REFERENCE   8  (bases 1 to 4399)
  AUTHORS   Kaupmann,K., Huggel,K., Heid,J., Flor,P.J., Bischoff,S.,
            Mickel,S.J., McMaster,G., Angst,C., Bittiger,H., Froestl,W. and
            Bettler,B.
  TITLE     Expression cloning of GABA(B) receptors uncovers similarity to
            metabotropic glutamate receptors
  JOURNAL   Nature 386 (6622), 239-246 (1997)
   PUBMED   9069281
REFERENCE   9  (bases 1 to 4399)
  AUTHORS   Cunningham,M.D. and Enna,S.J.
  TITLE     Evidence for pharmacologically distinct GABAB receptors associated
            with cAMP production in rat brain
  JOURNAL   Brain Res 720 (1-2), 220-224 (1996)
   PUBMED   8782915
REFERENCE   10 (bases 1 to 4399)
  AUTHORS   Martin,P., Massol,J., Pichat,P. and Puech,A.J.
  TITLE     Decreased central GABA B receptor binding sites in diabetic rats
  JOURNAL   Neuropsychobiology 19 (3), 146-148 (1988)
   PUBMED   2849069
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX883052.1.
            
            On Oct 20, 2009 this sequence version replaced NM_031028.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y10369.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-209               BX883052.1         106630-106838
            210-291             BX883052.1         107259-107340
            292-495             BX883052.1         107986-108189
            496-681             BX883052.1         108939-109124
            682-702             BX883052.1         110302-110322
            703-863             BX883052.1         111526-111686
            864-998             BX883052.1         114620-114754
            999-1169            BX883052.1         115149-115319
            1170-1271           BX883052.1         116211-116312
            1272-1337           BX883052.1         116608-116673
            1338-1529           BX883052.1         117205-117396
            1530-1772           BX883052.1         123072-123314
            1773-1836           BX883052.1         123903-123966
            1837-1914           BX883052.1         125274-125351
            1915-2065           BX883052.1         128014-128164
            2066-2198           BX883052.1         128595-128727
            2199-2315           BX883052.1         130670-130786
            2316-2423           BX883052.1         130873-130980
            2424-2517           BX883052.1         131526-131619
            2518-2645           BX883052.1         132188-132315
            2646-2774           BX883052.1         133662-133790
            2775-2918           BX883052.1         133896-134039
            2919-4399           BX883052.1         134606-136086
FEATURES             Location/Qualifiers
     source          1..4399
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..4399
                     /gene="Gabbr1"
                     /note="gamma-aminobutyric acid type B receptor subunit 1"
                     /db_xref="GeneID:81657"
                     /db_xref="RGD:621537"
     exon            1..209
                     /gene="Gabbr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             210..3092
                     /gene="Gabbr1"
                     /note="gb1; GABA-B-R1; GABA-B receptor 1; GABABR1;
                     GABA-BR1; gamma-aminobutyric acid (GABA) B receptor 1"
                     /codon_start=1
                     /product="gamma-aminobutyric acid type B receptor subunit
                     1 precursor"
                     /protein_id="NP_112290.2"
                     /db_xref="GeneID:81657"
                     /db_xref="RGD:621537"
                     /translation="MLLLLLVPLFLRPLGAGGAQTPNATSEGCQIIHPPWEGGIRYRG
                     LTRDQVKAINFLPVDYEIEYVCRGEREVVGPKVRKCLANGSWTDMDTPSRCVRICSKS
                     YLTLENGKVFLTGGDLPALDGARVEFRCDPDFHLVGSSRSVCSQGQWSTPKPHCQVNR
                     TPHSERRAVYIGALFPMSGGWPGGQACQPAVEMALEDVNSRRDILPDYELKLIHHDSK
                     CDPGQATKYLYELLYNDPIKIILMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNR
                     QRFPTFFRTHPSATLHNPTRVKLFEKWGWKKIATIQQTTEVFTSTLDDLEERVKEAGI
                     EITFRQSFFSDPAVPVKNLKRQDARIIVGLFYETEARKVFCEVYKERLFGKKYVWFLI
                     GWYADNWFKTYDPSINCTVEEMTEAVEGHITTEIVMLNPANTRSISNMTSQEFVEKLT
