LOCUS       NM_173838               6902 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus frizzled class receptor 5 (Fzd5), mRNA.
ACCESSION   NM_173838
VERSION     NM_173838.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6902)
  AUTHORS   Dai,Y., Lu,H., Wang,S., Chang,S., Li,C., Huang,Z., Zhang,F.,
            Yang,H., Shen,Y., Chen,Z., Qian,J. and Ge,J.
  TITLE     MicroRNA-216b actively modulates diabetic angiopathy through
            inverse regulation on FZD5
  JOURNAL   Gene 658, 129-135 (2018)
   PUBMED   29477872
  REMARK    GeneRIF: MicroRNA-216b was overexposed in diabetic myocardial
            microvascular endothelial cells and its downregulation may actively
            enhance angiogenesis in diabetic angiopathy through inverse
            regulation on FZD5.
REFERENCE   2  (bases 1 to 6902)
  AUTHORS   Voloshanenko,O., Gmach,P., Winter,J., Kranz,D. and Boutros,M.
  TITLE     Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting
            of receptor gene families
  JOURNAL   FASEB J 31 (11), 4832-4844 (2017)
   PUBMED   28733458
REFERENCE   3  (bases 1 to 6902)
  AUTHORS   Ivatt,R.M., Sanchez-Martinez,A., Godena,V.K., Brown,S., Ziviani,E.
            and Whitworth,A.J.
  TITLE     Genome-wide RNAi screen identifies the Parkinson disease GWAS risk
            locus SREBF1 as a regulator of mitophagy
  JOURNAL   Proc Natl Acad Sci U S A 111 (23), 8494-8499 (2014)
   PUBMED   24912190
REFERENCE   4  (bases 1 to 6902)
  AUTHORS   Xavier,C.P., Melikova,M., Chuman,Y., Uren,A., Baljinnyam,B. and
            Rubin,J.S.
  TITLE     Secreted Frizzled-related protein potentiation versus inhibition of
            Wnt3a/beta-catenin signaling
  JOURNAL   Cell Signal 26 (1), 94-101 (2014)
   PUBMED   24080158
REFERENCE   5  (bases 1 to 6902)
  AUTHORS   Slater,P.G., Ramirez,V.T., Gonzalez-Billault,C., Varela-Nallar,L.
            and Inestrosa,N.C.
  TITLE     Frizzled-5 receptor is involved in neuronal polarity and
            morphogenesis of hippocampal neurons
  JOURNAL   PLoS One 8 (10), e78892 (2013)
   PUBMED   24205342
  REMARK    GeneRIF: Fzd5 has a role in the establishment of neuronal polarity,
            and in the morphogenesis of neuronal processes
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6902)
  AUTHORS   Staal,F.J., Meeldijk,J., Moerer,P., Jay,P., van de Weerdt,B.C.,
            Vainio,S., Nolan,G.P. and Clevers,H.
  TITLE     Wnt signaling is required for thymocyte development and activates
            Tcf-1 mediated transcription
  JOURNAL   Eur J Immunol 31 (1), 285-293 (2001)
   PUBMED   11265645
REFERENCE   7  (bases 1 to 6902)
  AUTHORS   Ishikawa,T., Tamai,Y., Zorn,A.M., Yoshida,H., Seldin,M.F.,
            Nishikawa,S. and Taketo,M.M.
  TITLE     Mouse Wnt receptor gene Fzd5 is essential for yolk sac and
            placental angiogenesis
  JOURNAL   Development 128 (1), 25-33 (2001)
   PUBMED   11092808
REFERENCE   8  (bases 1 to 6902)
  AUTHORS   Tamai,K., Semenov,M., Kato,Y., Spokony,R., Liu,C., Katsuyama,Y.,
            Hess,F., Saint-Jeannet,J.P. and He,X.
  TITLE     LDL-receptor-related proteins in Wnt signal transduction
  JOURNAL   Nature 407 (6803), 530-535 (2000)
   PUBMED   11029007
REFERENCE   9  (bases 1 to 6902)
  AUTHORS   Medina,A. and Steinbeisser,H.
