LOCUS       NM_001106726            4952 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus G2/M-phase specific E3 ubiquitin protein ligase
            (G2e3), mRNA.
ACCESSION   NM_001106726 XM_001078619 XM_234110
VERSION     NM_001106726.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4952)
  AUTHORS   Brooks,W.S., Helton,E.S., Banerjee,S., Venable,M., Johnson,L.,
            Schoeb,T.R., Kesterson,R.A. and Crawford,D.F.
  TITLE     G2E3 is a dual function ubiquitin ligase required for early
            embryonic development
  JOURNAL   J Biol Chem 283 (32), 22304-22315 (2008)
   PUBMED   18511420
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473947.1.
            
            [WARNING] On Oct 24, 2024 this sequence was replaced by
            NM_001106726.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_234110.4, XM_001078619.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..4952
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q22"
     gene            1..4952
                     /gene="G2e3"
                     /gene_synonym="RGD1310263"
                     /note="G2/M-phase specific E3 ubiquitin protein ligase"
                     /db_xref="GeneID:299002"
                     /db_xref="RGD:1310263"
     exon            1..81
                     /gene="G2e3"
                     /gene_synonym="RGD1310263"
                     /inference="alignment:Splign:2.1.0"
     exon            82..122
                     /gene="G2e3"
                     /gene_synonym="RGD1310263"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..2239
                     /gene="G2e3"
                     /gene_synonym="RGD1310263"
                     /EC_number="2.3.2.26"
                     /note="G2/M-phase specific E3 ubiquitin ligase"
                     /codon_start=1
                     /product="G2/M phase-specific E3 ubiquitin-protein ligase"
                     /protein_id="NP_001100196.1"
                     /db_xref="GeneID:299002"
                     /db_xref="RGD:1310263"
                     /translation="MNENKPGNSQSLACVFCRKNDDCPNKYGEKKTCEKWNFSVHYYC
                     LLMSSGIWQRGKEEEGVYGFLIEDIRKEVNRASKLKCTVCKKNGASIGCVVPQCKRSY
                     HLPCGLQKECIFQFTDNFASFCWKHRPVQAITSNKYRDSLPCTICLEFVEPIPTYNIL
                     QSPCCKNAWFHRDCLQVQAINAGVFFFRCTLCNNTDIFQKEMLRMGIHIPEKDASWEL
                     EENAYQELLQSHDRCDVRRCHCKEGREYNEPNSKWEIKRCQCCGSSGTHLACSSLQSW
                     EKNWECLDCRRIAYTSDFQKAPKHPLANSTNVTVTDCLLEESSPKLPRQSTVAQQKEL
                     LRQGSKFRRDISTILIELGFQIKKKAKTLYINKANVWRSAVEQFQSQKFNPSYSIEVV
                     YVNDNDEVGSKHPGSKQEFLSHLMHHLENSSVFEGSLAKNLSLNSQAVKENLYYEAGK
                     MLAISLVHGGPSPGFFSETLFKCLAYGPENALPTLDDVSDLDVAQIIIKIDTAADLNI
                     LKSVINEYYNYLEFSGCLRLMTTLSDKYMLVKDILFYQVIKRVKAPFESFKQGLKTLG
                     VLEKIQAYPEAFYNILCHKPESLSAKNLSDLFTIHKLPDVKTSRFWNSYLQAVEDGKS
                     ATTLEDILHFATGCSSVPPTGFKPAPSIECLHGDFPVANKCNNCLALPVTNTYEEFQE
                     NMDFAIRDSIRLEKEERSHLLPRTLNVSSNEEMLF"
     exon            123..220
                     /gene="G2e3"
                     /gene_synonym="RGD1310263"
                     /inference="alignment:Splign:2.1.0"
     exon            221..322
                     /gene="G2e3"
                     /gene_synonym="RGD1310263"
                     /inference="alignment:Splign:2.1.0"
     exon            323..447
                     /gene="G2e3"
                     /gene_synonym="RGD1310263"
                     /inference="alignment:Splign:2.1.0"
     exon            448..613
                     /gene="G2e3"
                     /gene_synonym="RGD1310263"
                     /inference="alignment:Splign:2.1.0"
     exon            614..720
                     /gene="G2e3"
