LOCUS       NP_072145                538 aa            linear   ROD 03-APR-2024
DEFINITION  frizzled-4 precursor [Rattus norvegicus].
ACCESSION   NP_072145
VERSION     NP_072145.1
DBSOURCE    REFSEQ: accession NM_022623.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 538)
  AUTHORS   Wang,J., Xia,Y., Li,J. and Wang,W.
  TITLE     miR-129-5p in exosomes inhibits diabetes-associated osteogenesis in
            the jaw via targeting FZD4
  JOURNAL   Biochem Biophys Res Commun 566, 87-93 (2021)
   PUBMED   34119828
  REMARK    GeneRIF: miR-129-5p in exosomes inhibits diabetes-associated
            osteogenesis in the jaw via targeting FZD4.
REFERENCE   2  (residues 1 to 538)
  AUTHORS   Yang,S., Wu,Y., Xu,T.H., de Waal,P.W., He,Y., Pu,M., Chen,Y.,
            DeBruine,Z.J., Zhang,B., Zaidi,S.A., Popov,P., Guo,Y., Han,G.W.,
            Lu,Y., Suino-Powell,K., Dong,S., Harikumar,K.G., Miller,L.J.,
            Katritch,V., Xu,H.E., Shui,W., Stevens,R.C., Melcher,K., Zhao,S.
            and Xu,F.
  TITLE     Crystal structure of the Frizzled 4 receptor in a ligand-free state
  JOURNAL   Nature 560 (7720), 666-670 (2018)
   PUBMED   30135577
REFERENCE   3  (residues 1 to 538)
  AUTHORS   Voloshanenko,O., Gmach,P., Winter,J., Kranz,D. and Boutros,M.
  TITLE     Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting
            of receptor gene families
  JOURNAL   FASEB J 31 (11), 4832-4844 (2017)
   PUBMED   28733458
REFERENCE   4  (residues 1 to 538)
  AUTHORS   Bian,W.J., Miao,W.Y., He,S.J., Wan,Z.F., Luo,Z.G. and Yu,X.
  TITLE     A novel Wnt5a-Frizzled4 signaling pathway mediates
            activity-independent dendrite morphogenesis via the distal PDZ
            motif of Frizzled 4
  JOURNAL   Dev Neurobiol 75 (8), 805-822 (2015)
   PUBMED   25424568
  REMARK    GeneRIF: Study identified a novel Wnt5a/Fzd4 signaling pathway that
            contributes to the regulation of dendrite morphogenesis
REFERENCE   5  (residues 1 to 538)
  AUTHORS   Chen,Y., Zhang,Y., Tang,J., Liu,F., Hu,Q., Luo,C., Tang,J., Feng,H.
            and Zhang,J.H.
  TITLE     Norrin protected blood-brain barrier via frizzled-4/beta-catenin
            pathway after subarachnoid hemorrhage in rats
  JOURNAL   Stroke 46 (2), 529-536 (2015)
   PUBMED   25550365
  REMARK    GeneRIF: Activation of frizzled-4 receptor protected blood-brain
            barrier after subarachnoid hemorrhage.
REFERENCE   6  (residues 1 to 538)
  AUTHORS   Kaykas,A., Yang-Snyder,J., Heroux,M., Shah,K.V., Bouvier,M. and
            Moon,R.T.
  TITLE     Mutant Frizzled 4 associated with vitreoretinopathy traps wild-type
            Frizzled in the endoplasmic reticulum by oligomerization
  JOURNAL   Nat Cell Biol 6 (1), 52-58 (2004)
   PUBMED   14688793
REFERENCE   7  (residues 1 to 538)
  AUTHORS   Kubo,F., Takeichi,M. and Nakagawa,S.
  TITLE     Wnt2b controls retinal cell differentiation at the ciliary marginal
            zone
  JOURNAL   Development 130 (3), 587-598 (2003)
   PUBMED   12490564
REFERENCE   8  (residues 1 to 538)
  AUTHORS   Robitaille,J., MacDonald,M.L., Kaykas,A., Sheldahl,L.C.,
            Zeisler,J., Dube,M.P., Zhang,L.H., Singaraja,R.R., Guernsey,D.L.,
            Zheng,B., Siebert,L.F., Hoskin-Mott,A., Trese,M.T., Pimstone,S.N.,
            Shastry,B.S., Moon,R.T., Hayden,M.R., Goldberg,Y.P. and
            Samuels,M.E.
  TITLE     Mutant frizzled-4 disrupts retinal angiogenesis in familial
            exudative vitreoretinopathy
  JOURNAL   Nat Genet 32 (2), 326-330 (2002)
   PUBMED   12172548
REFERENCE   9  (residues 1 to 538)
  AUTHORS   Ricken,A., Lochhead,P., Kontogiannea,M. and Farookhi,R.
