LOCUS       NM_001009632             755 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus G0/G1switch 2 (G0s2), mRNA.
ACCESSION   NM_001009632 XM_213979
VERSION     NM_001009632.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 755)
  AUTHORS   Sugaya,Y. and Satoh,H.
  TITLE     Liver-specific G0 /G1 switch gene 2 (G0s2) expression promotes
            hepatic insulin resistance by exacerbating hepatic steatosis in
            male Wistar rats
  JOURNAL   J Diabetes 9 (8), 754-763 (2017)
   PUBMED   27624922
  REMARK    GeneRIF: results of the present study indicate that hepatic G0s2
            protein may promote hepatic insulin resistance by exacerbating
            hepatic steatosis
REFERENCE   2  (bases 1 to 755)
  AUTHORS   Dettlaff-Pokora,A., Sledzinski,T. and Swierczynski,J.
  TITLE     Upregulation of Pnpla2 and Abhd5 and downregulation of G0s2 gene
            expression in mesenteric white adipose tissue as a potential reason
            for elevated concentration of circulating NEFA after removal of
            retroperitoneal, epididymal, and inguinal adipose tissue
  JOURNAL   Mol Cell Biochem 422 (1-2), 21-29 (2016)
   PUBMED   27590244
  REMARK    GeneRIF: upregulation of Pnpla2 expression and activation of ATGL
            (due to an increase in ABHD5 and decrease in G0S2 levels), as well
            as a coordinated interplay of these genes with Lipe in mesenteric
            WAT, contribute, at least in part, to an increase in the
            concentration of circulating NEFA in rats with reduced fat mass.
REFERENCE   3  (bases 1 to 755)
  AUTHORS   Turnbull,P.C., Longo,A.B., Ramos,S.V., Roy,B.D., Ward,W.E. and
            Peters,S.J.
  TITLE     Increases in skeletal muscle ATGL and its inhibitor G0S2 following
            8 weeks of endurance training in metabolically different rat
            skeletal muscles
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 310 (2), R125-R133 (2016)
   PUBMED   26511521
  REMARK    GeneRIF: Report increased levels of ATGL and its inhibitor G0S2
            following endurance training in metabolically different rat
            skeletal muscles.
REFERENCE   4  (bases 1 to 755)
  AUTHORS   Turnbull,P.C., Ramos,S.V., MacPherson,R.E., Roy,B.D. and
            Peters,S.J.
  TITLE     Characterization of lipolytic inhibitor G(0)/G(1) switch gene-2
            protein (G0S2) expression in male Sprague-Dawley rat skeletal
            muscle compared to relative content of adipose triglyceride lipase
            (ATGL) and comparitive gene identification-58 (CGI-58)
  JOURNAL   PLoS One 10 (3), e0120136 (2015)
   PUBMED   25811590
  REMARK    GeneRIF: These data suggest that the content of G0S2 relative to
            the lipase in skeletal muscle would not predict lipolytic
            potential.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 755)
  AUTHORS   Wang,Y., Zhang,Y., Zhu,Y. and Zhang,P.
  TITLE     Lipolytic inhibitor G0/G1 switch gene 2 inhibits reactive oxygen
            species production and apoptosis in endothelial cells
  JOURNAL   Am J Physiol Cell Physiol 308 (6), C496-C504 (2015)
   PUBMED   25588877
  REMARK    GeneRIF: Results indicate that G0S2 acts as a prosurvival molecule
            in endothelial cells.
REFERENCE   6  (bases 1 to 755)
  AUTHORS   Stelmanska,E., Szrok,S. and Swierczynski,J.
  TITLE     Progesterone-induced down-regulation of hormone sensitive lipase
            (Lipe) and up-regulation of G0/G1 switch 2 (G0s2) genes expression
            in inguinal adipose tissue of female rats is reflected by
            diminished rate of lipolysis
  JOURNAL   J Steroid Biochem Mol Biol 147, 31-39 (2015)
   PUBMED   25448749
  REMARK    GeneRIF: Administration of progesterone resulted in an increase in
            the expression of Abhd5 gene (whose product increases ATGL
            activity) and G0s2 gene (whose product decreases ATGL activity) in
            the inguinal white adipose tissue of female rats.
