LOCUS       NM_133565               6549 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus G3BP stress granule assembly factor 1 (G3bp1),
            mRNA.
ACCESSION   NM_133565 XM_001074757 XM_340802
VERSION     NM_133565.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6549)
  AUTHORS   Dong,R., Li,X., Flores,A.D. and Lai,K.O.
  TITLE     The translation initiating factor eIF4E and arginine methylation
            underlie G3BP1 function in dendritic spine development of neurons
  JOURNAL   J Biol Chem 299 (8), 105029 (2023)
   PUBMED   37442236
  REMARK    GeneRIF: The translation initiating factor eIF4E and arginine
            methylation underlie G3BP1 function in dendritic spine development
            of neurons.
REFERENCE   2  (bases 1 to 6549)
  AUTHORS   Li,S., Liao,Z., Yin,H., Liu,O., Hua,W., Wu,X., Zhang,Y., Gao,Y. and
            Yang,C.
  TITLE     G3BP1 coordinates lysophagy activity to protect against
            compression-induced cell ferroptosis during intervertebral disc
            degeneration
  JOURNAL   Cell Prolif 56 (3), e13368 (2023)
   PUBMED   36450665
  REMARK    GeneRIF: G3BP1 coordinates lysophagy activity to protect against
            compression-induced cell ferroptosis during intervertebral disc
            degeneration.
REFERENCE   3  (bases 1 to 6549)
  AUTHORS   Sahoo,P.K., Kar,A.N., Samra,N., Terenzio,M., Patel,P., Lee,S.J.,
            Miller,S., Thames,E., Jones,B., Kawaguchi,R., Coppola,G.,
            Fainzilber,M. and Twiss,J.L.
  TITLE     A Ca2+-Dependent Switch Activates Axonal Casein Kinase 2alpha
            Translation and Drives G3BP1 Granule Disassembly for Axon
            Regeneration
  JOURNAL   Curr Biol 30 (24), 4882-4895 (2020)
   PUBMED   33065005
  REMARK    GeneRIF: A Ca(2+)-Dependent Switch Activates Axonal Casein Kinase
            2alpha Translation and Drives G3BP1 Granule Disassembly for Axon
            Regeneration.
REFERENCE   4  (bases 1 to 6549)
  AUTHORS   Kim,S.S., Sze,L., Liu,C. and Lam,K.P.
  TITLE     The stress granule protein G3BP1 binds viral dsRNA and RIG-I to
            enhance interferon-beta response
  JOURNAL   J Biol Chem 294 (16), 6430-6438 (2019)
   PUBMED   30804210
  REMARK    Erratum:[J Biol Chem. 2019 Jun 14;294(24):9655. PMID: 31201243]
REFERENCE   5  (bases 1 to 6549)
  AUTHORS   Liu,Z.S., Cai,H., Xue,W., Wang,M., Xia,T., Li,W.J., Xing,J.Q.,
            Zhao,M., Huang,Y.J., Chen,S., Wu,S.M., Wang,X., Liu,X., Pang,X.,
            Zhang,Z.Y., Li,T., Dai,J., Dong,F., Xia,Q., Li,A.L., Zhou,T.,
            Liu,Z.G., Zhang,X.M. and Li,T.
  TITLE     G3BP1 promotes DNA binding and activation of cGAS
  JOURNAL   Nat Immunol 20 (1), 18-28 (2019)
   PUBMED   30510222
REFERENCE   6  (bases 1 to 6549)
  AUTHORS   Bikkavilli,R.K. and Malbon,C.C.
  TITLE     Arginine methylation of G3BP1 in response to Wnt3a regulates
            beta-catenin mRNA
  JOURNAL   J Cell Sci 124 (Pt 13), 2310-2320 (2011)
   PUBMED   21652632
REFERENCE   7  (bases 1 to 6549)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   8  (bases 1 to 6549)
  AUTHORS   Cristea,I.M., Rozjabek,H., Molloy,K.R., Karki,S., White,L.L.,
            Rice,C.M., Rout,M.P., Chait,B.T. and MacDonald,M.R.
  TITLE     Host factors associated with the Sindbis virus RNA-dependent RNA
            polymerase: role for G3BP1 and G3BP2 in virus replication
  JOURNAL   J Virol 84 (13), 6720-6732 (2010)
   PUBMED   20392851
  REMARK    GeneRIF: Two related proteins found in association with nsP4 at
            both times of infection, GTPase-activating protein (SH3 domain)
            binding protein 1 (G3BP1) and G3BP2 were also previously identified
            as associated with sindbis virus nsP2 and nsP3.
