LOCUS       NM_001415069            3299 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus FMR1 autosomal homolog 1 (Fxr1), transcript
            variant 2, mRNA.
ACCESSION   NM_001415069 XM_039102582
VERSION     NM_001415069.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3299)
  AUTHORS   Nie,P.Y., Ji,L.L., Fu,C.H., Peng,J.B., Wang,Z.Y. and Tong,L.
  TITLE     miR-132 Regulates PTSD-like Behaviors in Rats Following
            Single-Prolonged Stress Through Fragile X-Related Protein 1
  JOURNAL   Cell Mol Neurobiol 41 (2), 327-340 (2021)
   PUBMED   32333305
  REMARK    GeneRIF: miR-132 Regulates PTSD-like Behaviors in Rats Following
            Single-Prolonged Stress Through Fragile X-Related Protein 1.
REFERENCE   2  (bases 1 to 3299)
  AUTHORS   Sopova,J.V., Koshel,E.I., Belashova,T.A., Zadorsky,S.P.,
            Sergeeva,A.V., Siniukova,V.A., Shenfeld,A.A., Velizhanina,M.E.,
            Volkov,K.V., Nizhnikov,A.A., Kachkin,D.V., Gaginskaya,E.R. and
            Galkin,A.P.
  TITLE     RNA-binding protein FXR1 is presented in rat brain in amyloid form
  JOURNAL   Sci Rep 9 (1), 18983 (2019)
   PUBMED   31831836
  REMARK    GeneRIF: RNA-binding protein FXR1 is presented in rat brain in
            amyloid form.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3299)
  AUTHORS   Chu,M., Novak,S.M., Cover,C., Wang,A.A., Chinyere,I.R.,
            Juneman,E.B., Zarnescu,D.C., Wong,P.K. and Gregorio,C.C.
  TITLE     Increased Cardiac Arrhythmogenesis Associated With Gap Junction
            Remodeling With Upregulation of RNA-Binding Protein FXR1
  JOURNAL   Circulation 137 (6), 605-618 (2018)
   PUBMED   29101288
  REMARK    GeneRIF: In dilated cardiomyopathy, increased FXR1 expression
            appears to play an important role in disease progression by
            regulating gap junction remodeling and increasing cardiac
            arrhythmogenesis.
REFERENCE   4  (bases 1 to 3299)
  AUTHORS   Wang,G.X., Smith,S.J. and Mourrain,P.
  TITLE     Sub-synaptic, multiplexed analysis of proteins reveals Fragile X
            related protein 2 is mislocalized in Fmr1 KO synapses
  JOURNAL   Elife 5, e20560 (2016)
   PUBMED   27770568
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3299)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (bases 1 to 3299)
  AUTHORS   Plante,I., Davidovic,L., Ouellet,D.L., Gobeil,L.A., Tremblay,S.,
            Khandjian,E.W. and Provost,P.
  TITLE     Dicer-derived microRNAs are utilized by the fragile X mental
            retardation protein for assembly on target RNAs
  JOURNAL   J Biomed Biotechnol 2006 (4), 64347 (2006)
   PUBMED   17057366
REFERENCE   7  (bases 1 to 3299)
  AUTHORS   Garnon,J., Lachance,C., Di Marco,S., Hel,Z., Marion,D., Ruiz,M.C.,
            Newkirk,M.M., Khandjian,E.W. and Radzioch,D.
  TITLE     Fragile X-related protein FXR1P regulates proinflammatory cytokine
            tumor necrosis factor expression at the post-transcriptional level
  JOURNAL   J Biol Chem 280 (7), 5750-5763 (2005)
   PUBMED   15548538
REFERENCE   8  (bases 1 to 3299)
  AUTHORS   Mientjes,E.J., Willemsen,R., Kirkpatrick,L.L., Nieuwenhuizen,I.M.,
            Hoogeveen-Westerveld,M., Verweij,M., Reis,S., Bardoni,B.,
            Hoogeveen,A.T., Oostra,B.A. and Nelson,D.L.
