LOCUS       NM_172036               1211 bp    mRNA    linear   ROD 08-APR-2024
DEFINITION  Rattus norvegicus GABA type A receptor-associated protein
            (Gabarap), mRNA.
ACCESSION   NM_172036
VERSION     NM_172036.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1211)
  AUTHORS   Szalai,P., Hagen,L.K., Saetre,F., Luhr,M., Sponheim,M., Overbye,A.,
            Mills,I.G., Seglen,P.O. and Engedal,N.
  TITLE     Autophagic bulk sequestration of cytosolic cargo is independent of
            LC3, but requires GABARAPs
  JOURNAL   Exp Cell Res 333 (1), 21-38 (2015)
   PUBMED   25684710
  REMARK    GeneRIF: Macroautophagic sequestration does not require the LC3
            subfamily but the GABARAP subfamily is essential.
REFERENCE   2  (bases 1 to 1211)
  AUTHORS   Mandell,M.A., Jain,A., Arko-Mensah,J., Chauhan,S., Kimura,T.,
            Dinkins,C., Silvestri,G., Munch,J., Kirchhoff,F., Simonsen,A.,
            Wei,Y., Levine,B., Johansen,T. and Deretic,V.
  TITLE     TRIM proteins regulate autophagy and can target autophagic
            substrates by direct recognition
  JOURNAL   Dev Cell 30 (4), 394-409 (2014)
   PUBMED   25127057
REFERENCE   3  (bases 1 to 1211)
  AUTHORS   Ma,P., Schwarten,M., Schneider,L., Boeske,A., Henke,N., Lisak,D.,
            Weber,S., Mohrluder,J., Stoldt,M., Strodel,B., Methner,A.,
            Hoffmann,S., Weiergraber,O.H. and Willbold,D.
  TITLE     Interaction of Bcl-2 with the autophagy-related GABAA
            receptor-associated protein (GABARAP): biophysical characterization
            and functional implications
  JOURNAL   J Biol Chem 288 (52), 37204-37215 (2013)
   PUBMED   24240096
  REMARK    GeneRIF: These results support the regulatory role of Bcl-2 in
            autophagy and define GABARAP as a novel interaction partner
            involved in this intricate connection.
REFERENCE   4  (bases 1 to 1211)
  AUTHORS   Pampliega,O., Orhon,I., Patel,B., Sridhar,S., Diaz-Carretero,A.,
            Beau,I., Codogno,P., Satir,B.H., Satir,P. and Cuervo,A.M.
  TITLE     Functional interaction between autophagy and ciliogenesis
  JOURNAL   Nature 502 (7470), 194-200 (2013)
   PUBMED   24089209
REFERENCE   5  (bases 1 to 1211)
  AUTHORS   Al Rawi,S., Louvet-Vallee,S., Djeddi,A., Sachse,M., Culetto,E.,
            Hajjar,C., Boyd,L., Legouis,R. and Galy,V.
  TITLE     Postfertilization autophagy of sperm organelles prevents paternal
            mitochondrial DNA transmission
  JOURNAL   Science 334 (6059), 1144-1147 (2011)
   PUBMED   22033522
REFERENCE   6  (bases 1 to 1211)
  AUTHORS   Kittler,J.T., Rostaing,P., Schiavo,G., Fritschy,J.M., Olsen,R.,
            Triller,A. and Moss,S.J.
  TITLE     The subcellular distribution of GABARAP and its ability to interact
            with NSF suggest a role for this protein in the intracellular
            transport of GABA(A) receptors
  JOURNAL   Mol Cell Neurosci 18 (1), 13-25 (2001)
   PUBMED   11461150
REFERENCE   7  (bases 1 to 1211)
  AUTHORS   Okazaki,N., Yan,J., Yuasa,S., Ueno,T., Kominami,E., Masuho,Y.,
            Koga,H. and Muramatsu,M.
  TITLE     Interaction of the Unc-51-like kinase and microtubule-associated
            protein light chain 3 related proteins in the brain: possible role
            of vesicular transport in axonal elongation
  JOURNAL   Brain Res Mol Brain Res 85 (1-2), 1-12 (2000)
   PUBMED   11146101
REFERENCE   8  (bases 1 to 1211)
  AUTHORS   Wang,H. and Olsen,R.W.
  TITLE     Binding of the GABA(A) receptor-associated protein (GABARAP) to
            microtubules and microfilaments suggests involvement of the
            cytoskeleton in GABARAPGABA(A) receptor interaction
  JOURNAL   J Neurochem 75 (2), 644-655 (2000)
   PUBMED   10899939
REFERENCE   9  (bases 1 to 1211)
  AUTHORS   Kneussel,M., Haverkamp,S., Fuhrmann,J.C., Wang,H., Wassle,H.,
            Olsen,R.W. and Betz,H.
