LOCUS       NM_001044251            3012 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus frizzled class receptor 8 (Fzd8), mRNA.
ACCESSION   NM_001044251 XM_001065082 XM_344616
VERSION     NM_001044251.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3012)
  AUTHORS   Feng,R., Wan,J., He,Y., Gong,H., Xu,Z. and Feng,J.
  TITLE     Angiotensin-receptor blocker losartan alleviates atrial
            fibrillation in rats by downregulating frizzled 8 and inhibiting
            the activation of WNT-5A pathway
  JOURNAL   Clin Exp Pharmacol Physiol 50 (1), 19-27 (2023)
   PUBMED   36047789
  REMARK    GeneRIF: Angiotensin-receptor blocker losartan alleviates atrial
            fibrillation in rats by downregulating frizzled 8 and inhibiting
            the activation of WNT-5A pathway.
REFERENCE   2  (bases 1 to 3012)
  AUTHORS   Voloshanenko,O., Gmach,P., Winter,J., Kranz,D. and Boutros,M.
  TITLE     Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting
            of receptor gene families
  JOURNAL   FASEB J 31 (11), 4832-4844 (2017)
   PUBMED   28733458
REFERENCE   3  (bases 1 to 3012)
  AUTHORS   Miao,C.G., Shi,W.J., Xiong,Y.Y., Yu,H., Zhang,X.L., Qin,M.S.,
            Du,C.L., Song,T.W. and Li,J.
  TITLE     miR-375 regulates the canonical Wnt pathway through FZD8 silencing
            in arthritis synovial fibroblasts
  JOURNAL   Immunol Lett 164 (1), 1-10 (2015)
   PUBMED   25619565
  REMARK    GeneRIF: miR-375 regulates the canonical Wnt pathway through FZD8
            silencing in arthritis synovial fibroblasts
REFERENCE   4  (bases 1 to 3012)
  AUTHORS   Janda,C.Y., Waghray,D., Levin,A.M., Thomas,C. and Garcia,K.C.
  TITLE     Structural basis of Wnt recognition by Frizzled
  JOURNAL   Science 337 (6090), 59-64 (2012)
   PUBMED   22653731
REFERENCE   5  (bases 1 to 3012)
  AUTHORS   Hao,H.X., Xie,Y., Zhang,Y., Charlat,O., Oster,E., Avello,M.,
            Lei,H., Mickanin,C., Liu,D., Ruffner,H., Mao,X., Ma,Q., Zamponi,R.,
            Bouwmeester,T., Finan,P.M., Kirschner,M.W., Porter,J.A.,
            Serluca,F.C. and Cong,F.
  TITLE     ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive
            manner
  JOURNAL   Nature 485 (7397), 195-200 (2012)
   PUBMED   22575959
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3012)
  AUTHORS   Yao,R., Maeda,T., Takada,S. and Noda,T.
  TITLE     Identification of a PDZ domain containing Golgi protein, GOPC, as
            an interaction partner of frizzled
  JOURNAL   Biochem Biophys Res Commun 286 (4), 771-778 (2001)
   PUBMED   11520064
REFERENCE   7  (bases 1 to 3012)
  AUTHORS   Semenov,M.V., Tamai,K., Brott,B.K., Kuhl,M., Sokol,S. and He,X.
  TITLE     Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6
  JOURNAL   Curr Biol 11 (12), 951-961 (2001)
   PUBMED   11448771
REFERENCE   8  (bases 1 to 3012)
  AUTHORS   Mao,B., Wu,W., Li,Y., Hoppe,D., Stannek,P., Glinka,A. and Niehrs,C.
  TITLE     LDL-receptor-related protein 6 is a receptor for Dickkopf proteins
  JOURNAL   Nature 411 (6835), 321-325 (2001)
   PUBMED   11357136
REFERENCE   9  (bases 1 to 3012)
  AUTHORS   Staal,F.J., Meeldijk,J., Moerer,P., Jay,P., van de Weerdt,B.C.,
            Vainio,S., Nolan,G.P. and Clevers,H.
  TITLE     Wnt signaling is required for thymocyte development and activates
            Tcf-1 mediated transcription
  JOURNAL   Eur J Immunol 31 (1), 285-293 (2001)
   PUBMED   11265645
REFERENCE   10 (bases 1 to 3012)
  AUTHORS   Tamai,K., Semenov,M., Kato,Y., Spokony,R., Liu,C., Katsuyama,Y.,
            Hess,F., Saint-Jeannet,J.P. and He,X.
