LOCUS       NM_001368663             547 bp    mRNA    linear   ROD 08-JUN-2024
DEFINITION  Rattus norvegicus FXYD domain-containing ion transport regulator 4
            (Fxyd4), mRNA.
ACCESSION   NM_001368663 XM_006237206
VERSION     NM_001368663.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 547)
  AUTHORS   Yamagami,K., Islam,M.R., Yoshii,Y., Mori,K., Tashiro,K. and
            Yamauchi,N.
  TITLE     Preimplantation embryo-secreted factors modulate maternal gene
            expression in rat uterus
  JOURNAL   Cell Tissue Res 364 (2), 453-463 (2016)
   PUBMED   26685865
REFERENCE   2  (bases 1 to 547)
  AUTHORS   Pestov,N.B., Korneenko,T.V., Shakhparonov,M.I. and Modyanov,N.N.
  TITLE     Postnatal regulation of X,K-ATPases in rat skin and conserved
            lateroapical polarization of Na,K-ATPase in vertebrate epidermis
  JOURNAL   Exp Dermatol 22 (6), 423-425 (2013)
   PUBMED   23651441
REFERENCE   3  (bases 1 to 547)
  AUTHORS   Franzin,C.M., Gong,X.M., Teriete,P. and Marassi,F.M.
  TITLE     Structures of the FXYD regulatory proteins in lipid micelles and
            membranes
  JOURNAL   J Bioenerg Biomembr 39 (5-6), 379-383 (2007)
   PUBMED   18000745
  REMARK    GeneRIF: structures of the FXYD proteins (with emphasis on 1-4), as
            well as their dynamics and their associations with the lipid
            bilayer membrane
            Review article
REFERENCE   4  (bases 1 to 547)
  AUTHORS   Pihakaski-Maunsbach,K., Vorum,H., Honore,B., Tokonabe,S.,
            Frokiaer,J., Garty,H., Karlish,S.J. and Maunsbach,A.B.
  TITLE     Locations, abundances, and possible functions of FXYD ion transport
            regulators in rat renal medulla
  JOURNAL   Am J Physiol Renal Physiol 291 (5), F1033-F1044 (2006)
   PUBMED   16757733
  REMARK    GeneRIF: the unchanged levels of FXYD2 and FXYD4 proteins suggest
            that they are not primary determinants for urine electrolyte
            composition during NaCl depletion
REFERENCE   5  (bases 1 to 547)
  AUTHORS   Jespersen,T., Grunnet,M., Rasmussen,H.B., Jorgensen,N.B.,
            Jensen,H.S., Angelo,K., Olesen,S.P. and Klaerke,D.A.
  TITLE     The corticosteroid hormone induced factor: a new modulator of KCNQ1
            channels?
  JOURNAL   Biochem Biophys Res Commun 341 (4), 979-988 (2006)
   PUBMED   16476578
  REMARK    GeneRIF: CHIF drastically modulates the KCNQ1 current; in the
            presence of CHIF, the KCNQ1 channels open at all membrane
            potentials.
REFERENCE   6  (bases 1 to 547)
  AUTHORS   Beguin,P., Crambert,G., Guennoun,S., Garty,H., Horisberger,J.D. and
            Geering,K.
  TITLE     CHIF, a member of the FXYD protein family, is a regulator of
            Na,K-ATPase distinct from the gamma-subunit
  JOURNAL   EMBO J 20 (15), 3993-4002 (2001)
   PUBMED   11483503
REFERENCE   7  (bases 1 to 547)
  AUTHORS   Shi,H., Levy-Holzman,R., Cluzeaud,F., Farman,N. and Garty,H.
  TITLE     Membrane topology and immunolocalization of CHIF in kidney and
            intestine
  JOURNAL   Am J Physiol Renal Physiol 280 (3), F505-F512 (2001)
   PUBMED   11181413
REFERENCE   8  (bases 1 to 547)
  AUTHORS   Sweadner,K.J. and Rael,E.
  TITLE     The FXYD gene family of small ion transport regulators or channels:
            cDNA sequence, protein signature sequence, and expression
  JOURNAL   Genomics 68 (1), 41-56 (2000)
   PUBMED   10950925
REFERENCE   9  (bases 1 to 547)
  AUTHORS   Capurro,C., Coutry,N., Bonvalet,J.P., Escoubet,B., Garty,H. and
            Farman,N.
  TITLE     Cellular localization and regulation of CHIF in kidney and colon
  JOURNAL   Am J Physiol 271 (3 Pt 1), C753-C762 (1996)
   PUBMED   8843704
REFERENCE   10 (bases 1 to 547)
  AUTHORS   Attali,B., Latter,H., Rachamim,N. and Garty,H.