  TITLE     Interaction of Frizzled 7 and Dishevelled in Xenopus
  JOURNAL   Dev Dyn 218 (4), 671-680 (2000)
   PUBMED   10906785
REFERENCE   10 (bases 1 to 6902)
  AUTHORS   He,X., Saint-Jeannet,J.P., Wang,Y., Nathans,J., Dawid,I. and
            Varmus,H.
  TITLE     A member of the Frizzled protein family mediating axis induction by
            Wnt-5A
  JOURNAL   Science 275 (5306), 1652-1654 (1997)
   PUBMED   9054360
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000214.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_173838.3.
            
            On Oct 18, 2022 this sequence version replaced NM_173838.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN12840111
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-619               JACYVU010000214.1  22114549-22115167   c
            620-6902            JACYVU010000214.1  22107987-22114269   c
FEATURES             Location/Qualifiers
     source          1..6902
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q32"
     gene            1..6902
                     /gene="Fzd5"
                     /note="frizzled class receptor 5"
                     /db_xref="GeneID:317674"
                     /db_xref="RGD:631406"
     exon            1..619
                     /gene="Fzd5"
                     /inference="alignment:Splign:2.1.0"
     exon            620..6902
                     /gene="Fzd5"
                     /inference="alignment:Splign:2.1.0"
     CDS             871..2628
                     /gene="Fzd5"
                     /note="frizzled-5; fz-5; frizzled family receptor 5"
                     /codon_start=1
                     /product="frizzled-5 precursor"
                     /protein_id="NP_776210.2"
                     /db_xref="GeneID:317674"
                     /db_xref="RGD:631406"
                     /translation="MARPDPSAPPSLLLLLLAQLVGRAAAASKAPVCQEITVPMCRGI
                     GYNLTHMPNQFNHDTQDEAGLEVHQFWPLVEIHCSPDLRFFLCSMYTPICLPDYHKPL
                     PPCRSVCERAKAGCSPLMRQYGFAWPERMSCDRLPVLGGDAEVLCMDYNRSEATTASP
                     KSFPAKPTLPGPPGAPSSGGECPSGGPSVCTCREPFVPILKESHPLYNKVRTGQVPNC
                     AVPCYQPSFSPDERTFATFWIGLWSVLCFISTSTTVATFLIDMERFRYPERPIIFLSA
                     CYLCVSLGFLVRLVVGHASVACSREHSHIHYETTGPALCTVVFLLVYFFGMASSIWWV
                     ILSLTWFLAAGMKWGNEAIAGYAQYFHLAAWLIPSVKSITALALSSVDGDPVAGICYV
                     GNQNLNSLRGFVLGPLVLYLLVGTLFLLAGFVSLFRIRSVIKQGGTKTDKLEKLMIRI
                     GIFTLLYTVPASIVVACYLYEQHYRESWEAALTCACPGSDAGQPRAKPEYWVLMLKYF
                     MCLVVGITSGVWIWSGKTLESWRRFTSRCCCSSRRGHKSGGAMVAGDYAEASAALTGR
                     TGPPGPAAAYHKQVSLSHV"
ORIGIN      
        1 agagggcagg cagcctgtag ccgagactcg tccgctgccg tcgcgcaccg tacggagctc
       61 cctggaggtg ggcgaaagag tgcgagagcg cgggggagga gccgagtggg gcgcgtcccg
