LOCUS       NM_012755               1845 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Rattus norvegicus FYN proto-oncogene, Src family tyrosine kinase
            (Fyn), mRNA.
ACCESSION   NM_012755 XM_001062721
VERSION     NM_012755.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1845)
  AUTHORS   Li,H., Zhou,X., Chen,R., Xiao,Y. and Zhou,T.
  TITLE     The Src-Kinase Fyn is Required for Cocaine-Associated Memory
            Through Regulation of Tau
  JOURNAL   Front Pharmacol 13, 769827 (2022)
   PUBMED   35185557
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1845)
  AUTHORS   Zhang,L., Wang,L., Xiao,H., Gan,H., Chen,H., Zheng,S., Jian,D.,
            Zhai,X., Jiang,N., Jing,Z. and Liang,P.
  TITLE     Tyrosine kinase Fyn promotes apoptosis after intracerebral
            hemorrhage in rats by activating Drp1 signaling
  JOURNAL   J Mol Med (Berl) 99 (3), 359-371 (2021)
   PUBMED   33409551
  REMARK    GeneRIF: Tyrosine kinase Fyn promotes apoptosis after intracerebral
            hemorrhage in rats by activating Drp1 signaling.
REFERENCE   3  (bases 1 to 1845)
  AUTHORS   Luo,X., Li,Z., Zhao,J., Deng,Y., Zhong,Y. and Zhang,M.
  TITLE     Fyn gene silencing reduces oligodendrocytes apoptosis through
            inhibiting ERK1/2 phosphorylation in epilepsy
  JOURNAL   Artif Cells Nanomed Biotechnol 48 (1), 298-304 (2020)
   PUBMED   31852295
  REMARK    GeneRIF: Fyn gene silencing reduced the apoptosis of OLs through
            inhibiting the phosphorylation of ERK1/2 in epileptic model
REFERENCE   4  (bases 1 to 1845)
  AUTHORS   Egervari,G., Akpoyibo,D., Rahman,T., Fullard,J.F., Callens,J.E.,
            Landry,J.A., Ly,A., Zhou,X., Warren,N., Hauberg,M.E., Hoffman,G.,
            Ellis,R., Ferland,J.N., Miller,M.L., Keller,E., Zhang,B.,
            Roussos,P. and Hurd,Y.L.
  TITLE     Chromatin accessibility mapping of the striatum identifies tyrosine
            kinase FYN as a therapeutic target for heroin use disorder
  JOURNAL   Nat Commun 11 (1), 4634 (2020)
   PUBMED   32929078
  REMARK    GeneRIF: Chromatin accessibility mapping of the striatum identifies
            tyrosine kinase FYN as a therapeutic target for heroin use
            disorder.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1845)
  AUTHORS   Mao,L.M. and Wang,J.Q.
  TITLE     Linkage of Non-receptor Tyrosine Kinase Fyn to mGlu5 Receptors in
            Striatal Neurons in a Depression Model
  JOURNAL   Neuroscience 433, 11-20 (2020)
   PUBMED   32145272
  REMARK    GeneRIF: Linkage of Non-receptor Tyrosine Kinase Fyn to mGlu5
            Receptors in Striatal Neurons in a Depression Model.
REFERENCE   6  (bases 1 to 1845)
  AUTHORS   Grant,S.G., O'Dell,T.J., Karl,K.A., Stein,P.L., Soriano,P. and
            Kandel,E.R.
  TITLE     Impaired long-term potentiation, spatial learning, and hippocampal
            development in fyn mutant mice
  JOURNAL   Science 258 (5090), 1903-1910 (1992)
   PUBMED   1361685
REFERENCE   7  (bases 1 to 1845)
  AUTHORS   Bell,G.M., Bolen,J.B. and Imboden,J.B.