  TITLE     A corticosteroid-induced gene expressing an 'IsK-like' K+ channel
            activity in Xenopus oocytes
  JOURNAL   Proc Natl Acad Sci U S A 92 (13), 6092-6096 (1995)
   PUBMED   7597086
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from JAXUCZ010000004.1.
            
            On Feb 14, 2019 this sequence version replaced XM_006237206.2.
            
            Summary: This gene encodes a member of a family of small membrane
            proteins that share a 35-amino acid signature sequence domain,
            beginning with the sequence PFXYD and containing 7 invariant and 6
            highly conserved amino acids. The approved human gene nomenclature
            for the family is FXYD-domain containing ion transport regulator.
            Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2,
            also known as the gamma subunit of the Na,K-ATPase, regulates the
            properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma),
            FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to
            induce channel activity in experimental expression systems.
            Transmembrane topology has been established for two family members
            (FXYD1 and FXYD2), with the N-terminus extracellular and the
            C-terminus on the cytoplasmic side of the membrane. [provided by
            RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AW917224.1, SRR26643294.19417.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676809 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                JAXUCZ010000004.1  152786014-152786045 c
            33-75               JAXUCZ010000004.1  152785468-152785510 c
            76-151              JAXUCZ010000004.1  152784571-152784646 c
            152-184             JAXUCZ010000004.1  152783729-152783761 c
            185-208             JAXUCZ010000004.1  152783583-152783606 c
            209-283             JAXUCZ010000004.1  152783036-152783110 c
            284-320             JAXUCZ010000004.1  152782925-152782961 c
            321-358             JAXUCZ010000004.1  152782457-152782494 c
            359-547             JAXUCZ010000004.1  152782181-152782369 c
FEATURES             Location/Qualifiers
     source          1..547
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..547
                     /gene="Fxyd4"
                     /gene_synonym="Chif"
                     /note="FXYD domain-containing ion transport regulator 4"
                     /db_xref="GeneID:64190"
                     /db_xref="RGD:70998"
     exon            1..32
                     /gene="Fxyd4"
                     /gene_synonym="Chif"
                     /inference="alignment:Splign:2.1.0"
     exon            33..75
                     /gene="Fxyd4"
                     /gene_synonym="Chif"
                     /inference="alignment:Splign:2.1.0"
     exon            76..151
                     /gene="Fxyd4"
                     /gene_synonym="Chif"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..375
                     /gene="Fxyd4"
                     /gene_synonym="Chif"
                     /note="corticosteroid-induced protein; channel-inducing
                     factor"
                     /codon_start=1
                     /product="FXYD domain-containing ion transport regulator 4
                     precursor"
                     /protein_id="NP_001355592.1"
                     /db_xref="GeneID:64190"
                     /db_xref="RGD:70998"
                     /translation="MEGITCAFLLVLAGLPVLEANGPVDKGSPFYYDWESLQLGGMIF
                     GGLLCIAGIAMALSGKCKCRRNHTPSSLPEKVTPLITPGSAST"
     exon            152..184
                     /gene="Fxyd4"
                     /gene_synonym="Chif"
                     /inference="alignment:Splign:2.1.0"
     exon            185..208
                     /gene="Fxyd4"
                     /gene_synonym="Chif"
                     /inference="alignment:Splign:2.1.0"
     exon            209..283
                     /gene="Fxyd4"
                     /gene_synonym="Chif"
                     /inference="alignment:Splign:2.1.0"
     exon            284..320
                     /gene="Fxyd4"
                     /gene_synonym="Chif"
                     /inference="alignment:Splign:2.1.0"
     exon            321..358
                     /gene="Fxyd4"
                     /gene_synonym="Chif"
                     /inference="alignment:Splign:2.1.0"
     exon            359..547
                     /gene="Fxyd4"
                     /gene_synonym="Chif"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcaccactca cctagctcgg gtcatctcca ggggcactga aacacagagg cattacctac
       61 taagtcacac acctgcccac ccagcagcct gcagcctcgc cctgggttga tatggaggga
      121 ataacctgtg cctttctcct ggtgctagca ggtctgcctg tcttggaagc caatggtcca
      181 gttgataaag gcagtccctt ctactacgac tgggagagcc tgcaactggg aggaatgatc
      241 tttggggggc tcctgtgcat cgctggaatt gccatggccc tgagtggcaa gtgcaaatgt
      301 aggcgcaacc atacgcccag ttccttacct gagaaagtca ctccactcat cactccaggc
      361 tctgccagta cctgacgaac tgaacacagg accaagtttg gaggcagctt tttgatgact
      421 tcctgctgta tctcccctct ggagatcttc ctctccaaaa tggcttccct agagcacact
      481 taagtcttca gtgacaggga agggtgttcc aaagttgatt ttatattaaa ctggtcttgc
      541 tgctctg
//