REFERENCE   9  (bases 1 to 6549)
  AUTHORS   Hinton,S.D., Myers,M.P., Roggero,V.R., Allison,L.A. and Tonks,N.K.
  TITLE     The pseudophosphatase MK-STYX interacts with G3BP and decreases
            stress granule formation
  JOURNAL   Biochem J 427 (3), 349-357 (2010)
   PUBMED   20180778
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 6549)
  AUTHORS   Zheng,D., Ezzeddine,N., Chen,C.Y., Zhu,W., He,X. and Shyu,A.B.
  TITLE     Deadenylation is prerequisite for P-body formation and mRNA decay
            in mammalian cells
  JOURNAL   J Cell Biol 182 (1), 89-101 (2008)
   PUBMED   18625844
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On or before Dec 17, 2009 this sequence version replaced
            XM_001074757.1, XM_340802.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2141139.1,
                                           SRR26360186.887606.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                JAXUCZ010000010.1  40087533-40087603
            72-184              JAXUCZ010000010.1  40102041-40102153
            185-266             JAXUCZ010000010.1  40103669-40103750
            267-440             JAXUCZ010000010.1  40104858-40105031
            441-531             JAXUCZ010000010.1  40107981-40108071
            532-625             JAXUCZ010000010.1  40109327-40109420
            626-824             JAXUCZ010000010.1  40111427-40111625
            825-926             JAXUCZ010000010.1  40112366-40112467
            927-1038            JAXUCZ010000010.1  40113814-40113925
            1039-1167           JAXUCZ010000010.1  40114075-40114203
            1168-1277           JAXUCZ010000010.1  40114719-40114828
            1278-6549           JAXUCZ010000010.1  40115660-40120931
FEATURES             Location/Qualifiers
     source          1..6549
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..6549
                     /gene="G3bp1"
                     /gene_synonym="G3bp; RGD1310666"
                     /note="G3BP stress granule assembly factor 1"
                     /db_xref="GeneID:171092"
                     /db_xref="RGD:621140"
     exon            1..71
                     /gene="G3bp1"
                     /gene_synonym="G3bp; RGD1310666"
                     /inference="alignment:Splign:2.1.0"
     exon            72..184
                     /gene="G3bp1"
                     /gene_synonym="G3bp; RGD1310666"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..1487
                     /gene="G3bp1"
                     /gene_synonym="G3bp; RGD1310666"
                     /EC_number="3.6.1.-"
                     /note="Ras-GTPase-activating protein SH3-domain binding
                     protein 1; GTPase activating protein (SH3 domain) binding
                     protein 1"
                     /codon_start=1
                     /product="ras GTPase-activating protein-binding protein 1"
                     /protein_id="NP_598249.1"
                     /db_xref="GeneID:171092"
                     /db_xref="RGD:621140"
                     /translation="MVMEKPSPLLVGREFVRQYYTLLNQAPDMLHRFYGKNSSYAHGG
                     LDSNGKPADAVYGQKEIHRKVMSQNFTNCHTKIRHVDAHATLNDGVVVQVMGLLSNNN
                     QALRRFMQTFVLAPEGSVANKFYVHNDIFRYQDEVFGGFVTEPQEESEEEVEEPEERQ
                     QSPEVVADDSGTFYDQTVSNDLEEHLEEPVVEPEPEPEPEPEPEPVSDIQEDKPEPAL
                     EEAAPEDVQKSASPAPADVAPAQEDLRTFSWASVTSKNLPPSGAVPVTGTPPHVVKVP
