LOCUS       NM_001108074            1821 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus fizzy and cell division cycle 20 related 1
            (Fzr1), mRNA.
ACCESSION   NM_001108074 XM_001075601 XM_243390
VERSION     NM_001108074.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1821)
  AUTHORS   Li J, Chen X, Li X, Hu R, Yao W, Mei W, Wan L, Gui L and Zhang C.
  TITLE     Upregulation of Cdh1 in the trigeminal spinal subnucleus caudalis
            attenuates trigeminal neuropathic pain via inhibiting GABAergic
            neuronal apoptosis
  JOURNAL   Neurochem Int 133, 104613 (2020)
   PUBMED   31785347
  REMARK    GeneRIF: Upregulation of Cdh1 in the trigeminal spinal subnucleus
            caudalis attenuates trigeminal neuropathic pain via inhibiting
            GABAergic neuronal apoptosis.
REFERENCE   2  (bases 1 to 1821)
  AUTHORS   Li Z, Zhang B, Yao W, Zhang C, Wan L and Zhang Y.
  TITLE     APC-Cdh1 Regulates Neuronal Apoptosis Through Modulating Glycolysis
            and Pentose-Phosphate Pathway After Oxygen-Glucose Deprivation and
            Reperfusion
  JOURNAL   Cell Mol Neurobiol 39 (1), 123-135 (2019)
   PUBMED   30460429
  REMARK    GeneRIF: under oxygen-glucose deprivation and reperfusion (OGD/R),
            APC-Cdh1 was decreased in primary cortical neurons.
REFERENCE   3  (bases 1 to 1821)
  AUTHORS   Fuchsberger T, Martinez-Bellver S, Giraldo E, Teruel-Marti V,
            Lloret A and Vina J.
  TITLE     Abeta Induces Excitotoxicity Mediated by APC/C-Cdh1 Depletion That
            Can Be Prevented by Glutaminase Inhibition Promoting Neuronal
            Survival
  JOURNAL   Sci Rep 6, 31158 (2016)
   PUBMED   27514492
  REMARK    GeneRIF: show here for the first time in vivo that both Abeta and
            glutamate cause nuclear exclusion of cdh1 and an increase in
            glutaminase
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1821)
  AUTHORS   Tan W, Yao WL, Hu R, Lv YY, Wan L, Zhang CH and Zhu C.
  TITLE     Alleviating neuropathic pain mechanical allodynia by increasing
            Cdh1 in the anterior cingulate cortex
  JOURNAL   Mol Pain 11, 56 (2015)
   PUBMED   26364211
  REMARK    GeneRIF: These results provide evidence that Cdh1 in anterior
            cingulate cortex synapses may offer a novel therapeutic strategy
            for treating chronic neuropathic pain
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1821)
  AUTHORS   Zhang Y, Yao W, Qiu J, Qian W, Zhu C and Zhang C.
  TITLE     The involvement of down-regulation of Cdh1-APC in hippocampal
            neuronal apoptosis after global cerebral ischemia in rat
  JOURNAL   Neurosci Lett 505 (2), 71-75 (2011)
   PUBMED   21982804
  REMARK    GeneRIF: Down-regulation of Cdh1 and coactivator anaphase-promoting
            complex (APC) is associated with neuronal apoptosis in the
            hippocampus following global cerebral ischemia.
REFERENCE   6  (bases 1 to 1821)
  AUTHORS   Wu G, Glickstein S, Liu W, Fujita T, Li W, Yang Q, Duvoisin R and
            Wan Y.
  TITLE     The anaphase-promoting complex coordinates initiation of lens
            differentiation
  JOURNAL   Mol Biol Cell 18 (3), 1018-1029 (2007)
   PUBMED   17215516
REFERENCE   7  (bases 1 to 1821)
  AUTHORS   Marangos P, Verschuren EW, Chen R, Jackson PK and Carroll J.