      121 agagcgccgc caccgccccc cggagtctgc tggagcgcgg agccccctgc aggggaggcg
      181 gcgagcggct ggcgggacgc ggcggcgggc gcggaccatg cagtccccgc ccggccagcg
      241 ctggctgctc gctgtgctgt gaggtggcgg ggtcccctcc ggctgccgca tccctccgcc
      301 ttccagttca agtgctgccc ggcgcccttg cccttcgtcc cggccccggg acgccggtgg
      361 aaggcacggc ctgcccctgc cttgctctgc ccgaatcatg cagggggccc cgaaggaaga
      421 gaagccgact gaccggcccg cgccgcccgt ggtcgagggg cgcccggctc tctgaaaggt
      481 cctccacctg ctgccatgtg tcgccgccac aggtacctag cttgtcctta aactttccca
      541 gctctgggcc gattcggagt cgcgggacgg aggagcccgg ctggctgcag acatctgccg
      601 cctagcagga tcctcagaga gttctgtcct tggagtcgga gccctaatag tccctccagc
      661 tctatctggc gtggagctga gcgctgccgg cggaggcagc gccttccaga aacagttgat
      721 ctttggacgg atttctttaa ggaaaagaaa ccaacaggtt gccagcccgg gcgtcacagt
      781 caagactcca gagagggaag ccccggccgc agattcgtcg gtcaacgcag accctctcgg
      841 gcagcgggtg gcaaagggaa gaagggggcg atggctagac ccgacccgtc cgcgccgccc
      901 tctcttctgc tgctgttgct ggcacagctg gtgggccggg cagcggccgc ctccaaggcc
      961 ccagtgtgcc aggaaatcac ggtgcccatg tgccgcggca tcggctacaa cctgacgcac
     1021 atgcccaacc agttcaacca tgacactcag gacgaagcag gcctggaggt gcaccaattc
     1081 tggccgctgg tggagatcca ctgttccccg gacctgcgct tcttcctgtg ctccatgtac
     1141 acgcccatct gcttgcctga ctaccacaag ccgctaccac cgtgccgctc cgtgtgcgag
     1201 cgcgccaagg ccggctgctc gccactcatg cgccagtacg gcttcgcctg gcccgagcgc
     1261 atgagttgcg accgcctccc agtgctgggc ggcgacgctg aggttctgtg catggattat
     1321 aaccgaagtg aagccaccac cgcgtcccct aagtccttcc cggccaaacc cacactccca
     1381 ggaccaccag gggcgccatc ttccgggggc gaatgtccct cgggaggccc gtctgtgtgc
     1441 acgtgccgcg agcccttcgt gcccatcctg aaggagtcac acccactcta caacaaggtg
     1501 cgcaccggcc aagtgcccaa ctgcgcagtg ccctgctacc agccgtcctt cagcccggat
     1561 gagcgcacgt tcgccacctt ctggattggc ctgtggtctg tgctgtgctt catctccacg
     1621 tccaccactg tagcgacctt cctcattgac atggaacgat tccgctaccc tgagcgcccc
     1681 atcatcttcc tgtctgcgtg ctacctgtgt gtgtcactgg gattcttggt gcgcctggtt
     1741 gtaggccatg ccagcgtcgc ctgcagccga gagcacagcc acattcacta tgagactacc
     1801 ggccctgcgc tgtgcacagt cgtcttcctc ttagtctact tctttggcat ggccagctcc
     1861 atctggtggg tcatcctgtc gctcacctgg ttcttggcgg ctggcatgaa gtggggcaat
     1921 gaagccatcg caggctatgc acagtacttc caccttgctg cctggctcat ccccagcgtc
     1981 aagtccatta cggcgctggc actgagctcc gtggacggag acccagtggc tggcatctgt
     2041 tatgtgggca accaaaacct gaactcgcta cgaggctttg tcttgggccc actggtgctg
     2101 tacctgttgg tgggcacgct cttccttctg gcaggcttcg tgtcactctt ccgcatccgg
     2161 agcgtcatca agcagggtgg cactaagacg gacaagctag agaagctcat gatccgcatt
     2221 ggcatcttca ctctgctcta cacggtgcca gccagcatcg tggtggcctg ctacctgtat
     2281 gaacagcact atcgggagag ctgggaggca gccctcacct gcgcgtgtcc ggggtcggac
     2341 gctggccagc cacgcgccaa acccgagtac tgggtgctca tgctcaagta cttcatgtgc
