LOCUS       NM_001100647            2671 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus FMR1 autosomal homolog 2 (Fxr2), mRNA.
ACCESSION   NM_001100647 XM_001079469 XM_213335
VERSION     NM_001100647.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2671)
  AUTHORS   Wang GX, Smith SJ and Mourrain P.
  TITLE     Sub-synaptic, multiplexed analysis of proteins reveals Fragile X
            related protein 2 is mislocalized in Fmr1 KO synapses
  JOURNAL   Elife 5, e20560 (2016)
   PUBMED   27770568
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2671)
  AUTHORS   Baltz AG, Munschauer M, Schwanhausser B, Vasile A, Murakawa Y,
            Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E,
            Bonneau R, Selbach M, Dieterich C and Landthaler M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 2671)
  AUTHORS   Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein
            C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J and
            Hentze MW.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 2671)
  AUTHORS   Sjekloca L, Pauwels K and Pastore A.
  TITLE     On the aggregation properties of FMRP--a link with the FXTAS
            syndrome?
  JOURNAL   FEBS J 278 (11), 1912-1921 (2011)
   PUBMED   21446998
REFERENCE   5  (bases 1 to 2671)
  AUTHORS   Cook D, Sanchez-Carbente Mdel R, Lachance C, Radzioch D, Tremblay
            S, Khandjian EW, DesGroseillers L and Murai KK.
  TITLE     Fragile X related protein 1 clusters with ribosomes and messenger
            RNAs at a subset of dendritic spines in the mouse hippocampus
  JOURNAL   PLoS One 6 (10), e26120 (2011)
   PUBMED   22022532
REFERENCE   6  (bases 1 to 2671)
  AUTHORS   Ghosh D, Lippert D, Krokhin O, Cortens JP and Wilkins JA.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   7  (bases 1 to 2671)
  AUTHORS   Behboudi A, Roshani L, Lundin L, Stahl F, Levan KK and Levan G.
  TITLE     The functional significance of absence: the chromosomal segment
            harboring Tp53 is absent from the T55 rat radiation hybrid mapping
            panel
  JOURNAL   Genomics 79 (6), 844-848 (2002)
   PUBMED   12036299
REFERENCE   8  (bases 1 to 2671)
  AUTHORS   Zhang Y, O'Connor JP, Siomi MC, Srinivasan S, Dutra A, Nussbaum RL
            and Dreyfuss G.
  TITLE     The fragile X mental retardation syndrome protein interacts with
            novel homologs FXR1 and FXR2
  JOURNAL   EMBO J 14 (21), 5358-5366 (1995)
   PUBMED   7489725
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC160929.1.
            
            On or before Jun 8, 2008 this sequence version replaced
            XM_001079469.1, XM_213335.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC160929.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2671
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..2671
                     /gene="Fxr2"
                     /gene_synonym="Fxr2h"
                     /note="FMR1 autosomal homolog 2"
                     /db_xref="GeneID:287433"
                     /db_xref="RGD:1307011"
     exon            1..100
                     /gene="Fxr2"
                     /gene_synonym="Fxr2h"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..2047
                     /gene="Fxr2"
                     /gene_synonym="Fxr2h"
                     /codon_start=1
                     /product="RNA-binding protein FXR2"
                     /protein_id="NP_001094117.1"
