LOCUS       NM_013098               2293 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus glucose-6-phosphatase catalytic subunit 1
            (G6pc1), mRNA.
ACCESSION   NM_013098
VERSION     NM_013098.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2293)
  AUTHORS   Monteillet,L., Gjorgjieva,M., Silva,M., Verzieux,V., Imikirene,L.,
            Duchampt,A., Guillou,H., Mithieux,G. and Rajas,F.
  TITLE     Intracellular lipids are an independent cause of liver injury and
            chronic kidney disease in non alcoholic fatty liver disease-like
            context
  JOURNAL   Mol Metab 16, 100-115 (2018)
   PUBMED   30100243
REFERENCE   2  (bases 1 to 2293)
  AUTHORS   Leibowitz,A., Bier,A., Gilboa,M., Peleg,E., Barshack,I. and
            Grossman,E.
  TITLE     Saccharin Increases Fasting Blood Glucose but Not Liver Insulin
            Resistance in Comparison to a High Fructose-Fed Rat Model
  JOURNAL   Nutrients 10 (3), 341 (2018)
   PUBMED   29534506
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2293)
  AUTHORS   Wang,T., Xu,D., Fan,Q., Rong,W., Zheng,J., Gao,C., Li,G., Zeng,N.,
            Guo,T., Zeng,L., Wang,F., Xiao,C., Cai,L., Tang,S., Deng,X.,
            Yin,X., Huang,M., Lu,F., Hu,Q., Chen,W., Huang,Z. and Wang,Q.
  TITLE     1,2-Dichloroethane impairs glucose and lipid homeostasis in the
            livers of NIH Swiss mice
  JOURNAL   Toxicology 380, 38-49 (2017)
   PUBMED   28189721
REFERENCE   4  (bases 1 to 2293)
  AUTHORS   Kim,G.Y., Lee,Y.M., Kwon,J.H., Cho,J.H., Pan,C.J., Starost,M.F.,
            Mansfield,B.C. and Chou,J.Y.
  TITLE     Glycogen storage disease type Ia mice with less than 2% of normal
            hepatic glucose-6-phosphatase-alpha activity restored are at risk
            of developing hepatic tumors
  JOURNAL   Mol Genet Metab 120 (3), 229-234 (2017)
   PUBMED   28096054
REFERENCE   5  (bases 1 to 2293)
  AUTHORS   Kong,Q., Zhang,H., Zhao,T., Zhang,W., Yan,M., Dong,X. and Li,P.
  TITLE     Tangshen formula attenuates hepatic steatosis by inhibiting hepatic
            lipogenesis and augmenting fatty acid oxidation in db/db mice
  JOURNAL   Int J Mol Med 38 (6), 1715-1726 (2016)
   PUBMED   27840945
REFERENCE   6  (bases 1 to 2293)
  AUTHORS   Haber,B.A., Chin,S., Chuang,E., Buikhuisen,W., Naji,A. and Taub,R.
  TITLE     High levels of glucose-6-phosphatase gene and protein expression
            reflect an adaptive response in proliferating liver and diabetes
  JOURNAL   J Clin Invest 95 (2), 832-841 (1995)
   PUBMED   7860767
REFERENCE   7  (bases 1 to 2293)
  AUTHORS   Lange,A.J., Argaud,D., el-Maghrabi,M.R., Pan,W., Maitra,S.R. and
            Pilkis,S.J.
  TITLE     Isolation of a cDNA for the catalytic subunit of rat liver
            glucose-6-phosphatase: regulation of gene expression in FAO
            hepatoma cells by insulin, dexamethasone and cAMP
  JOURNAL   Biochem Biophys Res Commun 201 (1), 302-309 (1994)
   PUBMED   8198588
REFERENCE   8  (bases 1 to 2293)
  AUTHORS   Lei,K.J., Shelly,L.L., Pan,C.J., Sidbury,J.B. and Chou,J.Y.
