LOCUS       NP_445869                664 aa            linear   ROD 27-MAR-2024
DEFINITION  GRB2-associated-binding protein 2 [Rattus norvegicus].
ACCESSION   NP_445869 XP_017445280
VERSION     NP_445869.2
DBSOURCE    REFSEQ: accession NM_053417.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 664)
  AUTHORS   Zhang,X., Lavoie,G., Fort,L., Huttlin,E.L., Tcherkezian,J.,
            Galan,J.A., Gu,H., Gygi,S.P., Carreno,S. and Roux,P.P.
  TITLE     Gab2 phosphorylation by RSK inhibits Shp2 recruitment and cell
            motility
  JOURNAL   Mol Cell Biol 33 (8), 1657-1670 (2013)
   PUBMED   23401857
REFERENCE   2  (residues 1 to 664)
  AUTHORS   Wohrle,F.U., Halbach,S., Aumann,K., Schwemmers,S., Braun,S.,
            Auberger,P., Schramek,D., Penninger,J.M., Lassmann,S., Werner,M.,
            Waller,C.F., Pahl,H.L., Zeiser,R., Daly,R.J. and Brummer,T.
  TITLE     Gab2 signaling in chronic myeloid leukemia cells confers resistance
            to multiple Bcr-Abl inhibitors
  JOURNAL   Leukemia 27 (1), 118-129 (2013)
   PUBMED   22858987
REFERENCE   3  (residues 1 to 664)
  AUTHORS   Hunzicker-Dunn,M.E., Lopez-Biladeau,B., Law,N.C., Fiedler,S.E.,
            Carr,D.W. and Maizels,E.T.
  TITLE     PKA and GAB2 play central roles in the FSH signaling pathway to
            PI3K and AKT in ovarian granulosa cells
  JOURNAL   Proc Natl Acad Sci U S A 109 (44), E2979-E2988 (2012)
   PUBMED   23045700
  REMARK    GeneRIF: Overexpression of GAB2 enhances FSH-stimulated AKT
            phosphorylation. GAB2, thus, seems to coordinate signals from the
            FSH-stimulated rise in cAMP that leads to activation of PI3K/AKT
REFERENCE   4  (residues 1 to 664)
  AUTHORS   Huang,F., Tong,X., Deng,H., Fu,L. and Zhang,R.
  TITLE     Inhibition of the antigen-induced activation of RBL-2H3 cells by
            Gab2 siRNA
  JOURNAL   Cell Mol Immunol 5 (6), 433-438 (2008)
   PUBMED   19118509
  REMARK    GeneRIF: Gab2 siRNA could suppress the antigen-induced activation
            of RBL-2H3 cells and suggested a possible mechanism through
            inhibition of signaling molecules downstream of Gab2 in the
            FcepsilonRI-mediated Ca(2+)-independent pathway.
REFERENCE   5  (residues 1 to 664)
  AUTHORS   Brummer,T., Larance,M., Herrera Abreu,M.T., Lyons,R.J., Timpson,P.,
            Emmerich,C.H., Fleuren,E.D., Lehrbach,G.M., Schramek,D.,
            Guilhaus,M., James,D.E. and Daly,R.J.
  TITLE     Phosphorylation-dependent binding of 14-3-3 terminates signalling
            by the Gab2 docking protein
  JOURNAL   EMBO J 27 (17), 2305-2316 (2008)
   PUBMED   19172738
REFERENCE   6  (residues 1 to 664)
  AUTHORS   Kong,M., Mounier,C., Balbis,A., Baquiran,G. and Posner,B.I.
  TITLE     Gab2 tyrosine phosphorylation by a pleckstrin homology
            domain-independent mechanism: role in epidermal growth
            factor-induced mitogenesis
  JOURNAL   Mol Endocrinol 17 (5), 935-944 (2003)
   PUBMED   12595575
  REMARK    GeneRIF: Gab2 tyrosine phosphorylation; role in epidermal growth
            factor-induced mitogenesis
REFERENCE   7  (residues 1 to 664)
  AUTHORS   Yu,W.M., Hawley,T.S., Hawley,R.G. and Qu,C.K.
