LOCUS       NM_053417               5951 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus GRB2-associated binding protein 2 (Gab2), mRNA.
ACCESSION   NM_053417 XM_017589791
VERSION     NM_053417.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5951)
  AUTHORS   Zhang,X., Lavoie,G., Fort,L., Huttlin,E.L., Tcherkezian,J.,
            Galan,J.A., Gu,H., Gygi,S.P., Carreno,S. and Roux,P.P.
  TITLE     Gab2 phosphorylation by RSK inhibits Shp2 recruitment and cell
            motility
  JOURNAL   Mol Cell Biol 33 (8), 1657-1670 (2013)
   PUBMED   23401857
REFERENCE   2  (bases 1 to 5951)
  AUTHORS   Wohrle,F.U., Halbach,S., Aumann,K., Schwemmers,S., Braun,S.,
            Auberger,P., Schramek,D., Penninger,J.M., Lassmann,S., Werner,M.,
            Waller,C.F., Pahl,H.L., Zeiser,R., Daly,R.J. and Brummer,T.
  TITLE     Gab2 signaling in chronic myeloid leukemia cells confers resistance
            to multiple Bcr-Abl inhibitors
  JOURNAL   Leukemia 27 (1), 118-129 (2013)
   PUBMED   22858987
REFERENCE   3  (bases 1 to 5951)
  AUTHORS   Hunzicker-Dunn,M.E., Lopez-Biladeau,B., Law,N.C., Fiedler,S.E.,
            Carr,D.W. and Maizels,E.T.
  TITLE     PKA and GAB2 play central roles in the FSH signaling pathway to
            PI3K and AKT in ovarian granulosa cells
  JOURNAL   Proc Natl Acad Sci U S A 109 (44), E2979-E2988 (2012)
   PUBMED   23045700
  REMARK    GeneRIF: Overexpression of GAB2 enhances FSH-stimulated AKT
            phosphorylation. GAB2, thus, seems to coordinate signals from the
            FSH-stimulated rise in cAMP that leads to activation of PI3K/AKT
REFERENCE   4  (bases 1 to 5951)
  AUTHORS   Huang,F., Tong,X., Deng,H., Fu,L. and Zhang,R.
  TITLE     Inhibition of the antigen-induced activation of RBL-2H3 cells by
            Gab2 siRNA
  JOURNAL   Cell Mol Immunol 5 (6), 433-438 (2008)
   PUBMED   19118509
  REMARK    GeneRIF: Gab2 siRNA could suppress the antigen-induced activation
            of RBL-2H3 cells and suggested a possible mechanism through
            inhibition of signaling molecules downstream of Gab2 in the
            FcepsilonRI-mediated Ca(2+)-independent pathway.
REFERENCE   5  (bases 1 to 5951)
  AUTHORS   Brummer,T., Larance,M., Herrera Abreu,M.T., Lyons,R.J., Timpson,P.,
            Emmerich,C.H., Fleuren,E.D., Lehrbach,G.M., Schramek,D.,
            Guilhaus,M., James,D.E. and Daly,R.J.
  TITLE     Phosphorylation-dependent binding of 14-3-3 terminates signalling
            by the Gab2 docking protein
  JOURNAL   EMBO J 27 (17), 2305-2316 (2008)
   PUBMED   19172738
REFERENCE   6  (bases 1 to 5951)
  AUTHORS   Kong,M., Mounier,C., Balbis,A., Baquiran,G. and Posner,B.I.
  TITLE     Gab2 tyrosine phosphorylation by a pleckstrin homology
            domain-independent mechanism: role in epidermal growth
            factor-induced mitogenesis
  JOURNAL   Mol Endocrinol 17 (5), 935-944 (2003)
   PUBMED   12595575
  REMARK    GeneRIF: Gab2 tyrosine phosphorylation; role in epidermal growth
            factor-induced mitogenesis
REFERENCE   7  (bases 1 to 5951)
  AUTHORS   Yu,W.M., Hawley,T.S., Hawley,R.G. and Qu,C.K.