                     ASQPRPESKPDSQIPPQRPQRDQRAREQRINIPPQRGPRPIREAGEPGDVEPRRMVRH
                     PDSHQLFIGNLPHEVDKSELKDFFQSYGNVVELRINSGGKLPNFGFVVFDDSEPVQKV
                     LNNRPIMFRGAVRLNVEEKKTRAAREGDRRDNRLRGPGGPRGGPSGGMRGPPRGGMVQ
                     KPGFGVGRGITTPRQ"
     exon            185..266
                     /gene="G3bp1"
                     /gene_synonym="G3bp; RGD1310666"
                     /inference="alignment:Splign:2.1.0"
     exon            267..440
                     /gene="G3bp1"
                     /gene_synonym="G3bp; RGD1310666"
                     /inference="alignment:Splign:2.1.0"
     exon            441..531
                     /gene="G3bp1"
                     /gene_synonym="G3bp; RGD1310666"
                     /inference="alignment:Splign:2.1.0"
     exon            532..625
                     /gene="G3bp1"
                     /gene_synonym="G3bp; RGD1310666"
                     /inference="alignment:Splign:2.1.0"
     exon            626..824
                     /gene="G3bp1"
                     /gene_synonym="G3bp; RGD1310666"
                     /inference="alignment:Splign:2.1.0"
     exon            825..926
                     /gene="G3bp1"
                     /gene_synonym="G3bp; RGD1310666"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1038
                     /gene="G3bp1"
                     /gene_synonym="G3bp; RGD1310666"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1167
                     /gene="G3bp1"
                     /gene_synonym="G3bp; RGD1310666"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1277
                     /gene="G3bp1"
                     /gene_synonym="G3bp; RGD1310666"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..6549
                     /gene="G3bp1"
                     /gene_synonym="G3bp; RGD1310666"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcggcatcg cgcgagggac gccgccacct cctcccacgc agcagccctg tcctcccgct
       61 cagccgcaca ggttgaatcc accaaagcga tggttatgga gaagcctagt cccctgctgg
      121 tcgggcggga gtttgtgcga cagtactaca ccctgctgaa ccaggccccg gacatgctgc
      181 acagatttta tggcaagaac tcttcctatg cccacggggg cttggattcc aacgggaagc
      241 cagcagatgc agtctacggg cagaaggaaa tccacaggaa agtgatgtca caaaacttca
      301 ccaactgcca caccaagatc cgccacgtgg atgctcacgc aactctgaat gacggggtgg
      361 tggtccaagt gatggggctg ctgtccaaca acaaccaggc tctgcggagg ttcatgcaga
      421 cctttgtcct tgcgcctgag ggctctgttg ccaacaaatt ctatgttcac aatgacatct
      481 tcagatacca agatgaggtc ttcggtggct ttgtcacaga gcctcaagag gaatctgagg
      541 aagaagtaga ggaacctgaa gaaagacagc agtcaccaga ggtggttgct gatgactctg
      601 gaactttcta tgatcagact gttagcaatg acttggagga acatttagag gagcctgttg
      661 tggaaccaga accagagccg gagccagagc cggaaccgga acctgtgtcc gacattcaag
      721 aggacaagcc tgagcctgca ttggaagaag ccgctcctga ggatgtgcag aagagcgcct
      781 ccccggcccc ggcagacgtg gccccagcac aggaggactt gaggacattt tcttgggcgt
      841 ctgtgactag taagaacctt cctcccagtg gggctgttcc agtgacaggg acaccacctc
      901 atgtggtcaa agtgccagca tcacagcccc gtccagaatc taagcctgac tctcagatcc
      961 caccacaaag gcctcagaga gatcagagag ctcgagagca gcggatcaat atccctcctc
     1021 agagaggacc ccggccaatt cgtgaggctg gtgaaccagg agatgtggaa ccccgaagga
     1081 tggtgaggca ccctgacagt caccagctct tcattgggaa cctgccacat gaggttgaca
     1141 agtcggaact gaaggatttt ttccaaagtt atgggaatgt tgtggagctg cgcatcaaca
