LOCUS       NM_022623               6809 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Rattus norvegicus frizzled class receptor 4 (Fzd4), mRNA.
ACCESSION   NM_022623
VERSION     NM_022623.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6809)
  AUTHORS   Wang,J., Xia,Y., Li,J. and Wang,W.
  TITLE     miR-129-5p in exosomes inhibits diabetes-associated osteogenesis in
            the jaw via targeting FZD4
  JOURNAL   Biochem Biophys Res Commun 566, 87-93 (2021)
   PUBMED   34119828
  REMARK    GeneRIF: miR-129-5p in exosomes inhibits diabetes-associated
            osteogenesis in the jaw via targeting FZD4.
REFERENCE   2  (bases 1 to 6809)
  AUTHORS   Yang,S., Wu,Y., Xu,T.H., de Waal,P.W., He,Y., Pu,M., Chen,Y.,
            DeBruine,Z.J., Zhang,B., Zaidi,S.A., Popov,P., Guo,Y., Han,G.W.,
            Lu,Y., Suino-Powell,K., Dong,S., Harikumar,K.G., Miller,L.J.,
            Katritch,V., Xu,H.E., Shui,W., Stevens,R.C., Melcher,K., Zhao,S.
            and Xu,F.
  TITLE     Crystal structure of the Frizzled 4 receptor in a ligand-free state
  JOURNAL   Nature 560 (7720), 666-670 (2018)
   PUBMED   30135577
REFERENCE   3  (bases 1 to 6809)
  AUTHORS   Voloshanenko,O., Gmach,P., Winter,J., Kranz,D. and Boutros,M.
  TITLE     Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting
            of receptor gene families
  JOURNAL   FASEB J 31 (11), 4832-4844 (2017)
   PUBMED   28733458
REFERENCE   4  (bases 1 to 6809)
  AUTHORS   Bian,W.J., Miao,W.Y., He,S.J., Wan,Z.F., Luo,Z.G. and Yu,X.
  TITLE     A novel Wnt5a-Frizzled4 signaling pathway mediates
            activity-independent dendrite morphogenesis via the distal PDZ
            motif of Frizzled 4
  JOURNAL   Dev Neurobiol 75 (8), 805-822 (2015)
   PUBMED   25424568
  REMARK    GeneRIF: Study identified a novel Wnt5a/Fzd4 signaling pathway that
            contributes to the regulation of dendrite morphogenesis
REFERENCE   5  (bases 1 to 6809)
  AUTHORS   Chen,Y., Zhang,Y., Tang,J., Liu,F., Hu,Q., Luo,C., Tang,J., Feng,H.
            and Zhang,J.H.
  TITLE     Norrin protected blood-brain barrier via frizzled-4/beta-catenin
            pathway after subarachnoid hemorrhage in rats
  JOURNAL   Stroke 46 (2), 529-536 (2015)
   PUBMED   25550365
  REMARK    GeneRIF: Activation of frizzled-4 receptor protected blood-brain
            barrier after subarachnoid hemorrhage.
REFERENCE   6  (bases 1 to 6809)
  AUTHORS   Kaykas,A., Yang-Snyder,J., Heroux,M., Shah,K.V., Bouvier,M. and
            Moon,R.T.
  TITLE     Mutant Frizzled 4 associated with vitreoretinopathy traps wild-type
            Frizzled in the endoplasmic reticulum by oligomerization
  JOURNAL   Nat Cell Biol 6 (1), 52-58 (2004)
   PUBMED   14688793
REFERENCE   7  (bases 1 to 6809)
  AUTHORS   Kubo,F., Takeichi,M. and Nakagawa,S.
  TITLE     Wnt2b controls retinal cell differentiation at the ciliary marginal
            zone
  JOURNAL   Development 130 (3), 587-598 (2003)
   PUBMED   12490564
REFERENCE   8  (bases 1 to 6809)
  AUTHORS   Robitaille,J., MacDonald,M.L., Kaykas,A., Sheldahl,L.C.,
            Zeisler,J., Dube,M.P., Zhang,L.H., Singaraja,R.R., Guernsey,D.L.,
            Zheng,B., Siebert,L.F., Hoskin-Mott,A., Trese,M.T., Pimstone,S.N.,
            Shastry,B.S., Moon,R.T., Hayden,M.R., Goldberg,Y.P. and
            Samuels,M.E.