  TITLE     Role of the docking protein Gab2 in beta(1)-integrin signaling
            pathway-mediated hematopoietic cell adhesion and migration
  JOURNAL   Blood 99 (7), 2351-2359 (2002)
   PUBMED   11895767
REFERENCE   8  (bases 1 to 5951)
  AUTHORS   Gu,H., Saito,K., Klaman,L.D., Shen,J., Fleming,T., Wang,Y.,
            Pratt,J.C., Lin,G., Lim,B., Kinet,J.P. and Neel,B.G.
  TITLE     Essential role for Gab2 in the allergic response
  JOURNAL   Nature 412 (6843), 186-190 (2001)
   PUBMED   11449275
REFERENCE   9  (bases 1 to 5951)
  AUTHORS   Yamada,K., Nishida,K., Hibi,M., Hirano,T. and Matsuda,Y.
  TITLE     Comparative FISH mapping of Gab1 and Gab2 genes in human, mouse and
            rat
  JOURNAL   Cytogenet Cell Genet 94 (1-2), 39-42 (2001)
   PUBMED   11701952
  REMARK    GeneRIF: comparative FISH mapping of Gab1 and Gab2 genes in human,
            mouse and rat
REFERENCE   10 (bases 1 to 5951)
  AUTHORS   Kong,M., Mounier,C., Wu,J. and Posner,B.I.
  TITLE     Epidermal growth factor-induced phosphatidylinositol 3-kinase
            activation and DNA synthesis. Identification of Grb2-associated
            binder 2 as the major mediator in rat hepatocytes
  JOURNAL   J Biol Chem 275 (46), 36035-36042 (2000)
   PUBMED   10973965
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Dec 5, 2020 this sequence version replaced
            XM_017589791.1, NM_053417.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.3303.1,
                                           SRR26643287.1639.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-184               JAXUCZ010000001.1  160841066-160841249
            185-485             JAXUCZ010000001.1  160967678-160967978
            486-726             JAXUCZ010000001.1  160999198-160999438
            727-1301            JAXUCZ010000001.1  161026754-161027328
            1302-1372           JAXUCZ010000001.1  161028234-161028304
            1373-1637           JAXUCZ010000001.1  161029288-161029552
            1638-1728           JAXUCZ010000001.1  161030331-161030421
            1729-1831           JAXUCZ010000001.1  161030992-161031094
            1832-1957           JAXUCZ010000001.1  161032090-161032215
            1958-5951           JAXUCZ010000001.1  161032947-161036940
FEATURES             Location/Qualifiers
     source          1..5951
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..5951
                     /gene="Gab2"
                     /note="GRB2-associated binding protein 2"
                     /db_xref="GeneID:84477"
                     /db_xref="RGD:621367"
     exon            1..184
                     /gene="Gab2"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..2101
                     /gene="Gab2"
                     /note="GRB2-associated binder 2; growth factor receptor
                     bound protein 2-associated protein 2"
                     /codon_start=1
                     /product="GRB2-associated-binding protein 2"
                     /protein_id="NP_445869.2"
                     /db_xref="GeneID:84477"
                     /db_xref="RGD:621367"
