LOCUS       NM_031648                533 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Rattus norvegicus FXYD domain-containing ion transport regulator 1
            (Fxyd1), mRNA.
ACCESSION   NM_031648
VERSION     NM_031648.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 533)
  AUTHORS   Hafver,T.L., Hodne,K., Wanichawan,P., Aronsen,J.M., Dalhus,B.,
            Lunde,P.K., Lunde,M., Martinsen,M., Enger,U.H., Fuller,W.,
            Sjaastad,I., Louch,W.E., Sejersted,O.M. and Carlson,C.R.
  TITLE     Protein Phosphatase 1c Associated with the Cardiac Sodium Calcium
            Exchanger 1 Regulates Its Activity by Dephosphorylating Serine
            68-phosphorylated Phospholemman
  JOURNAL   J Biol Chem 291 (9), 4561-4579 (2016)
   PUBMED   26668322
  REMARK    GeneRIF: Data suggest Ncx1 (sodium-calcium exchanger 1) is
            substrate-specifying Pp1c (protein phosphatase 1c) regulator
            protein, regulating Ncx1 activity via Ser-68-Plm dephosphorylation
            in cardiomyocytes; Plm/Ncx1/Pp1c complex is up-regulated in heart
            failure.
REFERENCE   2  (bases 1 to 533)
  AUTHORS   Correll,R.N., Eder,P., Burr,A.R., Despa,S., Davis,J., Bers,D.M. and
            Molkentin,J.D.
  TITLE     Overexpression of the Na+/K+ ATPase alpha2 but not alpha1 isoform
            attenuates pathological cardiac hypertrophy and remodeling
  JOURNAL   Circ Res 114 (2), 249-256 (2014)
   PUBMED   24218169
REFERENCE   3  (bases 1 to 533)
  AUTHORS   Wypijewski,K.J., Howie,J., Reilly,L., Tulloch,L.B., Aughton,K.L.,
            McLatchie,L.M., Shattock,M.J., Calaghan,S.C. and Fuller,W.
  TITLE     A separate pool of cardiac phospholemman that does not regulate or
            associate with the sodium pump: multimers of phospholemman in
            ventricular muscle
  JOURNAL   J Biol Chem 288 (19), 13808-13820 (2013)
   PUBMED   23532852
  REMARK    GeneRIF: PLM exists as a pump-inhibiting monomer and an
            unassociated oligomer.
REFERENCE   4  (bases 1 to 533)
  AUTHORS   Chibalin,A.V., Heiny,J.A., Benziane,B., Prokofiev,A.V.,
            Vasiliev,A.V., Kravtsova,V.V. and Krivoi,I.I.
  TITLE     Chronic nicotine modifies skeletal muscle Na,K-ATPase activity
            through its interaction with the nicotinic acetylcholine receptor
            and phospholemman
  JOURNAL   PLoS One 7 (3), e33719 (2012)
   PUBMED   22442718
  REMARK    GeneRIF: Chronic nicotine modifies skeletal muscle Na,K-ATPase
            activity through its interaction with the nicotinic acetylcholine
            receptor and phospholemman.
REFERENCE   5  (bases 1 to 533)
  AUTHORS   Tulloch,L.B., Howie,J., Wypijewski,K.J., Wilson,C.R., Bernard,W.G.,
            Shattock,M.J. and Fuller,W.
  TITLE     The inhibitory effect of phospholemman on the sodium pump requires
            its palmitoylation
  JOURNAL   J Biol Chem 286 (41), 36020-36031 (2011)
   PUBMED   21868384
  REMARK    GeneRIF: palmitoylation of PLM controls its turnover, and
            palmitoylated PLM inhibits the sodium pump.
REFERENCE   6  (bases 1 to 533)
  AUTHORS   Moran,J., Morales-Mulia,M. and Pasantes-Morales,H.
  TITLE     Reduction of phospholemman expression decreases osmosensitive
            taurine efflux in astrocytes
  JOURNAL   Biochim Biophys Acta 1538 (2-3), 313-320 (2001)
   PUBMED   11336802
REFERENCE   7  (bases 1 to 533)
  AUTHORS   Sweadner,K.J. and Rael,E.
  TITLE     The FXYD gene family of small ion transport regulators or channels:
            cDNA sequence, protein signature sequence, and expression
  JOURNAL   Genomics 68 (1), 41-56 (2000)
   PUBMED   10950925
REFERENCE   8  (bases 1 to 533)
  AUTHORS   Chen,Z., Jones,L.R., O'Brian,J.J., Moorman,J.R. and Cala,S.E.
  TITLE     Structural domains in phospholemman: a possible role for the
            carboxyl terminus in channel inactivation
  JOURNAL   Circ Res 82 (3), 367-374 (1998)
   PUBMED   9486665
  REMARK    Review article
REFERENCE   9  (bases 1 to 533)
  AUTHORS   Chen,L.S., Lo,C.F., Numann,R. and Cuddy,M.
