LOCUS       NM_001109176            2707 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Rattus norvegicus FYN binding protein 1 (Fyb1), mRNA.
ACCESSION   NM_001109176 XM_001054436 XM_574859
VERSION     NM_001109176.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2707)
  AUTHORS   Menasche,G., Kliche,S., Chen,E.J., Stradal,T.E., Schraven,B. and
            Koretzky,G.
  TITLE     RIAM links the ADAP/SKAP-55 signaling module to Rap1, facilitating
            T-cell-receptor-mediated integrin activation
  JOURNAL   Mol Cell Biol 27 (11), 4070-4081 (2007)
   PUBMED   17403904
REFERENCE   2  (bases 1 to 2707)
  AUTHORS   Wu,J.N., Jordan,M.S., Silverman,M.A., Peterson,E.J. and
            Koretzky,G.A.
  TITLE     Differential requirement for adapter proteins Src homology 2
            domain-containing leukocyte phosphoprotein of 76 kDa and adhesion-
            and degranulation-promoting adapter protein in FcepsilonRI
            signaling and mast cell function
  JOURNAL   J Immunol 172 (11), 6768-6774 (2004)
   PUBMED   15153494
REFERENCE   3  (bases 1 to 2707)
  AUTHORS   Fujii,Y., Wakahara,S., Nakao,T., Hara,T., Ohtake,H., Komurasaki,T.,
            Kitamura,K., Tatsuno,A., Fujiwara,N., Hozumi,N., Ra,C., Kitamura,D.
            and Goitsuka,R.
  TITLE     Targeting of MIST to Src-family kinases via SKAP55-SLAP-130 adaptor
            complex in mast cells
  JOURNAL   FEBS Lett 540 (1-3), 111-116 (2003)
   PUBMED   12681493
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474048.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_574859.2, XM_001054436.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132291,
                              SAMD00132295 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2707
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q16"
     gene            1..2707
                     /gene="Fyb1"
                     /gene_synonym="ADAP; Fyb; p120/p130; RGD1563421; SLAP-130"
                     /note="FYN binding protein 1"
                     /db_xref="GeneID:499537"
                     /db_xref="RGD:1563421"
     exon            1..1204
                     /gene="Fyb1"
                     /gene_synonym="ADAP; Fyb; p120/p130; RGD1563421; SLAP-130"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..2565
                     /gene="Fyb1"
                     /gene_synonym="ADAP; Fyb; p120/p130; RGD1563421; SLAP-130"
                     /note="FYN binding protein (FYB-120/130); FYN-binding
                     protein; FYN-T-binding protein; SLP-76-associated
                     phosphoprotein; adhesion and degranulation promoting
                     adaptor protein"
                     /codon_start=1
                     /product="FYN-binding protein 1"
                     /protein_id="NP_001102646.1"
                     /db_xref="GeneID:499537"
                     /db_xref="RGD:1563421"
                     /translation="MAKFNTGSNPTEEVSTSSRPFKVAGQNSPSGIQSKKNLFDNQGN
                     ASPPAGPSNMSKFGTTKPPLAAKPTYEEKSEKEPKPPFLKPTGVSPRFGTQPNSVSRD
                     PEVKVGFLKPVSPKPTSLTKEDSKPVILRPPGNKLHNLNQESDLKTLGPKPGSTPPVP
                     ENDLKPGFSKIAGAKSKFMPAPQDADSKPRFPRHTYGQKPSLSTEDAQEEESIPKNTP
                     VQKGSPVQLGAKSRGSPFKPAKEDPEDKDHGTPSSPFAGVVLKPAASRGSPGLSKNSE
                     EKKEERKTDIPKNIFLNKLNQEEPARFPKAPSKLTAGTPWGQSQEKEGDKDSATPKQK
                     PLPPLSVLGPPPSKPSRPPNVDLTRFRKADSANSSNKSQTPYSTTSLPPPPPTQPASQ
                     PPLPASHPAHLPAPSLPPRNIKPPLDLKHPINEENQDGVMHSDGTGNLEEEQESDGEM
                     YEDIESSKERDKKREKEEKKRLELERKEQKEREKKEQELRKKFKLTGPIQVIHHAKAC