                     /db_xref="GeneID:287433"
                     /db_xref="RGD:1307011"
                     /translation="MGGLASGGDVEPGLPVEVRGSNGAFYKGFVKDVHEDSVTIFFEN
                     NWQSERQIPFGDVRLPPPADYNKEITEGDEVEVYSRANEQEPCGWWLARVRMMKGDFY
                     VIEYAACDATYNEIVTLERLRPVNPNPLATKGSFFKVTMAVPEDLREACSNENVHKEF
                     KKALGANCIFLNITDSELFILSTTEAPVKRASLLGDMHFRSLRTKLLLMSRNEEATKH
                     LETSKQLAAAFQEEFTVREDLMGLAIGTHGANIQQARKVPGVTAIELGEETCTFRIYG
                     ETPEACRQARSYLEFSEDSVQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRVEGDNDK
                     KNPREEGMVPFIFVGTRENISNAQALLEYHLSYLQEVEQLRLERLQIDEQLRQIGLGF
                     RPPGSGRGGSGGGSDKAGYTTDESSSSSLHTTRTYGGSYGGRGRGRRTGGPAYGPSSD
                     PSTASETESEKREESNRAGPGDRDPPSRGEESRRRPIGGRGRGPPPVPRPTSRYNSSS
                     ISSVLKDPDSNPYSLLDTSEPEPPVDSEPGEPPPASARRRRSRRRRTDEDRTVMDGGL
                     ESDGPNVTENGLEDESRPQRRNRSRRRRNRGNRTDGSISGDRQPVTVADYISRAESQS
                     RQRPPLERTKPSEDSLSGQKGDSVSRLPKGPSENGELSAPLELGSLVNGVS"
     exon            101..153
                     /gene="Fxr2"
                     /gene_synonym="Fxr2h"
                     /inference="alignment:Splign:2.1.0"
     exon            154..247
                     /gene="Fxr2"
                     /gene_synonym="Fxr2h"
                     /inference="alignment:Splign:2.1.0"
     exon            248..319
                     /gene="Fxr2"
                     /gene_synonym="Fxr2h"
                     /inference="alignment:Splign:2.1.0"
     exon            320..468
                     /gene="Fxr2"
                     /gene_synonym="Fxr2h"
                     /inference="alignment:Splign:2.1.0"
     exon            469..562
                     /gene="Fxr2"
                     /gene_synonym="Fxr2h"
                     /inference="alignment:Splign:2.1.0"
     exon            563..679
                     /gene="Fxr2"
                     /gene_synonym="Fxr2h"
                     /inference="alignment:Splign:2.1.0"
     exon            680..850
                     /gene="Fxr2"
                     /gene_synonym="Fxr2h"
                     /inference="alignment:Splign:2.1.0"
     exon            851..929
                     /gene="Fxr2"
                     /gene_synonym="Fxr2h"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1039
                     /gene="Fxr2"
                     /gene_synonym="Fxr2h"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1126
                     /gene="Fxr2"
                     /gene_synonym="Fxr2h"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1355
                     /gene="Fxr2"
                     /gene_synonym="Fxr2h"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1553
                     /gene="Fxr2"
                     /gene_synonym="Fxr2h"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1754
                     /gene="Fxr2"
                     /gene_synonym="Fxr2h"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1850
                     /gene="Fxr2"
                     /gene_synonym="Fxr2h"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..1951
                     /gene="Fxr2"
                     /gene_synonym="Fxr2h"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2644
                     /gene="Fxr2"
