LOCUS       NM_021266               4399 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus frizzled class receptor 1 (Fzd1), mRNA.
ACCESSION   NM_021266 XM_346687
VERSION     NM_021266.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4399)
  AUTHORS   Voloshanenko,O., Gmach,P., Winter,J., Kranz,D. and Boutros,M.
  TITLE     Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting
            of receptor gene families
  JOURNAL   FASEB J 31 (11), 4832-4844 (2017)
   PUBMED   28733458
REFERENCE   2  (bases 1 to 4399)
  AUTHORS   Roet,K.C., Franssen,E.H., de Bree,F.M., Essing,A.H., Zijlstra,S.J.,
            Fagoe,N.D., Eggink,H.M., Eggers,R., Smit,A.B., van Kesteren,R.E.
            and Verhaagen,J.
  TITLE     A multilevel screening strategy defines a molecular fingerprint of
            proregenerative olfactory ensheathing cells and identifies SCARB2,
            a protein that improves regenerative sprouting of injured sensory
            spinal axons
  JOURNAL   J Neurosci 33 (27), 11116-11135 (2013)
   PUBMED   23825416
REFERENCE   3  (bases 1 to 4399)
  AUTHORS   L'episcopo,F., Serapide,M.F., Tirolo,C., Testa,N., Caniglia,S.,
            Morale,M.C., Pluchino,S. and Marchetti,B.
  TITLE     A Wnt1 regulated Frizzled-1/beta-Catenin signaling pathway as a
            candidate regulatory circuit controlling mesencephalic dopaminergic
            neuron-astrocyte crosstalk: Therapeutical relevance for neuron
            survival and neuroprotection
  JOURNAL   Mol Neurodegener 6, 49 (2011)
   PUBMED   21752258
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4399)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   5  (bases 1 to 4399)
  AUTHORS   Yu,H., Smallwood,P.M., Wang,Y., Vidaltamayo,R., Reed,R. and
            Nathans,J.
  TITLE     Frizzled 1 and frizzled 2 genes function in palate, ventricular
            septum and neural tube closure: general implications for tissue
            fusion processes
  JOURNAL   Development 137 (21), 3707-3717 (2010)
   PUBMED   20940229
REFERENCE   6  (bases 1 to 4399)
  AUTHORS   Bafico,A., Liu,G., Yaniv,A., Gazit,A. and Aaronson,S.A.
  TITLE     Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1
            interaction with LRP6/Arrow
  JOURNAL   Nat Cell Biol 3 (7), 683-686 (2001)
   PUBMED   11433302
REFERENCE   7  (bases 1 to 4399)
  AUTHORS   Liu,T., Liu,X., Wang,Hy., Moon,R.T. and Malbon,C.C.
  TITLE     Activation of rat frizzled-1 promotes Wnt signaling and
            differentiation of mouse F9 teratocarcinoma cells via pathways that
            require Galpha(q) and Galpha(o) function
  JOURNAL   J Biol Chem 274 (47), 33539-33544 (1999)
   PUBMED   10559239
REFERENCE   8  (bases 1 to 4399)
  AUTHORS   Gazit,A., Yaniv,A., Bafico,A., Pramila,T., Igarashi,M.,
            Kitajewski,J. and Aaronson,S.A.
  TITLE     Human frizzled 1 interacts with transforming Wnts to transduce a
            TCF dependent transcriptional response
  JOURNAL   Oncogene 18 (44), 5959-5966 (1999)
   PUBMED   10557084
REFERENCE   9  (bases 1 to 4399)
  AUTHORS   Sheldahl,L.C., Park,M., Malbon,C.C. and Moon,R.T.
  TITLE     Protein kinase C is differentially stimulated by Wnt and Frizzled
            homologs in a G-protein-dependent manner
  JOURNAL   Curr Biol 9 (13), 695-698 (1999)
   PUBMED   10395542
REFERENCE   10 (bases 1 to 4399)
  AUTHORS   Chan,S.D., Karpf,D.B., Fowlkes,M.E., Hooks,M., Bradley,M.S.,
            Vuong,V., Bambino,T., Liu,M.Y., Arnaud,C.D., Strewler,G.J. et al.
  TITLE     Two homologs of the Drosophila polarity gene frizzled (fz) are
            widely expressed in mammalian tissues
  JOURNAL   J Biol Chem 267 (35), 25202-25207 (1992)
   PUBMED   1334084
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC111275.4.