  TITLE     Fxr1 knockout mice show a striated muscle phenotype: implications
            for Fxr1p function in vivo
  JOURNAL   Hum Mol Genet 13 (13), 1291-1302 (2004)
   PUBMED   15128702
REFERENCE   9  (bases 1 to 3299)
  AUTHORS   Dube,M., Huot,M.E. and Khandjian,E.W.
  TITLE     Muscle specific fragile X related protein 1 isoforms are
            sequestered in the nucleus of undifferentiated myoblast
  JOURNAL   BMC Genet 1, 4 (2000)
   PUBMED   11178106
REFERENCE   10 (bases 1 to 3299)
  AUTHORS   Zhang,Y., O'Connor,J.P., Siomi,M.C., Srinivasan,S., Dutra,A.,
            Nussbaum,R.L. and Dreyfuss,G.
  TITLE     The fragile X mental retardation syndrome protein interacts with
            novel homologs FXR1 and FXR2
  JOURNAL   EMBO J 14 (21), 5358-5366 (1995)
   PUBMED   7489725
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Dec 21, 2022 this sequence version replaced XM_039102582.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.9481.1,
                                           SRR26643296.5928.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                JAXUCZ010000002.1  118812479-118812544
            67-119              JAXUCZ010000002.1  118833454-118833506
            120-213             JAXUCZ010000002.1  118834996-118835089
            214-285             JAXUCZ010000002.1  118840448-118840519
            286-434             JAXUCZ010000002.1  118840844-118840992
            435-528             JAXUCZ010000002.1  118841381-118841474
            529-645             JAXUCZ010000002.1  118841978-118842094
            646-816             JAXUCZ010000002.1  118843466-118843636
            817-895             JAXUCZ010000002.1  118844342-118844420
            896-1005            JAXUCZ010000002.1  118848398-118848507
            1006-1092           JAXUCZ010000002.1  118851750-118851836
            1093-1150           JAXUCZ010000002.1  118853349-118853406
            1151-1213           JAXUCZ010000002.1  118853494-118853556
            1214-1417           JAXUCZ010000002.1  118857111-118857314
            1418-1618           JAXUCZ010000002.1  118859498-118859698
            1619-1699           JAXUCZ010000002.1  118860342-118860422
            1700-1791           JAXUCZ010000002.1  118863551-118863642
            1792-3299           JAXUCZ010000002.1  118864306-118865813
FEATURES             Location/Qualifiers
     source          1..3299
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q24"
     gene            1..3299
                     /gene="Fxr1"
                     /gene_synonym="Fxr1h"
                     /note="FMR1 autosomal homolog 1"
                     /db_xref="GeneID:361927"
                     /db_xref="RGD:1311733"
     exon            1..66
                     /gene="Fxr1"
                     /gene_synonym="Fxr1h"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..1962
                     /gene="Fxr1"
                     /gene_synonym="Fxr1h"
                     /note="isoform 2 is encoded by transcript variant 2;
                     rCG41429-like; RNA-binding protein FXR1"
                     /codon_start=1
                     /product="RNA-binding protein FXR1 isoform 2"
                     /protein_id="NP_001401998.1"
                     /db_xref="GeneID:361927"
                     /db_xref="RGD:1311733"
                     /translation="MAELTVEVRGSNGAFYKGFIKDVHEDSLTVVFENNWQPERQVPF
                     NEVRLPPPPDIKKEISEGDEVEVYSRANDQEPCGWWLAKVRMMKGEFYVIEYAACDAT
                     YNEIVTFERLRPVNQNKTVKKNTFFKCTVDVPEDLREACANENAHKDFKKAVGACRIF
                     YHPETTQLMILSASEATVKRVNILSDMHLRSIRTKLMLMSRNEEATKHLECTKQLAAA