  TITLE     Mutant frizzled-4 disrupts retinal angiogenesis in familial
            exudative vitreoretinopathy
  JOURNAL   Nat Genet 32 (2), 326-330 (2002)
   PUBMED   12172548
REFERENCE   9  (bases 1 to 6809)
  AUTHORS   Ricken,A., Lochhead,P., Kontogiannea,M. and Farookhi,R.
  TITLE     Wnt signaling in the ovary: identification and compartmentalized
            expression of wnt-2, wnt-2b, and frizzled-4 mRNAs
  JOURNAL   Endocrinology 143 (7), 2741-2749 (2002)
   PUBMED   12072409
  REMARK    GeneRIF: detected expression of a putative wnt receptor, frizzled-4
            (fzd-4) in the ovary; analyses using both RT-PCR and ISH indicated
            that granulosa cells express fzd-4 mRNA
REFERENCE   10 (bases 1 to 6809)
  AUTHORS   Wang,Y., Huso,D., Cahill,H., Ryugo,D. and Nathans,J.
  TITLE     Progressive cerebellar, auditory, and esophageal dysfunction caused
            by targeted disruption of the frizzled-4 gene
  JOURNAL   J Neurosci 21 (13), 4761-4771 (2001)
   PUBMED   11425903
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000041.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_022623.4.
            
            On Mar 18, 2021 this sequence version replaced NM_022623.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF183910.1, SRR8487231.29732.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132264, SAMD00132267
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-595               JACYVU010000041.1  3905419-3906013
            596-6809            JACYVU010000041.1  3908071-3914284
FEATURES             Location/Qualifiers
     source          1..6809
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..6809
                     /gene="Fzd4"
                     /note="frizzled class receptor 4"
                     /db_xref="GeneID:64558"
                     /db_xref="RGD:71017"
     exon            1..595
                     /gene="Fzd4"
                     /inference="alignment:Splign:2.1.0"
     CDS             308..1924
                     /gene="Fzd4"
                     /note="frizzled-4; fz-4; rFz4; frizzled receptor 4;
                     frizzled family receptor 4"
                     /codon_start=1
                     /product="frizzled-4 precursor"
                     /protein_id="NP_072145.1"
                     /db_xref="GeneID:64558"
                     /db_xref="RGD:71017"
                     /translation="MAWQGTGPSVRGMPGGVRLRLGLLLLQLLLLQRPALGFGDEEER
                     RCDPIRIAMCQNLGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSV
                     YVPMCTEKINIPIGPCGGMCLSVKRRCEPVLKEFGFAWPDSLNCSKFPPQNDHNHMCM
                     EGPGDEEVPLPHKTPIQPGEECHSVGTNSDQYIWVKRSLNCVLKCGYDAGLYSRSAKE
                     FTDIWMAVWASLCFISTTFTVLTFLIDSSRFSYPERPIIFLSMCYNIYSIAYIVRLTV
                     GRERISCDFEEAAEPVLIQEGLKNTGCAIIFLLMYFFGMASSIWWVILTLTWFLAAGL
                     KWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVGNQSLDALTGFV
                     VAPLFTYLVIGTLFIAAGLVALFKIRSNLQKDGTKTDKLERLMVKIGVFSVLYTVPAT
                     CVIACYFYEISNWALFRYSADDSNMAVEMLKIFMSLLVGITSGMWIWSAKTLHTWQKC
                     SNRLVNSGKVKREKRGNGWVKPGKGNETVV"
     exon            596..6809
                     /gene="Fzd4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagaagagcg cggcgtagag tgcaggcggg cttcgccgaa aagccggact cggccggcgc
       61 cgggttctgg gatcgccgcc tgcagccatg accctagcag tccatccctc ggccccggct
      121 ccggacgtct gatatcccgc acagtctcct acagctgctg gagaagcggc cgctgccccc
      181 tcgtcgccct tggcgcccta ccgcattccc tatccggagc tgggagctgc gcggccaccg
      241 gcgcccctgt gcaaactggg ggtgtctgct agagcagcct ccgccgctgc tgcccgcggc
      301 tctggccatg gcttggcagg gcacagggcc aagcgtccgg gggatgcctg gaggcgtcag
      361 gctcaggctg gggctgctgc tgctgcagtt gctcctgctc cagcggcccg ccctggggtt
      421 cggggacgag gaggagcggc gttgcgaccc catccgcatc gccatgtgcc agaacctcgg
      481 ctacaacgtg accaagatgc ccaacttagt gggacacgag ctgcagacag acgcggagct
      541 gcagctgaca actttcacgc cgctcatcca gtacggctgc tccagccagc tgcagttctt
      601 cctttgttcg gtttatgtgc caatgtgcac agagaagatc aacatcccca tcggcccgtg
      661 cggtggcatg tgtctttcag tcaagagacg atgtgaacca gtcctgaaag aatttgggtt
      721 tgcctggccg gacagcctga actgcagcaa gttcccaccc cagaacgacc acaaccacat
      781 gtgcatggaa ggaccaggtg acgaagaggt acccttgccc cacaaaactc ccatccagcc
      841 gggggaagag tgccactccg tgggaaccaa ttccgatcag tacatctggg tgaaaaggag
      901 cctgaactgt gttctcaagt gtggctacga tgctggcttg tacagccgct cagctaagga
      961 gttcacggat atttggatgg ccgtgtgggc cagcctctgc ttcatctcta ccaccttcac
     1021 tgtgctgacc ttcctgattg attcgtccag gttttcttac cctgagcgcc ccatcatatt
     1081 cctcagtatg tgctataata tttatagcat tgcttatatt gttcggctta ctgtaggccg
     1141 ggaaaggata tcctgtgatt ttgaagaggc ggcagaaccc gttctcatcc aagagggact
     1201 taagaacaca ggatgtgcaa taattttctt gctgatgtac ttttttggaa tggccagctc
     1261 catttggtgg gttattctga cactcacttg gtttttggca gccggactca agtggggtca
     1321 cgaagccatt gaaatgcaca gttcttattt ccacatcgca gcctgggcta tccctgccgt
     1381 gaaaaccatt gtcatcttga ttatgagact agtggatgcc gatgagctga ctggcctgtg
     1441 ctatgtcggg aaccaaagcc tagatgccct caccggcttt gtggtggcac ctctctttac
     1501 ctatttggtg attggaactc tattcattgc tgcaggcttg gtggccctct tcaaaattcg
     1561 gtcaaatctt caaaaagatg ggaccaagac agacaagttg gaaaggctaa tggtcaagat
     1621 cggggtcttc tcggtcctgt acacggttcc tgcgacctgt gtgattgcct gttatttcta
     1681 tgaaatctca aactgggcac tctttcggta ttctgcagat gactcaaaca tggcagttga
     1741 aatgttgaaa atttttatgt ctttgctcgt gggcatcact tcaggcatgt ggatttggtc
     1801 tgccaaaact cttcacacgt ggcaaaaatg ttctaaccga ttggtgaatt ctgggaaggt
     1861 aaagagagag aagaggggga atggttgggt gaagccaggg aaaggcaacg aaactgtggt
     1921 gtaggactag ctagcttcca ctttcctcat tttgaaggaa aggatgcagt gaatctcagt
     1981 ttgaacaaac tagaaacact tcagcacaca cacacacaca cacacacaca cacacacaca
     2041 cacgtcagcc caccacccct cacccaactc agcgtcagaa cactaatgat tttgatgtag
