LOCUS       NM_001415068            3386 bp    mRNA    linear   ROD 07-DEC-2024
DEFINITION  Rattus norvegicus FMR1 autosomal homolog 1 (Fxr1), transcript
            variant 1, mRNA.
ACCESSION   NM_001415068 XM_039102580
VERSION     NM_001415068.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3386)
  AUTHORS   Nie,P.Y., Ji,L.L., Fu,C.H., Peng,J.B., Wang,Z.Y. and Tong,L.
  TITLE     miR-132 Regulates PTSD-like Behaviors in Rats Following
            Single-Prolonged Stress Through Fragile X-Related Protein 1
  JOURNAL   Cell Mol Neurobiol 41 (2), 327-340 (2021)
   PUBMED   32333305
  REMARK    GeneRIF: miR-132 Regulates PTSD-like Behaviors in Rats Following
            Single-Prolonged Stress Through Fragile X-Related Protein 1.
REFERENCE   2  (bases 1 to 3386)
  AUTHORS   Sopova,J.V., Koshel,E.I., Belashova,T.A., Zadorsky,S.P.,
            Sergeeva,A.V., Siniukova,V.A., Shenfeld,A.A., Velizhanina,M.E.,
            Volkov,K.V., Nizhnikov,A.A., Kachkin,D.V., Gaginskaya,E.R. and
            Galkin,A.P.
  TITLE     RNA-binding protein FXR1 is presented in rat brain in amyloid form
  JOURNAL   Sci Rep 9 (1), 18983 (2019)
   PUBMED   31831836
  REMARK    GeneRIF: RNA-binding protein FXR1 is presented in rat brain in
            amyloid form.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3386)
  AUTHORS   Chu,M., Novak,S.M., Cover,C., Wang,A.A., Chinyere,I.R.,
            Juneman,E.B., Zarnescu,D.C., Wong,P.K. and Gregorio,C.C.
  TITLE     Increased Cardiac Arrhythmogenesis Associated With Gap Junction
            Remodeling With Upregulation of RNA-Binding Protein FXR1
  JOURNAL   Circulation 137 (6), 605-618 (2018)
   PUBMED   29101288
  REMARK    GeneRIF: In dilated cardiomyopathy, increased FXR1 expression
            appears to play an important role in disease progression by
            regulating gap junction remodeling and increasing cardiac
            arrhythmogenesis.
REFERENCE   4  (bases 1 to 3386)
  AUTHORS   Wang,G.X., Smith,S.J. and Mourrain,P.
  TITLE     Sub-synaptic, multiplexed analysis of proteins reveals Fragile X
            related protein 2 is mislocalized in Fmr1 KO synapses
  JOURNAL   Elife 5, e20560 (2016)
   PUBMED   27770568
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3386)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (bases 1 to 3386)
  AUTHORS   Plante,I., Davidovic,L., Ouellet,D.L., Gobeil,L.A., Tremblay,S.,
            Khandjian,E.W. and Provost,P.
  TITLE     Dicer-derived microRNAs are utilized by the fragile X mental
            retardation protein for assembly on target RNAs
  JOURNAL   J Biomed Biotechnol 2006 (4), 64347 (2006)
   PUBMED   17057366
REFERENCE   7  (bases 1 to 3386)
  AUTHORS   Garnon,J., Lachance,C., Di Marco,S., Hel,Z., Marion,D., Ruiz,M.C.,
            Newkirk,M.M., Khandjian,E.W. and Radzioch,D.
  TITLE     Fragile X-related protein FXR1P regulates proinflammatory cytokine
            tumor necrosis factor expression at the post-transcriptional level
  JOURNAL   J Biol Chem 280 (7), 5750-5763 (2005)
   PUBMED   15548538
REFERENCE   8  (bases 1 to 3386)
  AUTHORS   Mientjes,E.J., Willemsen,R., Kirkpatrick,L.L., Nieuwenhuizen,I.M.,
            Hoogeveen-Westerveld,M., Verweij,M., Reis,S., Bardoni,B.,
            Hoogeveen,A.T., Oostra,B.A. and Nelson,D.L.