            
            On Oct 12, 2007 this sequence version replaced NM_021266.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4399              AC111275.4         206552-210950
FEATURES             Location/Qualifiers
     source          1..4399
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q13"
     gene            1..4399
                     /gene="Fzd1"
                     /note="frizzled class receptor 1"
                     /db_xref="GeneID:58868"
                     /db_xref="RGD:61916"
     exon            1..4399
                     /gene="Fzd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             413..2341
                     /gene="Fzd1"
                     /note="frizzled-1; fz-1; rFz1; Drosophila polarity gene
                     (frizzled) homologue; Drosophila polarity gene homolog 1;
                     frizzled family receptor 1"
                     /codon_start=1
                     /product="frizzled-1 precursor"
                     /protein_id="NP_067089.2"
                     /db_xref="GeneID:58868"
                     /db_xref="RGD:61916"
                     /translation="MAEEAVPSESRAAGRPSLELCAVALPGRREEVGHQDTAGHRRPR
                     ADSRCWARGLLLLLWLLEAPLLLGVRAQAAGQVSGPGQQAPPPPQPQQGGQQYNGERG
                     ISIPDHGYCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAEL
                     KFFLCSMYAPVCTVLEQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFPVHGA
                     GELCVGQNTSDKGTPTPSLLPEFWTSNPQHGGGGYRGGYPGGAGPVERGKFSCPRALR
                     VPSYLNYHFLGEKDCGAPCEPTKVYGLMYFGPEELRFSRTWIGIWSVLCCASTLFTVL
                     TYLVDMRRFSYPERPIIFLSGCYTAVAVAYIAGFLLEDRVVCNDKFAEDGARTVAQGT
                     KKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVP
                     AIKTITILALGQVDGDVLSGVCFVGLNNVDALRGFVLAPLFVYLFIGTSFLLAGFVSL
                     FRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFRDQWERSWVA
                     QSCKSYAIPCPHLQGGGGVPPHPPMSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNS
                     WRKFYTRLTNSKQGETTV"
ORIGIN      
        1 gacacaaatg gtctggcggc ggcggcggag gaggaggcgg aggcgcaggg gggacccggg
       61 gcggctaggc tgcccagagt tgcgcgctcc tctgcggggc tgcggccact agcaaggcgc
      121 tgccgggcaa gagccacagc ccgccgcggg ccgggaaaga gggacgcgac cccggcgcgc
      181 ccagaccact cctgctctcc tcgccgcccg cgcttcatga accgcaagtt tccgcggcgg
      241 cggcggcggc tgcgggacgc ggagcagaat cccggggagc gggcagagcg cggctttagc
      301 ccgacggagg gcacgggcga gaaccagatc tccccgaaca cagtgggaac tgccacccgc
      361 cacgccgctg cctgccctag ccgaccggcg ccgaggaggg agccgaaaaa gtatggctga
      421 ggaggcggtg cctagcgagt cccgggccgc cggccggccg agcttggaac tttgtgccgt
      481 agcactcccc ggccggcggg aggaggtggg gcaccaggac acggctggcc accgccggcc
      541 ccgggctgac tcccggtgct gggctagagg gctactgctg cttctttggc tgctggaggc
      601 tcctctgctt ttgggggtcc gagcgcaggc ggcgggccag gtatccgggc cgggccagca
      661 agctccgccg ccgccccagc cacagcaggg cgggcagcag tacaacggcg aacggggcat
      721 ctccatcccg gaccacggct actgtcagcc catctccatc ccgctgtgca cggacatcgc
      781 gtacaatcag accatcatgc ccaacctgct gggccacacg aatcaggagg acgccggcct
      841 ggaggtgcac cagttctacc cgttggtgaa ggtgcagtgc tcagccgagc tcaagttctt
      901 cctgtgctcc atgtacgcgc ctgtgtgcac cgtactggag caggcgctgc cgccctgccg
      961 ctccctgtgc gagcgcgcgc gccagggctg cgaggcactc atgaacaagt tcggcttcca
     1021 gtggccagac acgctcaagt gcgagaagtt ccctgtgcac ggcgcaggag agctgtgcgt
     1081 gggccagaac acttccgaca aaggcacccc gactccctcc ttgctgccgg agttctggac
     1141 cagcaatccg cagcacggcg gcggtggtta ccgcggcggc tacccgggag gtgccggccc
     1201 cgtggagcgg ggaaagttct cctgcccgcg cgccctcagg gtgccttcct acctcaacta
     1261 tcactttctg ggggagaagg actgcggcgc gccctgcgaa cccactaaag tatacgggct
     1321 catgtacttc gggcctgagg agttgcgctt ttcgcgcacc tggataggca tctggtcggt
