LOCUS       NM_001130536            4202 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus frizzled class receptor 6 (Fzd6), mRNA.
ACCESSION   NM_001130536 XM_001061748 XM_343230
VERSION     NM_001130536.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4202)
  AUTHORS   Zhou,F., Zhou,P., Jiang,X., Yang,Z., Cui,W., Liu,W. and Liu,R.
  TITLE     Fengshi Liuhe Decoction treatment for rheumatoid arthritis via the
            Fzd6/NF-kappaB signaling axis
  JOURNAL   Gene 920, 148538 (2024)
   PUBMED   38710294
  REMARK    GeneRIF: Fengshi Liuhe Decoction treatment for rheumatoid arthritis
            via the Fzd6/NF-kappaB signaling axis.
REFERENCE   2  (bases 1 to 4202)
  AUTHORS   Choi,J.H., Zhong,X., McAlpine,W., Liao,T.C., Zhang,D., Fang,B.,
            Russell,J., Ludwig,S., Nair-Gill,E., Zhang,Z., Wang,K.W.,
            Misawa,T., Zhan,X., Choi,M., Wang,T., Li,X., Tang,M., Sun,Q.,
            Yu,L., Murray,A.R., Moresco,E.M.Y. and Beutler,B.
  TITLE     LMBR1L regulates lymphopoiesis through Wnt/beta-catenin signaling
  JOURNAL   Science 364 (6440) (2019)
   PUBMED   31073040
REFERENCE   3  (bases 1 to 4202)
  AUTHORS   Chang,H., Cahill,H., Smallwood,P.M., Wang,Y. and Nathans,J.
  TITLE     Identification of Astrotactin2 as a Genetic Modifier That Regulates
            the Global Orientation of Mammalian Hair Follicles
  JOURNAL   PLoS Genet 11 (9), e1005532 (2015)
   PUBMED   26418459
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4202)
  AUTHORS   Cui,C.Y., Klar,J., Georgii-Heming,P., Frojmark,A.S., Baig,S.M.,
            Schlessinger,D. and Dahl,N.
  TITLE     Frizzled6 deficiency disrupts the differentiation process of nail
            development
  JOURNAL   J Invest Dermatol 133 (8), 1990-1997 (2013)
   PUBMED   23439395
REFERENCE   5  (bases 1 to 4202)
  AUTHORS   Hao,H.X., Xie,Y., Zhang,Y., Charlat,O., Oster,E., Avello,M.,
            Lei,H., Mickanin,C., Liu,D., Ruffner,H., Mao,X., Ma,Q., Zamponi,R.,
            Bouwmeester,T., Finan,P.M., Kirschner,M.W., Porter,J.A.,
            Serluca,F.C. and Cong,F.
  TITLE     ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive
            manner
  JOURNAL   Nature 485 (7397), 195-200 (2012)
   PUBMED   22575959
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4202)
  AUTHORS   Lyons,J.P., Mueller,U.W., Ji,H., Everett,C., Fang,X., Hsieh,J.C.,
            Barth,A.M. and McCrea,P.D.
  TITLE     Wnt-4 activates the canonical beta-catenin-mediated Wnt pathway and
            binds Frizzled-6 CRD: functional implications of Wnt/beta-catenin
            activity in kidney epithelial cells
  JOURNAL   Exp Cell Res 298 (2), 369-387 (2004)
   PUBMED   15265686
REFERENCE   7  (bases 1 to 4202)
  AUTHORS   Guo,N., Hawkins,C. and Nathans,J.
  TITLE     Frizzled6 controls hair patterning in mice
  JOURNAL   Proc Natl Acad Sci U S A 101 (25), 9277-9281 (2004)
   PUBMED   15169958
REFERENCE   8  (bases 1 to 4202)
  AUTHORS   Golan,T., Yaniv,A., Bafico,A., Liu,G. and Gazit,A.