                     /gene_synonym="RGD1310263"
                     /inference="alignment:Splign:2.1.0"
     exon            721..837
                     /gene="G2e3"
                     /gene_synonym="RGD1310263"
                     /inference="alignment:Splign:2.1.0"
     exon            838..962
                     /gene="G2e3"
                     /gene_synonym="RGD1310263"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1092
                     /gene="G2e3"
                     /gene_synonym="RGD1310263"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1400
                     /gene="G2e3"
                     /gene_synonym="RGD1310263"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1582
                     /gene="G2e3"
                     /gene_synonym="RGD1310263"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1755
                     /gene="G2e3"
                     /gene_synonym="RGD1310263"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1946
                     /gene="G2e3"
                     /gene_synonym="RGD1310263"
                     /inference="alignment:Splign:2.1.0"
     exon            1947..4952
                     /gene="G2e3"
                     /gene_synonym="RGD1310263"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtaacgcat cgaccctggg acttatactc cgcgcctggt gaggacgtgt cccggaggga
       61 ctgagggtca cgggcggccg gtaagatgaa tgaaaataaa cctggtaatt cacaaagtct
      121 tgcttgtgtt ttctgccgaa aaaatgatga ctgtcccaat aaatatggag aaaagaaaac
      181 gtgtgaaaaa tggaatttca gtgtccacta ctactgtttg ttaatgtcaa gtggaatttg
      241 gcagagaggt aaagaagaag aaggagttta tggcttccta atagaagaca tcaggaagga
      301 ggtcaataga gcttccaaac tgaaatgtac agtctgcaag aagaatggtg cttcaatcgg
      361 atgtgttgta ccccagtgta aacgaagtta tcacttgcct tgtggacttc agaaagaatg
      421 tattttccag ttcactgaca attttgcgtc attttgctgg aaacatcgac cggttcaagc
      481 aattacatct aataaatata gagactcttt accatgtact atctgtttgg aatttgtcga
      541 gccgattcct acttataaca tattacagag tccctgctgt aagaatgctt ggtttcatag
      601 agactgttta caggttcaag caataaacgc aggagtgttt ttctttagat gtacactatg
      661 caataatacc gacatctttc agaaagagat gttgagaatg ggaattcata ttcctgaaaa
      721 agatgcatcc tgggagttag aagaaaatgc ttatcaagag ctgttgcaga gccatgaccg
      781 ctgtgatgtc cgaagatgtc actgcaaaga gggcagagag tacaatgaac ctaatagcaa
      841 atgggaaata aagcgatgtc agtgttgtgg ttctagtgga acacacttgg cctgttcctc
      901 actccagtct tgggaaaaaa attgggagtg tttggactgt agaagaattg cctacacttc
      961 agatttccaa aaggccccca aacacccatt agccaactct actaatgtga cagttactga
     1021 ctgcttgttg gaagagtcgt cacctaagct ccccagacag tcaactgtag cccagcagaa
     1081 agaactactg aggcaaggca gcaaatttag gagagacatt tcaacaatat tgatagagtt
     1141 aggattccaa attaaaaaga aagctaagac attatacatc aacaaggcca atgtgtggag
     1201 gagtgcagta gagcaattcc agagccagaa gtttaaccct tcatactcca ttgaagtagt
     1261 gtatgttaat gacaatgatg aggttggaag caagcatcct ggatcaaagc aggaatttct
     1321 gagtcactta atgcaccatc ttgagaattc atcagtgttt gaagggtcct tggcaaagaa
     1381 cttgtctcta aattctcaag ctgtgaaaga gaatctttac tatgaagctg gcaaaatgct
     1441 tgccatttct ttagttcatg gtggtccttc gccaggtttc ttttctgaaa ccttgtttaa
     1501 gtgccttgct tatggaccag aaaacgcttt accaactctg gatgatgttt cagaccttga
     1561 tgtggcacag attataatca agatagacac tgcagctgat ttaaacattt taaaatcagt
     1621 aataaacgaa tactataact acctagagtt tagtggatgt ttaagactta tgacaacatt
     1681 aagtgataaa tacatgttgg taaaagacat ccttttctac caggtaatta agagagtcaa
     1741 agcacctttt gagagtttta aacagggtct gaaaacgctc ggtgttttag agaaaattca
     1801 agcttaccca gaagcatttt ataacatcct ctgtcataaa cctgagagtc tctctgcaaa
     1861 aaacctcagt gatcttttca caatccacaa gttaccagat gtaaaaactt cgaggttttg
     1921 gaacagttac ttacaggctg tagaggatgg aaagtctgca acaacactgg aagacattct