     2401 ctggtggtgg gcatcacgtc gggagtctgg atctggtccg gaaagaccct ggagtcttgg
     2461 cggcgcttca ccagccgctg ctgctgcagc tctcgacggg gccataaaag cggtggcgct
     2521 atggtcgcag gagactatgc ggaggccagc gccgcactca ctggcaggac cgggccgccg
     2581 ggccccgcgg ccgcatacca caagcaagtg tccctgtcgc acgtatagga aggcctggag
     2641 gccgaggccc agggacagtg ctggacgttg aagggggcgg ttgtgtagct tggtagcttt
     2701 gtgaaggtca cttccgttta ccttcttggt gctgatgccc cctccctgag cggcttggag
     2761 aggaaaaggg ggcggtttca aaagattacc tgtccccagt attctaccag ggggcgtggc
     2821 ttgcagtgct gtggggttaa gtgtattcta gtttgcattt cttactgctt tctttagaag
     2881 taccttgttt ttaatttata tgtatatttt aagttttaaa tttgttgcat tttggcaaca
     2941 aaatttacct ttgctttggg ggcttcataa tcctcaaact ggcgttgtaa tgaggttact
     3001 gttggttcag gtttttttgg actgtgtggt ctaaactagg aaaatatatt tcctacacgt
     3061 ctcttttttg tttttgtttt tttgcttttg ttttattaat gtgaacagtg aagggctgct
     3121 gtgactggga aggtgtaggg agagccttct tttttaggtg gtttcttctt agagtgctta
     3181 aaatgtccag gacactcaga ggccagaggc catctgctcc ttctgtgtct agcctcctca
     3241 agtcctctcc gggagtagaa tatgatgtgg ttaggaccat cccccagatg acacggttag
     3301 ggagccagga atttcgtgtg cctccttacc cttgctcagc aagccgtggg cagctcgctg
     3361 cggtcattct catccctctt agagccagct ggcccgcttg tcttgaataa gttagaggtg
     3421 gccttataga ccggacataa acatttgcca tagagcccaa gggctgggat tggttgactg
     3481 aactggtggg aaggtaagct ttctgacaga aggagggggt ggttcttaat aagcagtgcc
     3541 cccccacccc cagaattaaa aaaacgtgtg ctacaaattt cagtaaatgt agacccactc
     3601 cctttttctg gaagtagttt ggaatccctg ctaaaggggg gctctctttt agattaaagg
     3661 acaaaaaacg gatatgcttc cagtaattaa agtaaattcc cattgccttg tatctgctgc
     3721 tctcagccca cctcctttat catgttaaac agtctttctt gcttttctta ttcctcctgg
     3781 tggagagcag cgattagaaa ccacacccac ccaccaatga agagactggg ggagggaggc
     3841 tagttacctg ggaacaaaca ttggctccgg gaaaaccggt ctccctgaac tcgaaagttt
     3901 aaagccagat attcccccaa gcagctacca atccttagta gtctgaaaac aaacaagacc
     3961 ccaaacttaa gctttgtagg gcagtgtaaa gctgcgggag gagagacgat ttctcctcct
     4021 ccttttgaca gagcctgtgt agtgatggac agccccctca cacagtttct gtgccattag
     4081 aagagtctgt ttgctttcct aatctgttta actattcatt cactaagagc gtggggccat
     4141 tactgggaaa gaaatggcag ggcgtcagcc agcaagtacc aaggcagagt ggggactgaa
     4201 tttaaggaac taaaatggcc aaacaactga aacttcccaa agcttcccta gaaaaacagc
     4261 tggagtctag gcatcccgat tttcatttgc agcggttggg gggggggggg tagggagagt
     4321 taaggccaag ccagctctgc gttccttgta ctgagtggag aaaagagttc ccattgggaa
     4381 tttaagcacc cagggtatgt aaaataccct gcccttgctc acttgagtca gaattaaaat
     4441 ttcagtggct tccaaaagac cttctccacc taggtgcaga actctgaggg tctttttcta
     4501 cttattctga agccccttcc gggaagctca acacactccc tgctcagcac cacttctgtt
     4561 ttccaaatga ggtccttttc ttatcacctt gacctcttgc cttgtttagc acagtcttcc
     4621 cagaatctgc tgcaccccgc acccccaccc caccccagtc agctgtgcac agtttgggtt
