LOCUS       NM_153305               2315 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Rattus norvegicus frizzled class receptor 9 (Fzd9), mRNA.
ACCESSION   NM_153305 XM_346428 XM_347354
VERSION     NM_153305.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2315)
  AUTHORS   Shi,Q., Gui,J., Sun,L., Song,Y., Na,J., Zhang,J., Fan,Y. and
            Zheng,L.
  TITLE     Frizzled-9 triggers actin polymerization and activates
            mechano-transducer YAP to rescue simulated microgravity-induced
            osteoblast dysfunction
  JOURNAL   FASEB J 37 (9), e23147 (2023)
   PUBMED   37585277
  REMARK    GeneRIF: Frizzled-9 triggers actin polymerization and activates
            mechano-transducer YAP to rescue simulated microgravity-induced
            osteoblast dysfunction.
REFERENCE   2  (bases 1 to 2315)
  AUTHORS   Ramirez,V.T., Ramos-Fernandez,E., Henriquez,J.P., Lorenzo,A. and
            Inestrosa,N.C.
  TITLE     Wnt-5a/Frizzled9 Receptor Signaling through the Galphao-Gbetagamma
            Complex Regulates Dendritic Spine Formation
  JOURNAL   J Biol Chem 291 (36), 19092-19107 (2016)
   PUBMED   27402827
  REMARK    GeneRIF: findings reveal that FZD9 and heterotrimeric G proteins
            regulate Wnt-5a signaling and dendritic spines in cultured
            hippocampal neurons.
REFERENCE   3  (bases 1 to 2315)
  AUTHORS   Chailangkarn,T., Trujillo,C.A., Freitas,B.C., Hrvoj-Mihic,B.,
            Herai,R.H., Yu,D.X., Brown,T.T., Marchetto,M.C., Bardy,C.,
            McHenry,L., Stefanacci,L., Jarvinen,A., Searcy,Y.M., DeWitt,M.,
            Wong,W., Lai,P., Ard,M.C., Hanson,K.L., Romero,S., Jacobs,B.,
            Dale,A.M., Dai,L., Korenberg,J.R., Gage,F.H., Bellugi,U.,
            Halgren,E., Semendeferi,K. and Muotri,A.R.
  TITLE     A human neurodevelopmental model for Williams syndrome
  JOURNAL   Nature 536 (7616), 338-343 (2016)
   PUBMED   27509850
REFERENCE   4  (bases 1 to 2315)
  AUTHORS   Aviles,E.C., Pinto,C., Hanna,P., Ojeda,J., Perez,V., De
            Ferrari,G.V., Zamorano,P., Albistur,M., Sandoval,D. and
            Henriquez,J.P.
  TITLE     Frizzled-9 impairs acetylcholine receptor clustering in skeletal
            muscle cells
  JOURNAL   Front Cell Neurosci 8, 110 (2014)
   PUBMED   24860427
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2315)
  AUTHORS   Heilmann,A., Schinke,T., Bindl,R., Wehner,T., Rapp,A.,
            Haffner-Luntzer,M., Nemitz,C., Liedert,A., Amling,M. and
            Ignatius,A.
  TITLE     The Wnt serpentine receptor Frizzled-9 regulates new bone formation
            in fracture healing
  JOURNAL   PLoS One 8 (12), e84232 (2013)
   PUBMED   24391920
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2315)
  AUTHORS   Zhao,C., Aviles,C., Abel,R.A., Almli,C.R., McQuillen,P. and
            Pleasure,S.J.
  TITLE     Hippocampal and visuospatial learning defects in mice with a
            deletion of frizzled 9, a gene in the Williams syndrome deletion
            interval
  JOURNAL   Development 132 (12), 2917-2927 (2005)
   PUBMED   15930120
REFERENCE   7  (bases 1 to 2315)
  AUTHORS   Ranheim,E.A., Kwan,H.C., Reya,T., Wang,Y.K., Weissman,I.L. and
            Francke,U.
  TITLE     Frizzled 9 knock-out mice have abnormal B-cell development
  JOURNAL   Blood 105 (6), 2487-2494 (2005)
   PUBMED   15572594
REFERENCE   8  (bases 1 to 2315)
  AUTHORS   Kaykas,A., Yang-Snyder,J., Heroux,M., Shah,K.V., Bouvier,M. and
            Moon,R.T.