     2101 actttggaat ggtccaaaat ggaaaagcca gttcgaggct ttcaaagctg tgaaaactca
     2161 aaacgtcaat cactttagca ggtcacacag cttggagtct gaggaggtct ccctgagatt
     2221 cctaagtcca agactgatgg cgtctgctcc tactgggtgg gacttcagct gtgagttaat
     2281 agcgtgcaag gagaaagatt aatttttaaa actcttttaa attttaaata gtaactaggt
     2341 cttgcagata gcaaagtgat ctataaacac tggaaatgct gggttgggag acgtggtgca
     2401 gagttttata gtttggctgg cctaacataa acatcttctg gcctccactg tctgctgttt
     2461 agaactctgg agcgcactcc caagaggtgg tgtcaaaatc cttcagtgcc tttgtcgtaa
     2521 aacagaattg tttgagcaaa caaaagtact gtactaacac acataaggta tccaatggat
     2581 ttctctctgt tcttaaattt caacgtccct aattctaggc agcccctgtt ttcttcactt
     2641 tacactaatg actcaaaaaa aagttatttt tataggaatt tttttgcact gcagcatgcc
     2701 taatgagagg aaaaggaaag gtgattcatt ttctgacaat cacttaattc agaggaaaat
     2761 gagatttact aagttgactt accttaccga ccccagagac ctattgcatt tagctacgtt
     2821 agcaattggg acttaaaata ttttagtttg tgtgattgca tctaggcaga cgccagtctg
     2881 gaagaactga aatgttaaat ttcttggcaa ctttgcattc acacagatta actgtgtaat
     2941 ttgtgtgtgt caattacaat taaaagcaca ttcttggacc atgacatagt atactcaatt
     3001 gactttaaaa ctgtggtcaa cttgcattct tagtgtgata gtgcctttcc ccccctgtag
     3061 cataagaatg ttatcagagt ttggtctgct tgccacaatg gagacttatt caactttgca
     3121 aaggcaacta aggacagcag atccaaatac ttggtgcata attgttcctt agtaatgggc
     3181 aaaggctcct tataagattt cattggaggc agtgtggcct ggagtattta tatgatgcct
     3241 aatgaacctc cagaatgcca gccagaagct ggattggtta gcaggggata cggtgtagac
     3301 cgagtgaaat gagctgcaaa gtctaacagc gcaagtctta attgcctttt ctggggtatc
     3361 caaagccttt aaaatttatg ctttaagtcc ctcacaaggg ggtacccgct agcaacctat
     3421 caaaagctga agttccttta aaatcatgac tggccttttg cttaacctgc cttaggcctt
     3481 ttaatcacca gatctctggg acaaaacatt gtacatgcca caggttgctc tccttgtgtt
     3541 tcacactcgc ctgcttcagc aactgcagtt gttcattgag tggagtttat agtaagagag
     3601 ctcttaatgt tttgtccagt cacactttgt agagaaacat gtcagcgact ccaaatccca
     3661 aataggtgtg cagattcact ctctctctct ctctctctct ctctctctct ctctctctct
     3721 ctctctctct ctctccccct tccctccctc cctccctccc tccctccctc cctccctccc
     3781 ttcctccctc tcggtttgag ctttgtctct gactgtatat tttactttct ccccataccc
     3841 tttggttttg caagttctgt agatgtctgt taccaagatg catataagac ccatagttgt
     3901 gtttgaaaag gagagtcgtg gggcttgtga gatagagatc tcggtgaacc tggatggccc
     3961 ctggtcattt tcagtctgag tacctaaact ggactggggc ataaggctcc aggagcatga
     4021 gaactgatcc acggaagggc cagtttaact cctgaatgtg ctgcttctga gcacattctg
     4081 gggcgaaatg gacacgcccc gtgctgcttg cagacagttc ccatagctgt ccagggccct
     4141 ggagtgtgca cccaagggca gattctgccc ttactcacgc tctgcttcgg tgtcttggga
     4201 gttgtgcagt gactctggca caggaaaggg atgaagagca aggcagtagc tgactagcca
     4261 ggctgtacag gcttcctaaa gcaattctct ttgtaatgct tcagtgattg tagggccagg
     4321 actgcagcct ccaaagagca agctgtaggt gctgggcttg tttcaacaat aaccatggca
     4381 acagcaaccc cttaggtgaa accagccacc tgcgttctga attctagagc cagtgagtgt
