LOCUS       NM_022005               1766 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus FXYD domain-containing ion transport regulator 6
            (Fxyd6), mRNA.
ACCESSION   NM_022005 XM_343382
VERSION     NM_022005.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1766)
  AUTHORS   Biesemann,C., Gronborg,M., Luquet,E., Wichert,S.P., Bernard,V.,
            Bungers,S.R., Cooper,B., Varoqueaux,F., Li,L., Byrne,J.A.,
            Urlaub,H., Jahn,O., Brose,N. and Herzog,E.
  TITLE     Proteomic screening of glutamatergic mouse brain synaptosomes
            isolated by fluorescence activated sorting
  JOURNAL   EMBO J 33 (2), 157-170 (2014)
   PUBMED   24413018
REFERENCE   2  (bases 1 to 1766)
  AUTHORS   George,A.J., Gordon,L., Beissbarth,T., Koukoulas,I.,
            Holsinger,R.M., Perreau,V., Cappai,R., Tan,S.S., Masters,C.L.,
            Scott,H.S. and Li,Q.X.
  TITLE     A serial analysis of gene expression profile of the Alzheimer's
            disease Tg2576 mouse model
  JOURNAL   Neurotox Res 17 (4), 360-379 (2010)
   PUBMED   19760337
REFERENCE   3  (bases 1 to 1766)
  AUTHORS   Delprat,B., Puel,J.L. and Geering,K.
  TITLE     Dynamic expression of FXYD6 in the inner ear suggests a role of the
            protein in endolymph homeostasis and neuronal activity
  JOURNAL   Dev Dyn 236 (9), 2534-2540 (2007)
   PUBMED   17676640
  REMARK    GeneRIF: FXYD6 is expressed in the inner ear and may have a role in
            endolymph homeostasis and neuronal activity
REFERENCE   4  (bases 1 to 1766)
  AUTHORS   Kadowaki,K., Sugimoto,K., Yamaguchi,F., Song,T., Watanabe,Y.,
            Singh,K. and Tokuda,M.
  TITLE     Phosphohippolin expression in the rat central nervous system
  JOURNAL   Brain Res Mol Brain Res 125 (1-2), 105-112 (2004)
   PUBMED   15193427
  REMARK    GeneRIF: findings suggest that Php may play an important role in
            the excitability of neurons in the central nervous system during
            postnatal development, as well as those in the adult brain
REFERENCE   5  (bases 1 to 1766)
  AUTHORS   Yamaguchi,F., Yamaguchi,K., Tai,Y., Sugimoto,K. and Tokuda,M.
  TITLE     Molecular cloning and characterization of a novel
            phospholemman-like protein from rat hippocampus
  JOURNAL   Brain Res Mol Brain Res 86 (1-2), 189-192 (2001)
   PUBMED   11165386
REFERENCE   6  (bases 1 to 1766)
  AUTHORS   Sweadner,K.J. and Rael,E.
  TITLE     The FXYD gene family of small ion transport regulators or channels:
            cDNA sequence, protein signature sequence, and expression
  JOURNAL   Genomics 68 (1), 41-56 (2000)
   PUBMED   10950925
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Kathleen Sweadner. The reference sequence was
            derived from JAXUCZ010000008.1.
            
            On Nov 27, 2020 this sequence version replaced NM_022005.2.
            
            Summary: This reference sequence was derived from multiple
            replicate ESTs and a deposited cDNA, and validated by similar human
            genomic sequence. This gene encodes a member of a family of small
            membrane proteins that share a 35-amino acid signature sequence
            domain, beginning with the sequence PFXYD and containing 7
            invariant and 6 highly conserved amino acids. The approved human
            gene nomenclature for the family is FXYD-domain containing ion
            transport regulator. FXYD2, also known as the gamma subunit of the
            Na,K-ATPase, regulates the properties of that enzyme. FXYD1
            (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and
            FXYD5 (RIC) have been shown to induce channel activity in
            experimental expression systems. Transmembrane topology has been
            established for two family members (FXYD1 and FXYD2), with the
            N-terminus extracellular and the C-terminus on the cytoplasmic side
            of the membrane. This gene product, FXYD6, is novel and has not
            been characterized as a protein. The name 'phosphohippolin' has
            been used in GenBank, but there is no evidence yet of protein
            phosphorylation. [RefSeq curation by Kathleen J. Sweadner, Ph.D.,
            sweadner@helix.mgh.harvard.edu., Dec 2000].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB030908.1, BC072528.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-219               JAXUCZ010000008.1  54575825-54576043
            220-279             JAXUCZ010000008.1  54596285-54596344
            280-318             JAXUCZ010000008.1  54596949-54596987
            319-393             JAXUCZ010000008.1  54597092-54597166
            394-430             JAXUCZ010000008.1  54597948-54597984