  TITLE     Prophase I arrest and progression to metaphase I in mouse oocytes
            are controlled by Emi1-dependent regulation of APC(Cdh1)
  JOURNAL   J Cell Biol 176 (1), 65-75 (2007)
   PUBMED   17190794
REFERENCE   8  (bases 1 to 1821)
  AUTHORS   Konishi Y, Stegmuller J, Matsuda T, Bonni S and Bonni A.
  TITLE     Cdh1-APC controls axonal growth and patterning in the mammalian
            brain
  JOURNAL   Science 303 (5660), 1026-1030 (2004)
   PUBMED   14716021
REFERENCE   9  (bases 1 to 1821)
  AUTHORS   Chen J and Fang G.
  TITLE     MAD2B is an inhibitor of the anaphase-promoting complex
  JOURNAL   Genes Dev 15 (14), 1765-1770 (2001)
   PUBMED   11459826
REFERENCE   10 (bases 1 to 1821)
  AUTHORS   Pfleger CM, Salic A, Lee E and Kirschner MW.
  TITLE     Inhibition of Cdh1-APC by the MAD2-related protein MAD2L2: a novel
            mechanism for regulating Cdh1
  JOURNAL   Genes Dev 15 (14), 1759-1764 (2001)
   PUBMED   11459825
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC162059.1.
            
            On Nov 19, 2011 this sequence version replaced NM_001108074.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC162059.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1821
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..1821
                     /gene="Fzr1"
                     /gene_synonym="Cdh1"
                     /note="fizzy and cell division cycle 20 related 1"
                     /db_xref="GeneID:314642"
                     /db_xref="RGD:1308713"
     exon            1..112
                     /gene="Fzr1"
                     /gene_synonym="Cdh1"
                     /inference="alignment:Splign:2.1.0"
     exon            113..236
                     /gene="Fzr1"
                     /gene_synonym="Cdh1"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..1649
                     /gene="Fzr1"
                     /gene_synonym="Cdh1"
                     /note="fizzy/cell division cycle 20 related 1"
                     /codon_start=1
                     /product="fizzy-related protein homolog"
                     /protein_id="NP_001101544.2"
                     /db_xref="GeneID:314642"
                     /db_xref="RGD:1308713"
                     /translation="MDQDYERRLLRQIIIQNENTVPCVSEMRRTLTPANSPVSSPSKH
                     GDRFIPSRAGANWSVNFHRINENEKSPSQNRKAKDATSDNGKDGLAYSALLKNELLGA
                     GIEKVQDPQTEDRRLQPSTPEHKGLFTYSLSSKRSSPDDGNDVSPYSLSPVSNKSQKL
                     LRSPRKPTRKISKIPFKVLDAPELQDDFYLNLVDWSSLNVLSVGLGTCVYLWSACTSQ
                     VTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSVLEGHTARVGA
                     LAWNADQLSSGSRDRMILQRDIRTPALQSERRLQGHRQEVCGLKWSTDHQLLASGGND
                     NKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQP
                     LQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLA
                     MSPDGEAIVTGAGDETLRFWNVFSKTRSTKESVSVLNLFTRIR"
     exon            237..362
                     /gene="Fzr1"
                     /gene_synonym="Cdh1"
                     /inference="alignment:Splign:2.1.0"
     exon            363..426
                     /gene="Fzr1"
                     /gene_synonym="Cdh1"
                     /inference="alignment:Splign:2.1.0"
     exon            427..554
                     /gene="Fzr1"
                     /gene_synonym="Cdh1"
                     /inference="alignment:Splign:2.1.0"
     exon            555..637
                     /gene="Fzr1"
                     /gene_synonym="Cdh1"