  TITLE     Mutations in the glucose-6-phosphatase gene that cause glycogen
            storage disease type 1a
  JOURNAL   Science 262 (5133), 580-583 (1993)
   PUBMED   8211187
REFERENCE   9  (bases 1 to 2293)
  AUTHORS   Wimhurst,J.M. and Manchester,K.L.
  TITLE     Induction and suppression of the key enzymes of glycolysis and
            gluconeogenesis in isolated perfused rat liver in response to
            glucose, fructose and lactate
  JOURNAL   Biochem J 134 (1), 143-156 (1973)
   PUBMED   4353083
REFERENCE   10 (bases 1 to 2293)
  AUTHORS   Zorzoli,A., Turkenkopf,I.J. and Mueller,V.L.
  TITLE     Gluconeogenesis in developing rat kidney cortex
  JOURNAL   Biochem J 111 (2), 181-185 (1969)
   PUBMED   4303362
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC090067.1.
            
            On Apr 13, 2007 this sequence version replaced NM_013098.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC090067.1, D78592.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2293              BC090067.1         1-2293
FEATURES             Location/Qualifiers
     source          1..2293
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..2293
                     /gene="G6pc1"
                     /gene_synonym="G6Pase; G6pc; Psme3"
                     /note="glucose-6-phosphatase catalytic subunit 1"
                     /db_xref="GeneID:25634"
                     /db_xref="RGD:2644"
     exon            1..296
                     /gene="G6pc1"
                     /gene_synonym="G6Pase; G6pc; Psme3"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..1140
                     /gene="G6pc1"
                     /gene_synonym="G6Pase; G6pc; Psme3"
                     /EC_number="3.1.3.9"
                     /note="G-6-Pase; glucose-6-phosphatase, catalytic subunit;
                     proteasome activator subunit 3"
                     /codon_start=1
                     /product="glucose-6-phosphatase catalytic subunit 1"
                     /protein_id="NP_037230.2"
                     /db_xref="GeneID:25634"
                     /db_xref="RGD:2644"
                     /translation="MEERMNVLHDFGIQSTRYLQVNYEDSQDWFVLVSVIADLRNAFY
                     VLFPIWFHIQETVGINLLWVAVVGDWFNLVFKWILFGQRPYWWVLDTDYYSNSSVPLI
                     KQFPVTCETGPGSPSGHAMGTAGVYYVMVTSTLAIFRGKKKSTYGFRCLNVVLWLGYW
                     AVQLNVCLSRIYLAAHFPHQVVAGVLSGIAVAETFSHIRGIYNASLQRYCLITFFLFG
                     FALGFYLLLKGLGVDLLWTLEKAKRWCERPEWVHLDTTPFASLFKNLGTLLGLGLALN
                     SSMYRKSCKGELRKSLPFRLACIVASLGLLHLFDSLKPPSQIESIFYILSFCKSATVP
                     FASVSLIPYCLARLLGQTHKKSL"
     exon            297..406
                     /gene="G6pc1"
                     /gene_synonym="G6Pase; G6pc; Psme3"
                     /inference="alignment:Splign:2.1.0"
     exon            407..512
                     /gene="G6pc1"
                     /gene_synonym="G6Pase; G6pc; Psme3"
                     /inference="alignment:Splign:2.1.0"
     exon            513..628
                     /gene="G6pc1"
                     /gene_synonym="G6Pase; G6pc; Psme3"
