LOCUS       NM_001399381            1646 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus fuzzy planar cell polarity protein (Fuz),
            transcript variant 1, mRNA.
ACCESSION   NM_001399381 XM_006229059
VERSION     NM_001399381.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1646)
  AUTHORS   Tabler,J.M., Rigney,M.M., Berman,G.J., Gopalakrishnan,S., Heude,E.,
            Al-Lami,H.A., Yannakoudakis,B.Z., Fitch,R.D., Carter,C., Vokes,S.,
            Liu,K.J., Tajbakhsh,S., Egnor,S.R. and Wallingford,J.B.
  TITLE     Cilia-mediated Hedgehog signaling controls form and function in the
            mammalian larynx
  JOURNAL   Elife 6, e19153 (2017)
   PUBMED   28177282
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1646)
  AUTHORS   Tabler,J.M., Rice,C.P., Liu,K.J. and Wallingford,J.B.
  TITLE     A novel ciliopathic skull defect arising from excess neural crest
  JOURNAL   Dev Biol 417 (1), 4-10 (2016)
   PUBMED   27395007
REFERENCE   3  (bases 1 to 1646)
  AUTHORS   Toriyama,M., Lee,C., Taylor,S.P., Duran,I., Cohn,D.H., Bruel,A.L.,
            Tabler,J.M., Drew,K., Kelly,M.R., Kim,S., Park,T.J., Braun,D.A.,
            Pierquin,G., Biver,A., Wagner,K., Malfroot,A., Panigrahi,I.,
            Franco,B., Al-Lami,H.A., Yeung,Y., Choi,Y.J., Duffourd,Y.,
            Faivre,L., Riviere,J.B., Chen,J., Liu,K.J., Marcotte,E.M.,
            Hildebrandt,F., Thauvin-Robinet,C., Krakow,D., Jackson,P.K. and
            Wallingford,J.B.
  CONSRTM   University of Washington Center for Mendelian Genomics
  TITLE     The ciliopathy-associated CPLANE proteins direct basal body
            recruitment of intraflagellar transport machinery
  JOURNAL   Nat Genet 48 (6), 648-656 (2016)
   PUBMED   27158779
  REMARK    Erratum:[Nat Genet. 2016 Jul 27;48(8):970. doi:
            10.1038/ng0816-970b.. PMID: 27463398]
REFERENCE   4  (bases 1 to 1646)
  AUTHORS   Li,Y., Klena,N.T., Gabriel,G.C., Liu,X., Kim,A.J., Lemke,K.,
            Chen,Y., Chatterjee,B., Devine,W., Damerla,R.R., Chang,C., Yagi,H.,
            San Agustin,J.T., Thahir,M., Anderton,S., Lawhead,C., Vescovi,A.,
            Pratt,H., Morgan,J., Haynes,L., Smith,C.L., Eppig,J.T.,
            Reinholdt,L., Francis,R., Leatherbury,L., Ganapathiraju,M.K.,
            Tobita,K., Pazour,G.J. and Lo,C.W.
  TITLE     Global genetic analysis in mice unveils central role for cilia in
            congenital heart disease
  JOURNAL   Nature 521 (7553), 520-524 (2015)
   PUBMED   25807483
REFERENCE   5  (bases 1 to 1646)
  AUTHORS   Tabler,J.M., Barrell,W.B., Szabo-Rogers,H.L., Healy,C., Yeung,Y.,
            Perdiguero,E.G., Schulz,C., Yannakoudakis,B.Z., Mesbahi,A.,
            Wlodarczyk,B., Geissmann,F., Finnell,R.H., Wallingford,J.B. and
            Liu,K.J.
  TITLE     Fuz mutant mice reveal shared mechanisms between ciliopathies and
            FGF-related syndromes
  JOURNAL   Dev Cell 25 (6), 623-635 (2013)
   PUBMED   23806618
REFERENCE   6  (bases 1 to 1646)
  AUTHORS   Heydeck,W. and Liu,A.