            431-480             JAXUCZ010000008.1  54598633-54598682
            481-530             JAXUCZ010000008.1  54599072-54599121
            531-1766            JAXUCZ010000008.1  54601480-54602715
FEATURES             Location/Qualifiers
     source          1..1766
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..1766
                     /gene="Fxyd6"
                     /gene_synonym="Php"
                     /note="FXYD domain-containing ion transport regulator 6"
                     /db_xref="GeneID:63847"
                     /db_xref="RGD:69315"
     exon            1..219
                     /gene="Fxyd6"
                     /gene_synonym="Php"
                     /inference="alignment:Splign:2.1.0"
     exon            220..279
                     /gene="Fxyd6"
                     /gene_synonym="Php"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..509
                     /gene="Fxyd6"
                     /gene_synonym="Php"
                     /note="VESP6; vascular endothelial cell-specific protein
                     6; phosphohippolin"
                     /codon_start=1
                     /product="FXYD domain-containing ion transport regulator 6
                     precursor"
                     /protein_id="NP_071288.1"
                     /db_xref="GeneID:63847"
                     /db_xref="RGD:69315"
                     /translation="METVLILCSLLAPVVLASAAEKEKEKDPFYYDYQTLRIGGLVFA
                     VVLFSVGILLILSRRCKCSFNQKPRAPGDEEAQVENLITTNAAEPQKAEN"
     exon            280..318
                     /gene="Fxyd6"
                     /gene_synonym="Php"
                     /inference="alignment:Splign:2.1.0"
     exon            319..393
                     /gene="Fxyd6"
                     /gene_synonym="Php"
                     /inference="alignment:Splign:2.1.0"
     exon            394..430
                     /gene="Fxyd6"
                     /gene_synonym="Php"
                     /inference="alignment:Splign:2.1.0"
     exon            431..480
                     /gene="Fxyd6"
                     /gene_synonym="Php"
                     /inference="alignment:Splign:2.1.0"
     exon            481..530
                     /gene="Fxyd6"
                     /gene_synonym="Php"
                     /inference="alignment:Splign:2.1.0"
     exon            531..1766
                     /gene="Fxyd6"
                     /gene_synonym="Php"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctcaccga gaggagggcg caggcgacag cacagcggtc tgcgagggga cccagaagcc
       61 agtggacgcg ggccacccgg gagcccagcc agtcagcccc ctctgggagg cgggaaaact
      121 gcaagccgcg cccaccgccc tgcccccagc gcgccactcc cggctgctgg gactctgctc
      181 agactcctgg gatccgcttg gagggaaccc aacgcctaga caccatggag acggtgctga
      241 tcctctgcag cttgctggcc cctgtggtcc tggctagtgc agctgagaag gagaaagaaa
      301 aggatccttt ctattatgac taccagaccc tgaggattgg gggattggtg tttgctgtgg
      361 tcctcttctc tgttgggata cttctcatcc taagtcgcag gtgcaagtgc agtttcaatc
      421 agaaacccag ggctccaggt gatgaagagg cccaggtgga gaaccttatc accacaaatg
      481 ctgcggagcc ccagaaggca gagaactgaa gggcagcctc cagcatgaag cctccagaag
      541 ccaaggccag ctacccgaca ctttagaggc tgatgtcgag gcttgagaaa gccggctact
      601 tcataccaga cctttcccca ggagatgccg aggactcgtg ttccctgcgc ctctccccac
      661 cccctactaa ccctagtctt gtattaatga tgtgacactc acagcccttc ttctcactgc
      721 agccgggctc tggacccttt ctgtgccgcg tctgtgccgt gtctgtgtgt gtctgctgac
      781 tgtggtcgtt cgtggtcgtt tcattgttcc tgtgaactgt gtgcttcctc tcccatgcca
      841 ccgtcagcac cttgtgccct cctgtgacct ccatctactc ttgctctctg gagtctcccc
      901 gtccctgagg agcccttagt cccctctttc tggatttagg cttgagggag agttgtactg
      961 agggcaggag tccccagtga tcccggggct gagaaagttc gtaccctctt cactgatgtt
     1021 ccttgtggac tctgagaaga aacttgctcc agattccacc agtttagaag gtccgtttgc
     1081 agttggagat tcagattgcc tcccttgagg cgtctgccct ccaggcctcc tttttctttt
     1141 agggtgccca cttaggagtc ccaatccgcc ccacccttta cagaacaccc aggaattctt
     1201 gcctctgagg aatgagctcc ttacttaact tctgagcaat atccccatag gctttggagc
     1261 ccttctgcct tcatccacct tccctgcttc tgagacttcc atctctagcc caattcatct
     1321 gacagaggac tccttccttc tctgaagctg gtctgtggca ggagatagcc caggggacag
     1381 gcagcaggca gggtgccggt ggctctgtct ctctgccaca tggtgtggaa tctggcagac
     1441 tacagtttct ttcccctgcc tgtcaggggt cggagtggag agggctggaa gggttcaggg
     1501 gcagcgggag agagcaacag ggtatgcaca cccgtggatg caaacgccta cgggagtcaa
     1561 aggtcaccag agtggaaact cacaccagag cctgccccac ctgcccattg tgttcccttg
     1621 gaaacgaacc aagccacact gtgtactggg actgctgatc tctgtcttgt gatctattat
     1681 cctctgacaa cagaaaagta aataaataaa taaataaata aataaataaa taaataaata
     1741 aataaataca gcattgtttc ctagtg
//