                     FHEEFVVREDLMGLAIGTHGSNIQQARKVPGVTAIELDEDTGTFRIYGESAEAVKKAR
                     GFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVP
                     FVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRG
                     PNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRETRHQRDSRRRPGGRGRSVS
                     GGRGRGGPRGGKSSISSVLKDPDSNPYSLLDNTESDQTADTDASESHHSTNRRRRSRR
                     RRTDEDAVLMDGMTESDTASVNENGLDDSEKKPQRRNRSRRRRFRGQAEDRQPVTVAD
                     YISRAESQSRQRNLPRETLAKNKKEMAKDVIEEHGPSEKAINGPTSASGDEIPKLPRT
                     PGEEKTKTLKEESTQEAAVLNGVS"
     exon            67..119
                     /gene="Fxr1"
                     /gene_synonym="Fxr1h"
                     /inference="alignment:Splign:2.1.0"
     exon            120..213
                     /gene="Fxr1"
                     /gene_synonym="Fxr1h"
                     /inference="alignment:Splign:2.1.0"
     exon            214..285
                     /gene="Fxr1"
                     /gene_synonym="Fxr1h"
                     /inference="alignment:Splign:2.1.0"
     exon            286..434
                     /gene="Fxr1"
                     /gene_synonym="Fxr1h"
                     /inference="alignment:Splign:2.1.0"
     exon            435..528
                     /gene="Fxr1"
                     /gene_synonym="Fxr1h"
                     /inference="alignment:Splign:2.1.0"
     exon            529..645
                     /gene="Fxr1"
                     /gene_synonym="Fxr1h"
                     /inference="alignment:Splign:2.1.0"
     exon            646..816
                     /gene="Fxr1"
                     /gene_synonym="Fxr1h"
                     /inference="alignment:Splign:2.1.0"
     exon            817..895
                     /gene="Fxr1"
                     /gene_synonym="Fxr1h"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1005
                     /gene="Fxr1"
                     /gene_synonym="Fxr1h"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1092
                     /gene="Fxr1"
                     /gene_synonym="Fxr1h"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1150
                     /gene="Fxr1"
                     /gene_synonym="Fxr1h"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1213
                     /gene="Fxr1"
                     /gene_synonym="Fxr1h"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1417
                     /gene="Fxr1"
                     /gene_synonym="Fxr1h"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1618
                     /gene="Fxr1"
                     /gene_synonym="Fxr1h"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1699
                     /gene="Fxr1"
                     /gene_synonym="Fxr1h"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1791
                     /gene="Fxr1"
                     /gene_synonym="Fxr1h"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..3299
                     /gene="Fxr1"
                     /gene_synonym="Fxr1h"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctttgcggtt ccaacatggc ggagctgacg gtggaggttc gcggctccaa cggggctttc
       61 tacaagggat ttatcaaaga tgtccacgaa gactccctca cagttgtttt tgaaaataat
      121 tggcaaccag aacgccaggt tccgtttaat gaagttcgat taccaccacc acctgatata
      181 aaaaaagaaa ttagtgaagg agatgaagta gaggtatatt caagagcaaa tgaccaagaa
      241 ccatgtggat ggtggctggc taaagttcgg atgatgaaag gcgagtttta tgtcattgaa
      301 tatgctgctt gtgatgccac ttacaatgaa atagtcacat ttgaacgact tcggcctgtc
      361 aatcaaaata aaactgtcaa aaaaaatacc ttctttaagt gcacagtgga tgttcctgag