  TITLE     Fxr1 knockout mice show a striated muscle phenotype: implications
            for Fxr1p function in vivo
  JOURNAL   Hum Mol Genet 13 (13), 1291-1302 (2004)
   PUBMED   15128702
REFERENCE   9  (bases 1 to 3386)
  AUTHORS   Dube,M., Huot,M.E. and Khandjian,E.W.
  TITLE     Muscle specific fragile X related protein 1 isoforms are
            sequestered in the nucleus of undifferentiated myoblast
  JOURNAL   BMC Genet 1, 4 (2000)
   PUBMED   11178106
REFERENCE   10 (bases 1 to 3386)
  AUTHORS   Zhang,Y., O'Connor,J.P., Siomi,M.C., Srinivasan,S., Dutra,A.,
            Nussbaum,R.L. and Dreyfuss,G.
  TITLE     The fragile X mental retardation syndrome protein interacts with
            novel homologs FXR1 and FXR2
  JOURNAL   EMBO J 14 (21), 5358-5366 (1995)
   PUBMED   7489725
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Dec 21, 2022 this sequence version replaced XM_039102580.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.7982.1,
                                           SRR26643289.6091.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                JAXUCZ010000002.1  118812479-118812544
            67-119              JAXUCZ010000002.1  118833454-118833506
            120-213             JAXUCZ010000002.1  118834996-118835089
            214-285             JAXUCZ010000002.1  118840448-118840519
            286-434             JAXUCZ010000002.1  118840844-118840992
            435-528             JAXUCZ010000002.1  118841381-118841474
            529-645             JAXUCZ010000002.1  118841978-118842094
            646-816             JAXUCZ010000002.1  118843466-118843636
            817-895             JAXUCZ010000002.1  118844342-118844420
            896-1005            JAXUCZ010000002.1  118848398-118848507
            1006-1092           JAXUCZ010000002.1  118851750-118851836
            1093-1300           JAXUCZ010000002.1  118853349-118853556
            1301-1504           JAXUCZ010000002.1  118857111-118857314
            1505-1705           JAXUCZ010000002.1  118859498-118859698
            1706-1786           JAXUCZ010000002.1  118860342-118860422
            1787-1878           JAXUCZ010000002.1  118863551-118863642
            1879-3386           JAXUCZ010000002.1  118864306-118865813
FEATURES             Location/Qualifiers
     source          1..3386
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q24"
     gene            1..3386
                     /gene="Fxr1"
                     /gene_synonym="Fxr1h"
                     /note="FMR1 autosomal homolog 1"
                     /db_xref="GeneID:361927"
                     /db_xref="RGD:1311733"
     exon            1..66
                     /gene="Fxr1"
                     /gene_synonym="Fxr1h"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..2049
                     /gene="Fxr1"
                     /gene_synonym="Fxr1h"
                     /note="isoform 1 is encoded by transcript variant 1;
                     rCG41429-like; RNA-binding protein FXR1"
                     /codon_start=1
                     /product="RNA-binding protein FXR1 isoform 1"
                     /protein_id="NP_001401997.1"
                     /db_xref="GeneID:361927"
                     /db_xref="RGD:1311733"
                     /translation="MAELTVEVRGSNGAFYKGFIKDVHEDSLTVVFENNWQPERQVPF
                     NEVRLPPPPDIKKEISEGDEVEVYSRANDQEPCGWWLAKVRMMKGEFYVIEYAACDAT
                     YNEIVTFERLRPVNQNKTVKKNTFFKCTVDVPEDLREACANENAHKDFKKAVGACRIF
                     YHPETTQLMILSASEATVKRVNILSDMHLRSIRTKLMLMSRNEEATKHLECTKQLAAA
                     FHEEFVVREDLMGLAIGTHGSNIQQARKVPGVTAIELDEDTGTFRIYGESAEAVKKAR
