LOCUS       NM_001106870            7743 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus FYVE and coiled-coil domain autophagy adaptor 1
            (Fyco1), mRNA.
ACCESSION   NM_001106870 XM_001078714 XM_236739
VERSION     NM_001106870.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7743)
  AUTHORS   Olsvik,H.L., Lamark,T., Takagi,K., Larsen,K.B., Evjen,G.,
            Overvatn,A., Mizushima,T. and Johansen,T.
  TITLE     FYCO1 Contains a C-terminally Extended, LC3A/B-preferring
            LC3-interacting Region (LIR) Motif Required for Efficient
            Maturation of Autophagosomes during Basal Autophagy
  JOURNAL   J Biol Chem 290 (49), 29361-29374 (2015)
   PUBMED   26468287
REFERENCE   2  (bases 1 to 7743)
  AUTHORS   Pankiv,S., Alemu,E.A., Brech,A., Bruun,J.A., Lamark,T.,
            Overvatn,A., Bjorkoy,G. and Johansen,T.
  TITLE     FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate
            microtubule plus end-directed vesicle transport
  JOURNAL   J Cell Biol 188 (2), 253-269 (2010)
   PUBMED   20100911
REFERENCE   3  (bases 1 to 7743)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473954.2.
            
            [WARNING] On Aug 8, 2024 this sequence was replaced by
            NM_001106870.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001078714.1, XM_236739.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760383, SAMEA5760389
                              [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..7743
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..7743
                     /gene="Fyco1"
                     /note="FYVE and coiled-coil domain autophagy adaptor 1"
                     /db_xref="GeneID:301085"
                     /db_xref="RGD:1309069"
     exon            1..274
                     /gene="Fyco1"
                     /inference="alignment:Splign:2.1.0"
     exon            275..394
                     /gene="Fyco1"
                     /inference="alignment:Splign:2.1.0"
     exon            395..544
                     /gene="Fyco1"
                     /inference="alignment:Splign:2.1.0"
     CDS             490..4845
                     /gene="Fyco1"
                     /note="FYVE and coiled-coil domain containing 1"
                     /codon_start=1
                     /product="FYVE and coiled-coil domain-containing protein
                     1"
                     /protein_id="NP_001100340.1"
                     /db_xref="GeneID:301085"
                     /db_xref="RGD:1309069"
                     /translation="MASSSTETQLQRIIRDLQDAVTELSNEFKEGGEPITDDSTSLHK
                     FSYKLEYLLQFDQKEKASLLGSKKDYWDYFCACLAKVKGANDGIRFVRSISELRTSLG
                     KGRAFIRYSLVHQRLADTLQQCFMNTKVTSDWYYARSPFLKPKLSSDIVGQLYELTEV
                     QFDLASRGYDLDAAWPTFARRTLATSSSYMWKPPSRSSSMSSLVSNYLQTQEMASSLD
                     LNSSLNNEALESFDEMRLELDQLEVREKQLQEHVQQLNRENQALRMTISKQGGQLQVE
                     KETGYLAVEDSIDLVSLVAELQKQGEVTQATVKKLQTCLQALELAVDQKETSHSVLQL
                     ENVAQALDAVRDSLGRKNQLLASLSECLTRAEKREHPSLDTKLHQEPVPTDLALKFQE
                     LKGKLQTLEGENTKAQELNRQQSLKLEQLAKELQLKEEARASLEHLVKDAVPLQEELS
                     GKKQESAQLRRQLQESLAHLSSVEEELAEARQQEKQHREEKQLLEQEAKSLTWQLQLL