                     CDVKGGKNELSFKQGEDIEIIRITDNPEGKWLGRTARGSYGYIKTTAVKIDYDSLKRK
                     KNTINAVPPRPVEEDQDVYDDVAEQDAPNSHSQSGSGGMFPPPPADDDIYDGIEEEDA
                     DDGSVPQVDEKTNAWSWGILKMLKGKDERKKSIREKPKVSESDSNEGSSFPSPHKQLD
                     VGEEVYDDVDASDFPPPPAEMSQGMSVGKTKAEEKDPKKLKKQEKEEKDLRKKFKYDG
                     EIRVLYSTKVASSLTSKKWGTRDLQIKPGESLEVIQSTDDTKVLCRNEEGKYGYVLRS
                     YLVDNDGEIYDDIADGCIYDND"
     exon            1205..1361
                     /gene="Fyb1"
                     /gene_synonym="ADAP; Fyb; p120/p130; RGD1563421; SLAP-130"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1408
                     /gene="Fyb1"
                     /gene_synonym="ADAP; Fyb; p120/p130; RGD1563421; SLAP-130"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1428
                     /gene="Fyb1"
                     /gene_synonym="ADAP; Fyb; p120/p130; RGD1563421; SLAP-130"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1463
                     /gene="Fyb1"
                     /gene_synonym="ADAP; Fyb; p120/p130; RGD1563421; SLAP-130"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1584
                     /gene="Fyb1"
                     /gene_synonym="ADAP; Fyb; p120/p130; RGD1563421; SLAP-130"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1744
                     /gene="Fyb1"
                     /gene_synonym="ADAP; Fyb; p120/p130; RGD1563421; SLAP-130"
                     /inference="alignment:Splign:2.1.0"
     exon            1745..1889
                     /gene="Fyb1"
                     /gene_synonym="ADAP; Fyb; p120/p130; RGD1563421; SLAP-130"
                     /inference="alignment:Splign:2.1.0"
     exon            1890..1912
                     /gene="Fyb1"
                     /gene_synonym="ADAP; Fyb; p120/p130; RGD1563421; SLAP-130"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..1982
                     /gene="Fyb1"
                     /gene_synonym="ADAP; Fyb; p120/p130; RGD1563421; SLAP-130"
                     /inference="alignment:Splign:2.1.0"
     exon            1983..2120
                     /gene="Fyb1"
                     /gene_synonym="ADAP; Fyb; p120/p130; RGD1563421; SLAP-130"
                     /inference="alignment:Splign:2.1.0"
     exon            2121..2146
                     /gene="Fyb1"
                     /gene_synonym="ADAP; Fyb; p120/p130; RGD1563421; SLAP-130"
                     /inference="alignment:Splign:2.1.0"
     exon            2147..2213
                     /gene="Fyb1"
                     /gene_synonym="ADAP; Fyb; p120/p130; RGD1563421; SLAP-130"
                     /inference="alignment:Splign:2.1.0"
     exon            2214..2313
                     /gene="Fyb1"
                     /gene_synonym="ADAP; Fyb; p120/p130; RGD1563421; SLAP-130"
                     /inference="alignment:Splign:2.1.0"
     exon            2314..2476
                     /gene="Fyb1"
                     /gene_synonym="ADAP; Fyb; p120/p130; RGD1563421; SLAP-130"
                     /inference="alignment:Splign:2.1.0"
     exon            2477..2510
                     /gene="Fyb1"
                     /gene_synonym="ADAP; Fyb; p120/p130; RGD1563421; SLAP-130"
                     /inference="alignment:Splign:2.1.0"
     exon            2511..2542
                     /gene="Fyb1"
                     /gene_synonym="ADAP; Fyb; p120/p130; RGD1563421; SLAP-130"
                     /inference="alignment:Splign:2.1.0"
     exon            2543..2707