     1201 gtggtgggaa gttacccaac ttcggtttcg ttgtgtttga tgactcggaa ccagttcaga
     1261 aggtccttaa taacaggccc atcatgttcc gaggtgcggt tcgcctgaat gtggaagaga
     1321 agaagactcg agctgccagg gaaggcgacc gcagggataa ccgccttcgg ggacctggag
     1381 gcccccgtgg tgggccgagt ggtgggatga gaggccctcc ccgtggaggc atggtgcaga
     1441 aaccaggctt tggcgtgggc agggggatta caactccaag gcagtgaatt gcttggctca
     1501 gatctccaca cagcacacag ccccggctcc tgcagaatgg tgaattcctt caaccagcct
     1561 ttggtgtctt ggagtagtct attataaact gcttgagttt gtacaatttt aatttcgctt
     1621 gtgttcatgg tgtgtgctcc ccaaacccct ttcctccctt gaccttttag tccttcattc
     1681 ccagttttcc ggaatgatac tttaggagga atagatttgt aaagacgaag aggaaagact
     1741 gaccttcctg ctcacgctgc atacacagac tggagtctca cggccattcc ccagaagtgt
     1801 ctcggtttca ctgaccacgg atgtttcatt tgttgggaga cacaggattt gataaacatt
     1861 ttggaagcgg gaaaaatcaa gtcacaactc ctttctggtg tggaaaaatt gccttttggc
     1921 aactgccact gggtccctgc aggtgtggct aactgaataa aaggtgttct tttgacatgt
     1981 gattaccaaa caattctaaa cctccatttt taccattgga tttttaaatt gtgatgtagc
     2041 ctgtcaatgt ctagaacaca gctaaagact tttgttgaac tgttagattt ttttgaggta
     2101 gagtttttca tgttttattt gtatttgtaa aaaaaaaaaa agaaaaaaaa agaaaaaaga
     2161 aaaaaggaca aaaaattccc acgagaaaac aaaccccaaa tctgatgaca aaaccaagca
     2221 acactgtgcc ttctatttat cgttgactcc ggccctggca actgtttaaa ggaaagtaat
     2281 aaagattcca gagttgtttt cagattcaga gtatgtgggg gaactgcaca agttttttga
     2341 tcacgtgtat gtgtcgtgtt aacattgttc tgccttatcc taaatcacgc ctcagactgg
     2401 gatgcttttg aggaaaggtg cttctgtgag gcctctgacc tcagtggctc tgtgcgccac
     2461 actctactct gctgtctgtc tgggttcctg gtgggccata agaaggattt ggttgaatat
     2521 tggacttggc taatgtgctc cagggtctgc attttttttc tttaaatcat agccatatgg
     2581 taaattttct attttgttac ggttctcttt tactgatgga catgcagtgg gtgtttcttg
     2641 gaaaaaggcc aatttttatt aaaatatttc tggaagaaaa cttcatctgg caatgtagac
     2701 tgctaaaact cactttccag tgttgtgtgt tgagtgctgt gtgtgacatt gggtgaaggt
     2761 tttgtccgca caagcctcca tggacaagtc attagtctga aggcaaccag agtgtctaac
     2821 ttttcctaat gtttgtgtgt atgtctatgt atatgtgtat gtctatgtat gtgtgtatgt
     2881 atatgtatgt gggagtcttc atacatgcgt gcaccacagt atgcttgtgg aagtcagggc
     2941 aacttgggat ctaggcctta tactccactg tttgaaattg gcccatgagc cacaagcttc
     3001 tatgggctcc tgtttgtgcc tctcatcttg ctgtaagggc acaaggattt cagacatgtg
     3061 ctgccatgcc tgtcttccct gtggcttctg ggaattagtc aggtcttcat acttacacat
     3121 agtgctcagc cagctcgtct gactttagag ctgtcacata tgtatgctgg ttttgttagg
     3181 gtagttggga tgaaaatggt gtgaggttgt caggtttggt ctcaatacct cacagatcta
     3241 aatgttgaca gcatgttgtg aactgaggta accaaatccc acgactgggg gttcagttta
     3301 agcacttcat ttgaggtggt gacgatgcag atgtgtgcag catgtacttt gtagtaaagt
     3361 gtatggttac aaggacaact gagccaggct tggtgactca tgatgataac cccagcactc
     3421 aggaggcaaa agcatggtct gtgaagcaag ttccaccaag gttgcatagt gtgactttca
     3481 agaaacaagg caaaagggca gcaaagaaaa gtcccaagtg gcacacaatg gcacaggctt
     3541 gcctgtgtag tctcagatct ccggttcaag gctagtctgg cccatataat agtctcttaa
     3601 aagtttcagt aacttgggta aatctaaaaa tgattttcac aattgagtac taagacatgc
     3661 atttagaagt tttttcctag tcacctgatt aggtgattga catttgctgt acagagtaag
     3721 gtgtcatggc agcatccctc atttctctgg agaccaaggg tatcagagtg atctggattg
     3781 atctgagaaa gagcaacctg tgggtgggtt gggatatgag aagcccattc tcttctacct