                     ETQLGQVSQLVSDLEEQKKQLMQDKDHLSQKVGTLEQLAEAHGASKSKEAVPPQAGEM
                     PEKGQHCLQEEQVNNATVRGADQDELQKVNQELQKELQNMAVRNQLLEGKLQALQTDY
                     KALQQREAAIQGSLASLEAEQASIRQLGNQMEASLLAVRKAKETMKAQVAEKEAALQS
                     KEGECRQLQEEAEQCRLRTEAQAQELRALENQCQQQIQLIEVLSAEKGQQGLSLPQVN
                     TAQLALSQAQLEIHQGEAQRLQNEVVDLQAKLQVALGDRDKLQSQLGVAEAVLGEHKT
                     LVQQLKEQNEALNRAHIQELLQCSEREGILQEESIYKAQKQEQELRALQAELSQVRCS
                     SEGAHLEHAELQDQLHRANTDTAELGIQVCALTAEKDRMEGALASLAQELQDSKEAAL
                     QERKGLELQVMQLQQEKESLQEKLKATEEAASSFSVLQAQLAQAEQLAQSLQEAAHQE
                     QDALKFQLSAEIMDHQNRLKTANEECGSLRAQLEEQGQELQMTKEAVQELKITKATME
                     EKLNCTGSHLAECQATLLRKDEESAMLRINLERTQKELEKATSKFQEYYNKLCQEVTN
                     RERNDQKMLADLDDLNRTKKYLEERLIELLRDKDALWQKSDALEFQQKLSAEEKCLGD
                     MEANHCHDCKREFSWIVRRHHCRLCGRIFCYYCCNNYVVTKPSGKKERCCRACFQKFG
                     ESSGSPDSSGSGTSQGEPSPMVSPAEAAPQSIGSQGINPVCRPPDDAVFDIITDEELC
                     QIQESGSSLPETPTETDSMDPNMAEQDTTSNSLTPEDTEDMPLGQDAEICLLKSGELM
                     IKLPLTVEEIASFGEGNRELFVRSSTYSLIPITVAEPGLTISWVFSSDPKSISFSVVF
                     QETEDTPLDQCKVLIPTTRCNSHKESIRGQLKVRTPGIYLLIFDNTFSRFISKKVFYH
                     LTVDRPVIYDGSDFP"
     exon            545..651
                     /gene="Fyco1"
                     /inference="alignment:Splign:2.1.0"
     exon            652..777
                     /gene="Fyco1"
                     /inference="alignment:Splign:2.1.0"
     exon            778..884
                     /gene="Fyco1"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1028
                     /gene="Fyco1"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1116
                     /gene="Fyco1"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..3465
                     /gene="Fyco1"
                     /inference="alignment:Splign:2.1.0"
     exon            3466..3558
                     /gene="Fyco1"
                     /inference="alignment:Splign:2.1.0"
     exon            3559..3677
                     /gene="Fyco1"
                     /inference="alignment:Splign:2.1.0"
     exon            3678..3845
                     /gene="Fyco1"
                     /inference="alignment:Splign:2.1.0"
     exon            3846..3995
                     /gene="Fyco1"
                     /inference="alignment:Splign:2.1.0"
     exon            3996..4207
                     /gene="Fyco1"
                     /inference="alignment:Splign:2.1.0"
     exon            4208..4352
                     /gene="Fyco1"
                     /inference="alignment:Splign:2.1.0"
     exon            4353..4448
                     /gene="Fyco1"
                     /inference="alignment:Splign:2.1.0"
     exon            4449..4659
                     /gene="Fyco1"
                     /inference="alignment:Splign:2.1.0"
     exon            4660..4769
                     /gene="Fyco1"
                     /inference="alignment:Splign:2.1.0"
     exon            4770..7743
                     /gene="Fyco1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctcgccag aggggttggc tccaatacct aggctgtctg tggggccgta gaaagaccct