  TITLE     Wnt signaling in the ovary: identification and compartmentalized
            expression of wnt-2, wnt-2b, and frizzled-4 mRNAs
  JOURNAL   Endocrinology 143 (7), 2741-2749 (2002)
   PUBMED   12072409
  REMARK    GeneRIF: detected expression of a putative wnt receptor, frizzled-4
            (fzd-4) in the ovary; analyses using both RT-PCR and ISH indicated
            that granulosa cells express fzd-4 mRNA
REFERENCE   10 (residues 1 to 538)
  AUTHORS   Wang,Y., Huso,D., Cahill,H., Ryugo,D. and Nathans,J.
  TITLE     Progressive cerebellar, auditory, and esophageal dysfunction caused
            by targeted disruption of the frizzled-4 gene
  JOURNAL   J Neurosci 21 (13), 4761-4771 (2001)
   PUBMED   11425903
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643285.2712.1,
                                           SRR26643296.2001.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..538
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     Protein         1..538
                     /product="frizzled-4 precursor"
                     /note="frizzled-4; fz-4; rFz4; frizzled receptor 4;
                     frizzled family receptor 4"
                     /calculated_mol_wt=56433
     sig_peptide     1..37
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=3940
     mat_peptide     38..538
                     /product="Frizzled-4. /id=PRO_0000012987"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZH0.1)"
                     /calculated_mol_wt=56433
     Region          43..168
                     /region_name="CRD_FZ4"
                     /note="Cysteine-rich Wnt-binding domain of the frizzled 4
                     (Fz4) receptor; cd07448"
                     /db_xref="CDD:143557"
     Site            order(53,55..57,59..61)
                     /site_type="other"
                     /note="putative Wnt binding site [polypeptide binding]"
                     /db_xref="CDD:143557"
     Site            60
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9QZH0.1)"
     Site            145
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9QZH0.1)"
     Region          210..510
                     /region_name="7tmF_FZD4"
                     /note="class F frizzled subfamily 4, member of
                     7-transmembrane G protein-coupled receptors; cd15038"
                     /db_xref="CDD:320166"
     Site            order(211,220,270,372,377,379,382..383,388,463,466..467,
                     473,478,481..482)
                     /site_type="other"
                     /note="putative ligand binding site [chemical binding]"
                     /db_xref="CDD:320166"
     Site            214..244
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZH0.1)"
     Region          219..244
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:320166"
     Site            251..276
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZH0.1)"
     Region          253..274
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320166"
     Site            301..334
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZH0.1)"
     Region          304..330
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320166"
     Site            338..366
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZH0.1)"
     Region          347..363
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320166"
     Site            382
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9QZH0.1)"
     Site            385..419
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZH0.1)"
     Region          385..414
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320166"
     Site            433..461
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZH0.1)"
     Region          434..461
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320166"
     Region          471..496
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320166"
     Site            475..496
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZH0.1)"
     Region          500..505
                     /region_name="Lys-Thr-X-X-X-Trp motif, mediates
                     interaction with the PDZ domain of Dvl family members.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZH0.1)"
     Region          536..538
                     /region_name="PDZ-binding"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZH0.1)"
     CDS             1..538
                     /gene="Fzd4"
                     /coded_by="NM_022623.4:308..1924"
                     /db_xref="GeneID:64558"
                     /db_xref="RGD:71017"
ORIGIN      
        1 mawqgtgpsv rgmpggvrlr lgllllqlll lqrpalgfgd eeerrcdpir iamcqnlgyn
       61 vtkmpnlvgh elqtdaelql ttftpliqyg cssqlqfflc svyvpmctek inipigpcgg
      121 mclsvkrrce pvlkefgfaw pdslncskfp pqndhnhmcm egpgdeevpl phktpiqpge
      181 echsvgtnsd qyiwvkrsln cvlkcgydag lysrsakeft diwmavwasl cfisttftvl
      241 tflidssrfs yperpiifls mcyniysiay ivrltvgrer iscdfeeaae pvliqeglkn
      301 tgcaiifllm yffgmassiw wviltltwfl aaglkwghea iemhssyfhi aawaipavkt
      361 ivilimrlvd adeltglcyv gnqsldaltg fvvaplftyl vigtlfiaag lvalfkirsn
      421 lqkdgtktdk lerlmvkigv fsvlytvpat cviacyfyei snwalfrysa ddsnmaveml
      481 kifmsllvgi tsgmwiwsak tlhtwqkcsn rlvnsgkvkr ekrgngwvkp gkgnetvv
//