                     /gene_synonym="Fxr2h"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggaggtggt ggcggcgcca tgggcggcct ggcctctggg ggggatgtgg agccgggact
       61 gcccgtcgag gtgcggggct ccaacggggc cttctacaag ggctttgtta aggatgtcca
      121 tgaagactct gtcactatct tctttgaaaa caactggcag agtgagagac agattccctt
      181 tggggatgtc cgactaccac ctccagctga ctacaataag gagatcacag aaggagatga
      241 agtagaggtc tattcgagag ccaatgaaca ggaaccttgt ggttggtggc tggcccgggt
      301 gcggatgatg aagggagatt tctatgtcat tgagtatgct gcctgtgatg ctacctacaa
      361 tgagattgtc actctggagc gacttcggcc agtcaatccc aatccccttg caaccaaagg
      421 cagcttcttc aaggttacca tggctgtgcc tgaggatctt agagaggcct gctccaatga
      481 aaatgtccat aaagagttca agaaagcact gggagccaac tgcatcttcc tcaacatcac
      541 agacagtgag ctcttcattc tgtcaaccac agaagcccct gtgaagaggg catctttgct
      601 gggtgacatg catttccgaa gccttcgtac caaattgctg ctcatgtccc gcaatgaaga
      661 agctactaag cacctagaga caagtaagca attggcagca gcattccaag aggagtttac
      721 agttcgagag gacctgatgg gtctggcaat tgggactcac ggtgccaaca tccagcaggc
      781 tcgaaaagtg ccaggagtga ctgccattga gttgggtgaa gagacctgca ctttccgaat
      841 ctatggggag acgccagagg catgcagaca ggctcgaagc taccttgaat tttctgagga
      901 ctctgtacaa gtgcccagga acctggttgg caaagtgatt ggaaagaacg ggaaagtgat
      961 tcaggagatc gtggataagt ctggtgtggt gcgggttcgt gtggaaggtg ataacgacaa
     1021 gaagaacccc agggaggagg gaatggttcc cttcatattt gttggcaccc gagagaatat
     1081 cagcaatgcc caggcactgc tagagtatca cctctcctac ctgcaggagg ttgaacagct
     1141 tcgcttggag agactgcaaa ttgatgaaca gcttcggcag attgggctag gctttcgccc
     1201 tcctgggagt ggacggggtg gcagtggtgg tggcagtgac aaggcgggct ataccacaga
     1261 cgagagctcc tcctcttccc tgcacacgac cagaacctat gggggcagct atgggggccg
     1321 gggccggggc cggaggactg gtggtcctgc ctatggcccc agctcagacc cctccacagc
     1381 ttctgagaca gagtcagaaa agagagagga atctaatcga gcaggacctg gtgacagaga
     1441 tcccccaagc cgtggagaag aaagcaggag gcggccaatt gggggccggg gaaggggacc
     1501 cccacctgtt ccccggccta cctcaagata caactcatca tctattagct cagtgctaaa
     1561 ggatccagac agcaaccctt acagcctatt ggacacatct gaaccagagc ctccagttga
     1621 ttcagaacct ggtgaacctc ctccagcaag tgcccgtcgt cgccgttccc gccgccgtcg
     1681 tactgatgaa gacaggactg tcatggacgg aggcctggag tctgacggtc ctaacgtgac
     1741 agagaatggc ctggaagatg aatcaagacc ccagagacgt aatcgcagcc gccgccgccg
     1801 taatcgtggt aaccggactg atgggtccat cagcggagac cgccaaccag tgactgtggc
     1861 tgactacatc tcacgggcag agtctcagag ccgccagcgg ccacctctgg agcgcacaaa
     1921 accctcagag gattctcttt caggacagaa gggtgactct gtcagcaggc ttcccaaggg
     1981 cccctcagag aatggggagc tctctgcccc attggagttg ggtagtttgg tgaatggggt
     2041 ttcataaaac ctccagtcca catccctcct ttctccatct cgcttgctgc ccaccaccat
     2101 ggccctcatg ggtccaactg acctgcgctg gagctgctct tatctacggg ggaggggggt
     2161 ggcacagcag cttgggtccc ccccaacctc caggagctag tggaggggtg tgtaacaggg
     2221 tcataccccc tccctcttgt ccaccctacc cccagggtga ggggagcctc cccttcccta
     2281 tcagactgga tgtgccttta tcctctaatg ccccaacctc tgaacacccc cattctccgc
     2341 ctgttggtgg gggtgctcct tgacccaccc agatttgaca gttcaggggg gctcccctgc
     2401 tatccctcct cccatcctgt accccctatt tctggggcct catcactgtg gaagacgggg
     2461 atagtgaggg tatttgtggg tgggaggcat ggggaaggtt ttggaataga accaggggtg
     2521 tgtatgaagg gggttgacaa ggtctcccag ggagttggga aataaccttg tctggtggat
     2581 gagaaggcgt atttattttt cactgtacag tatttaaaaa gagaataaaa aaaatccaaa
     2641 tggcaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