  TITLE     Characterization of the human and rat phospholemman (PLM) cDNAs and
            localization of the human PLM gene to chromosome 19q13.1
  JOURNAL   Genomics 41 (3), 435-443 (1997)
   PUBMED   9169143
REFERENCE   10 (bases 1 to 533)
  AUTHORS   Palmer,C.J., Scott,B.T. and Jones,L.R.
  TITLE     Purification and complete sequence determination of the major
            plasma membrane substrate for cAMP-dependent protein kinase and
            protein kinase C in myocardium
  JOURNAL   J Biol Chem 266 (17), 11126-11130 (1991)
   PUBMED   1710217
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB712570.1 and FM109156.1.
            
            On May 10, 2012 this sequence version replaced NM_031648.1.
            
            Summary: This gene encodes a member of a family of small membrane
            proteins that share a 35-amino acid signature sequence domain,
            beginning with the sequence PFXYD and containing 7 invariant and 6
            highly conserved amino acids. The approved human gene nomenclature
            for the family is FXYD-domain containing ion transport regulator.
            Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2,
            also known as the gamma subunit of the Na,K-ATPase, regulates the
            properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma),
            FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to
            induce channel activity in experimental expression systems.
            Transmembrane topology has been established for two family members
            (FXYD1 and FXYD2), with the N-terminus extracellular and the
            C-terminus on the cytoplasmic side of the membrane. The protein
            encoded by this gene is a plasma membrane substrate for several
            kinases, including protein kinase A, protein kinase C, NIMA kinase,
            and myotonic dystrophy kinase. It is thought to form an ion channel
            or regulate ion channel activity. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ211349.1, CK476741.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-498               CB712570.1         1-498
            499-533             FM109156.1         453-487
FEATURES             Location/Qualifiers
     source          1..533
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..533
                     /gene="Fxyd1"
                     /gene_synonym="Plm"
                     /note="FXYD domain-containing ion transport regulator 1"
                     /db_xref="GeneID:58971"
                     /db_xref="RGD:69306"
     exon            1..82
                     /gene="Fxyd1"
                     /gene_synonym="Plm"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..365
                     /gene="Fxyd1"
                     /gene_synonym="Plm"
                     /note="phospholemman; sodium/potassium-transporting ATPase
                     subunit FXYD1"
                     /codon_start=1
                     /product="phospholemman precursor"
                     /protein_id="NP_113836.2"
                     /db_xref="GeneID:58971"
                     /db_xref="RGD:69306"
                     /translation="MGAMASPGHILIVCVCLLSMASAEAPQEPDPFTYDYHTLRIGGL
                     TIAGILFILGILIILSKRCRCKFNQQQRTGEPDEEEGTFRSSIRRLSTRRR"
     exon            83..147
                     /gene="Fxyd1"
                     /gene_synonym="Plm"
                     /inference="alignment:Splign:2.1.0"
     exon            148..180
                     /gene="Fxyd1"
                     /gene_synonym="Plm"
                     /inference="alignment:Splign:2.1.0"
     exon            181..255
                     /gene="Fxyd1"
                     /gene_synonym="Plm"
                     /inference="alignment:Splign:2.1.0"
     exon            256..292
                     /gene="Fxyd1"
                     /gene_synonym="Plm"
                     /inference="alignment:Splign:2.1.0"
     exon            293..342
                     /gene="Fxyd1"
                     /gene_synonym="Plm"
                     /inference="alignment:Splign:2.1.0"
     exon            343..397
                     /gene="Fxyd1"
                     /gene_synonym="Plm"
                     /inference="alignment:Splign:2.1.0"
     exon            398..533
                     /gene="Fxyd1"
                     /gene_synonym="Plm"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agggggtcca aagtgcttag ctcccagggt gcacagctgg aaatttgggg gtcttctgtc
       61 agcaggggac agcgtgaatg ggggcaatgg catctcccgg ccacatcctg attgtctgtg
      121 tgtgtctcct ctccatggcc agtgcagaag ctccgcagga accagatcca ttcacctacg
      181 attaccacac cctgcggatc ggcggcctca ctatcgctgg gatcctcttc atcttgggca
      241 tccttatcat ccttagcaaa agatgccggt gcaaattcaa ccaacagcag agaactgggg
      301 aacccgacga agaggaggga actttccgca gctccatccg ccgtctgtcc acccgcaggc
      361 ggtagaacct ccacctggct ccaggaaact cagccagagc ccccttggca cctgacacct
      421 ctccccaccc agctgctcgc ctgtgaccac ctccagcgtc ccctgcatca gccctgcttc
      481 tcggacaccc cttgctgctc agacctccaa taaaactcgg ttttccttct tga
//