     1981 tcattttgca accggctgta gttccgttcc acctactgga tttaaacccg ctccttccat
     2041 tgaatgtctg catggcgatt ttcctgttgc gaacaagtgt aataactgtt tagctctacc
     2101 tgtcaccaac acatatgagg agttccagga aaatatggat tttgccataa gagactctat
     2161 aagactagaa aaggaagaaa ggtctcactt attacctcgg acattaaatg tttcttctaa
     2221 tgaagaaatg ctgttttaaa ggctgctatt gatacctgtt cttattcatc acttttggac
     2281 actggccaac ctcttggcgc aacaaaaaat atatgacgtt ttcataaaag gatggtttgg
     2341 cttctgaact actgaagctt tggtccagac cttctagtca tgcttggtga tagctgtcca
     2401 tgactgctgc cgtcgtaacg tcaatccttc ctattggatc tttcctactg ctgtgctttc
     2461 ttgataactt cacggtttta gaatggtcgt acagaccgtt gagctgtaca ggagctcagc
     2521 tctattagta tgacatggaa gaattgcctt tgtaggatga cactttccta gttctgtgca
     2581 gtcatcaaat ttgtgttgtt ttgtttgttc tgcttcactg ttggtggttt tttgttttgt
     2641 tttgttttcc ttctacatag tcctggtagt cctggtagtc ctggttgtcc tggaacctgg
     2701 ctatgtagaa caagctgtca aatttctttt tttaaagcat taaatagaaa agttggctaa
     2761 gtcgtctcat aaatcagaga tattgtaaat gtattttaat taagtgacca atacaactat
     2821 ccaataatga ctaattggaa atactgtatg aaaagcaaag ctttacaaat aattctagga
     2881 tctatgtgtc ctccttaagc ttaaaatcat ggctcaggag ttttcaggtg tccttgaaaa
     2941 taccttagaa taccttgtgt ggtcagtgtg tctcatatat gaaaccatct cggtgtctga
     3001 agaatctctg aactttaata tggttttgct acataacaac tatttattat taagattgtt
     3061 gaatgattgg taagatctca ccatagcatt ctatagttac cttcttttgc tttcaaaaga
     3121 taccttgtat aatcaatgaa tgaattataa tttaaaacta caaattagaa aaatactcta
     3181 attttgccac atagagataa taatgtattt tgtatattct ttataaacta tttatttttc
     3241 aattttttat tatcttatga cagggtcttc tatagagccc gattgttata aattcccatc
     3301 ttcctgcctt agtcacagtc attgctgggg ctgtgacgta tatcaatgtg cccagcaatc
     3361 gttttttttt tttttttgag tatatgaatg ctatctagtg taacaagaaa ccatgtaata
     3421 aaatcaagtt atgtacagtc tcttttcaag gcatgaatgc acactcctgt aatccaagct
     3481 cgagagacta aggcaggagg atctggtatg atagcccaag tttaaaacca tcctgggctg
     3541 caggagaccc tgctcaataa agaaataagt acatgaccca ctcatggcaa tgtcttcaca
     3601 cattaacaca aagtatgtgt tagctgttgg tcatgtattg ttactcccaa gaaacacaag
     3661 acttaaaagg gatttcaacc ccttaaacaa caggactgac ttggtattgg taataccctt
     3721 cttaatgcca aaggaaaact cagttgtcat cacagtgcca ttttcttgct tacctcagaa
     3781 ccttccaagt tgtatgtaac agaactaata aagtttctct ttatcttgag catttagcat
     3841 gaagacattt ctttatcttg tgttacattt tgctagatgt ttcaaagtaa ttaaatgatc
     3901 catcatgaat aacttaaatc tcgaactcaa aagacagcat ttattccaag tgtgttgata
     3961 agttggatct tttgttttaa cctgttagtt cctaccgagt tttaaaggct gttaaatcca
     4021 tacaactcca aaatggtatt ttttagcttg cactttgagt tacccccgct cctgccccca
     4081 cgggatagta actaacacaa acacaatcct tagagtgttg ggtgggatta tagagccttg
     4141 gactggcggc aagtgatttt attgtactta atctgtacgt aaacatggcc ttgggagtga
     4201 gatggtctga atattaaaga cttaaagtgg aacatcagat ttcagaatgt cttctggttc
     4261 aaagcttttg ttgcatgttc tctagattag tctatatata tacttgaggc ttaacagaga
     4321 aactgcaatg ttactgtgtc atgcttgttg ttccaatttt gtttttttag tatagttctt
     4381 aaattagcat acttagtttg aaaattatga agggacagtt ttatgtttga tgtttatgtt
     4441 tcctcctaat tacattagaa gcttttggaa cttgcacagt cagtatttat aaagggattg
     4501 tataatggta agtttttcct gggactttcc tttagtgttc agtcataaga aaatggtaag
     4561 aactagactc tgttgataaa catggttact gttatgtatt tgttatgctt cctataatgc
     4621 agcgtaaagc attgaacaca cacaatgaag aattacttga atttatatta tctgtaactt
     4681 gggaaatttt gtaatccttg aaagagaccc agttttcaag atctattttg accaccttca
     4741 aatacactct aataccaact gtgtaccaga ttctgtgctc tgaaatagtt tataagtcag
     4801 cctgtttaaa atgaatcaaa aacgcacagt ggtagaatgg tttgtctacc tagcttgtgt
     4861 aaggccttgg gtttaatttt aaactatgac caaaacatta aaaaaaggca tgaacactta
     4921 acaataacat ttctaagtaa ctgtttttat aa
//
