LOCUS       NM_172035               1911 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus frizzled class receptor 2 (Fzd2), mRNA.
ACCESSION   NM_172035 XM_346408
VERSION     NM_172035.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1911)
  AUTHORS   White,J.J., Mazzeu,J.F., Coban-Akdemir,Z., Bayram,Y.,
            Bahrambeigi,V., Hoischen,A., van Bon,B.W.M., Gezdirici,A.,
            Gulec,E.Y., Ramond,F., Touraine,R., Thevenon,J., Shinawi,M.,
            Beaver,E., Heeley,J., Hoover-Fong,J., Durmaz,C.D., Karabulut,H.G.,
            Marzioglu-Ozdemir,E., Cayir,A., Duz,M.B., Seven,M., Price,S.,
            Ferreira,B.M., Vianna-Morgante,A.M., Ellard,S., Parrish,A.,
            Stals,K., Flores-Daboub,J., Jhangiani,S.N., Gibbs,R.A.,
            Brunner,H.G., Sutton,V.R., Lupski,J.R. and Carvalho,C.M.B.
  CONSRTM   Baylor-Hopkins Center for Mendelian Genomics
  TITLE     WNT Signaling Perturbations Underlie the Genetic Heterogeneity of
            Robinow Syndrome
  JOURNAL   Am J Hum Genet 102 (1), 27-43 (2018)
   PUBMED   29276006
REFERENCE   2  (bases 1 to 1911)
  AUTHORS   Ding,S., Xu,Z., Yang,J., Liu,L., Huang,X., Wang,X. and Zhuge,Q.
  TITLE     The Involvement of the Decrease of Astrocytic Wnt5a in the
            Cognitive Decline in Minimal Hepatic Encephalopathy
  JOURNAL   Mol Neurobiol 54 (10), 7949-7963 (2017)
   PUBMED   27878554
  REMARK    GeneRIF: a novel pathogenesis of the contribution of downregulation
            of neurotrophins to the inhibition of the interaction between Wnt5a
            and Frizzled-2 in astrocytes in minimal hepatic encephalopathy
REFERENCE   3  (bases 1 to 1911)
  AUTHORS   Voloshanenko,O., Gmach,P., Winter,J., Kranz,D. and Boutros,M.
  TITLE     Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting
            of receptor gene families
  JOURNAL   FASEB J 31 (11), 4832-4844 (2017)
   PUBMED   28733458
REFERENCE   4  (bases 1 to 1911)
  AUTHORS   Wu,X., Zhou,S., Zhu,N., Wang,X., Jin,W., Song,X. and Chen,A.
  TITLE     Resveratrol attenuates hypoxia/reoxygenation-induced Ca2+ overload
            by inhibiting the Wnt5a/Frizzled-2 pathway in rat H9c2 cells
  JOURNAL   Mol Med Rep 10 (5), 2542-2548 (2014)
   PUBMED   25120137
  REMARK    GeneRIF: H9c2 cell treatment with resveratrol significantly reduces
            the expression of Frizzled2 and Wnt5a.
REFERENCE   5  (bases 1 to 1911)
  AUTHORS   Xavier,C.P., Melikova,M., Chuman,Y., Uren,A., Baljinnyam,B. and
            Rubin,J.S.
  TITLE     Secreted Frizzled-related protein potentiation versus inhibition of
            Wnt3a/beta-catenin signaling
  JOURNAL   Cell Signal 26 (1), 94-101 (2014)
   PUBMED   24080158
REFERENCE   6  (bases 1 to 1911)
  AUTHORS   Toyofuku,T., Hong,Z., Kuzuya,T., Tada,M. and Hori,M.
  TITLE     Wnt/frizzled-2 signaling induces aggregation and adhesion among
            cardiac myocytes by increased cadherin-beta-catenin complex
  JOURNAL   J Cell Biol 150 (1), 225-241 (2000)
   PUBMED   10893270
REFERENCE   7  (bases 1 to 1911)
  AUTHORS   Sheldahl,L.C., Park,M., Malbon,C.C. and Moon,R.T.