  TITLE     The human Frizzled 6 (HFz6) acts as a negative regulator of the
            canonical Wnt. beta-catenin signaling cascade
  JOURNAL   J Biol Chem 279 (15), 14879-14888 (2004)
   PUBMED   14747478
REFERENCE   9  (bases 1 to 4202)
  AUTHORS   Daudet,N., Ripoll,C., Moles,J.P. and Rebillard,G.
  TITLE     Expression of members of Wnt and Frizzled gene families in the
            postnatal rat cochlea
  JOURNAL   Brain Res Mol Brain Res 105 (1-2), 98-107 (2002)
   PUBMED   12399112
REFERENCE   10 (bases 1 to 4202)
  AUTHORS   Bafico,A., Gazit,A., Pramila,T., Finch,P.W., Yaniv,A. and
            Aaronson,S.A.
  TITLE     Interaction of frizzled related protein (FRP) with Wnt ligands and
            the frizzled receptor suggests alternative mechanisms for FRP
            inhibition of Wnt signaling
  JOURNAL   J Biol Chem 274 (23), 16180-16187 (1999)
   PUBMED   10347172
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473950.2.
            
            On or before Jul 28, 2008 this sequence version replaced
            XM_343230.3, XM_001061748.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132263 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..4202
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..4202
                     /gene="Fzd6"
                     /note="frizzled class receptor 6"
                     /db_xref="GeneID:282581"
                     /db_xref="RGD:628816"
     exon            1..140
                     /gene="Fzd6"
                     /inference="alignment:Splign:2.1.0"
     exon            141..477
                     /gene="Fzd6"
                     /inference="alignment:Splign:2.1.0"
     CDS             301..2433
                     /gene="Fzd6"
                     /note="frizzled-6; frizzled family receptor 6"
                     /codon_start=1
                     /product="frizzled-6 precursor"
                     /protein_id="NP_001124008.1"
                     /db_xref="GeneID:282581"
                     /db_xref="RGD:628816"
                     /translation="MEASPFLSACILLPLIRGHSLFTCEPITVPRCMKMAYNMTFFPN
                     LMGHYDQGIAAVEMEHFLPLANLECSPNIEMFLCQAFVPTCTEQIDVVSPCRKLCEKI
                     LSDCQKLMDTFGIRWPEELECHRLPYCDGAVPVTSDPHTELFGPQKKTDQVPRDIGFW
                     CPKHLRTSGDQGYRFLGIDQCAPPCPNMYFKSDELDFAKSFIGIVSIFCLCATLFTFL
                     TFLIDVRRFRYPERPIIYYSVCYSIVSLMYFVGFLLGNSTACNKADEKLELGNTVVLG
                     SKNKACSVVFMFLYFFTMAGTVWWVILTITWFLAAGRKWSCEAIEQKAVWFHAVAWGM
                     PGFLTVMLLAMNKVEGDNISGVCFVGLYDLDASRYFVLLPLCLCVFVGLSLLLAGIIS
                     LNHVRQVIQHDGRNQEKLKKFMIRIGVFSGLYLVPLVTLLGCYVYELVNRVTWEMTWF
                     SDHCHQYRIPCPYQANPKARPELALFMIKYLMTLIVGISAVFWVGSKKTCTEWAGFCK
                     RNRKRDPISESRRVLQESCEFFLKHNSKVRHKKKHGKPGSHKLKVISKSMGTSTGVTT
                     DHGTSAVAIADHDYLGQETSAEVQTSPEASLKEGRADRANTPRAKGPDCGEPASTAAS
                     NSKFSGDQIDRKSRAGSVKEKSSVSEGAPSEGRVSPKGVPGTGLMECTLQIPSSPEPN