       61 caatactatc ccaagatctg agccggccga ggggggtcac cctgtggaac ctcacggtga
      121 agccgccctg tgaggcggag cttcggcagt tctcctgaaa ccctagcaca ggagccaaac
      181 cctaaagttc tcgcggtcag tgtggcttaa tccctagaaa gccaaaacct cctctctgcc
      241 tgattcctta cgccccttcg atccagggaa cacaggcttc cttgccccac ctcctgaaac
      301 cagaaggggg ccatagtact gagtgagtga gagctggtac atgttagaca gattcaaggt
      361 aacatgttat tgtgaaatgc tgaagttcag gatagtgcca ccatggactg tgaccattgc
      421 tgactggcag ccacacagca ctgaagtgat aacctgcttg gatctacacg tgtaagaaag
      481 aggaaaacta tggcttctag cagcactgag acgcagctcc agaggatcat ccgtgatcta
      541 caagatgcag tgacagaact aagcaatgaa tttaaggaag gcggagaacc aatcacagat
      601 gacagcacca gcttgcacaa gttttcttac aaacttgagt atcttctgca atttgatcag
      661 aaggagaagg ctagcctcct gggtagcaag aaggactact gggattactt ctgtgcgtgc
      721 ctagccaagg tgaaaggagc caatgatggg attcgattcg tcaggtccat ctctgagctc
      781 cgaacatctc taggaaaggg gagagccttc attcgctact ctttggtgca ccagaggttg
      841 gcagacacct tgcagcagtg cttcatgaac accaaagtga ccagtgactg gtattatgca
      901 agaagcccct ttctgaagcc aaagctgagc tctgacattg tgggccagct gtatgagctg
      961 actgaggttc agtttgatct agcatcaaga ggctacgact tggatgccgc ctggccaaca
     1021 tttgccagga ggacgctagc caccagctct tcttacatgt ggaaaccccc cagccgaagc
     1081 tccagcatga gtagtttagt gagcaactac ttgcagactc aggagatggc ctccagtctt
     1141 gacctgaata gttctctaaa caatgaagca ctagaaagct tcgatgagat gcggctggag
     1201 ctggaccagt tggaggttcg ggagaaacag ctacaagagc acgtgcagca gctaaacagg
     1261 gaaaaccaag cacttcgaat gacgatcagc aagcaagggg ggcaacttca ggtagagaag
     1321 gaaacggggt accttgcagt cgaggatagc attgacctcg tgagcctggt ggcagagctc
     1381 cagaagcagg gggaggtcac ccaggccaca gtgaagaagc tacagacatg tctacaggct
     1441 ctggagttag ctgtagacca gaaagagacc agccactcag tcttgcagct tgagaacgtg
     1501 gcacaggcac ttgacgctgt gagagactcc ttgggtagga agaaccagct tctagccagc
     1561 ctttctgaat gcctcactag ggctgaaaaa agggaacatc catctctgga cacaaagctt
     1621 catcaagagc cagttcctac tgacctggcc ctgaagttcc aggagctgaa gggaaaactt
     1681 caaaccctag aaggagagaa caccaaggcc caggagctaa acaggcagca aagtctcaag
     1741 ctagagcagc tggccaagga gctgcagctg aaggaggaag cccgagctag cctggaacac
     1801 ttagtgaagg atgcggtccc acttcaggaa gagctatccg gaaagaagca agagtcagct
     1861 cagctccgac gacagcttca ggaatccctg gcccacttga gctctgtgga ggaggagctg
     1921 gctgaagcca gacagcagga aaagcagcat cgagaagaaa aacagctact agagcaggag
     1981 gccaagtctc tgacatggca gctgcagctc ctagagaccc aactaggaca ggtgagtcag
     2041 cttgtgagtg acctggagga gcagaagaag caactcatgc aggacaaaga ccatctcagc
     2101 cagaaagtag gaacactaga gcagctagct gaggcccatg gggcaagtaa gagtaaagag
     2161 gctgtcccac cacaggctgg ggagatgcca gaaaaggggc agcactgcct ccaggaagaa
     2221 caggtaaaca atgccacagt gcgaggggca gaccaggacg agttacaaaa ggtcaaccag
     2281 gagctacaga aggagctgca gaacatggct gtgcgcaacc agctcctaga aggcaaactg
     2341 caggccttgc aaactgatta caaggcactg cagcagcgag aggcagcaat ccagggctct
     2401 ttagcctccc tggaagctga gcaggccagc atccggcagc tgggaaacca gatggaagca
     2461 agcctcctgg ctgtgaggaa agccaaagag actatgaagg cccaggtggc agagaaggag
     2521 gctgccctgc agagtaagga gggcgagtgc cggcagctgc aggaagaggc agagcagtgc
     2581 cggcttcgga cagaggccca ggcccaggag ctcagagctc ttgagaacca gtgccagcag