  TITLE     The gamma-aminobutyric acid type A receptor (GABAAR)-associated
            protein GABARAP interacts with gephyrin but is not involved in
            receptor anchoring at the synapse
  JOURNAL   Proc Natl Acad Sci U S A 97 (15), 8594-8599 (2000)
   PUBMED   10900017
REFERENCE   10 (bases 1 to 1211)
  AUTHORS   Wang,H., Bedford,F.K., Brandon,N.J., Moss,S.J. and Olsen,R.W.
  TITLE     GABA(A)-receptor-associated protein links GABA(A) receptors and the
            cytoskeleton
  JOURNAL   Nature 397 (6714), 69-72 (1999)
   PUBMED   9892355
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Mar 19, 2021 this sequence version replaced NM_172036.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ231156.1, FQ229256.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-196               JAXUCZ010000010.1  55213465-55213660
            197-275             JAXUCZ010000010.1  55214202-55214280
            276-394             JAXUCZ010000010.1  55214420-55214538
            395-1211            JAXUCZ010000010.1  55215971-55216787
FEATURES             Location/Qualifiers
     source          1..1211
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..1211
                     /gene="Gabarap"
                     /note="GABA type A receptor-associated protein"
                     /db_xref="GeneID:58974"
                     /db_xref="RGD:61911"
     exon            1..196
                     /gene="Gabarap"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..460
                     /gene="Gabarap"
                     /note="GABA(A) receptor-associated protein"
                     /codon_start=1
                     /product="gamma-aminobutyric acid receptor-associated
                     protein"
                     /protein_id="NP_742033.1"
                     /db_xref="GeneID:58974"
                     /db_xref="RGD:61911"
                     /translation="MKFVYKEEHPFEKRRSEGEKIRKKYPDRVPVIVEKAPKARIGDL
                     DKKKYLVPSDLTVGQFYFLIRKRIHLRAEDALFFFVNNVIPPTSATMGQLYQEHHEED
                     FFLYIAYSDESVYGL"
     exon            197..275
                     /gene="Gabarap"
                     /inference="alignment:Splign:2.1.0"
     exon            276..394
                     /gene="Gabarap"
                     /inference="alignment:Splign:2.1.0"
     exon            395..1211
                     /gene="Gabarap"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctccgctga gtctgttcgt cgaagccgcc tccgccgccg tcccctgtcc cggccccccc
       61 cctgggttcc ctcagcccag ctcggtccag cccggttctc gggagaatga agttcgtgta
      121 caaagaggag catccgttcg agaagcgccg ctctgagggc gagaaaatcc gaaagaaata
      181 cccagaccgg gtcccggtga tagtggaaaa agctcccaaa gctcggatag gggacctgga
      241 caaaaagaaa tacttggtgc cttctgatct tacagttggt caattctact tcttgatccg
      301 gaagcgaatt catctccgtg ctgaagatgc cttgtttttc tttgtcaaca atgtcattcc
      361 acccaccagt gccacgatgg gtcagctgta ccaggaacac catgaagaag acttctttct
      421 atacattgcc tacagtgatg aaagcgtcta cggtctgtga agttgctgtc ccggaggtgg
      481 gggttccatt ctacaaagag aggtggcgct ccttccttgg catccagttc ctccttcagg
      541 ctcaaacacc atctcctttc ttcaggacct gcacttaatg tttgaggctg tctctccagt
      601 ccctctgagc aggaggggta atggtagatg cagccgctgt acatctctct ttccccttgt
      661 ttaccctcca ttcccactct gctttagact tctggattgt cgatctctgt cacatcggat
      721 gattgttttg gtttctattc cctttctaac tgcccactgg gctcagaacc ccaataaacc
      781 cttcctttca ctaccttctt tttggggggt agatggaagg ggttgacatt gggtggggga
      841 ggtaggaggc acatcaataa agaggaaacc accgagctga attgaatttg ccctgtgtca
      901 ttctacctcc tggctttttg tttcaagtgt tgtgaacttc agtggtggga aaggaggatt
      961 gaggtataga tcagagaact aggaaggcat tgatgatgtt ggtctttcct ccttttttga
     1021 tgagtggaat aatgtaagca ttctctcatg aaactttaat tgtatttatg tatttgtgat
     1081 gtaaacaaag aggtggaggt tggtagtgtg gggtggtatg gagaaagttt gaaagaacta
     1141 ttttttggta aacatgtcca aatgttactt cccattaaag aagatatgtt cctgtttggg
     1201 aggtggtaaa a
//