                     KRLKRHPEETGGFQEAPLAYDAIWALALALNKTSGGGGRSGVRLEDFNYNNQTITDQI
                     YRAMNSSSFEGVSGHVVFDASGSRMAWTLIEQLQGGSYKKIGYYDSTKDDLSWSKTDK
                     WIGGSPPADQTLVIKTFRFLSQKLFISVSVLSSLGIVLAVVCLSFNIYNSHVRYIQNS
                     QPNLNNLTAVGCSLALAAVFPLGLDGYHIGRSQFPFVCQARLWLLGLGFSLGYGSMFT
                     KIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGMDVLTLAIWQIVDPLHRTIETF
                     AKEEPKEDIDVSILPQLEHCSSKKMNTWLGIFYGYKGLLLLLGIFLAYETKSVSTEKI
                     NDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAFAFASLAIVFSSYITLVVLFVPKM
                     RRLITRGEWQSETQDTMKTGSSTNNNEEEKSRLLEKENRELEKIIAEKEERVSELRHQ
                     LQSRQQLRSRRHPPTPPDPSGGLPRGPSEPPDRLSCDGSRVHLLYK"
     exon            210..291
                     /gene="Gabbr1"
                     /inference="alignment:Splign:2.1.0"
     exon            292..495
                     /gene="Gabbr1"
                     /inference="alignment:Splign:2.1.0"
     exon            496..681
                     /gene="Gabbr1"
                     /inference="alignment:Splign:2.1.0"
     exon            682..702
                     /gene="Gabbr1"
                     /inference="alignment:Splign:2.1.0"
     exon            703..863
                     /gene="Gabbr1"
                     /inference="alignment:Splign:2.1.0"
     exon            864..998
                     /gene="Gabbr1"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1169
                     /gene="Gabbr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1271
                     /gene="Gabbr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1337
                     /gene="Gabbr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1529
                     /gene="Gabbr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1772
                     /gene="Gabbr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..1836
                     /gene="Gabbr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..1914
                     /gene="Gabbr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..2065
                     /gene="Gabbr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2198
                     /gene="Gabbr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2199..2315
                     /gene="Gabbr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2316..2423
                     /gene="Gabbr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2424..2517
                     /gene="Gabbr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2518..2645
                     /gene="Gabbr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2646..2774
                     /gene="Gabbr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2775..2918
                     /gene="Gabbr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2919..4399
                     /gene="Gabbr1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgtcgcccc ggggaaggag agacgggggt ggggtttgcg ggtagcgatc gagaagggga
       61 gagaccccgg ccaggcagga gcctggattc ctgtggaaga agaacagggg gaggggaagc
      121 tggaggaccg ggagggagaa cggggagccg cggccgggcc tggggccttg aggcccgggg
      181 agagccgcgg agcgggaccg gccgccgaga tgctgctgct gctgctggtg cctctcttcc
      241 tccgccccct gggcgctggc ggggcgcaga cccccaacgc cacctcggaa ggttgccaga
      301 ttatacatcc gccctgggaa ggtggcatca ggtaccgtgg cttgactcgc gaccaggtga
      361 aggccatcaa cttcctgcct gtggactatg agatcgaata tgtgtgccga ggggagcgcg
      421 aggtggtggg gcccaaggtg cgcaaatgcc tggccaacgg ctcctggacg gatatggaca
      481 cacccagccg ctgtgtccga atctgctcca agtcttattt gaccctggaa aatgggaagg
      541 ttttcctgac gggtggggac ctcccagctc tggatggagc ccgggtggag ttccgatgtg
      601 accccgactt ccatctggtg ggcagctccc ggagcgtctg tagtcagggc cagtggagca
      661 cccccaagcc ccactgccag gtgaatcgaa cgccacactc agaacggcgt gcagtataca
      721 tcggggcgct gtttcccatg agcgggggct ggccgggggg ccaggcctgc cagcccgcgg
      781 tggagatggc gctggaggac gttaacagcc gcagagacat cctgccggac tacgagctca
      841 agcttatcca ccacgacagc aagtgtgacc cagggcaagc caccaagtac ttgtacgaac
      901 tactctacaa tgaccccatc aagatcattc tcatgcctgg ctgtagttct gtctccacac
      961 ttgtagctga ggctgcccgg atgtggaacc ttattgtgct ctcatatggc tccagttcac