     2641 cagattcaac tgattgaggt cctctctgca gaaaaaggcc aacagggact cagcctaccc
     2701 caggtcaaca cagcccaact ggccctgtct caagcacagc ttgaaattca ccagggggaa
     2761 gcccagcggt tacagaatga ggtggtggac ctccaggcca agctccaggt ggccctaggt
     2821 gatcgagaca agttacagag ccaactgggt gtggctgagg cagttctcgg ggagcacaag
     2881 accctggtgc aacaactgaa agaacagaat gaagccctca acagggccca tattcaggag
     2941 ctgctgcagt gctcagagag agaggggata ctgcaggagg agagcatcta caaggcccag
     3001 aagcaggagc aagagctacg agccctgcag gcagagctgt cacaggtgag gtgcagctct
     3061 gagggagccc acctggagca tgcagagcta caggaccagc tgcaccgagc caacacagac
     3121 acagctgagc taggcataca ggtctgtgca ctgacagctg agaaggatcg gatggagggg
     3181 gccctggcca gcctagccca ggagctccag gactccaaag aagcagcact acaggaacga
     3241 aagggcttag agctccaagt gatgcaactt cagcaagaga aggagagctt gcaggaaaag
     3301 ctgaaggcaa ctgaggaggc agccagttca ttctctgttc ttcaggcaca gctggcccag
     3361 gctgagcagc tggcccagag cctccaagag gctgcacacc aggaacaaga tgcccttaag
     3421 ttccagctaa gtgctgagat tatggaccac cagaacagac taaagacagc caatgaagag
     3481 tgtgggagcc tcagggccca gctagaagaa caaggccagg agctgcaaat gactaaggag
     3541 gctgtgcagg aactgaagat caccaaggcg accatggagg agaagctgaa ttgcaccggt
     3601 agccaccttg cagagtgcca ggccactttg ctacgcaaag atgaagaaag cgctatgctt
     3661 cgaatcaacc tagagagaac acagaaggaa cttgaaaagg ctacatcaaa attccaagaa
     3721 tattacaaca aactctgcca ggaggtgaca aacagggaaa ggaatgacca gaagatgctt
     3781 gcagacctag atgacctgaa cagaaccaag aaataccttg aggagcggct gatagagctg
     3841 ctcagggaca aagatgctct ctggcaaaag tccgatgcac tggaattcca gcagaagctc
     3901 agtgctgaag agaaatgtct tggggacatg gaggccaacc actgccatga ctgcaagcgg
     3961 gagttcagct ggatagtgcg gcggcaccac tgcaggttat gtggccgaat attctgttac
     4021 tactgctgta acaactatgt tgtgactaag cccagtggca agaaggaacg gtgctgccga
     4081 gcctgcttcc agaagtttgg tgaaagctct ggatcccctg acagcagtgg ttcgggcact
     4141 agccagggag agcccagccc catggtgtca ccagctgaag cagctcccca gtccatagga
     4201 agccaaggaa taaacccagt ctgcagacca ccagatgatg ctgtgtttga catcatcacc
     4261 gatgaggaac tgtgccagat ccaagaatct ggctcctcct tgcctgaaac acccaccgaa
     4321 actgattcga tggacccaaa tatggctgaa caggacacca catcaaactc attaacccct
     4381 gaagacactg aagacatgcc cctggggcag gatgctgaaa tctgcttgct gaagtcagga
     4441 gagctgatga tcaaattacc cctcacagta gaggagatcg ccagctttgg ggagggaaac
     4501 agggagctgt ttgtgaggtc cagtacctac agcctgatcc ccatcaccgt ggctgagccc
     4561 ggccttacca tcagctgggt cttctcttct gatcccaaga gcatctcctt cagtgtggtc
     4621 ttccaagaga cagaagacac gccactcgac cagtgcaagg tcctcattcc caccacacgc
     4681 tgcaattccc acaaggagag catccggggc cagctgaagg tccgaacccc tggcatctac
     4741 ttgctcatct ttgacaacac cttttccaga tttatctcca aaaaagtatt ttaccacctg
     4801 accgttgacc ggcctgtgat ctacgatgga agtgatttcc catagcatca gtacctgaac
     4861 tgtaattagc tcttcaccat ccacaggaga cactactcct cctcacctat ctcatcaaac
     4921 atgtacacac actctcatcc acaaaatttt aaatgttaaa aaattagaag caaaggaaag
     4981 aaaatcagct gtgccccagc tcagcagttc tgaagctctg acagaagcct tgggctccac
     5041 aatgtgcatg gctccatgca gccattactc tcaagtccca gagctcctaa gaacaagata
     5101 caagactcaa ctgtcttctc acccaaaggc acaccattag cctcacctgg gatcacagtc