  TITLE     PCP effector proteins inturned and fuzzy play nonredundant roles in
            the patterning but not convergent extension of mammalian neural
            tube
  JOURNAL   Dev Dyn 240 (8), 1938-1948 (2011)
   PUBMED   21761479
REFERENCE   7  (bases 1 to 1646)
  AUTHORS   Dai,D., Zhu,H., Wlodarczyk,B., Zhang,L., Li,L., Li,A.G.,
            Finnell,R.H., Roop,D.R. and Chen,J.
  TITLE     Fuz controls the morphogenesis and differentiation of hair
            follicles through the formation of primary cilia
  JOURNAL   J Invest Dermatol 131 (2), 302-310 (2011)
   PUBMED   20962855
REFERENCE   8  (bases 1 to 1646)
  AUTHORS   Heydeck,W., Zeng,H. and Liu,A.
  TITLE     Planar cell polarity effector gene Fuzzy regulates cilia formation
            and Hedgehog signal transduction in mouse
  JOURNAL   Dev Dyn 238 (12), 3035-3042 (2009)
   PUBMED   19877275
REFERENCE   9  (bases 1 to 1646)
  AUTHORS   Gray,R.S., Abitua,P.B., Wlodarczyk,B.J., Szabo-Rogers,H.L.,
            Blanchard,O., Lee,I., Weiss,G.S., Liu,K.J., Marcotte,E.M.,
            Wallingford,J.B. and Finnell,R.H.
  TITLE     The planar cell polarity effector Fuz is essential for targeted
            membrane trafficking, ciliogenesis and mouse embryonic development
  JOURNAL   Nat Cell Biol 11 (10), 1225-1232 (2009)
   PUBMED   19767740
REFERENCE   10 (bases 1 to 1646)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jan 7, 2022 this sequence version replaced XM_006229059.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ228777.1, SRR26643290.1918.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-248               JAXUCZ010000001.1  104516076-104516323
            249-370             JAXUCZ010000001.1  104516540-104516661
            371-455             JAXUCZ010000001.1  104516853-104516937
            456-524             JAXUCZ010000001.1  104517198-104517266
            525-629             JAXUCZ010000001.1  104517467-104517571
            630-827             JAXUCZ010000001.1  104518810-104519007
            828-923             JAXUCZ010000001.1  104519082-104519177
            924-1030            JAXUCZ010000001.1  104519319-104519425
            1031-1095           JAXUCZ010000001.1  104519506-104519570
            1096-1170           JAXUCZ010000001.1  104519644-104519718
            1171-1646           JAXUCZ010000001.1  104520543-104521018
FEATURES             Location/Qualifiers
     source          1..1646
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1646
                     /gene="Fuz"
                     /gene_synonym="RGD1310608"
                     /note="fuzzy planar cell polarity protein"
                     /db_xref="GeneID:308577"
                     /db_xref="RGD:1310608"
     exon            1..248
                     /gene="Fuz"
                     /gene_synonym="RGD1310608"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..1385
                     /gene="Fuz"
                     /gene_synonym="RGD1310608"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein fuzzy homolog"
                     /codon_start=1
                     /product="protein fuzzy homolog isoform 1"
                     /protein_id="NP_001386310.1"
                     /db_xref="GeneID:308577"
                     /db_xref="RGD:1310608"
                     /translation="MGDDGPGSTVHLLCLAASSGVPLFCRSSSGGAPSRQQLPFSVIG
                     SLNGVHMFGQNLDVQLNSARTEDTTVVWKNFHDSITLIALSSEEGTSELKLERMLHMV
                     FGAMVLIVGLEELTNIRNVERLKKELRASYCLIDSFLGNSELIGDLTQCVDCVIPPEG
                     SVMQETLSGFAEATGTAFVSLLVSGRVVAATDGWWRLGMPEAVLLPWLVGSLPPQAAR
                     DYPVYLPHGSPTVPHRLLTLTLLRGLELCLLCGPRPPLGELDPQLLERWWQPLLEPLR
                     ACLPLGPRALPDGFPLHSDILGLLLLHLELRRCLFTVEPSKDKEPSPEQRRRLLRNFY
