LOCUS       NM_017006               2408 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Rattus norvegicus glucose-6-phosphate dehydrogenase (G6pd), mRNA.
ACCESSION   NM_017006 XM_346880
VERSION     NM_017006.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2408)
  AUTHORS   Matsumura,S., Signoretti,C., Fatehi,S., Tumenbayar,B.I.,
            D'Addario,C., Nimmer,E., Thomas,C., Viswanathan,T., Wolf,A.,
            Garcia,V., Rocic,P., Bae,Y., Alam,S.S. and Gupte,S.A.
  TITLE     Loss-of-function G6PD variant moderated high-fat diet-induced
            obesity, adipocyte hypertrophy, and fatty liver in male rats
  JOURNAL   J Biol Chem 300 (7), 107460 (2024)
   PUBMED   38876306
  REMARK    GeneRIF: Loss-of-function G6PD variant moderated high-fat
            diet-induced obesity, adipocyte hypertrophy, and fatty liver in
            male rats.
REFERENCE   2  (bases 1 to 2408)
  AUTHORS   Signoretti,C. and Gupte,S.A.
  TITLE     G6PD Orchestrates Genome-Wide DNA Methylation and Gene Expression
            in the Vascular Wall
  JOURNAL   Int J Mol Sci 24 (23), 16727 (2023)
   PUBMED   38069050
  REMARK    GeneRIF: G6PD Orchestrates Genome-Wide DNA Methylation and Gene
            Expression in the Vascular Wall.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2408)
  AUTHORS   Dai,Y. and Hu,L.
  TITLE     HSPB1 overexpression improves hypoxic-ischemic brain damage by
            attenuating ferroptosis in rats through promoting G6PD expression
  JOURNAL   J Neurophysiol 128 (6), 1507-1517 (2022)
   PUBMED   36321738
  REMARK    GeneRIF: HSPB1 overexpression improves hypoxic-ischemic brain
            damage by attenuating ferroptosis in rats through promoting G6PD
            expression.
REFERENCE   4  (bases 1 to 2408)
  AUTHORS   Jacob,C., Kitagawa,A., Signoretti,C., Dzieciatkowska,M.,
            D'Alessandro,A., Gupte,A., Hossain,S., D'Addario,C.A., Gupte,R. and
            Gupte,S.A.
  TITLE     Mediterranean G6PD variant mitigates expression of DNA
            methyltransferases and right heart pressure in experimental model
            of pulmonary hypertension
  JOURNAL   J Biol Chem 298 (12), 102691 (2022)
   PUBMED   36372233
  REMARK    GeneRIF: Mediterranean G6PD variant mitigates expression of DNA
            methyltransferases and right heart pressure in experimental model
            of pulmonary hypertension.
REFERENCE   5  (bases 1 to 2408)
  AUTHORS   Wang,T., Dai,L., Shen,S., Yang,Y., Yang,M., Yang,X., Qiu,Y. and
            Wang,W.
  TITLE     Comprehensive Molecular Analyses of a Macrophage-Related Gene
            Signature With Regard to Prognosis, Immune Features, and Biomarkers
            for Immunotherapy in Hepatocellular Carcinoma Based on WGCNA and
            the LASSO Algorithm
  JOURNAL   Front Immunol 13, 843408 (2022)
   PUBMED   35693827
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2408)
  AUTHORS   Brand,I.A. and Heinickel,A.
  TITLE     Key enzymes of carbohydrate metabolism as targets of the 11.5-kDa
            Zn(2+)-binding protein (parathymosin)
  JOURNAL   J Biol Chem 266 (31), 20984-20989 (1991)
   PUBMED   1834654
REFERENCE   7  (bases 1 to 2408)
  AUTHORS   Beutler,E., Kuhl,W., Gelbart,T. and Forman,L.
  TITLE     DNA sequence abnormalities of human glucose-6-phosphate
            dehydrogenase variants
  JOURNAL   J Biol Chem 266 (7), 4145-4150 (1991)
   PUBMED   1999409
REFERENCE   8  (bases 1 to 2408)
  AUTHORS   Neifer,S., Jung,A. and Bienzle,U.
  TITLE     Characterization of erythrocytic glucose-6-phosphate dehydrogenase
            in a mouse strain with reduced G6PD activity
  JOURNAL   Biomed Biochim Acta 50 (3), 233-238 (1991)
   PUBMED   1953691
REFERENCE   9  (bases 1 to 2408)
  AUTHORS   Benatti,U., Morelli,A., Frascio,M., Melloni,E., Salamino,F.,
            Sparatore,B., Pontremoli,S. and De Flora,A.