REFERENCE   7  (bases 1 to 755)
  AUTHORS   Ma,T., Lopez-Aguiar,A.G., Li,A., Lu,Y., Sekula,D., Nattie,E.E.,
            Freemantle,S. and Dmitrovsky,E.
  TITLE     Mice lacking G0S2 are lean and cold-tolerant
  JOURNAL   Cancer Biol Ther 15 (5), 643-650 (2014)
   PUBMED   24556704
REFERENCE   8  (bases 1 to 755)
  AUTHORS   Kioka,H., Kato,H., Fujikawa,M., Tsukamoto,O., Suzuki,T.,
            Imamura,H., Nakano,A., Higo,S., Yamazaki,S., Matsuzaki,T.,
            Takafuji,K., Asanuma,H., Asakura,M., Minamino,T., Shintani,Y.,
            Yoshida,M., Noji,H., Kitakaze,M., Komuro,I., Asano,Y. and
            Takashima,S.
  TITLE     Evaluation of intramitochondrial ATP levels identifies G0/G1 switch
            gene 2 as a positive regulator of oxidative phosphorylation
  JOURNAL   Proc Natl Acad Sci U S A 111 (1), 273-278 (2014)
   PUBMED   24344269
  REMARK    GeneRIF: G0/G1 switch gene 2 has a role as a positive regulator of
            oxidative phosphorylation
REFERENCE   9  (bases 1 to 755)
  AUTHORS   Welch,C., Santra,M.K., El-Assaad,W., Zhu,X., Huber,W.E., Keys,R.A.,
            Teodoro,J.G. and Green,M.R.
  TITLE     Identification of a protein, G0S2, that lacks Bcl-2 homology
            domains and interacts with and antagonizes Bcl-2
  JOURNAL   Cancer Res 69 (17), 6782-6789 (2009)
   PUBMED   19706769
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC088248.1.
            
            On Jan 13, 2005 this sequence version replaced XM_213979.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088248.1, CO560140.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..755
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q27"
     gene            1..755
                     /gene="G0s2"
                     /note="G0/G1switch 2"
                     /db_xref="GeneID:289388"
                     /db_xref="RGD:1311675"
     exon            1..67
                     /gene="G0s2"
                     /inference="alignment:Splign:2.1.0"
     exon            68..729
                     /gene="G0s2"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..408
                     /gene="G0s2"
                     /note="G0/G1 switch gene 2; putative lymphocyte G0/G1
                     switch; G0S2-like protein"
                     /codon_start=1
                     /product="G0/G1 switch protein 2"
                     /protein_id="NP_001009632.1"
                     /db_xref="GeneID:289388"
                     /db_xref="RGD:1311675"
                     /translation="MESVQELIPLAKEMMTQKSRGKLVKLYVLGSVLAFFGVVLGLVE
                     TVCSPFTAASRLRDQEAAVAELRDACEQQSLHKQALIAEGKTQEATLCSRALSLRQHA
                     S"
ORIGIN      
        1 ggccagtctg ccgcctggac gcctgacctc cttcagcgag tgctgcctct gttcccacgc
       61 accctaggcc cagccaaccc acagcccaga gctcagatgg aaagtgtgca ggagctgatc
      121 cctctggcta aggagatgat gacgcagaag tcccgaggga agctagtgaa gctgtacgtg
      181 ctgggcagtg tgctagcgtt cttcggtgtg gtgctcggtc tagtggagac tgtgtgcagc
      241 cctttcacag ctgccagccg tctgcgcgac caggaggcgg cagtggcaga gctgcgggat
      301 gcttgtgagc agcagtccct ccacaagcag gccctgatag cagaaggcaa gacacaggag
      361 gcgactttgt gcagccgggc cctgtccctc cggcagcatg cctcttaagg ctggtgactg
      421 gcagagaagc gagacacaga gagatcatga ctgaggtggg cgagagagag tcacatgctg
      481 tttcaaggtg ccaccgaatc cagaactgac cctgcacaga tcacccaagg gatctgggac
      541 tgacttgctg ctgtgcagca tgcactgtga tttgtccaag gctgtgggag cgatcaagga
      601 gctgtcactt tgcattaggg aaggagacat gctttttata ctgttatttt tattgttgtt
      661 gttattatta ttattattat tacaacgaat atcattttgc attttgaaat aaaaacattt
      721 tatattctga aaaaaaaaaa aaaaaaaaaa aaaaa
//