  TITLE     LDL-receptor-related proteins in Wnt signal transduction
  JOURNAL   Nature 407 (6803), 530-535 (2000)
   PUBMED   11029007
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC100088.1.
            
            On Aug 31, 2012 this sequence version replaced NM_001044251.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC100088.1 [ECO:0000345]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3012              BC100088.1         4-3015
FEATURES             Location/Qualifiers
     source          1..3012
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.1"
     gene            1..3012
                     /gene="Fzd8"
                     /note="frizzled class receptor 8"
                     /db_xref="GeneID:364754"
                     /db_xref="RGD:1560525"
     exon            1..2986
                     /gene="Fzd8"
                     /inference="alignment:Splign:2.1.0"
     CDS             241..2295
                     /gene="Fzd8"
                     /note="frizzled-8; fz-8; frizzled family receptor 8;
                     frizzled-8-like"
                     /codon_start=1
                     /product="frizzled-8 precursor"
                     /protein_id="NP_001037716.1"
                     /db_xref="GeneID:364754"
                     /db_xref="RGD:1560525"
                     /translation="MEWGYLLEVTSLLAALAVLQRSSGAAAASAKELACQEITVPLCK
                     GIGYNYTYMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLKFFLCSMYTPICLEDYKK
                     PLPPCRSVCERAKAGCAPLMRQYGFAWPDRMRCDRLPEQGNPDTLCMDYNRTDLTTAA
                     PSPPRRLPPPQPGEQPPSGSGHSRPPGARPPHRGGSSRGSGDTAAAPPSRGGKARPPG
                     GGAAPCEPGCQCRAPMVSVSSERHPLYNRVKTGQIANCALPCHNPFFSQDERAFTVFW
                     IGLWSVLCFVSTFATVSTFLIDMERFKYPERPIIFLSACYLFVSVGYLVRLVAGHEKV
                     ACSGGAPGAGGAGGAGGAATAGAGAAGAGASSPGARGEYEELGAVEQHVRYETTGPAL
                     CTVVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYSQYFHLAAWLVPSVKS
                     IAVLALSSVDGDPVAGICYVGNQSLDNLRGFVLAPLVIYLFIGTMFLLAGFVSLFRIR
                     SVIKQQGGPTKTHKLEKLMIRLGLFTVLYTVPAAVVVACLFYEQHNRPRWEATHNCPC
                     LRDLQPDQARRPDYAVFMLKYFMCLVVGITSGVWVWSGKTLESWRALCTRCCWASKGA
                     AVGAGAGGSGPGGGGPGPGGGGGHGGGGGSLYSDVSTGLTWRSGTASSVSYPKQMPLS
                     QV"
ORIGIN      
        1 gtctgcggtc accccaggag aggcgtgggg gagggccgga cgagtcctgc ctaggtttcc
       61 gaccctgctg ccacagacgc tgcctgaaaa ggagataaat tgttggcaga ttctcctctc
      121 ggcagagaaa agccggacaa gaccttctgg tcgcctgcac tccctttact caggttcctc
      181 accgtagagc ccttctgcgc ggcgcccgga gaaggaggac ttggggtccc ggcgctcagc
      241 atggagtggg gttacctgtt ggaagtgacc tcgctactag ccgccttggc ggtgctacag
      301 cgctcgagcg gcgctgccgc ggcttcggcc aaggagctgg cgtgccaaga gatcacagtg
      361 ccgctgtgca agggcatcgg ttacaactac acctacatgc ccaaccagtt caaccacgac
      421 acgcaagatg aggcgggcct agaggtacac cagttctggc cgctggtgga gatccagtgc
      481 tccccggacc tcaagttctt tctgtgtagc atgtacacgc ccatctgcct ggaggactac
      541 aagaaacctc tgccgccttg ccgctctgtg tgtgaacgcg ccaaggccgg ctgcgcgccg