  TITLE     Protein kinase C is differentially stimulated by Wnt and Frizzled
            homologs in a G-protein-dependent manner
  JOURNAL   Curr Biol 9 (13), 695-698 (1999)
   PUBMED   10395542
REFERENCE   8  (bases 1 to 1911)
  AUTHORS   Blankesteijn,W.M., Essers-Janssen,Y.P., Verluyten,M.J., Daemen,M.J.
            and Smits,J.F.
  TITLE     A homologue of Drosophila tissue polarity gene frizzled is
            expressed in migrating myofibroblasts in the infarcted rat heart
  JOURNAL   Nat Med 3 (5), 541-544 (1997)
   PUBMED   9142123
REFERENCE   9  (bases 1 to 1911)
  AUTHORS   Blankesteijn,W.M., Essers-Janssen,Y.P., Ulrich,M.M. and Smits,J.F.
  TITLE     Increased expression of a homologue of drosophila tissue polarity
            gene 'frizzled' in left ventricular hypertrophy in the rat, as
            identified by subtractive hybridization
  JOURNAL   J Mol Cell Cardiol 28 (5), 1187-1191 (1996)
   PUBMED   8762054
REFERENCE   10 (bases 1 to 1911)
  AUTHORS   Chan,S.D., Karpf,D.B., Fowlkes,M.E., Hooks,M., Bradley,M.S.,
            Vuong,V., Bambino,T., Liu,M.Y., Arnaud,C.D., Strewler,G.J. et al.
  TITLE     Two homologs of the Drosophila polarity gene frizzled (fz) are
            widely expressed in mammalian tissues
  JOURNAL   J Biol Chem 267 (35), 25202-25207 (1992)
   PUBMED   1334084
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 27, 2020 this sequence version replaced NM_172035.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: L02530.1, SRR26643291.29731.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1911              JAXUCZ010000010.1  88061988-88063898
FEATURES             Location/Qualifiers
     source          1..1911
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..1911
                     /gene="Fzd2"
                     /gene_synonym="Fz-10; Fzd10"
                     /note="frizzled class receptor 2"
                     /db_xref="GeneID:64512"
                     /db_xref="RGD:71012"
     exon            1..1911
                     /gene="Fzd2"
                     /gene_synonym="Fz-10; Fzd10"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1790
                     /gene="Fzd2"
                     /gene_synonym="Fz-10; Fzd10"
                     /note="frizzled-2; fz-2; rFz2; Drosophila polarity gene
                     homolog 2; Drosophila polarity gene (frizzled) homologue;
                     frizzled family receptor 2"
                     /codon_start=1
                     /product="frizzled-2 precursor"
                     /protein_id="NP_742032.2"
                     /db_xref="GeneID:64512"
                     /db_xref="RGD:71012"
                     /translation="MRARSALPRSALPRLLLPLLLLPAAGPAQFHGEKGISIPDHGFC
                     QPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYA
                     PVCTVLEQAIPPCRSICERARQGCEALMNKFGFQWPERLRCEHFPRHGAEQICVGQNH
                     SEDGTPALLTTAPPSGLQPGAGGTPGGPGGGGAPPRYATLEHPFHCPRVLKVPSYLSY