     3841 cagataagtg tgtagcagta caaccgcgcg cgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     3901 tgtgtggtgt gtagggatgt agcagtaccc ctattgcttg tgactggggt tggggaactg
     3961 cttcagccct accctatttc ccagcagtgg cactggggat cagagtgtgc tttggaaggg
     4021 catgggtctc agcttggcag cccgttttgc actggagaat ctggatgcca atgacaccac
     4081 gtgaagccta aaccttggag cttaagaggt gctcatggtt acagaaagca caggctattt
     4141 cagaagtggc tgctgatgtc agccttctca tgtcaagatt tgatctgcag ggaagactca
     4201 ggatgtcgtt ctttgttatt gagcttaact aggatccgtg atgggtattt tagccaagtg
     4261 agactttatg tatgtgtaca tgtctatgtg gatgttggcc acatgtgcag gtgcctcaga
     4321 acacctatgg ccccttggag ctggagttac aggtgagtga gccctcccac ataggagctg
     4381 ggaatcgaac ttaaagtcct ggaagagcag cagggtactc ttaggcatga gtctctgttc
     4441 agacctattg gaagtaagta accagacctt gaccagacct ttcatttgct ttccttgtga
     4501 ggtggcactc ctgtgctctg cagtctcagc tgctgctttg gaacagggac agtgacagtt
     4561 ggagagttgc aatcagggcc tgtggcacac gcttaatcct ggtgctcagg agactgaggt
     4621 gaggattgtg aattcaaaac cagccttgat tacaaagcaa agcccacttt tgtttacagc
     4681 aaaacaagtg agcccactta gctttcatgt gtgccttgga ttatggcaca gtaataaagg
     4741 gaagagatgg tgggaagcag ttgagcgaac agggctttca ggagcaggcg gggcttcggg
     4801 cagtacctac agtattgagc caggagcccg gttcctgtga gtgcctgtga gctggatgtc
     4861 tagggtggaa tttccacctc tcagaccact tggggtgcca ttcaggacac agtagcgccc
     4921 tgcaaagtta gctcaccagt tgccctctac atagctgctc cctgcccacc tttagggatg
     4981 gatttactgt gtcaacaagc tgggtcttgt gaggtgtgag gaagggaaca ggtggttctg
     5041 tgtgtgtctg tgtgtggaag ccttgggcgt tccacaggag ccgtccacca tgtttttgct
     5101 tgtttttgtt tttttgtgac gtttcattgt gtattcattt ctagctgttc tggaacttgc
     5161 tacatagctt agcctcctat taactcagaa atttgccttc ctctctgcct gccaaaagtt
     5221 ggtatttaag gtgtgcacca acacaccagg ctctaccttg tctttttaaa ataaggcttc
     5281 tcacctgtta ccctgattaa gctgtgatta agtcagtgaa ctccagggac ccacccgtct
     5341 acctacatgg tgacaccatg tgtgttctac agactgaatt caggtcctca ctttacagaa
     5401 caaacaattt ctccagagac agtgtctctg tgtatcctgg aatgcacgct gtagacaagg
     5461 ctgccctcaa actcagaggt ccacctgtct gcctagtggg attaaaggcc tgcatcaaca
     5521 ccgcttggct gctaatgtga tgctttaata cctaaaacgt ggctgccact ttctctgagg
     5581 tcctttagca ttctgtgttc tgaacctcgg tgtttttgcc ccaggggcag cgttttgggt
     5641 ggaaatacac ccagctgtca ggacgtgtat gtgtcatgtg cggattaaga acccactgtt
     5701 tctttccatt tgactcgcac ttgtgtgatg agtccccatg acactcctgg gtatgctgag
     5761 accttagcgt catgtgactt ctccctgcac gtgtgcctgt gtgctccagc cccacctctg
     5821 tctcacgctg gtttttgtct agacctgcac tgttgagcac tgtaagtgaa cagattgatc
     5881 ccccttcatt ttgtttgtcc ctttatggtt ctgtcccatc cattgtcata agcagggtct
     5941 tcctagagga ctctgcccct cttatggttc agcctggagt tggaattacc actgggttag
     6001 gttgtggctt cttaaggaat tgagacctga cactttgaag tccccatgat ggttgagtca
     6061 gtgactgggg gtagccttcc atcaatttca gatcggaaat ttcagtatag gaaattgttg
     6121 ggaggctggg ggttgggagg tggggcatgt gtgaggagga agtccccggt ctcagactta
     6181 cttcctgctt gttcctagtc cctgcagaac aactgatttg ttgtaagctc agaactcaag
     6241 ctccaccctg ctagaggaga gtggtcagtt tccttccttc ctccctgcac ccaaggttca
     6301 gttaaatccc atcatgctac ctcagcagac tccccaggtc actcctccca cctccaggat
     6361 cttgctggtc tttgcatcat ctttagatga gtctttctga aacaaccttg gccttgtatc
     6421 ccccacacgt gtgttttctc tcaccagtcc catagactgt aagcccctgt ggcagggtct
     6481 atgagtgagt cgcctgtgtt aaccttcagt ggtacctacc aataaatatt cttggctgaa
     6541 taaatgaaa
//