      601 ctcatgcgcc agtacggctt tgcctggcct gaccgaatgc gctgcgatcg gctgccggag
      661 cagggcaacc ccgacactct gtgcatggac tacaaccgca ccgacctcac cacggccgcg
      721 cccagcccac cgcgccgcct gccgccgccg cagcctggcg agcagccgcc ctccggcagc
      781 ggccacagcc gcccgccagg ggccaggccc ccacatcgtg gcggcagcag taggggcagc
      841 ggggacacgg cggctgcgcc cccctctcgc ggcgggaagg cgaggccccc tggtggcggc
      901 gccgctccct gcgagcccgg gtgccagtgc cgcgcgccca tggtgagtgt gtccagcgaa
      961 cgccacccgc tctacaaccg cgtcaagacc ggccagatcg ccaactgtgc gctgccctgc
     1021 cacaacccct tctttagcca ggatgagcgc gccttcactg tcttctggat cggcttgtgg
     1081 tcggtgctct gcttcgtctc caccttcgcc actgtctcta ccttcctcat cgatatggag
     1141 cgctttaagt acccggaacg gcccattata ttcctctctg cctgctacct cttcgtgtct
     1201 gtcgggtacc tggtgcgcct ggtggctgga cacgagaaag tggcctgcag cggcggcgcg
     1261 ccgggtgcag gaggagctgg gggtgctggc ggcgcggcga ccgctggcgc gggggcggcg
     1321 ggagcggggg cgagcagccc gggcgcgcgc ggcgagtacg aggagctggg tgcagtggag
     1381 cagcacgtgc gctatgagac cactggcccc gcgctgtgca cggtagtctt cctccttgtc
     1441 tacttttttg gcatggctag ctccatctgg tgggtaatcc tgtctctcac gtggttcttg
     1501 gcggctggta tgaaatgggg caacgaggcc atagcaggct actcgcaata cttccacctt
     1561 gccgcgtggc tcgtgcccag cgtcaagtcc atagcggtgc tggcgctcag ctccgtggac
     1621 ggcgacccgg tggcgggcat ctgctacgtg ggcaaccaga gccttgacaa cctacgcggc
     1681 tttgtactgg cgccactggt catctacctc ttcattggga ctatgtttct gttagctggc
     1741 ttcgtgtcgc tgttccgaat ccgctcagtc atcaagcaac aaggaggccc aaccaagact
     1801 cacaagctag aaaagctcat gatccgcttg ggcctcttca ccgtgctcta cacggtgccc
     1861 gccgccgtcg ttgtcgcctg ccttttctat gagcagcaca accgaccgcg ctgggaggcc
     1921 acgcacaact gcccatgcct tcgcgacctg cagccagacc aggctcgcag gcccgactac
     1981 gcggtcttca tgctcaagta cttcatgtgc ctagtggtgg gcatcacatc aggcgtgtgg
     2041 gtctggtccg gcaagactct ggagtcctgg cgtgcgttgt gtactcgctg ctgctgggcc
     2101 agcaagggcg ctgcagttgg cgcgggcgcc ggaggcagcg gccctggggg cggtggcccc
     2161 gggcccggtg ggggtggggg gcacggcgga ggtgggggat ccctctacag cgacgtcagc
     2221 accggcctga cgtggcggtc tggcacggcc agctctgtat cttaccctaa gcaaatgcca
     2281 ttgtcccaag tctgaaccct gaacggaagc ccagaagggg cggagagggg tgggggatgg
     2341 agaacccgag ggcggcgaag ggaccccaga tcggccgggg ttcccacccc ttcaccgtgt
     2401 tgactgctat tagcatgata atgaactctt aatggtatcc attagccaca gggacttaaa
     2461 tgattccctt agaacaaagt acctggcatt gaagcctccc agacctagcc cctcccctcc
     2521 gatgctccgg agcgcctacc ctagacaatg gtttcagtgg gctagcatag ttggaaccct
     2581 cctggatacc ctggatgagt cttgaggtaa taccactaca aacttcaccc aagggactgc
     2641 ttcaccctcg acttcttcag cataaattca acccttcata catcctagag gagggacaac
     2701 tgctaccttg tgggactgca cggtttgggt attcttaatg accaggcaga tgccttaaat
     2761 aaacaataaa tgtcttaatt atacacccca agtaaatacg ggtttcttac attaaaggat
     2821 gtatttatat aattatttgt taagttgtaa aaaaaaaaaa ggtgtaaatt atgtatatat
     2881 ccaaagatat acaatgtgta cattatttgt aaaaagttta gaggctaccc tgtaagaaca
     2941 aatataagta ttctattttg tcaataaaat gacttttgat aaatgaaaaa aaaaaaaaaa
     3001 aaaaaaaaaa aa
//