                     KFLGERDCAAPCEPARPDGSMFFSQEETRFARLWILTWSVLCCASTFFTVTTYLVDMQ
                     RFRYPERPIIFLSGCYTMVSVAYIAGFVLQERVVCNERFSEDGYRTVVQGTKKEGCTI
                     LFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITI
                     LAMGQIDGDLLSGVCFVGLNSLDPLRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIM
                     KHDGTKTEKLERLMVRIGVFSVLYTVPATIVIACYFYEQAFREHWERSWVSQHCKSLA
                     IPCPAHYTPRMSPDFTVYMIKYLMTLIVGITSGFWIWSGKTLHSWRKFYTRLTNSRHG
                     ETTV"
ORIGIN      
        1 ggggaaggcg cgcggtctct gggttggggg cgggggctgg ggggcgccca ggagccgagt
       61 ggggggcggc ggccagcatg cgggcccgca gcgccctgcc ccgcagcgcc ctgccccgcc
      121 tgctgctgcc actgctgctg ctgccggctg ccgggccggc tcagttccac ggggagaagg
      181 gcatctccat cccggaccac ggcttctgcc agcccatctc catcccgctg tgcacggaca
      241 tcgcctacaa ccagaccatc atgcccaacc ttcttgggca cacgaaccaa gaggacgcgg
      301 gcctggaggt gcatcaattc tacccgctgg tgaaggtgca gtgctcgccc gagctgcgct
      361 tcttcctgtg ctccatgtac gctccggtgt gcacggtgct ggagcaggcc atcccgccgt
      421 gccgctccat ctgcgagcgc gcgcgccaag gctgcgaggc gctcatgaac aagttcggct
      481 tccagtggcc cgagcgcctc cgctgcgagc atttcccgcg tcacggcgcg gagcagatct
      541 gcgtgggcca gaaccactcc gaggacggaa ctcctgcgct actcaccacc gcgccaccgt
      601 ctgggctgca gcctggcgct ggtggcaccc cgggcggccc tggcggtggt ggcgcgcccc
      661 cgcgctacgc cactctggag caccctttcc actgtccccg cgtcctcaag gtgccgtcct
      721 atctcagcta taagtttctg ggtgagcgcg attgtgccgc gccctgcgag cctgcacggc
      781 ccgacggctc catgttcttc tcgcaggagg agactcgttt tgcccgtctc tggatcctca
      841 catggtcggt gctgtgctgc gcttctactt tcttcacggt caccacctat ttagtggaca
      901 tgcagcgatt ccgctaccca gagcggccca tcatcttcct gtccggttgc tacaccatgg
      961 tgtcagtggc ctacattgcg ggcttcgtgc tccaggagcg cgtggtgtgc aacgagcgct
     1021 tctctgagga cggttatcgc acggtggtgc agggcactaa gaaagaaggc tgtactatac
     1081 tcttcatgat gctgtacttc ttcagtatgg ccagctccat ctggtgggtg attctgtccc
     1141 tcacctggtt cctggcagcc ggtatgaagt ggggccacga ggccatcgag gccaattcgc
     1201 agtacttcca cctggccgcc tgggcggtgc cggccgtcaa aaccatcacc atcctggcca
     1261 tgggccagat cgacggcgac ctgctgagcg gcgtgtgctt cgtgggcctc aacagcctgg
     1321 acccgctgcg aggcttcgtg ctggcgccgc tcttcgtgta cctgttcatc ggcacatcct
     1381 tcctgctggc gggcttcgtg tcactcttcc gcatccgcac catcatgaag cacgacggca
     1441 ccaagacgga gaagctggag aggctcatgg tgcgtatcgg cgtcttctcc gtgctctaca
     1501 ccgtaccggc caccatcgtc atcgcctgct acttctatga gcaggccttc cgcgagcact
     1561 gggagcgctc gtgggtaagc cagcactgca agagcctagc catcccctgc ccggcccact
     1621 acacgccccg catgtcgccc gacttcacag tctacatgat caaatacctc atgacgctca
     1681 tcgtgggcat cacgtcgggc ttctggatct ggtccggcaa gacgctgcac tcgtggagga
     1741 agttctacac gcgtctcacc aacagccggc atggagagac caccgtgtga agcggtctcg
     1801 cctgctgggc gcccccctct cccaggtccg gactgcaccg tgccctcctt cactcgggag
     1861 gggggtgcac cctacggact cctattttat ttttttaaat aaagaacagt g
//