                     SLKGSTSLLVRSASGTRKEQGAGGHSDT"
     exon            478..674
                     /gene="Fzd6"
                     /inference="alignment:Splign:2.1.0"
     exon            675..1692
                     /gene="Fzd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1841
                     /gene="Fzd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..2270
                     /gene="Fzd6"
                     /inference="alignment:Splign:2.1.0"
     exon            2271..4202
                     /gene="Fzd6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggctgccg gcacgccggg gctgtctgaa gtggcggggc cgatcgacgc cagagacagc
       61 cgccaccgcc cccgccgccc gaggtgaggc gtccccggcc cgacggggcg ggcgggcagc
      121 ggccgggacc cgagccgcag cagttgtccc agaactcatt ttcaggaaac ggcttctttc
      181 aaaatggtaa aaataatgaa atgaggaatt tgtccatttt atctccaatt tgagaatctt
      241 ttgatgcgga aaggagcata agagtaatcc aagccatgtg gtaatcggag tctggggaag
      301 atggaagcgt ccccgtttct gtcggcctgc attcttctgc ccctcataag agggcacagc
      361 cttttcacct gtgagccaat cactgttccc agatgtatga aaatggccta caacatgacg
      421 tttttcccta acctgatggg tcattatgac cagggcattg ctgctgtgga aatggagcac
      481 tttctgcctc ttgcaaatct ggaatgttca ccaaacattg aaatgtttct ttgccaagct
      541 tttgtaccaa cctgcacaga gcaaattgat gtggtttcac cttgtcggaa attgtgtgag
      601 aaaatacttt ctgattgcca aaagttaatg gacacttttg ggatccgatg gcctgaagaa
      661 cttgaatgtc acagattgcc gtactgtgat ggcgctgttc ctgttacttc tgatccacac
      721 acagagcttt ttggtccaca gaagaaaaca gatcaagtcc caagggacat tggattttgg
      781 tgtccaaagc accttaggac ttccggggac caaggctata ggtttctggg aattgaccag
      841 tgtgcccctc cgtgtcctaa catgtacttt aaaagtgatg aactagactt tgccaaaagt
      901 ttcataggaa tagtttcaat attttgtctt tgtgcaactt tgttcacgtt tcttactttt
      961 ttaattgacg tcagaagatt caggtaccca gagagaccaa ttatatacta ctccgtctgt
     1021 tacagcatcg tctctctcat gtactttgtt gggtttttgc tgggcaatag cacagcttgt
     1081 aataaggcag atgagaagct ggaactcggg aacacagtcg ttctagggtc aaagaataag
     1141 gcttgcagcg tggtgtttat gtttctgtac tttttcacaa tggccggcac cgtgtggtgg
     1201 gtgatcctca ccattacgtg gttcttagcc gccggaagaa aatggagttg cgaagctatt
     1261 gaacaaaaag cagtgtggtt tcacgccgtt gcctggggga tgcccgggtt cctgactgtc
     1321 atgctgctcg ctatgaacaa ggttgaagga gacaacatta gcggcgtttg cttcgttggc
     1381 ctgtatgact tagatgcctc ccgctacttc gtccttctgc ctctgtgcct ctgtgtgttt
     1441 gttgggctgt ctctcctctt agctggcatc atttccttaa atcacgttcg acaagttata
     1501 caacatgatg gccgaaacca agagaagctc aagaagttca tgatccgcat tggagtcttc
     1561 agtggcctgt atcttgtgcc cttagtgacg cttcttggct gctatgtcta tgagctagtg
     1621 aacagggtca cctgggagat gacgtggttc tctgatcact gtcaccagta ccgcatcccg
     1681 tgtccttacc aggcaaaccc aaaagctcga ccagaattgg ctttatttat gataaaatat
     1741 ctgatgacat taattgttgg tatctctgcg gtcttctggg ttggaagcaa aaagacgtgc
     1801 acagaatggg ccgggttctg taagcgaaac cgcaagcgcg accccatcag tgagagccga