  TITLE     Association of Src-like protein tyrosine kinases with the CD2 cell
            surface molecule in rat T lymphocytes and natural killer cells
  JOURNAL   Mol Cell Biol 12 (12), 5548-5554 (1992)
   PUBMED   1280324
REFERENCE   8  (bases 1 to 1845)
  AUTHORS   Alai,M., Mui,A.L., Cutler,R.L., Bustelo,X.R., Barbacid,M. and
            Krystal,G.
  TITLE     Steel factor stimulates the tyrosine phosphorylation of the
            proto-oncogene product, p95vav, in human hemopoietic cells
  JOURNAL   J Biol Chem 267 (25), 18021-18025 (1992)
   PUBMED   1381360
REFERENCE   9  (bases 1 to 1845)
  AUTHORS   Appleby,M.W., Gross,J.A., Cooke,M.P., Levin,S.D., Qian,X. and
            Perlmutter,R.M.
  TITLE     Defective T cell receptor signaling in mice lacking the thymic
            isoform of p59fyn
  JOURNAL   Cell 70 (5), 751-763 (1992)
   PUBMED   1516132
REFERENCE   10 (bases 1 to 1845)
  AUTHORS   Beyers,A.D., Spruyt,L.L. and Williams,A.F.
  TITLE     Molecular associations between the T-lymphocyte antigen receptor
            complex and the surface antigens CD2, CD4, or CD8 and CD5
  JOURNAL   Proc Natl Acad Sci U S A 89 (7), 2945-2949 (1992)
   PUBMED   1372996
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Nov 26, 2020 this sequence version replaced NM_012755.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U35365.1, SRR26643295.60207.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               JAXUCZ010000020.1  44322664-44322773
            111-150             JAXUCZ010000020.1  44346789-44346828
            151-220             JAXUCZ010000020.1  44407131-44407200
            221-478             JAXUCZ010000020.1  44462141-44462398
            479-575             JAXUCZ010000020.1  44465992-44466088
            576-674             JAXUCZ010000020.1  44473109-44473207
            675-778             JAXUCZ010000020.1  44475735-44475838
            779-928             JAXUCZ010000020.1  44477285-44477434
            929-1093            JAXUCZ010000020.1  44480547-44480711
            1094-1273           JAXUCZ010000020.1  44483787-44483966
            1274-1350           JAXUCZ010000020.1  44485776-44485852
            1351-1504           JAXUCZ010000020.1  44485950-44486103
            1505-1636           JAXUCZ010000020.1  44501888-44502019
            1637-1845           JAXUCZ010000020.1  44513854-44514062
FEATURES             Location/Qualifiers
     source          1..1845
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q12"
     gene            1..1845
                     /gene="Fyn"
                     /note="FYN proto-oncogene, Src family tyrosine kinase"
                     /db_xref="GeneID:25150"
                     /db_xref="RGD:2641"
     exon            1..110
                     /gene="Fyn"
                     /inference="alignment:Splign:2.1.0"
     exon            111..150
                     /gene="Fyn"
                     /inference="alignment:Splign:2.1.0"
     exon            151..220
                     /gene="Fyn"
                     /inference="alignment:Splign:2.1.0"
     exon            221..478
                     /gene="Fyn"
                     /inference="alignment:Splign:2.1.0"
     CDS             232..1845
                     /gene="Fyn"
                     /EC_number="2.7.10.2"
                     /note="proto-oncogene tyrosine-protein kinase Fyn; FYN
                     oncogene related to SRC, FGR, YES; p59-Fyn; proto-oncogene
                     c-Fyn"
                     /codon_start=1
                     /product="tyrosine-protein kinase Fyn"
                     /protein_id="NP_036887.1"
                     /db_xref="GeneID:25150"
                     /db_xref="RGD:2641"
                     /translation="MGCVQCKDKEAAKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGV
                     TSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLS
                     FHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAE
                     RQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTR
                     AQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKR
                     LGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVS
                     EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLR
                     SANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVW
                     SFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPE
                     ERPTFEYLQGFLEDYFTATEPQYQPGENL"
     exon            479..575
                     /gene="Fyn"
                     /inference="alignment:Splign:2.1.0"
     exon            576..674
                     /gene="Fyn"
                     /inference="alignment:Splign:2.1.0"
     exon            675..778
                     /gene="Fyn"
                     /inference="alignment:Splign:2.1.0"
     exon            779..928
                     /gene="Fyn"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1093
                     /gene="Fyn"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1273
                     /gene="Fyn"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1350
                     /gene="Fyn"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1504
                     /gene="Fyn"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1636
                     /gene="Fyn"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1845
                     /gene="Fyn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagctcctgg gcccggccgc ggagccaccg gagccgccag ggcctcgccg gaggagggcg
       61 gggagaggac catgtgaatg tgctccggaa ccgagcgcca cgccacgcag tgtttgaaag
      121 gaacacaatg ctgatctagt cgtggcaaaa ggtcagtcct actgctggtt tagaagacat
      181 gtggtgtata taacgtttgt gatagttggt ggaaatttgg gagcttggat aatgggctgt
      241 gtgcaatgta aggataaaga agcagcgaaa ctgacggagg agagggacgg cagcctgaac
      301 cagagctctg ggtaccgcta tggcacagac cccacccctc agcactaccc cagcttcggt
      361 gtgacctcca tcccgaacta caacaacttc cacgcagccg ggggccaggg actcacggtc
      421 tttgggggtg tgaactcctc ctctcacacc gggaccctgc gtactagagg agggacagga
      481 gtgacactat ttgtggcact ttatgactat gaagcacgga cagaagatga cctgagtttt
      541 cacaaaggag aaaaatttca aatattgaac agctcggaag gagactggtg ggaagcccgc
      601 tccttgacaa ctggggaaac tggttacatt cctagcaact acgtggctcc agttgactcc
      661 atccaggcag aagagtggta ctttggaaaa cttggccgca aggatgctga gagacagctc
      721 ctgtcctttg gaaacccaag aggtaccttt cttatccgcg agagcgaaac caccaaaggt
      781 gcctactccc tctccatccg agactgggac gacatgaagg gagaccacgt caaacattac
      841 aaaatccgca agcttgacaa cggcgggtac tacatcacca cgagggccca gtttgagacc
      901 cttcagcagc ttgtacagca ttactcagag agagccgcgg gtctctgctg ccgtctagta
      961 gttccctgtc acaaagggat gccaaggctt accgatctgt ctgtcaaaac caaagatgtc
     1021 tgggaaatcc ctcgagaatc cctgcagttg atcaagagac tgggaaatgg gcagtttggg
     1081 gaagtatgga tgggtacctg gaatggaaac acaaaagtag ccataaagac tcttaagcca
     1141 ggcacaatgt ccccggaatc cttcctggag gaagcacaga tcatgaagaa gctgaagcac
     1201 gacaagctgg tgcagctcta tgcagttgtg tccgaagagc ccatttacat tgtcacggaa
     1261 tacatgaaca aaggaagttt gctcgacttc ttaaaagacg gtgaaggacg ggctctgaaa
     1321 ttgccaaacc tcgtggacat ggcggcacag gttgctgcag gaatggctta catcgaacgc
     1381 atgaattata tccacagaga tctgcggtca gctaacattc tggtggggaa cggactcatt
     1441 tgcaagattg ctgacttcgg attggcccgg ttgattgaag acaatgagta cacagccaga
     1501 caaggtgcaa agtttcccat taagtggaca gcccccgaag cggccctgta tggaaggttc
     1561 acaatcaagt ctgacgtgtg gtcctttgga atcttactca cagagctggt caccaaaggc
     1621 agagtgccgt acccaggcat gaacaaccgt gaggtgctgg agcaggtgga gagaggctac
     1681 aggatgccct gcccgcagga ctgcccgatc tccctgcacg agctcatgat ccactgctgg
     1741 aaaaaggatc cggaggagcg ccccactttc gagtacttgc agggcttcct ggaggactac
     1801 tttaccgcca cagagcccca gtatcagccc ggtgaaaacc tgtga
//