                     /translation="MSGGGDDVVCTGWLRKSPPEKKLRRYAWKKRWFILRSGRMSGDP
                     DVLEYYKNEHSKKPLRIINLNFCEQVDAGLTFNKKELQDSFVFDIKTSERTFYLVAET
                     EADMNKWVQSICQICGFNQAEESTDSLRNLSSASHGPRSSPAEFSSSQHLLRERKSSA
                     PSHSSQPTLFTFEPPMSSHMQPALSTSAPQEYLYLHQCISRRTENSRSASFSQGTRQK
                     SDTAVQKLAQSNGHCINGVSNQVHGFYSLPKPSRHNTEFKDSTYDLPRSLASHGHTKS
                     SLTGSETDNEDVYTFKMPSNTLCREFGDLLVDNMDVPTTPLSAYQIPRTFTLDKNHNA
                     MTVATSGDSAIAPPPRPPKPSQAETPRWGSPQQKPPIGENSRSVAATIPRRNTLPAMD
                     NSRLHRASSCETYEYPTRGSGESASWSAESPGKTAVGRSNSASSDDNYVPMNPGSSTL
                     LAMERAGDNSQSAYIPMSPGPHHFDPLGYPSTALPIHRGPSRGSEIQPPPVNRNLKPD
                     RKAKPTPLDLRNNTVIDELPFKSPVTKSWSRINHTFNSSSSQYCRPISTQSITSTDSG
                     DSEENYVPMQNPVSASPVPSGTNSPAPRKSTGSVDYLALDFQPGSPSPHRKPSTSSVT
                     SDEKVDYVQVDKEKTQALQNTMQEWTDVRQSSEPSKGAKL"
     exon            185..485
                     /gene="Gab2"
                     /inference="alignment:Splign:2.1.0"
     exon            486..726
                     /gene="Gab2"
                     /inference="alignment:Splign:2.1.0"
     exon            727..1301
                     /gene="Gab2"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1372
                     /gene="Gab2"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1637
                     /gene="Gab2"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1728
                     /gene="Gab2"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1831
                     /gene="Gab2"
                     /inference="alignment:Splign:2.1.0"
     exon            1832..1957
                     /gene="Gab2"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..5951
                     /gene="Gab2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccctcccctc ccccgcgagc tgcgcaccgg cagccggctg acccagcagc ccgcgcccgc
       61 gcccttgtcc gcgcgagccg gcggcgggct ccagtcagcg ggcgacatga gcggcggcgg
      121 cgacgacgtg gtgtgtaccg gctggctgag gaaatcgcct ccggaaaaga agttgaggcg
      181 ctatgcctgg aagaaacgct ggtttatact gcggagtggc cggatgagtg gagacccaga
      241 tgttctggaa tactacaaga acgagcactc caagaaaccc ctgcggatca tcaacctgaa
      301 cttctgtgag caggtggatg caggcctgac cttcaacaag aaagagctac aggatagctt
      361 tgtgtttgat atcaagacca gcgagcgcac gttttacctg gtggctgaga cggaggctga
      421 catgaacaag tgggtccaga gcatctgcca gatttgcggt ttcaatcaag ccgaagagag
      481 cacagactcc ctgagaaacc tttcttcagc cagtcacggt ccccgctcct ctccagctga
      541 gttcagctcc agtcagcacc tgctccgaga acggaagtcc tcagcccctt cacactctag
      601 ccagcccact ttattcacat ttgagccccc tatgtcaagc cacatgcagc ctgccttgtc
      661 caccagtgca cctcaggagt atctctactt gcaccagtgc ataagcagaa ggacagaaaa
      721 ctcaaggagt gccagcttct ctcagggcac ccggcagaag agtgatacag ccgtgcaaaa
      781 acttgcccag agcaatggac actgtatcaa tggagtcagc aatcaagtcc atggtttcta
      841 tagccttccc aagccaagcc gacacaatac agaattcaaa gacagtactt atgatctccc
      901 gaggagcctg gcgtcacatg gccacaccaa gagcagcctc acagggtctg agactgataa
      961 cgaggatgtg tataccttca agatgcccag caacaccctg tgtcgggagt ttggagacct