     1021 cagccttgtc aaaccgacag cggtttccca cgttcttccg gacgcatcca tccgccacac
     1081 tccacaatcc cacccgggtg aaactcttcg aaaagtgggg ctggaagaag atcgctacca
     1141 tccaacagac caccgaggtc ttcacctcaa cgctggatga cctggaggag cgagtgaaag
     1201 aggctgggat cgagatcact ttccgacaga gtttcttctc ggatccagct gtgcctgtta
     1261 aaaacctgaa gcgtcaagat gctcgaatca tcgtgggact tttctatgag acggaagccc
     1321 ggaaagtttt ttgtgaggtc tataaggaaa ggctctttgg gaagaagtac gtctggttcc
     1381 tcatcgggtg gtatgctgac aactggttca agacctatga cccgtcaatc aattgtacag
     1441 tggaagaaat gaccgaggcg gtggagggcc acatcaccac ggagattgtc atgctgaacc
     1501 ctgccaacac ccgaagcatt tccaacatga cgtcacagga atttgtggag aaactaacca
     1561 agcggctgaa aagacacccc gaggagactg gaggcttcca ggaggcacca ctggcctatg
     1621 atgctatctg ggccttggct ttggccttga acaagacgtc tggaggaggt ggtcgttccg
     1681 gcgtgcgcct ggaggacttt aactacaaca accagaccat tacagaccag atctaccggg
     1741 ccatgaactc ctcctccttt gagggcgttt ctggccatgt ggtctttgat gccagcggct
     1801 cccggatggc atggacactt atcgagcagc tacagggcgg cagctacaag aagatcggct
     1861 actacgacag caccaaggat gatctttcct ggtccaaaac ggacaagtgg attggagggt
     1921 ctcccccagc tgaccagacc ttggtcatca agacattccg tttcctgtct cagaaactct
     1981 ttatctccgt ctcagttctc tccagcctgg gcattgttct tgctgttgtc tgtctgtcct
     2041 ttaacatcta caactcccac gttcgttata tccagaactc ccagcccaac ctgaacaatc
     2101 tgactgctgt gggctgctca ctggcactgg ctgctgtctt ccctctcggg ctggatggtt
     2161 accacatagg gagaagccag ttcccgtttg tctgccaggc ccgcctttgg ctcttgggct
     2221 tgggctttag tctgggctat ggctctatgt tcaccaagat ctggtgggtc cacacagtct
     2281 tcacgaagaa ggaggagaag aaggagtgga ggaagaccct agagccctgg aaactctatg
     2341 ccactgtggg cctgctggtg ggcatggatg tcctgactct tgccatctgg cagattgtgg
     2401 accccttgca ccgaaccatt gagacttttg ccaaggagga accaaaggaa gacatcgatg
     2461 tctccattct gccccagttg gagcactgca gctccaagaa gatgaatacg tggcttggca
     2521 ttttctatgg ttacaagggg ctgctgctgc tgctgggaat ctttcttgct tacgaaacca
     2581 agagcgtgtc cactgaaaag atcaatgacc acagggccgt gggcatggct atctacaatg
     2641 tcgcggtcct gtgtctcatc actgctcctg tgaccatgat cctttccagt cagcaggacg
     2701 cagcctttgc ctttgcctct ctggccatcg tgttctcttc ctacatcact ctggttgtgc
     2761 tctttgtgcc caagatgcgc aggctgatca cccgagggga atggcagtct gaaacgcagg
     2821 acaccatgaa aacaggatca tccaccaaca acaacgagga agagaagtcc cgactgttgg
     2881 agaaggaaaa ccgagaactg gaaaagatca tcgctgagaa agaggagcgc gtctctgaac
     2941 tgcgccatca gctccagtct cggcagcaac tccgctcacg gcgccacccc ccaacacccc
     3001 cagatccctc tgggggcctt cccaggggac cctctgagcc ccctgaccgg cttagctgtg
     3061 atgggagtcg agtacatttg ctttacaagt gagggggcat ggagaaggat caagccagta
     3121 ggggagggaa gggtctggga agagggtggg ggcctgggag gagggtaagg actcctatct
     3181 ccaacctgga gagcacacgc tccaatcccc ctcttataaa tacatgtcgc tctgtgcatc
     3241 tggggttatt tgggtctcca gtactctggg aaacagactg ttttctttct cccctataat
     3301 tttatatctc cacttcacag gttttgtttg aaccctgctt ggagttatta ttcactcatg
     3361 gctccagagg ggcatctcat ttttctccgg tagcctgtct tgtacagtta ccacagcaac
     3421 tcctgtcatt tcagcagcag gggtcttcct acactagcag ggctctcgct ctctccattt
     3481 ttcagcctca gaatctcctt ccattattct tctccttcta catgtctcca tggcttcctc
     3541 tcccagggga ctcgttctac acacacacac acacacacac acacacacac acacacacac
     3601 acacacaccc cgcatcctgc cctctcctag gcagctgcat gtcgtcctgt acaaatgtgc
     3661 tcgcttctga gtgctttgtg cggccgttca cttgtgctgt ctgcataagc tgcgtctgtg
     3721 agtgcacggt ggtttgtggg tgcgtgaagt ggcatgctcc ggtaggtgtg tatgatgcgt
     3781 tgagcacgct acgctgtctc cctcatgtgc acgcattgtg tctgcttatg ttttacttgt
     3841 atgcctctgt gtactgtgtg tgtgtgtgtg tgcccacgcg tgcgcccgtg tgcatgcgtt
     3901 cgtgttgccc tgactggctg tctcagcctt ctgagtaatt gggattccag ttgtctgtct
     3961 agctcatgtc ctgtcttctt ccagtagagc cgtgaacacc caacacacac agttaatcgg
     4021 gctcccccca gtccatgttt tctgagccat ccaaaaactc tccttggcct taggttcatc
     4081 cgcagatgtt ccctctgttc tttgctctcg tgcgtccacc ttcattctct tcagtcattt
     4141 ctcagatctg ctgcgtcgtg gtttcctttc cttcattatc atcgtcatta tttttcagaa
     4201 cttaagggaa aaagaaatgg ggacaggttg gaggctgttt ccagtggaat agtgggtgcg
     4261 agtcctgacc aaatgaaggc acggacagat ggactgacgg ggcgggaggc ggcgtccctt
     4321 tcacactgtg gtgtctcttg ggggggaagg atctccccga atctcaataa agcagtgaac
     4381 agtatgactc agcacctca
//