     5161 ggtaacaatc tactgtgtga tatttttcag gccagaagtg gttttgatag catatctact
     5221 ctcaacagcc agaattatag gccaagggcc actgcgctgg ccacgttgtg aagccttggg
     5281 tagttctggg agaaaaacac tacagggcca tcatgtcaga gatgcccctg tcccttaatt
     5341 tccccataag tgggggctgc ttcttccgct cagcaatctt ggggaggcct gagttatgct
     5401 gttcttctga gcctttgtct gctcggggcc tttgctcacc aagatcatta gatctaaata
     5461 acctcccttc gccccccacc ccaactcaca gacactcagg aaccaaccag aggtttagga
     5521 aaaagcaact cccacatgaa ggattcagct ctgcatatgg acagtgggag tgcaaatacg
     5581 gctaagttcc ctaccgtgga actcaagttg gcaccaaagc tcatgtgttg cctatgccca
     5641 tctttgatta taaactagac tgtctgcctc agctgcagac agttgtttac tgatgagcag
     5701 agctggtgta agaactactt tcagtacctg gaacctttct attaaaaagt ctttggtaac
     5761 ttaagaaaca atgtagtgga agaatggggc gtaacttccg tttgccctcc acctcccagt
     5821 ccctccctcc ccatctgtct gcttccttct agtcagctca catctgacac tgcagacagt
     5881 ttactgtttc cttttctagg acaggcaaat agatagcttc ctgttgttct ctgtggccct
     5941 tttttactcc taccaacaaa aattcaccct tgatggcgat tttgttcagt gtgaggccag
     6001 catgtgcagc tgagccttca aaaactgtcc tgggtccttg taggtctgta tgcggcctga
     6061 gattgctgaa ggccaaatca tcttaccttt gaaccctata ccctcttgca aatggaatgt
     6121 tgaagccagc ttgttcgcta ggccaacagc acccaacacc aaagaggatc tcatctttat
     6181 tgcttggctt ttccagggta tactggagac actggccaaa ctcatggctt tctgctggtg
     6241 tcactgccac catcttcatc aagagccatc attcactgag ttgctgctgt gttggtggtc
     6301 tgggaggggc ctgagacctt acatttgcgt tcaccctgaa ctctgtcact catcaggagg
     6361 tccatgtggt tcttgtgaag ctcagacctg agtcgagagg ctccagtgct gactgcgtag
     6421 aactccactg ggcgcacacc gactctgttt ttaatagcat acttttggct aaatgggctt
     6481 tgtactgtcc gtgttctggt tttctgagca ctagcttact agagaacgtt cggccctgtg
     6541 tcagtgcctt tcatgcatag ctttgcttta agtcgttccc aattttactg aggttcagtc
     6601 attggagtaa gtttttgaaa aatgcagtga caactgaaga atcactaagg aagatggttg
     6661 acccagctgg acgtaattac actaaagacc ataaggaaac atccttgaga tcctgggtga
     6721 ttcataacag tcgtgttagt agcattgcca gctgcctgtt caccagtacc actgaagcac
     6781 tactagactt cacccaagga atgaactagc cactcagaca cagtggccct ccatgtccaa
     6841 atggacttga agagtattgc tgacagaagc acccaggatt ctagctagtc ctaaagcaat
     6901 agcaggcaaa ggaattccca aacaggaatc tggaactgga aatctccata tctttttgga
     6961 agtgggaatg aagagccata tataaataaa gatgttattt ctgaacaatt tcaattgttc
     7021 cccaggtaat caagcacctc ctggcccaaa aagaaggaaa tcttcttata gatatggttt
     7081 gatgttcata gttttgtttt taaactgaga cttggttcag tctgtgagaa ttctttaaac
     7141 cgagagcaaa cattcttggc tcacaggttt tggagaagga ggcagagagg agagttcttt
     7201 ggagagacat ctttgactcc tcagaaccag ggagtgcaat acaaagactg agtgctgctc
     7261 acattcacag aaacagacac tacttggtag aatcttagca caatttcctc atgttactta
     7321 atttcttcta aggaaacagg aaagttaatt cataatttcc tttttcctct caagcacttt
     7381 ttaaatttca ggagacctct ctgatcaagg ggcatttttt agagcctttt gatgtgtgtt
     7441 taatctcagt gttctacttt tggtgactgc agtgacactg agcctccatg ggaaggctta
     7501 acagttagag tgcactttaa ttcattaatc ctcgctttat gtggccttat aagataatgg
     7561 gtcagggaac ccattttatt cttacctgcc aaagagttac acagaaacac atcaaacacc
     7621 agcacttcat ctgcacaaag ggatgagact ttggtatctc tgagtgtact tctttaatag
     7681 tgtgtgctat gccatttgga aatgttttta acctcaggtt ttaaataaag caaacactgt
     7741 ggc
//