  TITLE     Mutant Frizzled 4 associated with vitreoretinopathy traps wild-type
            Frizzled in the endoplasmic reticulum by oligomerization
  JOURNAL   Nat Cell Biol 6 (1), 52-58 (2004)
   PUBMED   14688793
REFERENCE   9  (bases 1 to 2315)
  AUTHORS   Karasawa,T., Yokokura,H., Kitajewski,J. and Lombroso,P.J.
  TITLE     Frizzled-9 is activated by Wnt-2 and functions in Wnt/beta -catenin
            signaling
  JOURNAL   J Biol Chem 277 (40), 37479-37486 (2002)
   PUBMED   12138115
  REMARK    GeneRIF: functions as a Wnt receptor, and is acivated by it
REFERENCE   10 (bases 1 to 2315)
  AUTHORS   Wang,Y.K., Sporle,R., Paperna,T., Schughart,K. and Francke,U.
  TITLE     Characterization and expression pattern of the frizzled gene Fzd9,
            the mouse homolog of FZD9 which is deleted in Williams-Beuren
            syndrome
  JOURNAL   Genomics 57 (2), 235-248 (1999)
   PUBMED   10198163
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF455054.1.
            
            On or before Dec 17, 2003 this sequence version replaced
            XM_346428.1, XM_347354.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AF455054.1, DQ211688.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2315
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..2315
                     /gene="Fzd9"
                     /gene_synonym="rFz9"
                     /note="frizzled class receptor 9"
                     /db_xref="GeneID:266608"
                     /db_xref="RGD:628817"
     exon            1..2315
                     /gene="Fzd9"
                     /gene_synonym="rFz9"
                     /inference="alignment:Splign:2.1.0"
     CDS             239..2017
                     /gene="Fzd9"
                     /gene_synonym="rFz9"
                     /note="Frizzled-like protein 9; frizzled-9; frizzled
                     family receptor 9"
                     /codon_start=1
                     /product="frizzled-9 precursor"
                     /protein_id="NP_695217.1"
                     /db_xref="GeneID:266608"
                     /db_xref="RGD:628817"
                     /translation="MAVPPLLRGALLLWQLLATGGAALEIGRFDPERGRGPAPCQAME
                     IPMCRGIGYNLTRMPNLLGHTSQGEAAAQLAEFSPLVQYGCHSHLRFFLCSLYAPMCT
                     DQVSTPIPACRPMCEQARLRCAPIMEQFNFGWPDSLDCARLPTRNDPHALCMEAPENA
                     TAGPTEPHKGLGMLPVAPRPARPPGDSAPGPGSGGTCDNPEKFQYVEKSRSCAPRCGP
                     GVEVFWSRRDKDFALVWMAVWSALCFFSTAFTVFTFLLEPHRFQYPERPIIFLSMCYN
                     VYSLAFLIRAVAGAQSVACDQEAGALYVIQEGLENTGCTLVFLLLYYFGMASSLWWVV
                     LTLTWFLAAGKKWGHEAIEAHGSYFHMAAWGLPALKTIVVLTLRKVAGDELTGLCYVA
                     SMDPAALTGFVLVPLSCYLVLGTSFLLTGFVALFHIRKIMKTGGTNTEKLEKLMVKIG
                     VFSILYTVPATCVIVCYVYERLNMDFWRLRATEQPCTAAAVPGGRRDCSLPGGSVPTV
                     AVFMLKIFMSLVVGITSGVWVWSSKTFQTWQSLCYRKMAAGRARAKACRTPGGYGRGT
                     HCHYKAPTVVLHMTKTDPSLENPTHL"