  TITLE     Glucose 6-phosphate dehydrogenase activity in membranes of
            erythrocytes from normal individuals and subjects with
            Mediterranean G6PD deficiency
  JOURNAL   Biochem Biophys Res Commun 85 (4), 1318-1324 (1978)
   PUBMED   743300
REFERENCE   10 (bases 1 to 2408)
  AUTHORS   Chapman,V.M. and Shows,T.B.
  TITLE     Somatic cell genetic evidence for X-chromosome linkage of three
            enzymes in the mouse
  JOURNAL   Nature 259 (5545), 665-667 (1976)
   PUBMED   943046
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB729647.1 and BC081820.1.
            
            On Oct 13, 2007 this sequence version replaced NM_017006.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081820.1, X07467.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                CB729647.1         231-317
            88-2408             BC081820.1         1-2321
FEATURES             Location/Qualifiers
     source          1..2408
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq37"
     gene            1..2408
                     /gene="G6pd"
                     /gene_synonym="G6pdx"
                     /note="glucose-6-phosphate dehydrogenase"
                     /db_xref="GeneID:24377"
                     /db_xref="RGD:2645"
     exon            1..107
                     /gene="G6pd"
                     /gene_synonym="G6pdx"
                     /inference="alignment:Splign:2.1.0"
     exon            108..235
                     /gene="G6pd"
                     /gene_synonym="G6pdx"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..1663
                     /gene="G6pd"
                     /gene_synonym="G6pdx"
                     /EC_number="1.1.1.49"
                     /note="glucose-6-phosphate dehydrogenase X-linked"
                     /codon_start=1
                     /product="glucose-6-phosphate 1-dehydrogenase"
                     /protein_id="NP_058702.1"
                     /db_xref="GeneID:24377"
                     /db_xref="RGD:2645"
                     /translation="MAEQVALSRTQVCGILREELYQGDAFHQADTHIFIIMGASGDLA
                     KKKIYPTIWWLFRDGLLPEDTFIVGYARSRLTVDDIRKQSEPFFKVTPEERPKLEEFF
                     ARNSYVAGQYDDPASYKHLNSHMNALHQGMQANRLFYLALPPTVYEAVTKNIQEICMS
                     QTGWNRIIVEKPFGRDLQSSNQLSNHISSLFREDQIYRIDHYLGKEMVQNLMVLRFAN
                     RIFGPIWNRDNIACVILTFKEPFGTEGRGGYFDEFGIIRDVMQNHLLQMLCLVAMEKP
                     ASTDSDDVRDEKVKVLKCISEVETDNVVLGQYVGNPSGEGEATNGYLDDPTVPHGSTT
                     ATFAAAVLYVENERWDGVPFILRCGKALNERKAEVRLQFRDVAGDIFHQQCKRNELVI
                     RVQPNEAVYTKMMTKKPGMFFNPEESELDLTYGNRYKNVKLPDAYERLILDVFCGSQM
                     HFVRSDELREAWRIFTPLLHKIDREKPQPIPYVYGSRGPTEADELMKRVGFQYEGTYK
                     WVNPHKL"
     exon            236..273
                     /gene="G6pd"
                     /gene_synonym="G6pdx"
                     /inference="alignment:Splign:2.1.0"
     exon            274..382
                     /gene="G6pd"
                     /gene_synonym="G6pdx"
                     /inference="alignment:Splign:2.1.0"
     exon            383..600
                     /gene="G6pd"
                     /gene_synonym="G6pdx"
                     /inference="alignment:Splign:2.1.0"
     exon            601..759
                     /gene="G6pd"
                     /gene_synonym="G6pdx"
                     /inference="alignment:Splign:2.1.0"
     exon            760..885
                     /gene="G6pd"
                     /gene_synonym="G6pdx"
                     /inference="alignment:Splign:2.1.0"
     exon            886..979
                     /gene="G6pd"
                     /gene_synonym="G6pdx"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1166