                     /inference="alignment:Splign:2.1.0"
     exon            638..821
                     /gene="Fzr1"
                     /gene_synonym="Cdh1"
                     /inference="alignment:Splign:2.1.0"
     exon            822..887
                     /gene="Fzr1"
                     /gene_synonym="Cdh1"
                     /inference="alignment:Splign:2.1.0"
     exon            888..990
                     /gene="Fzr1"
                     /gene_synonym="Cdh1"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1175
                     /gene="Fzr1"
                     /gene_synonym="Cdh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1409
                     /gene="Fzr1"
                     /gene_synonym="Cdh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1514
                     /gene="Fzr1"
                     /gene_synonym="Cdh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1607
                     /gene="Fzr1"
                     /gene_synonym="Cdh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1794
                     /gene="Fzr1"
                     /gene_synonym="Cdh1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgtgagcggc ggcggcgggg cctggcgcag cggcggagcc tcgaacgggc gcggcgtgtt
       61 cctgagacta gcgggaaccg gcgggagccg gctggcgacc ggagcgaggc aggctaccct
      121 cgcaggctaa cctcggctgc gggccccgcc ccgcctgccc gcctgccatg gaccaggact
      181 atgagcgacg gctcctgcga cagatcatca tccaaaatga gaacaccgtg ccgtgtgtct
      241 cagagatgcg gagaaccctg acaccagcca actccccagt gtcctctccc agcaagcatg
      301 gtgaccgctt catcccctcg cgggccgggg ccaactggag cgtaaacttc cataggatca
      361 atgaaaatga gaagtccccc agccagaacc gcaaagccaa ggatgccacc tcagacaacg
      421 gcaaagatgg ccttgcttac tccgcactgc tgaagaatga gctgctgggt gccggcatcg
      481 agaaggtgca ggacccacag acagaggatc ggcggctgca gccatccacc ccagagcaca
      541 agggtctctt tacgtattcc ctcagcagca agcgctcgag tccagatgat ggcaacgacg
      601 tgtccccata ttctctatcc ccagttagca acaaaagtca gaagctgctg cggtcgcctc
      661 ggaagcccac gcgcaagatt tccaagattc ccttcaaggt gctggacgcg ccagagcttc
      721 aggacgactt ctacctcaac ctggtggact ggtcctccct caatgtgctc agcgtggggc
      781 taggcacctg cgtgtacctg tggagcgcat gcaccagcca ggtgacccgg ctctgtgacc
      841 tctccgtaga aggggactca gtgacttccg tgggctggtc tgagcggggg aacctggtgg
      901 cagtcggcac acataagggc ttcgtgcaga tctgggatgc tgccgctggc aagaagctat
      961 ctgtgctgga gggacacaca gcgcgcgtgg gggcgctggc ctggaatgct gaccagctgt
     1021 catccggtag ccgggaccgc atgatcctgc aacgggacat ccgcacacca gcactgcagt
     1081 cagagcggcg gctgcaaggc catcgacagg aagtatgcgg cctgaagtgg tccacagacc
     1141 accagctgct cgcctcgggg ggcaatgaca acaagctgct cgtgtggaac cactcaagtc
     1201 taagccctgt gcagcagtac acggagcacc tggcagccgt gaaggctatt gcctggtcac
     1261 cacaccagca tggactgctg gcctctggtg gtggcactgc cgaccgctgc atccggttct
     1321 ggaacactct gacaggccag cctctgcagt gcattgacac aggctcacaa gtgtgcaacc
     1381 tggcctggtc caagcatgcc aacgagctgg tgagcacaca tggctactca cagaaccaga
     1441 tcctcgtgtg gaagtacccg tcccttacac aggtggccaa gctcactggc cactcgtatc
     1501 gtgtcctcta cctggccatg tcccctgacg gggaggccat cgtcactgga gctggagatg
     1561 agacccttcg gttctggaac gtcttcagca agacacgctc tacaaaggaa tccgtgtctg
     1621 tgctcaacct ctttacccgg atccgataga cccgcaggcg ggatgcacgg ccccatgggc
     1681 agagatggag tagccagcat gcatgggccc tgctgtacct accgttccca gacgcatctg
     1741 gcgggcggga gtcgggccgg agaccccaga gtctcattaa atgcctcatt gggaaaaaaa
     1801 aaaaaaaaaa aaaaaaaaaa a
//