                     GFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVP
                     FVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGMGFRPSSTRGPEK
                     EKGYATDESTVSSVQGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSD
                     WSLAGEDDRETRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNPYSL
                     LDNTESDQTADTDASESHHSTNRRRRSRRRRTDEDAVLMDGMTESDTASVNENGLDDS
                     EKKPQRRNRSRRRRFRGQAEDRQPVTVADYISRAESQSRQRNLPRETLAKNKKEMAKD
                     VIEEHGPSEKAINGPTSASGDEIPKLPRTPGEEKTKTLKEESTQEAAVLNGVS"
     exon            67..119
                     /gene="Fxr1"
                     /gene_synonym="Fxr1h"
                     /inference="alignment:Splign:2.1.0"
     exon            120..213
                     /gene="Fxr1"
                     /gene_synonym="Fxr1h"
                     /inference="alignment:Splign:2.1.0"
     exon            214..285
                     /gene="Fxr1"
                     /gene_synonym="Fxr1h"
                     /inference="alignment:Splign:2.1.0"
     exon            286..434
                     /gene="Fxr1"
                     /gene_synonym="Fxr1h"
                     /inference="alignment:Splign:2.1.0"
     exon            435..528
                     /gene="Fxr1"
                     /gene_synonym="Fxr1h"
                     /inference="alignment:Splign:2.1.0"
     exon            529..645
                     /gene="Fxr1"
                     /gene_synonym="Fxr1h"
                     /inference="alignment:Splign:2.1.0"
     exon            646..816
                     /gene="Fxr1"
                     /gene_synonym="Fxr1h"
                     /inference="alignment:Splign:2.1.0"
     exon            817..895
                     /gene="Fxr1"
                     /gene_synonym="Fxr1h"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1005
                     /gene="Fxr1"
                     /gene_synonym="Fxr1h"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1092
                     /gene="Fxr1"
                     /gene_synonym="Fxr1h"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1300
                     /gene="Fxr1"
                     /gene_synonym="Fxr1h"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1504
                     /gene="Fxr1"
                     /gene_synonym="Fxr1h"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1705
                     /gene="Fxr1"
                     /gene_synonym="Fxr1h"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1786
                     /gene="Fxr1"
                     /gene_synonym="Fxr1h"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1878
                     /gene="Fxr1"
                     /gene_synonym="Fxr1h"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..3386
                     /gene="Fxr1"
                     /gene_synonym="Fxr1h"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctttgcggtt ccaacatggc ggagctgacg gtggaggttc gcggctccaa cggggctttc
       61 tacaagggat ttatcaaaga tgtccacgaa gactccctca cagttgtttt tgaaaataat
      121 tggcaaccag aacgccaggt tccgtttaat gaagttcgat taccaccacc acctgatata
      181 aaaaaagaaa ttagtgaagg agatgaagta gaggtatatt caagagcaaa tgaccaagaa
      241 ccatgtggat ggtggctggc taaagttcgg atgatgaaag gcgagtttta tgtcattgaa
      301 tatgctgctt gtgatgccac ttacaatgaa atagtcacat ttgaacgact tcggcctgtc
      361 aatcaaaata aaactgtcaa aaaaaatacc ttctttaagt gcacagtgga tgttcctgag
      421 gatttgagag aagcgtgtgc taatgaaaat gcccataaag atttcaagaa agcagtagga
      481 gcgtgcagaa ttttctatca tcctgaaact acccagctaa tgatactgtc ggccagtgaa