      421 gatttgagag aagcgtgtgc taatgaaaat gcccataaag atttcaagaa agcagtagga
      481 gcgtgcagaa ttttctatca tcctgaaact acccagctaa tgatactgtc ggccagtgaa
      541 gcaactgtga agagagtaaa tatcttaagt gatatgcatt tgcgaagtat tcggacgaag
      601 ttgatgctta tgtccagaaa tgaagaggcc actaagcatt tagaatgcac aaaacagctt
      661 gcagcagctt ttcatgaaga atttgttgtg agagaagatc taatgggcct ggcaatagga
      721 acgcatggta gtaacataca gcaagctagg aaggtccctg gagttactgc cattgagtta
      781 gatgaagata ctggaacgtt tagaatctac ggagagagtg ctgaggctgt aaagaaagca
      841 agaggtttct tggaatttgt ggaagatttt attcaagttc ccaggaatct tgttggaaaa
      901 gttattggaa aaaatggcaa agttattcaa gaaatagtgg ataaatctgg tgtggttcga
      961 gtaagaattg aaggagacaa tgaaaataaa ctacctagag aagatggaat ggttccattt
     1021 gtatttgttg gcactaaaga aagtattgga aatgtgcaag ttcttctaga gtatcacatt
     1081 gcttacttaa aggaagtgga acaactaaga atggaacgcc tgcagatcga tgaacagctg
     1141 cgacagattg gttctaggtc ttatagtgga agaggcagag gtcgtcgggg ccctaattac
     1201 acctccggtt atggtacaaa ttctgagctg tctaacccct ccgaaacaga atctgagcgt
     1261 aaagatgagc tgagtgattg gtcattggca ggagaagatg atcgagagac tcgacatcag
     1321 cgagacagca ggagacgccc aggaggaaga ggcagaagtg tttctggggg acgaggtcgt
     1381 ggtggaccac gtggtggcaa atcctccatc agttctgtgc tcaaagatcc agacagcaat
     1441 ccatacagct tacttgataa tacagaatca gatcagactg cagacactga cgccagcgaa
     1501 tctcaccaca gtactaaccg tcgtaggcgg tctcgtagac gaaggactga tgaagatgct
     1561 gttctgatgg atggaatgac tgaatctgat acagcctcag ttaatgagaa tgggctagat
     1621 gatagtgaaa aaaaacccca gcgacgcaat cgtagccgca ggcgtcgttt caggggtcag
     1681 gcagaagata gacagccagt cacagttgca gattatattt ctagagctga gtctcagagc
     1741 agacaaagaa acctcccaag ggaaactttg gctaaaaaca agaaagaaat ggcaaaagat
     1801 gtgattgaag agcatggtcc atcagaaaag gcaataaatg gtccaactag cgcttctggc
     1861 gatgaaattc ctaagctacc gcgtactcca ggagaagaaa agactaaaac cttaaaagaa
     1921 gagagcactc aagaagcagc agtcctgaat ggtgtttcat aactgaagga agttcctagt
     1981 ttacagttct tttacattac agttacaata gtgcttgtac aagcttgcca aagatagaat
     2041 acggatcgcc agtcttacat cgcactttca gttcctccat ttggaattca gaaaggggag
     2101 ggatcctgac gaaatcatat gttaaacata ctttgacacc tactgtgtta aaaatatatc
     2161 atcagatgtg ccttgagaat agtatatgta acattaaaaa aaagttgctg gctataggaa
     2221 atgttatttt gttttcaaaa tatggcagag atggggggag gtgggtgggg tggggtccct
     2281 aacgtaatat tctttatgaa agcattagct gcttttgtta catttttaat aatatgcaac
     2341 cacttcttca cctgaggaaa actagaatga agcagtctaa aatattttgc actgaattgt
     2401 aatttcatta gtttagtctg gaaactggtc tgtttaatgt gttttttaaa tgctgtttgt
     2461 agaggcaatt ctgcagacca ctggaaatac atgttaactc atctgcaggg atactgggtg
     2521 atattggcag tgactgttct acattgaggc tttgtttggt ttatttatta aagtgtacag
     2581 tatttaaaaa tcaaacatag ctttagttga aacactaagc tgattagtca tgtccattca
     2641 gacatagcct gaactactga aaagatcaat ttccagaagg tttattctgt ataaactaca
     2701 tgtttagtct tcagtagagt atctttcaca ttttctttct accctttttt ttcctttttt
     2761 cccccccttt tttgattttg gttgtttgat gtgcaatatg tttttgtatg caggtagtaa
     2821 aataaacttt gatcttccat ttgctgattt ttaactttct actttttatg ccaattgttt
     2881 gaaagtagga gtacttgagg cctagaatag atagcattct tcgattgctt ttcagaagca
     2941 tttgtttctc agatctagtg ttaaaatcta accattttat catttgtaat ggaccctcca
     3001 aagttaacac ttaagttttg gctagtaaac gattcaggaa atgtataatg tctttgccat
     3061 tggagaaaca tctttgtatt aaattctaat caaaggcgat ttgtgggaga taatataatg
     3121 ggaggcagaa gataagcttt tcacttttgc ctttagttct ttattaaaaa ctatttttaa
     3181 agtatggtaa gcagttttta ataggccaat aatgtgcttt ttgagtgata aatcattttg
     3241 aaggttttcg taccagtgat tgaaaatgag taattaaaag tttaaagagc tttcattca
//