                     TLVATTHFPPEPGPAEKQEDTVHPAQTPRACYLVLGPGMGWQLVAVQLGLRLLLLMLS
                     PQTPTHGLRSLATHTLQALTPLL"
     exon            249..370
                     /gene="Fuz"
                     /gene_synonym="RGD1310608"
                     /inference="alignment:Splign:2.1.0"
     exon            371..455
                     /gene="Fuz"
                     /gene_synonym="RGD1310608"
                     /inference="alignment:Splign:2.1.0"
     exon            456..524
                     /gene="Fuz"
                     /gene_synonym="RGD1310608"
                     /inference="alignment:Splign:2.1.0"
     exon            525..629
                     /gene="Fuz"
                     /gene_synonym="RGD1310608"
                     /inference="alignment:Splign:2.1.0"
     exon            630..827
                     /gene="Fuz"
                     /gene_synonym="RGD1310608"
                     /inference="alignment:Splign:2.1.0"
     exon            828..923
                     /gene="Fuz"
                     /gene_synonym="RGD1310608"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1030
                     /gene="Fuz"
                     /gene_synonym="RGD1310608"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1095
                     /gene="Fuz"
                     /gene_synonym="RGD1310608"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1170
                     /gene="Fuz"
                     /gene_synonym="RGD1310608"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1646
                     /gene="Fuz"
                     /gene_synonym="RGD1310608"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttggagggg ctgaattgat gatcccgctt ctcgcccttt ggcggctcca aacagcaggc
       61 cactttgcct acccgcatgc tcccagatcc acaccgagag tctccagggg cgtgactttc
      121 cgggtgcggg cttcgagatg ggggatgacg ggccaggaag cacggtgcat ctgctgtgcc
      181 tcgcagcctc tagcggggtt cccctgttct gtcggagcag cagcggaggc gccccctccc
      241 gtcaacagct ccctttttct gtcatcgggt ccctcaatgg agtccacatg ttcggccaga
      301 atctggatgt gcaactgaac tccgcaagaa cagaagacac caccgtagtg tggaagaact
      361 tccatgacag catcaccctc attgctctgt catctgagga gggcacctct gagctgaagc
      421 tggaaagaat gctccacatg gtgtttgggg ccatggttct cattgtggga cttgaggagc
      481 tgaccaatat ccggaatgta gagagactga agaaagagct gagggccagc tactgtctca
      541 ttgacagctt cctggggaat tcagagctca tcggggacct gacccagtgt gtggactgtg
      601 tcattcctcc agaggggtct gtcatgcagg aaaccctctc agggttcgca gaggccactg
      661 gcacagcctt tgtcagcctg ctggtatcag gccgggtggt ggcagcgacc gatggctggt
      721 ggcgcctagg catgcctgaa gccgtgctac tcccttggct ggtggggtcc ttgccaccgc
      781 aagctgctcg tgactaccca gtgtacctgc cccacgggag ccccacggtc ccccatcggt
      841 tgttgacctt gactctgctg cggggcctgg agctgtgtct gctctgcggg ccgcgcccgc
      901 ccctcggtga gctggaccca cagttgctgg aacgctggtg gcagcctctg ctggagcccc
      961 tccgggcttg cctgccactg ggccctaggg cgctccctga cgggttcccg ctacacagcg
     1021 atattcttgg cctgttgtta ctccacttgg aactgagacg ctgcctcttt accgtggagc
     1081 cctcaaagga taaagagcct tcccctgagc aacgcaggcg cctccttaga aatttctata
     1141 cgttggtggc caccacccac ttcccaccag aaccggggcc agcagagaaa caagaagata
     1201 cagtccaccc agcccagaca cccagggcct gctatcttgt gctagggcca ggcatggggt
     1261 ggcagctggt ggctgtgcag ctagggctac ggctgctgct gttgatgctg tccccgcaga
     1321 ctcccaccca tgggctgaga agcctggcca cccacactct acaagccctc accccgctcc
     1381 tttgatcact tagggtgggc agtcaataga tgggggtaat attagcgtct ctctgtttat
     1441 tcgctcacaa taatacacgg cccctggacg gggagaggga gggagggagg agggtgaaaa
     1501 ggagggaggg ggaggggagg aggtacctac ttccccggcc cccctcccct ctgtgcttcg
     1561 ggggacaagg aagggagggt gcttcccttg accccccaga atgtaaacag cagcagatga
     1621 acaaaaataa aatacaaagg ccagag
//
