LOCUS       NM_001270688             826 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus FXYD domain-containing ion transport regulator 5
            (Fxyd5), transcript variant 2, mRNA.
ACCESSION   NM_001270688
VERSION     NM_001270688.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 826)
  AUTHORS   Ding,L. and Li,J.
  TITLE     FXYD domain containing ion transport regulator 5 (FXYD5) silencing
            promotes cell viability and alleviates inflammatory response in
            cerulein-induced AR42J cells by blocking JAK2/STAT3 signaling
            pathway
  JOURNAL   Bioengineered 13 (2), 2639-2647 (2022)
   PUBMED   35042436
  REMARK    GeneRIF: FXYD domain containing ion transport regulator 5 (FXYD5)
            silencing promotes cell viability and alleviates inflammatory
            response in cerulein-induced AR42J cells by blocking JAK2/STAT3
            signaling pathway.
REFERENCE   2  (bases 1 to 826)
  AUTHORS   Huang,X., Wang,B., Yang,D., Shi,X., Hong,J., Wang,S., Dai,X.,
            Zhou,X. and Geng,Y.J.
  TITLE     Reduced expression of FXYD domain containing ion transport
            regulator 5 in association with hypertension
  JOURNAL   Int J Mol Med 29 (2), 231-238 (2012)
   PUBMED   22085977
  REMARK    GeneRIF: FXYD5 may have profound impact on the regulation of blood
            pressure.
REFERENCE   3  (bases 1 to 826)
  AUTHORS   Ino,Y., Gotoh,M., Sakamoto,M., Tsukagoshi,K. and Hirohashi,S.
  TITLE     Dysadherin, a cancer-associated cell membrane glycoprotein,
            down-regulates E-cadherin and promotes metastasis
  JOURNAL   Proc Natl Acad Sci U S A 99 (1), 365-370 (2002)
   PUBMED   11756660
REFERENCE   4  (bases 1 to 826)
  AUTHORS   Sweadner,K.J. and Rael,E.
  TITLE     The FXYD gene family of small ion transport regulators or channels:
            cDNA sequence, protein signature sequence, and expression
  JOURNAL   Genomics 68 (1), 41-56 (2000)
   PUBMED   10950925
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from FM112735.1, JAXUCZ010000001.1,
            FM122563.1 and DV726876.1.
            
            Summary: This reference sequence was derived from multiple
            replicate ESTs and validated by similar mouse cDNA sequence and
            human genomic sequence. This gene encodes a member of a family of
            small membrane proteins that share a 35-amino acid signature
            sequence domain, beginning with the sequence PFXYD and containing 7
            invariant and 6 highly conserved amino acids. The approved human
            gene nomenclature for the family is FXYD-domain containing ion
            transport regulator. Mouse FXYD5 has been termed RIC (Related to
            Ion Channel). FXYD2, also known as the gamma subunit of the
            Na,K-ATPase, regulates the properties of that enzyme. FXYD1
            (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and
            FXYD5 (RIC) have been shown to induce channel activity in
            experimental expression systems. Transmembrane topology has been
            established for two family members (FXYD1 and FXYD2), with the
            N-terminus extracellular and the C-terminus on the cytoplasmic side
            of the membrane. Three transcript variants encoding the same
            protein have been found for this gene. [RefSeq curation by Kathleen
            J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Dec 2000].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. All three variants encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060571.1, FM092197.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676806 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                FM112735.1         1-19
            20-270518199        JAXUCZ010000001.1  1-270518180
            270518200-270518220 FM112735.1         21-41
            270518221-270518799 FM122563.1         20-598
            270518800-270519005 DV726876.1         391-596
FEATURES             Location/Qualifiers
     source          1..826
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..826
                     /gene="Fxyd5"
                     /gene_synonym="RIC"
                     /note="FXYD domain-containing ion transport regulator 5"
                     /db_xref="GeneID:60338"
                     /db_xref="RGD:620827"
     exon            1..41
                     /gene="Fxyd5"
                     /gene_synonym="RIC"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..578
                     /gene="Fxyd5"
                     /gene_synonym="RIC"
                     /note="oncoprotein induced transcript 2"
                     /codon_start=1
                     /product="FXYD domain-containing ion transport regulator 5
                     precursor"
                     /protein_id="NP_001257617.1"
                     /db_xref="GeneID:60338"
                     /db_xref="RGD:620827"
                     /translation="MSPPSQLCLLTIVALILPSEGQTPEKPRSSFTAHQSSVTTHVPV
                     PDQTSPGVQTTPPIWTSEAGEATGSQTAAKTKTQQLTEMATANPVTDPGPLTSSEKGT
                     PALSRIKSPSPPKGYMPPSYIENPLDPNENSPFYYDNTTLRKRGLLVAAVLFITGIII
                     LTSGKCRQFSQLCLNRHR"
     exon            42..102
                     /gene="Fxyd5"
                     /gene_synonym="RIC"
                     /inference="alignment:Splign:2.1.0"
     exon            103..171
                     /gene="Fxyd5"
                     /gene_synonym="RIC"
                     /inference="alignment:Splign:2.1.0"
     exon            172..234
                     /gene="Fxyd5"
                     /gene_synonym="RIC"
                     /inference="alignment:Splign:2.1.0"
     exon            235..342
                     /gene="Fxyd5"
                     /gene_synonym="RIC"
                     /inference="alignment:Splign:2.1.0"
     exon            343..423
                     /gene="Fxyd5"
                     /gene_synonym="RIC"
                     /inference="alignment:Splign:2.1.0"
     exon            424..453
                     /gene="Fxyd5"
                     /gene_synonym="RIC"
                     /inference="alignment:Splign:2.1.0"
     exon            454..528
                     /gene="Fxyd5"
                     /gene_synonym="RIC"
                     /inference="alignment:Splign:2.1.0"
     exon            529..826
                     /gene="Fxyd5"
                     /gene_synonym="RIC"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggtactctg acacttcagt ctggagacct tgggctcgga catgtcaccg cccagtcagc
       61 tgtgtctcct caccattgtc gccctgattc tgcctagtga agggcagaca ccagaaaaac
      121 ccagatccag ttttacagcg caccagagtt ctgtgactac tcatgtccca gttccagatc
      181 aaaccagccc aggagtccag accactcctc ccatctggac cagtgaagct ggcgaagcca
      241 caggaagcca gacagcagcc aaaaccaaga cccagcaact gaccgaaatg gccactgcga
      301 atccagtgac agatccaggg ccacttacaa gcagcgagaa aggtaccccg gcactctcca
      361 ggatcaaatc tcccagccca cccaaaggtt acatgcctcc atcctacatt gagaatccac
      421 tggatcccaa tgagaacagc cccttctact acgacaatac caccctccgg aaacgggggc
      481 tgctggtggc ggcagtgctg ttcattactg gaattatcat cctcactagt gggaagtgta
      541 gacagttctc tcagttatgc ctgaatcgcc acaggtgagt gggagccagc accctgatgg
      601 gcaccccaac tggagccgcc ataccatacc agttcaccac ccctgcctcc ctccctctgc
      661 tccaagagcc aacagagtgg tcaacataaa tggatcctca aaggaagagg ccaccggagg
      721 gagccaggcc taaggctaaa tggtcttccc accctgagga gagaggtctc cccaggcact
      781 gctgtgatcc tgcctatcct gttcagataa atccacatgg tctctc
//