     4441 actgacactt tttctatctt ctcaagcact ttgccctttc agggggaagt taatgtttga
     4501 gcaaagggac ctggcagttc agactagttt aatagtctca acaacaccac agagtttccg
     4561 gccgtccctt tcctatctca tgcacactgg agagaaatgg ctccactttc caggaaatga
     4621 actcggtgac tgaggagtcc cttacaatgc ccgacaagaa cctgtatcac ttcttcccat
     4681 cattaccaca aatctctttc taggtctctc tacctccccc ataattcctt ctaaattaat
     4741 ggcagaaagc accagctctg gttcatgaca atcttcatat aaactcccta ggaaaacaga
     4801 gtaggcccga agaactggct ccagcatcta actgtggctt tggggatagg agggtcaggg
     4861 tttgggttgt tccgtgggac ttacacaggc atatttgagg acagcggcat gctgaggaga
     4921 aagtaaggtt tgttttcctt cctctgagat ctggagtacg tatgcacaat tgtaattttc
     4981 aaggaaagtc ctcaagtttc agatattcta ctaagcacaa ctaagggcac cactgtccaa
     5041 cctcctcttt gataaactac ttgatcttgc ttcataaaag ccagaccata aagcacagga
     5101 gccctgtgta gggtagaagt ggccagagcc acctggctga gctactcagc tgatcatatc
     5161 tttcttcctt tacggtgacc cacttcctgg ttgctgagat ggcttcggag ctggcacggt
     5221 gcccagaggc ctgaaacaag ggacaggtga cagacactat ttccttagag ttccctttct
     5281 gtcattccct cacgtgtacc ctaaccctca tgtccataaa gccagaacca gagacctatc
     5341 attaccagat tctgacctgt ggtcacattt aactcgtcca actgtgtact cagccctttg
     5401 ctcacagaat ttagtgtctt tggtattgag tgcaatgttg ggccatggga catcgcgatg
     5461 aagttgacat cctcagtccc caaagagcag gtacacttga aagaggtctc acccatgagt
     5521 ggcagttagg aagggaaacc aagagggcat ggactttggc aggaagtgct tcatgtgtaa
     5581 attctatcct gagacggagg gcagtggaga aagttgccat ccctaccagt catgacgagc
     5641 ccccggactt gggcagtgct ctttgtcttc ttattgtatt tgacttcaga gtccccgtct
     5701 gagtgtgcag tgtgtctgtc aaaggaccca ggttatcttt ttcccttcat gcctaggaca
     5761 aagaacttgg aactcccgag agagcatttt gctcctacaa atgatcagat actgaagtcc
     5821 caagtaatag atcttgttcc actggctcct ggatcgagtt ctctgctcct gcctttcccc
     5881 atgcagtttg tgcagtaatg gcccagtgcc aagaggaagt gtatcacgcc cccaccccac
     5941 ccagacatgc ttgttcccct gaaaatcacg tttgtgtcat catcatcatc atcatcatca
     6001 tcaccatcac catcaccatc accatcactt gtctttgtct ttcatttgcc ttattttcct
     6061 tctaagcagc gctcaattcc tagtagtctc ccgagcagtt ggtaaagagt ctcgaatgag
     6121 ccacttcctc aaagcactcg tgcctgccag agctcccgga atgttccgct agtgactagt
     6181 gtcatcccgg aaagctgaaa cagggtgaca acaactctgc cccacgaagc tcaggttcgt
     6241 ctcccctccc aggttgagca catttcaaag tcctgagagt ttagcaggct ggggccttga
     6301 ctttactgtg gctgtgggga gcggtaagtt ggtttctaga atttccatag tgccacatcc
     6361 agacacttct gagttcttct acctcacagg gacggtgtga ggctatagaa ggcctcgggg
     6421 tgaggcccct tggctcttca taagaaggat gaactaaaat aataatccca gtctgcaagc
     6481 cgataaaata cagttagaag tcttttgtgc agcagtttac ccagatgctc tctgcctttt
     6541 acgtggatcc tcgtgccttt cagtaactgc agaaccctgg aggcaacctg gggccattcg
     6601 gatgcttagt gtagaggtac ctggcaaacc cctgctatcc atgccctgaa caaattgctg
     6661 aatttccaag gaaatatatc ccccttttta aggatgtaca aaagtgtgtc tacattgatg
     6721 tctgtactgt aaatttctaa tttatcactg tattaaaaaa cttgctattt aatttttgta
     6781 ttaaaggaaa ataaagtttt gtttattga
//
