LOCUS       NM_176077               1496 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus glucose 6 phosphatase catalytic subunit 3
            (G6pc3), mRNA.
ACCESSION   NM_176077
VERSION     NM_176077.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1496)
  AUTHORS   Lin,S.R., Pan,C.J., Mansfield,B.C. and Chou,J.Y.
  TITLE     Functional analysis of mutations in a severe congenital neutropenia
            syndrome caused by glucose-6-phosphatase-beta deficiency
  JOURNAL   Mol Genet Metab 114 (1), 41-45 (2015)
   PUBMED   25492228
REFERENCE   2  (bases 1 to 1496)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   3  (bases 1 to 1496)
  AUTHORS   Ghosh,A., Cheung,Y.Y., Mansfield,B.C. and Chou,J.Y.
  TITLE     Brain contains a functional glucose-6-phosphatase complex capable
            of endogenous glucose production
  JOURNAL   J Biol Chem 280 (12), 11114-11119 (2005)
   PUBMED   15661744
REFERENCE   4  (bases 1 to 1496)
  AUTHORS   Ghosh,A., Shieh,J.J., Pan,C.J. and Chou,J.Y.
  TITLE     Histidine 167 is the phosphate acceptor in
            glucose-6-phosphatase-beta forming a phosphohistidine enzyme
            intermediate during catalysis
  JOURNAL   J Biol Chem 279 (13), 12479-12483 (2004)
   PUBMED   14718531
REFERENCE   5  (bases 1 to 1496)
  AUTHORS   Martin,C.C., Oeser,J.K., Svitek,C.A., Hunter,S.I., Hutton,J.C. and
            O'Brien,R.M.
  TITLE     Identification and characterization of a human cDNA and gene
            encoding a ubiquitously expressed glucose-6-phosphatase catalytic
            subunit-related protein
  JOURNAL   J Mol Endocrinol 29 (2), 205-222 (2002)
   PUBMED   12370122
REFERENCE   6  (bases 1 to 1496)
  AUTHORS   Song,S., Andrikopoulos,S., Filippis,C., Thorburn,A.W., Khan,D. and
            Proietto,J.
  TITLE     Mechanism of fat-induced hepatic gluconeogenesis: effect of
            metformin
  JOURNAL   Am J Physiol Endocrinol Metab 281 (2), E275-E282 (2001)
   PUBMED   11440903
REFERENCE   7  (bases 1 to 1496)
  AUTHORS   Garver,W.S., Heidenreich,R.A., Erickson,R.P., Thomas,M.A. and
            Wilson,J.M.
  TITLE     Localization of the murine Niemann-Pick C1 protein to two distinct
            intracellular compartments
  JOURNAL   J Lipid Res 41 (5), 673-687 (2000)
   PUBMED   10787428
REFERENCE   8  (bases 1 to 1496)
  AUTHORS   Wimhurst,J.M. and Manchester,K.L.
  TITLE     Induction and suppression of the key enzymes of glycolysis and
            gluconeogenesis in isolated perfused rat liver in response to
            glucose, fructose and lactate
  JOURNAL   Biochem J 134 (1), 143-156 (1973)
   PUBMED   4353083
REFERENCE   9  (bases 1 to 1496)
  AUTHORS   Zorzoli,A., Turkenkopf,I.J. and Mueller,V.L.
  TITLE     Gluconeogenesis in developing rat kidney cortex
  JOURNAL   Biochem J 111 (2), 181-185 (1969)
   PUBMED   4303362
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078689.1.