     4681 gttccctcct cacaaagaaa attgagttgt tgaattgtgg caaaatcaag aaaagacgta
     4741 gagagtaaaa gttgtggggt gaagtggatg aaagcgattt cattcatttt ttagaatggt
     4801 tatttttttt cccccaccta agcaatgtgc cagagctcta aaaaaaaaaa aaatgagcta
     4861 atcagttaat tccctttgga aatacagcag ttgaaatggc tatgacgcca gagtagggac
     4921 tgtgtgggga ctgcctttgg aaggagcgtc agaagcctct tgttttctgt tctctgtgcc
     4981 cccctttcct ctcccatgcc cttagagaga caaagcacac ctgcttcctc gaggccaact
     5041 ggagtttctg gccagcccta ggggagggaa gagggaagca gccttcagat ggctacccca
     5101 ccacacgttt cctccacttt gcatgtctgt accgataaca agacggtgaa atgggaagct
     5161 gtggagtagc ccggcaacct ctgtactgcc aactttgtga gaggacaggg gatggggggg
     5221 tggaggggga gggtgggttt gggcccagcc catgtgcctt tggccgaccc actcacctct
     5281 ttaagcgttg ggatggatgc ctcccagatt agagggtgag ggtttagata atctaaagaa
     5341 acaagacctc aatgactcca atggccagat attaggaagg tttgattata ttttgttttt
     5401 taatttaact ttatattatt tccctcacat tttgaagttg tctaagttgg atgaaaaatc
     5461 atttttcttg gtgccttatt ggtttattct cgaaatccct ttgtcgtagt ttcctgtgat
     5521 cattgccagt gaccagggcc tgtgtgtgtg tgtgtgtgtg tgtgtgcgcg cgcgcgcgtg
     5581 tgcgcgcgca cttgtgcgca tgtacaagct taaataatgt gccgatggca ctggttctaa
     5641 gttggtattc attaggctgt tccctcctgg gccagggcag cactaatctt gacaccggct
     5701 gcccggagaa aacatcatgg atcatacact gaaccttaat aacagcaccc gtgacctgca
     5761 ccggcgcgtg cagaacggga accccagagc taggaagcac agttgtatat tttaatgaac
     5821 tgctacccct gctaaggaag ctgctttcac ttttgtgctc cacagaaaga ccgagggggg
     5881 taggagggac aaagctttga ataagtgctt tctaacactg gcaaacagga ccgagcacat
     5941 cacaaatcaa ggcaggtgtg aggtatagcg gctaagaatt gcctgctgcc tctctgtgtc
     6001 ctttcttgtc tccaaagtcc aatcaaggga tcctgggaaa gaagcagcct ggcttgggga
     6061 ggaaggctca aagagaaaac ctaaagagac tttaaagaag ggcgaagggc agggagggtg
     6121 tgggcaggga gggtgcaact aacctgtttc agactctcag agccgtctgg aagcctggtg
     6181 acaattgcag catttatttc atccaggatc ttgtctgtct gtggtatatc attttttaaa
     6241 gagaatatta attcatgttg ttacaaacta tgtatagtgt gtatgttttg tgggtgtgta
     6301 tatactaata tatataatat atatatgaaa gagagattta gtgacttttg atacgggttg
     6361 gtgcaggtga atttattact gagccacttg aggcacatat cgagtctgta gtggagtcca
     6421 gggcagtcat ggtttgcatt cttctgtagt gcccgtccta tgcagtaagg atcatcactg
     6481 gcgtgccaca tccagcactc acaactcaga accagcaata ttttacttgt agacaatcag
     6541 cttgaatcta tagatcatgc ctggccaatg attataactc tgaatccata acactcgcaa
     6601 aaggaaaccc agagcatctt gaagagatga ttggtttcgt ttggttttgt gcctggcagt
     6661 cagtacaaca gcaatcgtac atggttatgt ttagtctaag atccttaact tgttgacatt
     6721 attattattt tggaaatttt ttgtattata tttgtgggaa ggtaaaataa tggtttaaga
     6781 tttttatcaa atatggagat tagttattta tgaaaaacaa agaaatgtct atttttgttt
     6841 ctttgttcag aattaatgta gataactttt ttaaatggca ttaaagcaat ggtgaagaaa
     6901 at
//