                     /gene="Fyb1"
                     /gene_synonym="ADAP; Fyb; p120/p130; RGD1563421; SLAP-130"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccttgaagct atagtatttt aaactgcaag tgtgatttcg gactctcagc tggtttttgt
       61 tccctgtgct tataggacgg aaaaacggat gtaaagtccc tcatggcgaa gttcaacacc
      121 gggagtaacc cgacagagga ggtctccacc agcagcaggc ccttcaaagt tgcaggacaa
      181 aactcccctt ctggaataca atcaaaaaag aatttatttg acaaccaagg aaatgccagc
      241 ccacccgcag gacccagcaa catgtctaaa tttgggacca caaaaccacc cttggcagcg
      301 aaacctacct atgaggagaa gtctgagaaa gagcctaaac ctccgttttt aaaaccgact
      361 ggagtgagcc caaggtttgg aacacagcca aactcggttt ctagggatcc tgaggtcaaa
      421 gtggggtttc tgaaacctgt aagccccaaa cccaccagct tgaccaaaga agattccaaa
      481 cctgtgattt tacggcctcc tgggaataag cttcacaatt tgaaccaaga gtctgactta
      541 aagacgctag gaccgaagcc agggtctact cccccagtcc cagaaaatga tctgaagcca
      601 gggttctcaa agatagctgg agctaagagc aagttcatgc cagcaccgca agatgctgac
      661 tccaaacccc gatttcccag acacacctac ggccaaaagc catccctaag tacagaggac
      721 gcccaagaag aggaaagcat ccctaagaat acgcctgtcc agaagggatc cccagtgcag
      781 ctcggagcca agtccagggg cagccctttc aaaccagcta aggaagaccc agaagataaa
      841 gaccatggaa caccaagttc gccctttgct ggagtggttc tgaaacctgc tgcgagcaga
      901 gggagcccgg ggctctccaa aaactctgaa gagaaaaaag aagagagaaa aacagatatt
      961 ccaaagaaca tctttctgaa caaactgaat caggaagagc cggccagatt ccctaaggcc
     1021 ccttccaagc tgacagcggg gacaccatgg ggccaaagtc aggagaagga aggagacaag
     1081 gattcagcaa ccccgaagca gaagcccctg cctcccctgt ccgtcttggg cccgcctcca
     1141 tccaagccca gcagaccacc caacgttgac ctgaccagat tccgaaaagc tgactctgca
     1201 aacagttcca acaaaagcca gacaccttac tcgacaacct ccctgccacc acctccgcct
     1261 acacagccag ccagccagcc accgctgccg gcgtctcacc cagcacatct gccagccccc
     1321 agcctgcccc ccagaaacat taagcctccc cttgacctga aacatcctat aaatgaagaa
     1381 aatcaagatg gtgtcatgca ttctgatggt actggaaatc tagaagagga acaagagagt
     1441 gatggagaaa tgtatgaaga catagagtca tccaaggaac gagacaagaa acgggaaaaa
     1501 gaagaaaaga agagattaga gctagaacga aaggagcaga aggagagaga gaagaaagag
     1561 caagaactga ggaagaaatt caagcttact ggccccattc aagtcatcca tcatgcaaaa
     1621 gcctgctgtg atgtcaaagg aggaaagaac gaactgagct tcaagcaagg agaggacatt
     1681 gaaataatcc gcatcacaga caatccagaa gggaaatggc tgggcagaac tgcaagggga
     1741 tcatatggtt atattaaaac gactgccgtc aagattgact atgattccct gaaacggaag
     1801 aagaatacca tcaatgctgt tccaccgaga cctgttgaag aggaccaaga tgtctatgat
     1861 gatgtggctg agcaggatgc tcctaacagc cacagtcaga gtggaagtgg agggatgttc
     1921 ccaccaccgc cagcagacga cgacatctat gatgggatag aagaggaaga tgctgatgac
     1981 ggatccgtgc cgcaggttga tgagaagact aacgcgtggt cctgggggat tttgaagatg
     2041 ttaaagggaa aagatgaaag aaagaaaagc attcgagaga aacctaaagt ctctgagtca
     2101 gacagtaatg aaggttcatc tttcccttct cctcataaac aactggatgt gggagaagaa
     2161 gtttacgatg atgtggatgc ctcagacttc ccccctccac ctgcagaaat gagtcaaggt
     2221 atgagtgttg gaaagacaaa agctgaagag aaagatccta agaagctaaa aaagcaggaa
     2281 aaggaagaaa aagacctcag gaaaaaattc aagtacgacg gtgaaattcg agttctatat
     2341 tcaactaaag ttgcatcctc cttaacttct aaaaagtggg gaacgagaga tctgcagata
     2401 aaacctgggg agtctcttga agttatacaa agcacagacg acaccaaagt tctctgcagg
     2461 aatgaagagg gcaaatatgg ttacgtcctt cggagttacc tggtggacaa tgatggagaa
     2521 atctacgacg acatcgctga tggttgcatc tatgacaacg actagcacgt agctctgtcc
     2581 atcccgctgt gcctctgagt ggccaacatg aattttaatt ggaatgttct tgggtgttat
     2641 aggaaaagaa atgaatgtac aaaatgaaat ttcaatctct ttataaagtt ttgaagtttt
     2701 aaacttg
//