     1021 ccttgtggac aatatggatg ttccaaccac ccctctctca gcctaccaga tccctagaac
     1081 atttacactg gacaagaatc acaatgccat gacagtggcc acttctggag actcagccat
     1141 agctccccca ccccggccac ccaagccaag tcaagcagaa acacctcgat ggggcagccc
     1201 tcagcaaaaa cctccgatcg gcgagaatag cagatctgta gctgctacta tccccaggcg
     1261 caataccctc cctgcaatgg acaacagccg gctccaccga gcttcctcct gtgagaccta
     1321 tgaataccca acacgaggca gcggagagag tgccagctgg tctgctgaat ctccaggaaa
     1381 gactgccgtg ggtcgatcaa acagtgccag ctctgatgac aactacgtgc ccatgaaccc
     1441 aggttcttct accctgctgg ccatggaacg agccggggac aattcccaga gtgcctacat
     1501 acccatgagc ccagggcctc atcactttga tccacttggg tacccatcca cagcccttcc
     1561 tattcacaga ggccccagcc gaggaagtga gatccagcca cccccagtca accgaaacct
     1621 caaacctgac cgaaaagcaa agccaacacc ccttgacctg agaaacaaca ctgtcatcga
     1681 tgagctcccc ttcaagtcac ctgtcaccaa gtcttggtcc aggatcaacc acacctttaa
     1741 ctccagttcc tcccagtact gccgtcctat ctccacacag agcatcacca gcacagactc
     1801 aggagacagt gaggagaact atgtccctat gcaaaaccca gtatctgcgt cccctgttcc
     1861 cagtggcact aacagcccag ctcccaggaa gagtactggc agtgtggatt acctagccct
     1921 ggacttccag ccgggctccc caagccctca ccgcaagcca tccacatcat ctgtcacatc
     1981 ggatgagaag gtagactatg tccaagtgga taaagagaag acacaggccc tgcagaacac
     2041 catgcaggag tggacagatg tacggcagtc ctcagaacct tccaagggtg ccaagctgtg
     2101 aagggggcca ccgagttcaa gagccatgag gcagctgccc agactgcctc ttctgtcacc
     2161 ttcttctcca tttcttccta cacctcctct cccctgtacc actttcagcc ttcaaagcac
     2221 tcaacgtcag ggacctgacc ctttcccatc agaggcaagg gcctggtaga gacacttcct
     2281 ctgccacttg ggttccacct atgacttctg tcaaaagtag ctgtgcctcc accaccttag
     2341 ttaggagctg ttgccaaaaa tgcttcctgc tttggaccca tttgtctgct gcttggactc
     2401 ttggagggag ggctgaagct ctgagctagg ctcatgcctc atgtctgctc accgctctct
     2461 accctctacc tcagggctgc ttctccatcc ccagcagagg atgataaccc agtgagccaa
     2521 gaaccagcag accaaagtac acatgggctt tcatatccct gctattttgg caaggaaaag
     2581 gcaaggtgcc acaagaagaa atagttgata ctggaagtcg gaagttgcct tgaggaagaa
     2641 attaggcccc agacatggga gtgtagctga taacttgttg ggtggtaccc aatatcaggc
     2701 catagtgtac ctctgctata gactgggaga gacaaagtat gaaagagagc aggaaggaaa
     2761 actgataatg ataagcaacc aggacagcaa agagcagaag tctttgaggt gacaaagctt
     2821 ggagctagag gactctgcca ctctgggaca gacagtcctc ttccctggcc ctgatgaaga
     2881 gatgagacag agtgaggaag acagcagcag gttatgtggg gggagaaggg caggaggatc
     2941 ctgggacagg agtgtgctag gcacagggca gtgcggagac actgccatgg aaagaaagtt
     3001 tctagtaggt aggagggtgc agagatgact tagggaccag gaggcaggca agacatgtag
     3061 caagtgagga catgtgtcca aagggcctgg cggggagccc aaagccacaa gcaggagtac
     3121 agcagggagc agaatgagga gtcatacttt gaccaaggaa atctagagag tgcataaggg
     3181 tctggccgat ggcttgtgcc agacagaagc acctctgacc tagtcctagt gccaggccag
     3241 gtcttttctc ttctctgctg tcctcagctg caggggtggt aggaactaac cctctcctcc
     3301 aatggcttca gatgtcacca gggcagatgg gatgggaagc tgttgttgct aaggctttta
     3361 agatagggca gggagatttc aatgtgtttg tcttaaaagt tgttgaccaa attttcaagc
     3421 atttcagagg aaaaacaggg caaaccagga tttcattttg ccctagagaa acaggttgtc
