LOCUS       NP_001100196             717 aa            linear   ROD 24-OCT-2024
DEFINITION  G2/M phase-specific E3 ubiquitin-protein ligase isoform 1 [Rattus
            norvegicus].
ACCESSION   NP_001100196 XP_001078619 XP_234110
VERSION     NP_001100196.1
DBSOURCE    REFSEQ: accession NM_001106726.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 717)
  AUTHORS   Brooks,W.S., Helton,E.S., Banerjee,S., Venable,M., Johnson,L.,
            Schoeb,T.R., Kesterson,R.A. and Crawford,D.F.
  TITLE     G2E3 is a dual function ubiquitin ligase required for early
            embryonic development
  JOURNAL   J Biol Chem 283 (32), 22304-22315 (2008)
   PUBMED   18511420
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XP_234110.3, XP_001078619.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.2696865.1,
                                           SRR26360190.3103276.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..717
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q22"
     Protein         1..717
                     /product="G2/M phase-specific E3 ubiquitin-protein ligase
                     isoform 1"
                     /EC_number="2.3.2.26"
                     /note="G2/M-phase specific E3 ubiquitin ligase"
                     /calculated_mol_wt=81725
     Region          14..127
                     /region_name="ePHD_PHF7_G2E3_like"
                     /note="Extended PHD finger found in PHD finger protein 7
                     (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase
                     (G2E3); cd15669"
                     /db_xref="CDD:277139"
     Site            order(80,89..93,99,122)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277139"
     Region          232..285
                     /region_name="PHD_PHF7_G2E3_like"
                     /note="PHD finger found in PHD finger protein 7 (PHF7) and
                     G2/M phase-specific E3 ubiquitin-protein ligase (G2E3);
                     cd15496"
                     /db_xref="CDD:276971"
     Site            order(232,254..258,262,280)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:276971"
     Region          365..688
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cl27008"
                     /db_xref="CDD:474882"
     Site            order(367,399,410,463,634,659..660,663..667,687)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     CDS             1..717
                     /gene="G2e3"
                     /gene_synonym="RGD1310263"
                     /coded_by="NM_001106726.2:147..2300"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:299002"
                     /db_xref="RGD:1310263"
ORIGIN      
        1 mnenkpgnsq slacvfcrkn ddcpnkygek ktcekwnfsv hyycllmssg iwqrgkeeeg
       61 vygfliedir kevnrasklk ctvckkngas igcvvpqckr syhlpcglqk ecifqftdnf
      121 asfcwkhrpv qaitsnkyrd slpcticlef vepiptynil qspccknawf hrdclqvqai
      181 nagvfffrct lcnntdifqk emlrmgihip ekdaswelee nayqellqsh drcdvrrchc
      241 kegreynepn skweikrcqc cgssgthlac sslqsweknw ecldcrriay tsdfqkapkh
      301 planstnvtv tdclleessp klprqstvaq qkellrqgsk frrdistili elgfqikkka
      361 ktlyinkanv wrsaveqfqs qkfnpsysie vvyvndndev gskhpgskqe flshlmhhle
      421 nssvfegsla knlslnsqav kenlyyeagk mlaislvhgg pspgffsetl fkclaygpen
      481 alptlddvsd ldvaqiiiki dtaadlnilk svineyynyl efsgclrlmt tlsdkymlvk
      541 dilfyqvikr vkapfesfkq glktlgvlek iqaypeafyn ilchkpesls aknlsdlfti
      601 hklpdvktsr fwnsylqave dgksattled ilhfatgcss vpptgfkpap sieclhgdfp
      661 vankcnncla lpvtntyeef qenmdfaird sirlekeers hllprtlnvs sneemlf
//