      541 gcaactgtga agagagtaaa tatcttaagt gatatgcatt tgcgaagtat tcggacgaag
      601 ttgatgctta tgtccagaaa tgaagaggcc actaagcatt tagaatgcac aaaacagctt
      661 gcagcagctt ttcatgaaga atttgttgtg agagaagatc taatgggcct ggcaatagga
      721 acgcatggta gtaacataca gcaagctagg aaggtccctg gagttactgc cattgagtta
      781 gatgaagata ctggaacgtt tagaatctac ggagagagtg ctgaggctgt aaagaaagca
      841 agaggtttct tggaatttgt ggaagatttt attcaagttc ccaggaatct tgttggaaaa
      901 gttattggaa aaaatggcaa agttattcaa gaaatagtgg ataaatctgg tgtggttcga
      961 gtaagaattg aaggagacaa tgaaaataaa ctacctagag aagatggaat ggttccattt
     1021 gtatttgttg gcactaaaga aagtattgga aatgtgcaag ttcttctaga gtatcacatt
     1081 gcttacttaa aggaagtgga acaactaaga atggaacgcc tgcagatcga tgaacagctg
     1141 cgacagattg gtatgggttt cagaccttct tccaccagag ggcctgaaaa agagaaagga
     1201 tatgccactg atgaaagtac cgtctcttct gtacaaggtt ctaggtctta tagtggaaga
     1261 ggcagaggtc gtcggggccc taattacacc tccggttatg gtacaaattc tgagctgtct
     1321 aacccctccg aaacagaatc tgagcgtaaa gatgagctga gtgattggtc attggcagga
     1381 gaagatgatc gagagactcg acatcagcga gacagcagga gacgcccagg aggaagaggc
     1441 agaagtgttt ctgggggacg aggtcgtggt ggaccacgtg gtggcaaatc ctccatcagt
     1501 tctgtgctca aagatccaga cagcaatcca tacagcttac ttgataatac agaatcagat
     1561 cagactgcag acactgacgc cagcgaatct caccacagta ctaaccgtcg taggcggtct
     1621 cgtagacgaa ggactgatga agatgctgtt ctgatggatg gaatgactga atctgataca
     1681 gcctcagtta atgagaatgg gctagatgat agtgaaaaaa aaccccagcg acgcaatcgt
     1741 agccgcaggc gtcgtttcag gggtcaggca gaagatagac agccagtcac agttgcagat
     1801 tatatttcta gagctgagtc tcagagcaga caaagaaacc tcccaaggga aactttggct
     1861 aaaaacaaga aagaaatggc aaaagatgtg attgaagagc atggtccatc agaaaaggca
     1921 ataaatggtc caactagcgc ttctggcgat gaaattccta agctaccgcg tactccagga
     1981 gaagaaaaga ctaaaacctt aaaagaagag agcactcaag aagcagcagt cctgaatggt
     2041 gtttcataac tgaaggaagt tcctagttta cagttctttt acattacagt tacaatagtg
     2101 cttgtacaag cttgccaaag atagaatacg gatcgccagt cttacatcgc actttcagtt
     2161 cctccatttg gaattcagaa aggggaggga tcctgacgaa atcatatgtt aaacatactt
     2221 tgacacctac tgtgttaaaa atatatcatc agatgtgcct tgagaatagt atatgtaaca
     2281 ttaaaaaaaa gttgctggct ataggaaatg ttattttgtt ttcaaaatat ggcagagatg
     2341 gggggaggtg ggtggggtgg ggtccctaac gtaatattct ttatgaaagc attagctgct
     2401 tttgttacat ttttaataat atgcaaccac ttcttcacct gaggaaaact agaatgaagc
     2461 agtctaaaat attttgcact gaattgtaat ttcattagtt tagtctggaa actggtctgt
     2521 ttaatgtgtt ttttaaatgc tgtttgtaga ggcaattctg cagaccactg gaaatacatg
     2581 ttaactcatc tgcagggata ctgggtgata ttggcagtga ctgttctaca ttgaggcttt
     2641 gtttggttta tttattaaag tgtacagtat ttaaaaatca aacatagctt tagttgaaac
     2701 actaagctga ttagtcatgt ccattcagac atagcctgaa ctactgaaaa gatcaatttc
     2761 cagaaggttt attctgtata aactacatgt ttagtcttca gtagagtatc tttcacattt
     2821 tctttctacc cttttttttc cttttttccc cccctttttt gattttggtt gtttgatgtg
     2881 caatatgttt ttgtatgcag gtagtaaaat aaactttgat cttccatttg ctgattttta
     2941 actttctact ttttatgcca attgtttgaa agtaggagta cttgaggcct agaatagata
     3001 gcattcttcg attgcttttc agaagcattt gtttctcaga tctagtgtta aaatctaacc
     3061 attttatcat ttgtaatgga ccctccaaag ttaacactta agttttggct agtaaacgat
     3121 tcaggaaatg tataatgtct ttgccattgg agaaacatct ttgtattaaa ttctaatcaa
     3181 aggcgatttg tgggagataa tataatggga ggcagaagat aagcttttca cttttgcctt
     3241 tagttcttta ttaaaaacta tttttaaagt atggtaagca gtttttaata ggccaataat
     3301 gtgctttttg agtgataaat cattttgaag gttttcgtac cagtgattga aaatgagtaa
     3361 ttaaaagttt aaagagcttt cattca
//