     3481 ctctaaaaac taggactgtt cagcaactaa aggcacactt tacctctctc ctctcgagtg
     3541 ccctgtcgaa gagttcctcg gaggtggtcc ctcttctcac agtagtgatg gttgccaagc
     3601 cctgagcaac aaggagactg agccatgggg aggggaagcc tcaaggagag atcagagtga
     3661 gttttgtgca gaaagagtag gcaggggtgg gttgtggagg agacaggggg tgggttgtgg
     3721 aggagacagg agggatgggg gaagcctcag ctttgggaac gggtggtctt tgaaggtgtg
     3781 aagccagcct cagaagtgtg cagtcacctt gagtgaaacg gggctggaga tggttgcatt
     3841 gagcaaggtt acaagatact tggctggctc tgcccatcct cacgatgtcc tttaaggcct
     3901 tagtgggcct cccatgtggc taagctcttg attggtgctg ctggagctca tagcaggtcc
     3961 atgtgtcgtt ggcctcagca gccaccccat agacacagag tgcattttct gagttgagtg
     4021 tgccatgtga atggagctgg ctgccactta ccaagactca agtattctag ttagtctcaa
     4081 ggcctctgtc ctgctctggt ccaacctgtg gaaagctgag ctctggctca caatttccag
     4141 attgctagcc atgtctaatt tacccaccca ccctccaacc cccaaataag aaaagccaat
     4201 tccatttaga aaaaaaaaaa ttggcttact catgagtcaa agttcacctc ccctagtggc
     4261 tgagctgtca aggactgaga gccaagaaca cctatcatct cttagcacag ctcccacaag
     4321 tacctatcct ggagggcctc ttcccactcc actctgcaaa gattaaagtt tagtaggaca
     4381 gtgaagaaag ggggtggcat ctccttgaga cttgccgttc tgtaaaatgg gatgatcaca
     4441 gctgatattc tgcggctgta agaacctggg tgatcctttg aaggtctggg ttactggggt
     4501 agagcacaca aagtattagc tcattagctg cctccctctc tatcgatttc actgattgct
     4561 atattgactc tgtgaaaaga agccacattc tcagaacaga agcacaaccc ttctgaagtt
     4621 aatggaacga gggttcaggt cctgtctgcc tttgggccct ttatttgcca gtggctatag
     4681 tcccagccat ggctccctcc cctccctgca acagagcttt gcagactatg agaggaagta
     4741 gctcttcctc tccatctggg cctttggctg taaagtgggg aagcaggctg accttagagg
     4801 gccattttac tgggacttcc cttatttggg gtcttagcaa ggcaggaaca accagacttg
     4861 ccaagggcgc ctgctaataa tttgtgctgt tgtggtatct ggtggtgtgt gttcttgtgt
     4921 aatctgttgg ttatttgtgt cttgaaattt agaatcattt cattcaggat tgttactatt
     4981 tgttgggaag aaaaatgaaa tagaagcagc ctagtcttac atcgtgtctt gttaccattt
     5041 aagattgaca tttaattttt caagtcattg ttggtgccta atcacttaag ttattaattt
     5101 attctgtttt caaaaaattg taacatattt atcttgtgaa gtctgggggc ggggtgggaa
     5161 atatgttcaa gtgagtcatg tttcacagtg gtaacaaatg gtacaggcct ggagcttgca
     5221 ggtccctttt tattatggtg tagaagcagg acaataaagt cctttagaaa tgcaacccag
     5281 agtaggctac tggagactgt ctttacgggt gtggaaactt actcttgtcc catcctgggc
     5341 agtcttagaa ctgatgctgt cctacagata ccttctctga caaactcatt tcacagtcat
     5401 ttcatgaata accccagaac tggtgtgctc aattctgctc atcttgatgg gctgcaattg
     5461 gacacttttc caggccaggg gcgggaatga accttcttca gaccagcatc ggcatctgca
     5521 atggagcaga cctgtagtcc agcactccag aagctgaaac agggacagga caattggtat
     5581 ccttgacagc tccagagtct ggcatttgga cagaatcgtc tacccctggt catagcacca
     5641 ttttgacctt ccagatgctt ctgttcttag gaagatgatc ttgggtgcag gccagtccca
     5701 gaccctccct cagtatacag ccacccatgt ccctcttcag ctttaagatt atgaactgaa
     5761 agagctggat gttgggacta gagagagggc tcagctattt ggttcccagc accgacattg
     5821 ggtgactcac aacagcttgt aactccagtt ccagggaatc tgatgtcctc tactggccct
     5881 cacacataca tggtacatac acctaacaga gatacacatt catacaataa aaataaattt
     5941 ttaaagctct a
//