                     /inference="alignment:Splign:2.1.0"
     exon            629..2269
                     /gene="G6pc1"
                     /gene_synonym="G6Pase; G6pc; Psme3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggccagccag gctggactca ctgcacgggc tctgctggca gcttcctgag gtaccaagga
       61 ggaaggatgg aggaaagaat gaacgtgctc cacgactttg ggatccagtc gactcgctac
      121 ctccaagtga attacgaaga ctcccaggac tggtttgtct tggtgtctgt gatcgctgac
      181 ctcaggaacg ccttctatgt cctctttccc atctggttcc acattcaaga gactgtgggc
      241 atcaatctcc tctgggtggc agtggttgga gactggttca acctcgtctt taagtggatt
      301 ctttttggac agcgcccgta ttggtgggtc ctggacactg actattacag caacagctcc
      361 gtgcctctga taaaacagtt ccccgtcacc tgtgagactg gaccagggag tccctcgggc
      421 catgccatgg gcacagcagg tgtatactac gttatggtta cttctactct cgctatcttt
      481 cgtggaaaga aaaagtcaac gtatggattc cggtgcttga atgtcgtctt gtggttggga
      541 tactgggctg tgcagctgaa cgtctgtctg tcccggatct accttgcggc tcactttccc
      601 catcaggtgg tggctggagt cttgtcaggc attgctgtgg ctgaaacttt cagccacatc
      661 cggggcatct acaatgccag cctccagagg tactgtctca tcaccttctt cctgtttggt
      721 ttcgcacttg gattttacct gctgctaaag gggctagggg tggacctcct gtggactttg
      781 gagaaggcca agagatggtg tgagcgcccc gagtgggtcc accttgacac tacacccttt
      841 gccagcctct tcaaaaacct ggggaccctc ttggggttgg ggctggccct caactccagc
      901 atgtaccgca agagctgcaa aggagaactg cgcaagtcgc tcccattccg tttggcctgc
      961 atcgtggcct ccttgggcct gctgcatctc tttgactcgc tgaagccccc gtcccagatt
     1021 gagtcgatct tctacatctt gtctttctgc aagagtgcga ccgtcccctt tgcatctgtc
     1081 agtcttatcc cctactgcct agcccggctc ctgggacaga cacacaagaa gtctttgtaa
     1141 agcgttaagt ctctgacaca agtcagcggc cgtgcaaagg actaggagca acccaagcct
     1201 tgtgcaaccc agtgtggggc cagaggtgtt cacagccacc ctggtagccc tgtctttctt
     1261 tgccatcgta accaaaaagg tgaattttta aaagctaaca gggctgtttg aggaaagcgt
     1321 gaatgctgga agatgtttcc ctgatgaatc acttccggtc tcctgtccga cacagaagag
     1381 aaagcccaga ctagagatcc tgacagaatg ctctcactgt gcagaatcct ccaggccgag
     1441 ggtaaaagaa aagagcgttg tgcatttgct aggaagagaa ggaaggatcg ggaggagggg
     1501 gagtgtttgg tggattgagc aaaccatatg caagccatgt ctacccggct tcagttatgc
     1561 ctgggtcttt agatatgtag gacactctca ataatgatag accagcccgt gtaatgagta
     1621 gccagttaga ggcgatcatt ctgctcccag atttttctct actgtacatg aaagtcacac
     1681 cgtgtgcttg tattcctgaa tggtaatggt gactgtcact caggaaccac caccttctct
     1741 gtcacaccac agctttgtcc tcctcggccc aggtctgcgt gccataggac tcatcactgc
     1801 ttccctgacc acgctgctgg accctgcatt gctgaacccc atgctgctgg accctgtggt
     1861 gtacggtggg caattgtttg ctggtgcttt tgtagggtta agttaaactc tgagatcttg
     1921 ggcaaaacgg caaggggaga gtcaggattc ctctctccaa aggtcactcc gaagttactt
     1981 ttgattcctg gagcagaaat gactccttcc tctagcccaa gccagccaag aactcattct
     2041 tagaggcaaa gcagcccaag cccgactgtg cctgtcctcc agcctgggct ggtttgcaga
     2101 gtgtgtcttc aagaagaaaa aatggtaaag ctatttattc aaaatgcttt gttttttgct
     2161 atgaatgatg cctgtgtttc cacccacgcc aagcactttg ttcctattgt ctttgataag
     2221 aaaactacat gtgtgcagta ttttattaaa acgacatttt atttaagaaa aaaaaaaaaa
     2281 aaaaaaaaaa aaa
//
