LOCUS       NM_172317                470 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus FXYD domain-containing ion transport regulator 3
            (Fxyd3), mRNA.
ACCESSION   NM_172317
VERSION     NM_172317.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Crambert,G., Li,C., Claeys,D. and Geering,K.
  TITLE     FXYD3 (Mat-8), a new regulator of Na,K-ATPase
  JOURNAL   Mol Biol Cell 16 (5), 2363-2371 (2005)
   PUBMED   15743908
REFERENCE   3  (bases 1 to 470)
  AUTHORS   Sweadner,K.J. and Rael,E.
  TITLE     The FXYD gene family of small ion transport regulators or channels:
            cDNA sequence, protein signature sequence, and expression
  JOURNAL   Genomics 68 (1), 41-56 (2000)
   PUBMED   10950925
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DY471861.1 and BG373727.1.
            
            On Aug 28, 2007 this sequence version replaced NM_172317.1.
            
            Summary: This gene encodes a member of a family of small membrane
            proteins that share a 35-amino acid signature sequence domain,
            beginning with the sequence PFXYD and containing 7 invariant and 6
            highly conserved amino acids. The approved human gene nomenclature
            for the family is FXYD-domain containing ion transport regulator.
            Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2,
            also known as the gamma subunit of the Na,K-ATPase, regulates the
            properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma),
            FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to
            induce channel activity in experimental expression systems.
            Transmembrane topology has been established for two family members
            (FXYD1 and FXYD2), with the N-terminus extracellular and the
            C-terminus on the cytoplasmic side of the membrane. [provided by
            RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AW142066.1, DY471861.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676810, SAMN16676811
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-378               DY471861.1         373-750
            379-470             BG373727.1         1-92                c
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..470
                     /gene="Fxyd3"
                     /gene_synonym="MAT8"
                     /note="FXYD domain-containing ion transport regulator 3"
                     /db_xref="GeneID:116831"
                     /db_xref="RGD:620825"
     exon            1..17
                     /gene="Fxyd3"
                     /gene_synonym="MAT8"
                     /inference="alignment:Splign:2.1.0"
     exon            18..69
                     /gene="Fxyd3"
                     /gene_synonym="MAT8"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..296
                     /gene="Fxyd3"
                     /gene_synonym="MAT8"
                     /note="sodium/potassium-transporting ATPase subunit FXYD3"
                     /codon_start=1
                     /product="FXYD domain-containing ion transport regulator 3
                     precursor"
                     /protein_id="NP_758528.1"
                     /db_xref="GeneID:116831"
                     /db_xref="RGD:620825"
                     /translation="MQEFALSLLVLLAGLPTLDANDPEDKDSPFYYDWHSLRVGGLIC
                     AGILCALGIIVLMSGKCKCKFSQKPSHRPGDGPPLITPGSAHNC"
     exon            70..102
                     /gene="Fxyd3"
                     /gene_synonym="MAT8"
                     /inference="alignment:Splign:2.1.0"
     exon            103..126
                     /gene="Fxyd3"
                     /gene_synonym="MAT8"
                     /inference="alignment:Splign:2.1.0"
     exon            127..201
                     /gene="Fxyd3"
                     /gene_synonym="MAT8"
                     /inference="alignment:Splign:2.1.0"
     exon            202..238
                     /gene="Fxyd3"
                     /gene_synonym="MAT8"
                     /inference="alignment:Splign:2.1.0"
     exon            239..276
                     /gene="Fxyd3"
                     /gene_synonym="MAT8"
                     /inference="alignment:Splign:2.1.0"
     exon            277..453
                     /gene="Fxyd3"
                     /gene_synonym="MAT8"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      453
                     /gene="Fxyd3"
                     /gene_synonym="MAT8"
ORIGIN      
        1 cctgttgagc tactcaggtc aacgctgaca tgcaagagtt tgctctgagc ctgttggtcc
       61 ttctagcagg cctgcctact ttggatgcca atgaccctga agataaagat agccctttct
      121 actatgattg gcacagcctc cgagtcggcg ggctcatctg tgcagggatt ctctgtgccc
      181 tgggcattat agttctcatg agtggcaagt gcaaatgcaa gttcagccag aaacccagcc
      241 accgtccagg agatgggcca cccctcatca caccaggctc tgctcacaac tgctgaggat
      301 ggatcagtta aaaaagtgca ggtcctgtct ctggagatgg gcttgaactc caagatgtct
      361 gggctcctcc tctcctgaca ctgccttccc cgagcctcat ctcatggtag caggttcttt
      421 gttcagttgt taatataaaa tgattttacg tcaaaaaaaa aaaaaaaaaa
//