     1381 gctgtgctgc gcctccacgc tcttcacggt gctcacgtac ctagtagaca tgcggcgctt
     1441 cagctacccg gagcggccca ttattttcct gtccggctgt tacacagcgg tggcggtggc
     1501 ctatatcgcc ggctttctgt tggaggaccg ggtggtgtgc aacgacaagt ttgcagagga
     1561 cggggcgcgc acggtggcgc agggcactaa gaaggagggg tgcaccatcc tctttatgat
     1621 gctctacttc ttcagcatgg ccagctccat ctggtgggta atcctgtccc tcacctggtt
     1681 cctggcagcc ggcatgaagt ggggccacga agccatcgag gccaactcac aatattttca
     1741 cctagccgcc tgggctgtac cagccattaa aactataacc atcctggcgc tgggccaagt
     1801 ggatggcgac gtactgagtg gagtgtgttt tgtggggctc aataacgtgg atgctctgcg
     1861 gggctttgtg ctggcgccgc tcttcgtcta tctgttcatc ggcacctctt tcctgctggc
     1921 tggtttcgtg tcgctcttcc gcatccgcac catcatgaag catgacggca ccaagacaga
     1981 gaaactggaa aagctcatgg tgcgcatcgg agtcttcagt gtgctctaca ccgtgccggc
     2041 caccatcgtc atcgcctgct acttctatga gcaggccttt cgggaccagt gggagcgcag
     2101 ctgggtggcc cagagctgca agagttatgc catcccttgc cctcacctcc aaggaggtgg
     2161 aggcgtccca ccacacccac ccatgagccc cgactttaca gtcttcatga tcaagtatct
     2221 catgacgcta attgtgggca tcacatcagg cttctggatc tggtccggca agacactgaa
     2281 ttcctggagg aagttctaca cgaggcttac caacagcaaa cagggggaga ctaccgtctg
     2341 aaacccagaa tcttacctgc ccttttctgg ccggatccca gctatcgcct gaaagctagc
     2401 tccaaggaat tcctgccaag cctagtcact ccaggcttcc tcgccagaca cacacttttg
     2461 caggctcctt tttcaacaaa cagcacaggt tctgcaaaag cttccgtccc tggggtaaag
     2521 gaacgagagg gcccaactgc tagaggggtt tgtttgtgtg gacagacctc tctagccctc
     2581 gctccgatac taggactgta cccttttatg attgtaaata acctgtgtaa gatttttgta
     2641 cgtatatttg tatttaaata ttatcgaata cgcgtttttt ctttttaaaa atgtttaatt
     2701 atttagggcg atttaagcat ctcggagctt ttctcacttg ctgtttcctg cggactgtag
     2761 aggaagtaac acagaacaca tttgatgagt gctttgccct gtgccctcat ccttgttatg
     2821 ggagcatggg cctggctctt gcactgaggg ctgtgacagg ggctgcctct ccagggtcaa
     2881 ttccttcagg ttcttccgcc cctccccttt cttgcttgca gtgggaaatt ttaaggtgca
     2941 gaactccata aagtttccag atcccgaggt gggccccgcc tattccagtt cctccccctt
     3001 tcagctgtag agtgtggagg gctgtccctg agacttcatg atgctgcttt tttgagaatc
     3061 acctttcaac ttcattagag gccctagcat gggcacagcc agttaaccca gcctccctct
     3121 actctggtgt ccctcgccca gtttctttct ccttccacct aagttggtca gagggaatgc
     3181 agtcaccagt accaaacttt ggaaagtctg actttttaat ggatgagctc atatttactt
     3241 tctagtgtct ggaacctgct atgggtctgg tccccatcgt ggaaagtgca gcaagctttg
     3301 tgggttggga cagatataaa acgttagttc taattgcatt ctgatgtctg gcaatcaatc
     3361 tcctttcttc ccccggtgat gctgcttgct tcttgctttt acccttctat gagatgcaga
     3421 catcgaggtc acccggcaag tttggtgaag gagttggttt ttaccttcct aaacgggata
     3481 gtagaacata accagaacat gaaaactgaa ggagatttca gtggagcgca gttcctccaa
     3541 gtgaaacggc tgttttctgg ttttaaccga actgcaatta gacataaatc agtcgtcaca
     3601 atctaaaagt tctacactat caacattatg cttacttctc agcagcacat tctgagggag
     3661 gagcagtcac acccccacag aaagcctggg acttccgaag acagaggagg tggactgact
     3721 gatgggtgag agaaacaaac acaaactggg catgcatgct gaaggggaag tgtgtccatt
     3781 cctactgcgt cccatcttgt gtgctcttgt ctggattcac ggcagtgtgt tcaatgtaaa
     3841 tctctcagag ccatttaaaa atactcactt tagttctcca tgaagaagag gaaaaaaagc
     3901 agtcctcccg attgtagtat tcaaactttt aagagtttat cacaaatgcc ggtacatagg
     3961 acctaaattt atctatgtct gtcataccct taaatgacat tggttttgaa tttggtatgc
     4021 gttattatta ttattgttat tattattatt ctcaccacca tgagatcatc tatatttata
     4081 gaggaataga agtttatata tataaaatgc catattttta atttcgcaaa taaaaaaagt
     4141 gaaagttttg tacaaaatta cgttgttttt gtgcctgaaa ataaccatcc tatctgaact
     4201 gcctttacat tttacagtgc ctcacaacca gtccacaaca tacaaaccga aagattcggt
     4261 ggacaaaccc gcccttccaa agagcaacca gtctgccttc cgagtggcat ttgtaaagca
     4321 ctattttcat gacacagaaa acagaaggtt tcagtccttt aaccaaacaa tgtcgtcatt
     4381 aaagtataac taattttaa
//
