LOCUS       NM_022008                714 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus FXYD domain-containing ion transport regulator 7
            (Fxyd7), mRNA.
ACCESSION   NM_022008
VERSION     NM_022008.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 714)
  AUTHORS   Moshitzky,S., Asher,C. and Garty,H.
  TITLE     Intracellular trafficking of FXYD1 (phospholemman) and FXYD7
            proteins in Xenopus oocytes and mammalian cells
  JOURNAL   J Biol Chem 287 (25), 21130-21141 (2012)
   PUBMED   22535957
REFERENCE   2  (bases 1 to 714)
  AUTHORS   Beguin,P., Crambert,G., Monnet-Tschudi,F., Uldry,M.,
            Horisberger,J.D., Garty,H. and Geering,K.
  TITLE     FXYD7 is a brain-specific regulator of Na,K-ATPase alpha 1-beta
            isozymes
  JOURNAL   EMBO J 21 (13), 3264-3273 (2002)
   PUBMED   12093728
  REMARK    GeneRIF: Expressed only in brain, rat FXYD7 is a type I membrane
            protein with N-terminal, post-translational Thr modifications,
            important for stability. FXYD7 is a tissue- and isoform-specific
            Na,K-ATPase regulator. It may play a role in neuronal excitability.
REFERENCE   3  (bases 1 to 714)
  AUTHORS   Sweadner,K.J. and Rael,E.
  TITLE     The FXYD gene family of small ion transport regulators or channels:
            cDNA sequence, protein signature sequence, and expression
  JOURNAL   Genomics 68 (1), 41-56 (2000)
   PUBMED   10950925
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Kathleen Sweadner. The reference sequence was
            derived from AW914994.1.
            
            Summary: This reference sequence was derived from multiple ESTs and
            validated by similar mouse cDNA and human genomic sequence. This
            gene encodes a member of a family of small membrane proteins that
            share a 35-amino acid signature sequence domain, beginning with the
            sequence PFXYD and containing 7 invariant and 6 highly conserved
            amino acids. The approved human gene nomenclature for the family is
            FXYD-domain containing ion transport regulator. Transmembrane
            topology has been established for two family members (FXYD1 and
            FXYD2), with the N-terminus extracellular and the C-terminus on the
            cytoplasmic side of the membrane. FXYD2, also known as the gamma
            subunit of the Na,K-ATPase, regulates the properties of that
            enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4
            (CHIF), and FXYD5 (RIC) have been shown to induce channel activity
            in experimental expression systems. This gene product, FXYD7, is
            novel and has not been characterized as a protein. [RefSeq curation
            by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu.,
            Dec 2000].
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB616439.1, CB614424.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16418971, SAMN16418986
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..714
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..714
                     /gene="Fxyd7"
                     /note="FXYD domain-containing ion transport regulator 7"
                     /db_xref="GeneID:63848"
                     /db_xref="RGD:620830"
     exon            1..118
                     /gene="Fxyd7"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..330
                     /gene="Fxyd7"
                     /codon_start=1
                     /product="FXYD domain-containing ion transport regulator
                     7"
                     /protein_id="NP_071291.1"
                     /db_xref="GeneID:63848"
                     /db_xref="RGD:620830"
                     /translation="MATPTQSPTNVPEETDPFFYDYATVQTVGMTLATIMFVLGIIII
                     ISKKVKCRKADSRSESPTCKSCKSELPSSAPGGGGV"
     exon            119..148
                     /gene="Fxyd7"
                     /inference="alignment:Splign:2.1.0"
     exon            149..223
                     /gene="Fxyd7"
                     /inference="alignment:Splign:2.1.0"
     exon            224..266
                     /gene="Fxyd7"
                     /inference="alignment:Splign:2.1.0"
     exon            267..307
                     /gene="Fxyd7"
                     /inference="alignment:Splign:2.1.0"
     exon            308..714
                     /gene="Fxyd7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      688..693
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fxyd7"
     polyA_site      714
                     /gene="Fxyd7"
ORIGIN      
        1 cccaccacat cagtctgtcc tgcttccagc tgctgcagcc gcgccttcgc tgcctcagca
       61 ttcagcaacc ccctgctcag gctcagcatg gccaccccaa cccagagccc cacaaacgtt
      121 cctgaagaaa cagatccttt tttctatgac tatgccaccg tgcagactgt ggggatgacc
      181 ctggccacta tcatgttcgt gctgggcatc atcatcatca tcagcaagaa ggttaagtgc
      241 aggaaggcgg actccaggtc tgagagccca acatgcaaat cctgtaagtc ggaactgccc
      301 tcctcagccc ctggaggtgg cggtgtgtag gatcctctgc agatttccac tgctgtccct
      361 ggccagagcg caggagcctg aggacccaga gaaggcggtg gggacccagc ctggcgccag
      421 ggagtgctcc cccaatgagc cgccacaccc ataccaaggc cggagccaat gcaccctgct
      481 cgctctccct ccccaggccg tggcaacgac gacgatcccc aaagagccta tttgtacccc
      541 agacccagag actcaggcct ccagctcctg ggattcagga gtctgtcccc agtgccctgg
      601 gatcctcgtg tccctccttc ctgcatctcc tggtctcctt ctccaggacc ttccccgctg
      661 tcccctcagg gtccacatct tgagcttaat aaatgtgcaa tcggtttctc ccgg
//