            
            On Aug 8, 2004 this sequence version replaced NM_176077.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078689.1, FQ231610.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1496
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..1496
                     /gene="G6pc3"
                     /note="glucose 6 phosphatase catalytic subunit 3"
                     /db_xref="GeneID:303565"
                     /db_xref="RGD:727875"
     exon            1..390
                     /gene="G6pc3"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..1213
                     /gene="G6pc3"
                     /EC_number="3.1.3.9"
                     /note="G6Pase 3; G-6-Pase 3; glucose-6-phosphatase
                     catalytic subunit-related; glucose 6 phosphatase,
                     catalytic, 3"
                     /codon_start=1
                     /product="glucose-6-phosphatase 3"
                     /protein_id="NP_788266.2"
                     /db_xref="GeneID:303565"
                     /db_xref="RGD:727875"
                     /translation="MESTLSAGIMMAEALQNQLPGLENMWLWVTFLADPKNLFQFYFP
                     AVYYASRRLGISLFWIAFITEWLNLVFKWFLFGDRPFWWVHESGYSAQTPVQIHQFPS
                     SCETGPGSPSGHCMITGAALWPVMIAISSQVASQTRSPWVRVIPGLAYCTFLLAVGLS
                     RVFLLAHFPHQVLAGLLAGVILGWLLSPRVPMERELSFYGLTALTLMLGASLMYWTLF
                     TLGLDLSWSINLASKWCDRPEWVLVDSRPFASLSRDSGSALGLGIALHTPCYAQIRRV
                     HLGNGQKIACFVLAMGLLVFLEWLGHPPQISLFYIFNFLKFTLWPCLVVALVPWMVHT
                     LSAQEAPPIRSS"
     exon            391..497
                     /gene="G6pc3"
                     /inference="alignment:Splign:2.1.0"
     exon            498..588
                     /gene="G6pc3"
                     /inference="alignment:Splign:2.1.0"
     exon            589..707
                     /gene="G6pc3"
                     /inference="alignment:Splign:2.1.0"
     exon            708..849
                     /gene="G6pc3"
                     /inference="alignment:Splign:2.1.0"
     exon            850..1471
                     /gene="G6pc3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggcggggca gggcgggggt gggacttggc ttagaccctt ggcggggagg gcagggctgg
       61 ggattagaaa gggtgggctt tagaagacta gcaggtagcc gcttcatttc tcctaaggtt
      121 cctcgacttg ctccctataa ccagctccag cctggaggat tcctgactcg ccatggagtc
      181 cactctgagc gccggcatca tgatggctga agcactacaa aaccagcttc ccgggctaga
      241 gaatatgtgg ctctgggtca cctttctggc cgatcccaag aacctctttc agttctactt
      301 ccccgcggtc tactacgcct cccgccgcct gggcatctcc ctgttctgga tcgccttcat
      361 tactgagtgg ctcaacctcg tcttcaagtg gtttctgttt ggagacaggc ccttctggtg
      421 ggtgcatgaa tccgggtact ccgcccagac tccagtccag attcaccagt tcccttcttc
      481 ttgtgagact ggtccaggca gcccctctgg tcactgcatg atcacaggcg cagctttgtg
      541 gcccgtaatg atagccattt catctcaggt ggcctctcag acccgcagcc cctgggtgag
      601 ggtgattcct ggcctggcct actgcacctt cctattggca gtcggcctgt ctcgggtctt
      661 cctcttagca catttccctc accaagtgtt ggctggcctt ctagctggtg ttatccttgg
      721 ctggctgttg agtccccggg tgcccatgga gcgggaactt agcttttatg ggttgactgc
      781 tctgaccctc atgctgggtg ccagcctcat gtattggacg ctctttacac tgggcctaga
      841 tctttcctgg tccatcaacc tggcttccaa gtggtgtgat cggcccgagt gggtgctcgt
      901 tgacagtcgg ccctttgcct cactgagccg tgactcagga tctgccctag gtctgggcat
      961 cgccctccac actccctgtt atgcccagat tcggcgagta cacctaggaa atggccagaa
     1021 aatagcttgc tttgtgctag ccatggggct gctggtcttc ctggaatggc tgggccatcc
     1081 acctcagata agcctcttct acatcttcaa cttcctcaaa tttacactct ggccatgcct
     1141 ggtcgtggcc ctcgtgccct ggatggtgca tacattgagt gcccaggaag ccccacccat
     1201 tcgctcttct tgatgagttt tgcctccctc tccccaaaga caacactcct tgaccaccac
     1261 aggagcaggc ccgctcacct tgaactccat ttctgcctca tgctttgcag tcttaccccc
     1321 cttttaaaaa aggacctctg tttccaggag gctaagcctt tccccaggtc cccacaaagc
     1381 aagaacaacg ggaggcctgg tgggatgggg agctgggttc ctgacactga caagctgctc
     1441 aggaaggccc caataaagcc cttgaaacct caaaaaaaaa aaaaaaaaaa aaaaaa
//