                     /gene="G6pd"
                     /gene_synonym="G6pdx"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1402
                     /gene="G6pd"
                     /gene_synonym="G6pdx"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1479
                     /gene="G6pd"
                     /gene_synonym="G6pdx"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1572
                     /gene="G6pd"
                     /gene_synonym="G6pdx"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..2389
                     /gene="G6pd"
                     /gene_synonym="G6pdx"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaagcacacg ccctcttgcg ttaaatgggc caacgaagct tagcccccgg aaacgggctg
       61 tgcactccag atctgtgaac gtgtttggca gcggcaacta aattcagaaa acatcatggc
      121 agagcaggtg gctttgagcc ggacccaggt gtgtgggatc ctgagggaag agttgtacca
      181 gggtgatgcc ttccaccaag ctgatacaca catatttatc atcatgggtg catcgggtga
      241 cctggccaag aagaagattt atcctaccat ctggtggctg ttccgggatg gccttctacc
      301 cgaagacacc ttcattgtag gctatgcccg ctcacgactc acagtggatg acatccgcaa
      361 acagagtgag cccttcttta aagtcactcc agaagaaaga cccaagctag aggagttctt
      421 tgcccgtaac tcctatgtag ctggccagta tgatgatcca gcctcctaca agcacctcaa
      481 cagccacatg aatgccctgc accagggaat gcaggccaac cgtctgttct acctggcctt
      541 gccccccact gtctatgaag cagtcaccaa gaacattcaa gagatctgca tgagtcagac
      601 aggctggaac cgcatcatag tggagaagcc cttcgggaga gacctgcaga gctccaatca
      661 actgtcgaac cacatctcct ctctgtttcg tgaggaccag atctaccgca ttgaccacta
      721 cctgggcaaa gagatggtcc agaacctcat ggtgctgaga tttgccaaca ggatctttgg
      781 acccatctgg aatcgagaca acattgcttg tgtgatcctt acatttaaag agccctttgg
      841 tactgagggt cgtgggggct attttgatga atttgggatc atcagggatg tcatgcagaa
      901 ccacctcctg cagatgttgt gtctagtggc catggaaaag cctgcctcta cagattcaga
      961 tgatgtccgt gatgagaagg tcaaagtgtt aaaatgtatc tcagaggtgg aaactgacaa
     1021 cgtggtcctt ggccagtatg tggggaaccc cagtggagaa ggagaagcta ccaatgggta
     1081 cttagatgac cccacagtac cccatgggtc taccactgct acctttgcag cagctgtcct
     1141 ctatgtggag aatgaacggt gggatggagt acccttcatc ctgcgctgtg gcaaagctct
     1201 gaatgagcgc aaagctgaag tgagacttca gttccgcgat gtggcaggtg acatcttcca
     1261 ccagcagtgc aagcgtaacg agctggtcat ccgtgtgcag cccaatgagg cggtatacac
     1321 caagatgatg accaagaagc ctggcatgtt cttcaaccct gaggagtctg agctggacct
     1381 aacctatggc aacagataca agaatgtgaa gctccctgat gcctatgaac gcctcatcct
     1441 ggatgtcttc tgtgggagcc aaatgcactt tgtccgtagt gatgaactca gggaagcctg
     1501 gcgtatcttc acaccattgc tgcacaagat tgatcgagag aagccccagc ccatcccgta
     1561 tgtctatggc agccgaggtc ccacagaggc agatgagctg atgaagagag tgggcttcca
     1621 gtatgagggt acctacaagt gggtgaaccc tcacaagctc tgagccctgg aaacttacac
     1681 catctgcact ctgcctcttc tggccaccct ttctgcatct gcccttctca ccatctaacc
     1741 ctctattagg actattgacc tcatattgga aagactttgg gaccataggc cttagctaca
     1801 cattctagtc cctgggctta ggccaccatt ctgtcctatg ctgctgccac tgccactacc
     1861 actaagccca gctacattcc tcagatacca ggcattcaaa acgcattgca atgctttcag
     1921 gaccaccact gtccctatct gagccaccca tctttccaca agacctgaat cacctcctcc
     1981 cctcaatccc ctgcagaaag aacgcctatc agtctgtccc tggactcctt aagataggag
     2041 ttaggaacaa ttgggaggag ccttgggcct tggagggaca atgaccaaac cacacttccc
     2101 tgagactgtg ggcaagctcc tcaaaactta aagtgatcaa ggacacccat ctgagaggac
     2161 ctgcccatag ccacactagc cttagtgcta cttgacattc ctcctcacca gctggaagaa
     2221 ctctcatgct gcctagcaat attttggggg ccatagatat ctcctaaaca attccatagt
     2281 ccatagtcaa cctcatccaa cccatgggca gcctccttac caaaggaagg taagagcagc
     2341 agctagaatt ttcctacccc aaccctgcca ttaaatcctc aaaaaagtta aaaaaaaaaa
     2401 aaaaaaaa
//