     1861 agagtgctgc aagagtcctg tgagttcttc ctgaagcaca attccaaagt gaggcacaag
     1921 aagaagcatg gcaaaccagg ctcacataaa ctgaaggtca tttccaagtc catgggaact
     1981 agcacgggcg tgaccacaga ccatggcacc tctgccgtag caattgccga ccatgattac
     2041 ttagggcagg aaacttcagc agaagtccag acctccccag aagcatccct gaaagagggg
     2101 agagcagacc gagcaaacac gcccagagcc aaaggtccag actgtggaga acctgcttcc
     2161 acagcagcgt ccaactccaa gttctctggg gaccagatcg acaggaaaag ccgagcaggc
     2221 agcgtgaagg agaaaagcag cgtatcggaa ggggctccaa gtgaaggaag ggtaagtcca
     2281 aagggcgttc ctgggactgg cctgatggag tgcactttac agatccccag ctctccagaa
     2341 ccaaacagcc tcaaaggttc cacatctctg cttgttcgct cagcttccgg aactaggaaa
     2401 gagcagggtg ctggcggcca ttctgatact tgaagaaaac tgtctctacc ccgggagctg
     2461 tacactacac tggagacgac cttgtcttat aaaagaacac tgtggagctg ggagttgccc
     2521 agtggcagag tgctcacctg ggatacttga ggacctgggt ttacctctca gcacagcaga
     2581 aagagagttc actgttgccg tcttccatgc acttaagcca gctttgtcta ctggtttttt
     2641 tggcttggct tttatttttg ttgcttttat ttttgttgtt gttgttgttc gtttgtttgt
     2701 ttgtttgttt gattcagggt ttctttgtga gccctggctg tcctggaact ccctctgtag
     2761 accaggctag cctcaaagtt ccagagattc gcctgcctct gcctcccggg tgctgggaat
     2821 aatggtgtgg ctaccaccgc ccagcctttt gtctactgtt aaactggaaa gaaacaacag
     2881 cccagatttc aaaaataata taatgcattt atacctaaaa aaaaggaatg tccaggttaa
     2941 taatattttt taaatgtggg ggtaggaagg gcattagaaa tttccttctg tttatgaaga
     3001 ttctttcatt aaagtattta agatatttta tgctgtttca ctcttttttt tttttttttt
     3061 ttttggttcg tttttttcgg agctggagac cgaacccagg gccttgcgct tcctaggtaa
     3121 gcgctctacc actgagctaa agccccagcc ccttgtttca ctcttttgat ataaattcag
     3181 gatttttctt tgctgaagta tttaaaactt atcattgaac ctttatatgt agatacataa
     3241 gtatttgaac ttttttgaaa atcctagaaa attgaatcaa atatgtttat gatgttttta
     3301 atattttggc tactttgcaa ctatggtagc tgttacactg gattctaagg agcttacgca
     3361 gcagcctctc tccagtaacg gagtaggtgt cacactgaaa ggtttgtaag aagcgctcag
     3421 ctctcagagc cgctcttgcc ttccctggac tgaggaactt gctgacagtc tctcccaagt
     3481 gtatggtccc tttcctcctg cgtgttcgca aattagcagg tgagatgtta gttctttaca
     3541 aattaggcca ctctgtttat ttcctttttg ttttaagtgt ttcatgacca ctcaagattg
     3601 aattatggcc atttttaatg gctcgtgcct gttttatttt atcttactct tctattttct
     3661 gagacagggt ctcactgtcg ctctccttgg ctgtctggtg ctcagtgaga cttcgcacat
     3721 cacagaggtc caccctctgc agttcactca tctcccaagt gctggggtta aaggcttgaa
     3781 ccaccacact cagcttttat cttttttaaa aaatttaaac ttaaaaaatg tttttagaat
     3841 gctacagaca cattgtgttg tatctttctt agacagttta caaaattcct atctgcagct
     3901 aaacctgata aagaaaatgt gctgaggaca gagtggggca gggagagtgt agtgtagcaa
     3961 atacagtgtg aaaagacact taaagtgcta agagagtttc ttaatgttgt ttctccccaa
     4021 gtattatctc tgcagcaagg ttctcttggc taccttgagc ctgttggacc cctgttaaag
     4081 tttaaaatga aagttatcat gtactgtatg gaaaatgtaa atactaactt ttccacaaat
     4141 gtaaactttg gacacaagaa cttttttgtg tgatcttttc atcaataaaa ttttctttgt
     4201 at
//