  TITLE     Role of the docking protein Gab2 in beta(1)-integrin signaling
            pathway-mediated hematopoietic cell adhesion and migration
  JOURNAL   Blood 99 (7), 2351-2359 (2002)
   PUBMED   11895767
REFERENCE   8  (residues 1 to 664)
  AUTHORS   Gu,H., Saito,K., Klaman,L.D., Shen,J., Fleming,T., Wang,Y.,
            Pratt,J.C., Lin,G., Lim,B., Kinet,J.P. and Neel,B.G.
  TITLE     Essential role for Gab2 in the allergic response
  JOURNAL   Nature 412 (6843), 186-190 (2001)
   PUBMED   11449275
REFERENCE   9  (residues 1 to 664)
  AUTHORS   Yamada,K., Nishida,K., Hibi,M., Hirano,T. and Matsuda,Y.
  TITLE     Comparative FISH mapping of Gab1 and Gab2 genes in human, mouse and
            rat
  JOURNAL   Cytogenet Cell Genet 94 (1-2), 39-42 (2001)
   PUBMED   11701952
  REMARK    GeneRIF: comparative FISH mapping of Gab1 and Gab2 genes in human,
            mouse and rat
REFERENCE   10 (residues 1 to 664)
  AUTHORS   Kong,M., Mounier,C., Wu,J. and Posner,B.I.
  TITLE     Epidermal growth factor-induced phosphatidylinositol 3-kinase
            activation and DNA synthesis. Identification of Grb2-associated
            binder 2 as the major mediator in rat hepatocytes
  JOURNAL   J Biol Chem 275 (46), 36035-36042 (2000)
   PUBMED   10973965
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Dec 5, 2020 this sequence version replaced
            XP_017445280.1, NP_445869.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.3303.1,
                                           SRR26643287.1639.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..664
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     Protein         1..664
                     /product="GRB2-associated-binding protein 2"
                     /note="GRB2-associated binder 2; growth factor receptor
                     bound protein 2-associated protein 2"
                     /calculated_mol_wt=73141
     Region          5..127
                     /region_name="PH-like"
                     /note="Pleckstrin homology-like domain; cl17171"
                     /db_xref="CDD:473070"
     Region          <541..>627
                     /region_name="Plasmodium_Vir"
                     /note="Plasmodium vivax Vir protein; cl23751"
                     /db_xref="CDD:329056"
     CDS             1..664
                     /gene="Gab2"
                     /coded_by="NM_053417.2:107..2101"
                     /db_xref="GeneID:84477"
                     /db_xref="RGD:621367"
ORIGIN      
        1 msgggddvvc tgwlrksppe kklrryawkk rwfilrsgrm sgdpdvleyy knehskkplr
       61 iinlnfceqv dagltfnkke lqdsfvfdik tsertfylva eteadmnkwv qsicqicgfn
      121 qaeestdslr nlssashgpr sspaefsssq hllrerkssa pshssqptlf tfeppmsshm
      181 qpalstsapq eylylhqcis rrtensrsas fsqgtrqksd tavqklaqsn ghcingvsnq
      241 vhgfyslpkp srhntefkds tydlprslas hghtkssltg setdnedvyt fkmpsntlcr
      301 efgdllvdnm dvpttplsay qiprtftldk nhnamtvats gdsaiapppr ppkpsqaetp
      361 rwgspqqkpp igensrsvaa tiprrntlpa mdnsrlhras scetyeyptr gsgesaswsa
      421 espgktavgr snsassddny vpmnpgsstl lameragdns qsayipmspg phhfdplgyp
      481 stalpihrgp srgseiqppp vnrnlkpdrk akptpldlrn ntvidelpfk spvtkswsri
      541 nhtfnssssq ycrpistqsi tstdsgdsee nyvpmqnpvs aspvpsgtns paprkstgsv
      601 dylaldfqpg spsphrkpst ssvtsdekvd yvqvdkektq alqntmqewt dvrqssepsk
      661 gakl
//