ORIGIN      
        1 ggagctgctg cggctggcgg ctgagaccgc gccggctctg gctggagtgg cggcggcagc
       61 ggcggcggcg acagcgacgg cgacggcggt ggtagcggct gttcttccga aggcgccgcg
      121 cgctccagga cacacgtggg cggccgagag atggcgtggg acccgcgacg tggcgcgcag
      181 atcccgggac gcgggatgga gcggcgcgtg tgagccgggg cggccgcgcc gcggggcgat
      241 ggcggtgcca ccgctgctcc gcggggcgct gctgctgtgg cagctgctgg cgacgggcgg
      301 cgcggcgctg gagatcggcc gctttgatcc ggagcgcggc cgtggccccg caccgtgcca
      361 agcgatggag atccccatgt gccggggcat cggctacaac ctgacccgca tgcccaacct
      421 actgggccac acgtcgcagg gcgaggcggc cgcgcagctg gccgagttct cgcctctcgt
      481 gcagtacggc tgccacagcc acctgcgctt cttcctctgc tcgctctacg ccccaatgtg
      541 caccgaccag gtctccactc ccatccccgc ctgccggccc atgtgcgagc aggctcgcct
      601 gcgctgcgcc cccatcatgg agcaattcaa tttcggctgg ccggactccc tcgactgtgc
      661 ccggctcccc acgcgcaacg acccgcacgc gctctgcatg gaggcacccg agaacgctac
      721 cgcaggcccc acagaacccc acaagggcct gggcatgctt cctgtagcac ctcggcccgc
      781 gaggccaccg ggagattcag cccccggtcc gggcagtgga ggcacctgcg acaaccccga
      841 gaagttccag tacgtggaga agagtcgctc gtgcgctccg cgctgcgggc caggcgtcga
      901 ggtgttctgg tctcggcgcg ataaggactt cgcgctggtc tggatggctg tgtggtccgc
      961 gttgtgtttc ttctccacgg ccttcaccgt gttcaccttc ctgctggagc ctcaccgatt
     1021 ccagtaccca gagcgcccta taatcttcct ttccatgtgc tacaatgtct actccttggc
     1081 cttcctgatc agagcggtgg caggtgcaca gagtgtggcc tgcgaccagg aggcaggggc
     1141 tctgtatgtg atccaggagg gtttggaaaa cacaggctgc accctggtct tcctattgct
     1201 ctattatttc gggatggcca gctcactttg gtgggtggtt ttgactctca cctggttcct
     1261 ggctgcaggc aaaaagtggg gccacgaagc catcgaggct cacggtagtt acttccacat
     1321 ggcagcgtgg ggcttgccag cactcaagac tatcgtggtc ctgactctac gtaaggtggc
     1381 tggggatgag ctgactgggc tctgctatgt agctagcatg gacccggcag ctctcactgg
     1441 ctttgtgttg gtgcccctct cttgctactt ggtactgggc accagtttcc tcctgacagg
     1501 ttttgtggct ctcttccata tccgcaaaat tatgaagacg ggcggcacca atacagagaa
     1561 gctggagaag ctgatggtga aaatcggagt cttttccatc ctttacacag tgccggctac
     1621 ctgcgtcatt gtctgctatg tttacgaacg cctcaacatg gacttctggc gtcttcgggc
     1681 cacagagcaa ccatgcactg ccgctgccgt gcctggaggc cggagagact gctcgctgcc
     1741 agggggctcg gtgcccactg tggccgtctt catgctcaaa atcttcatgt ccttggtggt
     1801 gggcatcacc agtggagtct gggtatggag ttccaagact ttccagactt ggcagagtct
     1861 atgttaccga aaaatggcag ctggtcgagc ccgggccaag gcctgccgaa ccccaggggg
     1921 ctatggccgg ggtacccact gtcactacaa agcccccacg gtggtcttgc acatgactaa
     1981 gacagacccc tctctggaga accccacaca cctctagaac ataggctggg ctgagttatg
     2041 gttgctccct ccttgccctc ccctcccccc ctccagagac agctgactaa cagctgccca
     2101 gctgtcaagg tcagacaagt gagacacagg gggctgagga ctagggtggg gacccagtaa
     2161 agctcagggc cttgtctttc cttctcaggc agggagtggg cctagttaag tccacagagg
     2221 gtcctaggat cagaaggggc agaggtgggg cagggtccag agcagagttt atttaatgat
     2281 gtaatttatt gtggcatttc tctggaagct gtgac
//
